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  1. Article: A Nationwide Evaluation of the Prevalence of Human Papillomavirus in Brazil (POP-Brazil Study): Protocol for Data Quality Assurance and Control.

    Horvath, Jaqueline Driemeyer Correia / Bessel, Marina / Kops, Natália Luiza / Souza, Flávia Moreno Alves / Pereira, Gerson Mendes / Wendland, Eliana Marcia

    JMIR research protocols

    2022  Volume 11, Issue 1, Page(s) e31365

    Abstract: Background: The credibility of a study and its internal and external validity depend crucially on the quality of the data produced. An in-depth knowledge of quality control processes is essential as large and integrative epidemiological studies are ... ...

    Abstract Background: The credibility of a study and its internal and external validity depend crucially on the quality of the data produced. An in-depth knowledge of quality control processes is essential as large and integrative epidemiological studies are increasingly prioritized.
    Objective: This study aimed to describe the stages of quality control in the POP-Brazil study and to present an analysis of the quality indicators.
    Methods: Quality assurance and control were initiated with the planning of this nationwide, multicentric study and continued through the development of the project. All quality control protocol strategies, such as training, protocol implementation, audits, and inspection, were discussed one by one. We highlight the importance of conducting a pilot study that provides the researcher the opportunity to refine or modify the research methodology and validating the results through double data entry, test-retest, and analysis of nonresponse rates.
    Results: This cross-sectional, nationwide, multicentric study recruited 8628 sexually active young adults (16-25 years old) in 119 public health units between September 2016 and November 2017. The Human Research Ethics Committee of the Moinhos de Vento Hospital approved this project.
    Conclusions: Quality control processes are a continuum, not restricted to a single event, and are fundamental to the success of data integrity and the minimization of bias in epidemiological studies. The quality control steps described can be used as a guide to implement evidence-based, valid, reliable, and useful procedures in most observational studies to ensure data integrity.
    International registered report identifier (irrid): RR1-10.2196/31365.
    Language English
    Publishing date 2022-01-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/31365
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  2. Article ; Online: Perception of Primary Health Care professionals as participants in a national survey about HPV in Brazil: an experience report.

    Hohenberger, Glaucia Fragoso / Kops, Natália Luiza / Bessel, Marina / Horvath, Jaqueline Driemeyer / Wendland, Eliana Marcia

    Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

    2019  Volume 28, Issue 3, Page(s) e2018234

    Abstract: Objective: to describe the perception of data collection performed by primary health care professionals as collaborators of the national POP-Brasil survey - Epidemiological Study of National Prevalence of HPV Infection.: Methods: in all, 217 ... ...

    Title translation Percepção dos profissionais da Atenção Primária à Saúde como participantes de uma pesquisa nacional sobre HPV: um relato de experiência.
    Abstract Objective: to describe the perception of data collection performed by primary health care professionals as collaborators of the national POP-Brasil survey - Epidemiological Study of National Prevalence of HPV Infection.
    Methods: in all, 217 professionals from 119 primary care units participated in the POP-Brasil Study conducted in the 26 Brazilian capitals and the Federal District.
    Results: the professionals were trained and certified locally for collecting data and biological material from 8,580 participants; participation in the study allowed professionals to recognize the importance of their work.
    Conclusion: the successful experience confirms how important it is to do research as part of work practice, as long as professionals are trained and have adequate support, given that their work routine is compatible with the execution of the research protocol.
    MeSH term(s) Brazil ; Data Collection/methods ; Health Personnel/organization & administration ; Humans ; Papillomavirus Infections/epidemiology ; Primary Health Care ; Surveys and Questionnaires
    Language Portuguese
    Publishing date 2019-10-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2880588-4
    ISSN 2237-9622 ; 1679-4974
    ISSN (online) 2237-9622
    ISSN 1679-4974
    DOI 10.5123/S1679-49742019000300007
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  3. Article ; Online: Impact of waitlist time on post-HSCT survival: a cohort study at a hospital in southern Brazil.

    Silva, Tatiana Schnorr / Horvath, Jaqueline Driemeyer Correia / Pereira, Mariana Pinto / David, Caroline Nespolo de / Vargas, Dora Fraga / Rigoni, Lisandra Della Costa / Sartor, Ivaine Tais Sauthier / Kern, Luciane Beatriz / da Silva, Priscila de Oliveira / Paz, Alessandra Aparecida / Daudt, Liane Esteves / Astigarraga, Claudia Caceres

    Hematology, transfusion and cell therapy

    2023  

    Abstract: Introduction: The time elapsed from diagnosis to hematopoietic stem cell transplantation (HSCT) is influenced by numerous factors. In Brazil, patients using the public health system are also dependent on the availability of HSCT-specific beds in the ... ...

