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Article ; Online: Sustained large-amplitude chemomechanical oscillations induced by the Landolt clock reaction.

Horváth, Judit

The journal of physical chemistry. B

2014 Volume 118, Issue 29, Page(s) 8891–8900

Abstract: Synergetic chemomechanical oscillators represent a fundamentally new class of oscillators, where a clock reaction, owning no oscillatory chemical kinetics, generates shrinking-swelling cycles in a chemoresponsive gel under appropriate fixed ... ...

Abstract	Synergetic chemomechanical oscillators represent a fundamentally new class of oscillators, where a clock reaction, owning no oscillatory chemical kinetics, generates shrinking-swelling cycles in a chemoresponsive gel under appropriate fixed nonequilibrium boundary conditions. Sufficiently large size-changes are a condition for continually switching between a reacted and an unreacted chemical state in the gel through sufficiently large differences in the diffusion time between the environment and the core of the gel. Two former experimental demonstrations with acid autocatalytic reactions were frustrated either by complex behaviors (chlorite-tetrathionate system) or by side reactions with the gel matrix (bromate-sulfite system). With the Landolt (iodate-sulfite) reaction, regular large-amplitude chemomechanical oscillations can be sustained for more than a week. This enabled a fine study of the temperature and stoichiometry range of operation. I have identified several key steps that are experimentally essential to the systematic design of further synergetic oscillators. The robust realization of this type of self-organization in artificial systems is currently unique.
MeSH term(s)	Carboxylic Acids/chemistry ; Diffusion ; Hydrogels/chemistry ; Hydrogen-Ion Concentration ; Kinetics ; Mechanical Phenomena ; Temperature
Chemical Substances	Carboxylic Acids ; Hydrogels
Language	English
Publishing date	2014-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/jp5050964
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Article ; Online: Effectiveness of hospital-based low intensity and inspected aerobic training on functionality and cardiorespiratory fitness in unconditioned stroke patients: Importance of submaximal aerobic fitness markers.

Horváth, Judit / Debreceni Nagy, Adél / Fülöp, Péter / Jenei, Zoltán

Medicine

2022 Volume 101, Issue 42, Page(s) e31035

Abstract: Introduction: The purpose of our study was to evaluate the effectiveness of low-to moderate intensity aerobic training on cardiorespiratory functions in chronic unconditioned stroke patients. The oxygen uptake efficiency slope (OUES) and the ventilatory ...

Abstract	Introduction: The purpose of our study was to evaluate the effectiveness of low-to moderate intensity aerobic training on cardiorespiratory functions in chronic unconditioned stroke patients. The oxygen uptake efficiency slope (OUES) and the ventilatory threshold (VO2-VT) could represent the aerobic capacity in submaximal test. Our study examined the application of the submaximal parameters for evaluating aerobic capacity of chronic stroke patients. Materials and methods: In our assessor-blinded controlled pilot study 37 patients were randomized into 2 groups named: intervention group (IG, n: 21) and control group (CG, n:16), respectively. Cardiorespiratory functions were evaluated by ergospirometer before and after the 4-week (20 days) program. Both groups participated in daily occupational therapy (30 minutes) and conventional, customized physiotherapy CG (60 minutes), IG (30 minutes). Only IG performed aerobic training by bicycles (30 minutes) aiming to reach low-to moderate training intensity. Outcome measures included peak oxygen uptake (VO2 peak), OUES, VO2-VT, functional exercise capacity 6-Minute Walking Test (6MWT) and Functional Independence Measure. Results: Thirty-five subjects completed the study. The VO2 peak uptake was very low in both groups (IG: 11.9 mL/kg/min, CG: 12.45 mL/kg/min) and did not improve after the program, but submaximal parameters such as VO2-VT (P < .01) and OUES (P < .001) have shown significant improvement, but only in IG regardless of insufficient impact on VO2 peak. Each participant in both groups was unable to permanently reach the moderate intensity zone. Functional Independence Measure changed for the better in both groups, but 6MWT only in the IG. Discussion and conclusions: Four-week exercise training even at low intensity by lower limb cycle ergometer may provide benefit on aerobic and functional capacity without improvement of VO2 peak on unconditioned chronic stroke patients.
MeSH term(s)	Humans ; Cardiorespiratory Fitness ; Oxygen Consumption ; Exercise ; Stroke ; Oxygen ; Hospitals
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031035
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Ua VI Zs.171: Show issues

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Book ; Online: Educating Young Children through Natural Water

Horvath, Judit

How to use coastlines, rivers and lakes to promote learning and development

2015

Language	English
Size	Online-Ressource (148 p)
Publisher	Taylor and Francis
Publishing place	s.l
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780415728904 ; 0415728908
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: In-vitro characterization of ranibizumab release from the Port Delivery System

Yohe, Stefan / Maass, Katie F. / Horvath, Judit / Rea, Jennifer / Barteselli, Giulio / Ranade, Shrirang V.