    Abstract Introduction: The time elapsed from diagnosis to hematopoietic stem cell transplantation (HSCT) is influenced by numerous factors. In Brazil, patients using the public health system are also dependent on the availability of HSCT-specific beds in the hematology ward.
    Objective and methods: We conducted a cohort study of listed patients who underwent allogeneic HSCT at a Brazilian public hospital to investigate the impact of the waitlist time on post-HSCT survival.
    Results: The median time from diagnosis to HSCT was 19 months (IQR, 10 - 43), of which 6 months (IQR, 3 - 9) were spent on the waitlist. The time on the waitlist for HSCT appeared to influence mainly the survival of adult patients (≥ 18 years), with an increasing risk according to this time (RR, 3.53 and 95%CI, 1.81 - 6.88 for > 3 and ≤ 6 months; RR 5.86 and 95%CI, 3.26 - 10.53 for > 6 and ≤ 12 months, and; RR 4.24 and 95%CI, 2.32 - 7.75 for > 12 months).
    Conclusion: Patients who remained on the waitlist for less than 3 months had the highest survival (median survival, 856 days; IQR, 131 - 1607). The risk of reduced survival was about 6-fold higher (95%CI, 2.8 - 11.5) in patients with malignancies.
    Language English
    Publishing date 2023-05-22
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2023.03.021
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  4. Article: A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol.

    Arns, Beatriz / Horvath, Jaqueline Driemeyer C / Rech, Gabriela Soares / Sesin, Guilhermo Prates / Agani, Crepin Aziz Jose Oluwafoumi / da Rosa, Bruna Silveira / Dos Santos, Tiago Marcon / Brochier, Liliane Spencer Bittencourt / Cavalcanti, Alexandre Biasi / Tomazini, Bruno Martins / Pereira, Adriano Jose / Veiga, Viviane Cordeiro / Nascimento, Giovana Marssola / Kalil, Andre C / Zavascki, Alexandre P

    Infectious diseases and therapy

    2023  Volume 13, Issue 1, Page(s) 237–250

    Abstract: Introduction: Shorter courses of antimicrobials have been shown to be non-inferior to longer, "traditional" duration of therapies, including for some severe healthcare-associated infections, with a few exceptions. However, evidence is lacking regarding ... ...

    Abstract Introduction: Shorter courses of antimicrobials have been shown to be non-inferior to longer, "traditional" duration of therapies, including for some severe healthcare-associated infections, with a few exceptions. However, evidence is lacking regarding shorter regimes against severe infections by multidrug-resistant Gram-negative bacteria (MDR-GNB), which are often caused by distinct strains and commonly treated with second-line antimicrobials. In the duratiOn of theraPy in severe infecTIons by MultIdrug-reSistant gram-nEgative bacteria (OPTIMISE) trial, we aim to assess the non-inferiority of 7-day versus 14-day antimicrobial therapy in critically ill patients with severe infections caused by MDR-GNB.
    Methods: This is a randomized, multicenter, open-label, parallel controlled trial to assess the non-inferiority of 7-day versus 14-day of adequate antimicrobial therapy for intensive care unit (ICU)-acquired severe infections by MDR-GNB. Adult patients with severe infections by MDR-GNB initiated after 48 h of ICU admission are screened for eligibility. Patients are eligible if they proved to be hemodynamically stable and without fever for at least 48 h on the 7th day of adequate antimicrobial therapy. After consenting, patients are 1:1 randomized to discontinue antimicrobial therapy on the 7th (± 1) day or to continue for a total of 14th (± 1) days.
    Planned outcomes: The primary outcome is treatment failure, defined as death or relapse of infection within 28 days after randomization. Non-inferiority will be achieved if the upper edge of the two-tailed 95% confidence interval of the difference between the clinical failure rate in the 7-day and the 14-day group is not higher than 10%.
    Conclusion: The OPTIMISE trial is the first randomized controlled trial specifically designed to assess the duration of antimicrobial therapy in patients with severe infections by MDR-GNB.
    Trial registration: ClinicalTrials.gov, NCT05210387. Registered on 27 January 2022. Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (OPTIMISE).
    Language English
    Publishing date 2023-12-16
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-023-00897-9
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  5. Article ; Online: Binge eating scores pre-bariatric surgery and subsequent weight loss: A prospective, 5 years follow-up study.