Journal of controlled release. 2022 May, v. 345

2022

Abstract: The Port Delivery System with ranibizumab (PDS) consists of an implant that is a permanent, indwelling drug delivery device that can be refilled through a self-sealing septum and is designed to continuously release a customized formulation of ranibizumab ...

Abstract	The Port Delivery System with ranibizumab (PDS) consists of an implant that is a permanent, indwelling drug delivery device that can be refilled through a self-sealing septum and is designed to continuously release a customized formulation of ranibizumab into the vitreous by passive diffusion through a porous titanium release control element. Target release rates of ranibizumab via the implant used in studies of the PDS in patients with neovascular age-related macular degeneration were selected based on clinical and pharmacokinetic (PK) data from previously conducted intravitreal ranibizumab injection studies. In-vitro testing was performed to verify release rates with a range of ranibizumab concentrations before the phase II Ladder (NCT02510794) and phase III Archway (NCT03677934) trials of the PDS. Implants were filled with ranibizumab and were regularly transferred to new buffer-containing tubes to represent ocular ranibizumab clearance and release kinetics. Ranibizumab concentrations were measured and release rates calculated. Release rate data were fit to an exponential model and compared with expected release kinetics of diffusion. Release profiles of the implant releasing ranibizumab at concentrations of 10 mg/mL, 40 mg/mL, and 100 mg/mL were determined in the pre–phase II in-vitro studies. At day 3.5, mean (SD) ranibizumab release rates were 1.75 (0.07), 6.42 (0.35), and 16.69 (0.67) μg/d for PDS 10 mg/mL, 40 mg/mL, and 100 mg/mL, respectively. At month 6, mean (SD) release rates were 1.68 (0.05) and 4.16 (0.05) μg/d for PDS 40 mg/mL and 100 mg/mL, respectively. Measured release rates were within 90% of theoretical release rates during the course of drug release. PDS 100 mg/mL released 73% (SD, 1.92) of drug by month 6. In the pre–phase III in-vitro studies, mean (SD) release rates with PDS 100 mg/mL were 17.97 (0.90), 4.44 (0.11), and 2.45 (0.08) μg/d at 3.5 days, 6 months, and 9 months, respectively. Cumulative release (SD) was 73% (1.92) by month 6 and 87% (1.88) by month 9. The sustained, continuous, and reproducible release from the PDS observed in the in-vitro studies was also observed in Ladder and Archway. In conclusion, in-vitro studies were a powerful tool for characterizing and verifying ranibizumab release from the PDS implant and supported clinical evaluation of the PDS. PDS 100 mg/mL, which was associated with the longest therapeutic-level delivery of ranibizumab among the concentrations tested, was selected for evaluation in the pivotal phase III Archway trial.
Keywords	clinical examination ; drugs ; macular degeneration ; models ; pharmacokinetics ; titanium
Language	English
Dates of publication	2022-05
Size	p. 101-107.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.03.005
Database	NAL-Catalogue (AGRICOLA)

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Article: Aspects génétiques des mouvements anormaux de l’âge adulte.

Horvath, Judit / Ranza, Emmanuelle

Revue medicale suisse

2018 Volume 14, Issue 604, Page(s) 879–882

Abstract: Movement disorders of monogenic origin are rare. In case of a specific phenotype, classical targeted sequencing of the gene can be used. When the clinical picture is not well defined, or when there is genetic heterogeneity or a large differential ... ...

Title translation	Genetic aspects of movement disorders of adulthood.
Abstract	Movement disorders of monogenic origin are rare. In case of a specific phenotype, classical targeted sequencing of the gene can be used. When the clinical picture is not well defined, or when there is genetic heterogeneity or a large differential diagnosis, high-throughput sequencing is a useful tool for the analysis of numerous genes simultaneously. To discuss which approach is optimal, a multidisciplinary consultation by a movement disorders specialist and a geneticist is recommended. For some genetic movement disorders there is specific treatment available. The most common movement disorders, such as Parkinson's disease and essential tremor, have probably a complex etiology, including polygenic and environmental factors. Less than 5 % of Parkinsonian patients have a monogenic, hereditary form of the disease.
Language	French
Publishing date	2018-04-25
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Zs.A 5998: Show issues

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Article: Real-Time Monitoring of the Effectiveness of Six COVID-19 Vaccines against Laboratory-Confirmed COVID-19 in Hungary in 2021 Using the Screening Method.

Horváth, Judit K / Ferenci, Tamás / Ferenczi, Annamária / Túri, Gergő / Röst, Gergely / Oroszi, Beatrix

Vaccines

2022 Volume 10, Issue 11

Abstract: Several studies have reported the waning effectiveness of COVID-19 vaccines. This study aims to demonstrate the applicability of the screening method for estimating vaccine effectiveness (VE) in a pandemic. We report VE in Hungary, estimated with the ... ...

Abstract	Several studies have reported the waning effectiveness of COVID-19 vaccines. This study aims to demonstrate the applicability of the screening method for estimating vaccine effectiveness (VE) in a pandemic. We report VE in Hungary, estimated with the screening method, in 2021, covering a period of Alpha and the Delta variant, including the booster dose roll-out. Hungary is in a unique position to use six different vaccines in the same population. All vaccines provided a high level of protection initially, which declined over time. While the picture is different in each age group, the waning of immunity is apparent for all vaccines, especially in the younger age groups and the Sinopharm, Sputnik-V, and AstraZeneca vaccines, which performed similarly. This is clearly reversed by booster doses, more prominent for those three vaccines, where the decline in protection is more evident. Overall, two vaccines, Pfizer/BioNTech and Moderna, tend to produce the best results in all age groups, even with waning immunity considered. Using the screening method in future pandemic waves is worthwhile, especially in countries struggling with a lack of resources or when there is a need to deliver VE results within a short timeframe due to urgent decision-making.
Language	English
Publishing date	2022-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10111824
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Article ; Online: In-vitro characterization of ranibizumab release from the Port Delivery System.

Yohe, Stefan / Maass, Katie F / Horvath, Judit / Rea, Jennifer / Barteselli, Giulio / Ranade, Shrirang V

Journal of controlled release : official journal of the Controlled Release Society

2022 Volume 345, Page(s) 101–107

Abstract	The Port Delivery System with ranibizumab (PDS) consists of an implant that is a permanent, indwelling drug delivery device that can be refilled through a self-sealing septum and is designed to continuously release a customized formulation of ranibizumab into the vitreous by passive diffusion through a porous titanium release control element. Target release rates of ranibizumab via the implant used in studies of the PDS in patients with neovascular age-related macular degeneration were selected based on clinical and pharmacokinetic (PK) data from previously conducted intravitreal ranibizumab injection studies. In-vitro testing was performed to verify release rates with a range of ranibizumab concentrations before the phase II Ladder (NCT02510794) and phase III Archway (NCT03677934) trials of the PDS. Implants were filled with ranibizumab and were regularly transferred to new buffer-containing tubes to represent ocular ranibizumab clearance and release kinetics. Ranibizumab concentrations were measured and release rates calculated. Release rate data were fit to an exponential model and compared with expected release kinetics of diffusion. Release profiles of the implant releasing ranibizumab at concentrations of 10 mg/mL, 40 mg/mL, and 100 mg/mL were determined in the pre-phase II in-vitro studies. At day 3.5, mean (SD) ranibizumab release rates were 1.75 (0.07), 6.42 (0.35), and 16.69 (0.67) μg/d for PDS 10 mg/mL, 40 mg/mL, and 100 mg/mL, respectively. At month 6, mean (SD) release rates were 1.68 (0.05) and 4.16 (0.05) μg/d for PDS 40 mg/mL and 100 mg/mL, respectively. Measured release rates were within 90% of theoretical release rates during the course of drug release. PDS 100 mg/mL released 73% (SD, 1.92) of drug by month 6. In the pre-phase III in-vitro studies, mean (SD) release rates with PDS 100 mg/mL were 17.97 (0.90), 4.44 (0.11), and 2.45 (0.08) μg/d at 3.5 days, 6 months, and 9 months, respectively. Cumulative release (SD) was 73% (1.92) by month 6 and 87% (1.88) by month 9. The sustained, continuous, and reproducible release from the PDS observed in the in-vitro studies was also observed in Ladder and Archway. In conclusion, in-vitro studies were a powerful tool for characterizing and verifying ranibizumab release from the PDS implant and supported clinical evaluation of the PDS. PDS 100 mg/mL, which was associated with the longest therapeutic-level delivery of ranibizumab among the concentrations tested, was selected for evaluation in the pivotal phase III Archway trial.
MeSH term(s)	Angiogenesis Inhibitors ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Drug Delivery Systems ; Drug Liberation ; Humans ; Intravitreal Injections ; Ranibizumab ; Treatment Outcome
Chemical Substances	Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2022-03-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.03.005
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Article ; Online: Stability of ranibizumab during continuous delivery from the Port Delivery Platform.

Hieb, Aaron R / Horvath, Judit / Rea, Jennifer / Tam, Tammy / Chang, Debby P / de Jong, Isabella / Zheng, Kai / Yohe, Stefan T / Ranade, Shrirang V

Journal of controlled release : official journal of the Controlled Release Society

2024 Volume 366, Page(s) 170–181

Abstract: The Port Delivery System with ranibizumab (PDS) is an innovative intraocular drug delivery system that has the potential to reduce treatment burden in patients with retinovascular diseases. The Port Delivery Platform (PD-P) implant is a permanent, ... ...