    Kops, Natalia Luiza / Vivan, Manoela Astolfi / de Castro, Mariana L Dias / Horvath, Jaqueline D Correia / Costa, Fabiana Silva / Friedman, Rogério

    Clinical nutrition ESPEN

    2020  Volume 38, Page(s) 146–152

    Abstract: Background & aims: To compare groups of bariatric patients with preoperative scores of Binge Eating Scale (BES) above and below the clinical cut off value on weight outcomes up to 60 months following surgery.: Methods: This is a prospective ... ...

    Abstract Background & aims: To compare groups of bariatric patients with preoperative scores of Binge Eating Scale (BES) above and below the clinical cut off value on weight outcomes up to 60 months following surgery.
    Methods: This is a prospective observational study involving 108 Brazilian patients (follow-up rate: 48.1%) operated by Roux-en-Y gastric bypass. In the preoperative period, they were clinically evaluated, and BES was applied. Based on the scores, patients were categorized as high or low according to established cut off 17 for binge eaters. Follow-up weight loss was obtained (3, 6, 12, 24, 36, 48, and 60 months) using data from medical records. The percentage of total weight loss (%TWL) was examined by generalized linear model.
    Results: 41.7% of patients had BES scores higher than 17 at baseline. Weight loss was significant up to 12 months. The greatest weight loss was at 24 months of follow-up, ranging from 2.7 to 110.4 kg (mean 42.9 ± 17.8 kg). In the short postoperative period (3, 24, and 36 months), %TWL was significantly different between groups. At 24 months, patients with higher scores lost more %TWL than those with lower scores (35.1 ± 0.8% vs 31.6 ± 0.7%, p = 0.029). However, this difference was not fount at 60 months postoperatively (mean 28.9 ± 9.6%). In a multivariate analysis, the presence of depression, age, and BES score were not associated with %TWL at 24 and 60 months.
    Conclusions: The results suggest that preoperative BES scores point to a similar weight loss after bariatric surgery. Further studies with long-term follow-up are necessary to evaluate this finding.
    MeSH term(s) Bariatric Surgery ; Binge-Eating Disorder/diagnosis ; Follow-Up Studies ; Humans ; Obesity, Morbid/surgery ; Prospective Studies ; Treatment Outcome ; Weight Loss
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2020.05.013
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  6. Article: Binge eating scores pre-bariatric surgery and subsequent weight loss: A prospective, 5 years follow-up study

    Kops, Natalia Luiza / Vivan, Manoela Astolfi / de Castro, Mariana L. Dias / Horvath, Jaqueline D. Correia / Costa, Fabiana Silva / Friedman, Rogério

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2020 Aug., v. 38

    2020  

    Abstract: To compare groups of bariatric patients with preoperative scores of Binge Eating Scale (BES) above and below the clinical cut off value on weight outcomes up to 60 months following surgery.This is a prospective observational study involving 108 Brazilian ...

    Abstract To compare groups of bariatric patients with preoperative scores of Binge Eating Scale (BES) above and below the clinical cut off value on weight outcomes up to 60 months following surgery.This is a prospective observational study involving 108 Brazilian patients (follow-up rate: 48.1%) operated by Roux-en-Y gastric bypass. In the preoperative period, they were clinically evaluated, and BES was applied. Based on the scores, patients were categorized as high or low according to established cut off 17 for binge eaters. Follow-up weight loss was obtained (3, 6, 12, 24, 36, 48, and 60 months) using data from medical records. The percentage of total weight loss (%TWL) was examined by generalized linear model.41.7% of patients had BES scores higher than 17 at baseline. Weight loss was significant up to 12 months. The greatest weight loss was at 24 months of follow-up, ranging from 2.7 to 110.4 kg (mean 42.9 ± 17.8 kg). In the short postoperative period (3, 24, and 36 months), %TWL was significantly different between groups. At 24 months, patients with higher scores lost more %TWL than those with lower scores (35.1 ± 0.8% vs 31.6 ± 0.7%, p = 0.029). However, this difference was not fount at 60 months postoperatively (mean 28.9 ± 9.6%). In a multivariate analysis, the presence of depression, age, and BES score were not associated with %TWL at 24 and 60 months.The results suggest that preoperative BES scores point to a similar weight loss after bariatric surgery. Further studies with long-term follow-up are necessary to evaluate this finding.
    Keywords age ; bariatric surgery ; binging ; clinical nutrition ; medical records ; multivariate analysis ; observational studies ; patients ; weight loss
    Language English
    Dates of publication 2020-08
    Size p. 146-152.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2020.05.013
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Human papillomavirus knowledge, beliefs, and behaviors: A questionnaire adaptation.