Abstract	The Port Delivery System with ranibizumab (PDS) is an innovative intraocular drug delivery system that has the potential to reduce treatment burden in patients with retinovascular diseases. The Port Delivery Platform (PD-P) implant is a permanent, indwelling device that can be refilled in situ through a self-sealing septum and is designed to continuously deliver ranibizumab by passive diffusion through a porous titanium release control element. We present results for the studies carried out to characterize the stability of ranibizumab for use with the PD-P. Simulated administration, in vitro release studies, and modeling studies were performed to evaluate the compatibility of ranibizumab with the PD-P administration components, and degradation and photostability in the implant. Simulated administration studies demonstrated that ranibizumab was highly compatible with the PD-P administration components (initial fill and refill needles) and commercially available administration components (syringe, transfer needle, syringe closure). Subsequent simulated in vitro release studies examining continuous delivery for up to 12 months in phosphate buffered saline, a surrogate for human vitreous, showed that the primary degradation products of ranibizumab were acidic variants. The presence of these variants increased over time and potency remained high. The stability attributes of ranibizumab were consistent across multiple implant refill-exchanges. Despite some degradation within the implant, the absolute mass of variants released daily from the implant was low due to the continuous release mechanism of the implant. Simulated light exposure within the implant resulted in small increases in the relative amount of ranibizumab degradants compared with those seen over 6 months.
MeSH term(s)	Humans ; Ranibizumab ; Drug Delivery Systems ; Diffusion ; Needles ; Porosity
Chemical Substances	Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2024-01-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.12.027
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Article: Unequal burden of COVID-19 in Hungary: a geographical and socioeconomic analysis of the second wave of the pandemic.

Oroszi, Beatrix / Juhász, Attila / Nagy, Csilla / Horváth, Judit Krisztina / McKee, Martin / Ádány, Róza

BMJ global health

2021 Volume 6, Issue 9

Abstract: Introduction: We describe COVID-19 morbidity, mortality, case fatality and excess death in a country-wide study of municipalities in Hungary, exploring the association with socioeconomic status.: Methods: The spatial distribution of morbidity, ... ...

Abstract	Introduction: We describe COVID-19 morbidity, mortality, case fatality and excess death in a country-wide study of municipalities in Hungary, exploring the association with socioeconomic status. Methods: The spatial distribution of morbidity, mortality and case fatality was mapped using hierarchical Bayesian smoothed indirectly standardised ratios. Indirectly standardised ratios were used to evaluate the association between deprivation and the outcome measures. We looked separately at morbidity and mortality in the 10 districts with the highest and 10 districts with the lowest share of Roma population. Results: Compared with the national average, the relative incidence of cases was 30%-36% lower in the most deprived quintile but the relative mortality and case fatality were 27%-32% higher. Expressed as incidence ratios relative to the national average, the most deprived municipalities had a relative incidence ratio of 0.64 (CI: 0.62 to 0.65) and 0.70 (CI: 0.69 to 0.72) for males and females, respectively. The corresponding figures for mortality were 1.32 (CI: 1.20 to 1.44) for males and 1.27 (CI: 1.16 to 1.39) for females and for case fatality 1.27 (CI: 1.16 to 1.39) and 1.32 (CI: 1.20 to 1.44) for males and females, respectively. The excess death rate (per 100 000) increased with deprivation levels (least deprived: 114.12 (CI: 108.60 to 119.84) and most deprived: 158.07 (CI: 149.30 to 167.23)). The 10 districts where Roma formed the greatest share of the population had an excess mortality rate 17.46% higher than the average for the most deprived quintile. Conclusions: Those living in more deprived municipalities had a lower risk of being identified as a confirmed COVID-19 case but had a higher risk of death. An inverse association between trends in morbidity and mortality by socioeconomic conditions should be a cause for concern and points to the need for responses, including those involving vaccination, to pay particular attention to inequalities and their causes.
MeSH term(s)	Bayes Theorem ; COVID-19 ; Female ; Humans ; Hungary/epidemiology ; Male ; Pandemics ; Risk Factors ; SARS-CoV-2 ; Socioeconomic Factors
Language	English
Publishing date	2021-09-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2021-006427
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Article ; Online: Presence Hallucinations during Locomotion in Patients with Parkinson's Disease.

Potheegadoo, Jevita / Dhanis, Herberto / Horvath, Judit / Burkhard, Pierre R / Blanke, Olaf

Movement disorders clinical practice

2021 Volume 9, Issue 1, Page(s) 127–129

Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.13367
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