    Horvath, Jaqueline D C / Kops, Natália L / Caierão, Juliana / Bessel, Marina / Hohenberger, Glaucia / Wendland, Eliana M

    European journal of obstetrics, gynecology, and reproductive biology

    2018  Volume 230, Page(s) 103–108

    Abstract: Objective: This study aims to adapt a questionnaire about the knowledge, beliefs and behaviors regarding HPV and related subjects into Brazilian Portuguese.: Study design: National Survey.: Methods: The instrument was translated into Portuguese ... ...

    Abstract Objective: This study aims to adapt a questionnaire about the knowledge, beliefs and behaviors regarding HPV and related subjects into Brazilian Portuguese.
    Study design: National Survey.
    Methods: The instrument was translated into Portuguese and retranslated into English separately. Experts assessed the validity of the content and cross-cultural adaptation of the instrument. The instrument was administered to 8580 male and female Brazilian adolescents and young adults (aged between 16 and 25 years) who participated in the National Survey of Human Papillomavirus Prevalence (POP-Brazil). This large-scale survey enrolled participants from 26 Brazilian capitals and the Federal District.
    Results: The full questionnaire is composed of 30 questions, with a good absolute agreement between its two halves (61.16 ± 9.97). The preventive behavior section showed the lowest agreement. Men and women showed a difference concerning their knowledge about HPV (score for men 0.48 (± 8.93) vs. women 0.55 (± 4.51), p < 0.001).
    Conclusion: The proposed questionnaire is the first instrument able to describe the knowledge, beliefs and behaviors regarding HPV and related subjects in Brazilian women and men. This questionnaire appears to be adequate for use in future studies that may produce evidence and knowledge on these specific topics.
    MeSH term(s) Adolescent ; Adult ; Brazil ; Cross-Cultural Comparison ; Female ; Health Behavior ; Health Knowledge, Attitudes, Practice ; Humans ; Language ; Male ; Papillomaviridae ; Papillomavirus Infections/psychology ; Reproducibility of Results ; Surveys and Questionnaires/standards ; Translations ; Young Adult
    Language English
    Publishing date 2018-09-13
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2018.09.023
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    Zs.A 837: Show issues Location:
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  8. Article ; Online: FABP2, LEPR223, LEP656, and FTO Polymorphisms: Effect on Weight Loss 2 Years After Bariatric Surgery.

    Kops, Natália Luiza / Vivan, Manoela A / Horvath, Jaqueline D C / de Castro, Mariana L D / Friedman, Rogério

    Obesity surgery

    2018  Volume 28, Issue 9, Page(s) 2705–2711

    Abstract: Purpose: Differences in weight loss outcomes after bariatric surgery may be related to individual preoperative characteristics. The aim of this study was to evaluate the potential effect of fatty acid binding protein-2 (rs1799883), leptin receptor ( ... ...

    Abstract Purpose: Differences in weight loss outcomes after bariatric surgery may be related to individual preoperative characteristics. The aim of this study was to evaluate the potential effect of fatty acid binding protein-2 (rs1799883), leptin receptor (LEP223, rs1137101 and LEP656, rs1805094), and fat mass and obesity-related (rs9939609) genotypes on weight loss 2 years after bariatric surgery in Brazilian patients.
    Materials and methods: Prospective observational study involving 105 patients (lost to follow-up, 25.7%). In the preoperative period, patients were clinically evaluated and a fasting blood sample for genetic analysis (by real-time DNA amplification technique) was collected. From the patient's medical records, follow-up weight loss (3, 6, 12, 24 months) was obtained. Percentage of excess weight loss (%EWL) was examined by pairwise comparison across the polymorphisms.
    Results: At baseline, the mean weight was 127.5 (23.3) kg and age 43.1 (10.9) years old. The %EWL was significant over time (p < 0.01). Only the LEP223 genotype showed association (p < 0.01). Up to 6 months after surgery, no differences were observed. At 12 months, a significant difference (p = 0.03) between AA (n = 19) and GG (n = 34) groups was observed, with 76.5% EWL versus 52.0%, respectively. This difference remained at 24 months. Other genotypes did not present any significant association.
    Conclusions: There is a different evolution of weight loss in carriers of the LEP223 after bariatric surgery. The AA genotype seems to be associated with a higher weight loss. However, this pattern was evident only at 12 months after surgery.
    MeSH term(s) Adult ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Bariatric Surgery/statistics & numerical data ; Brazil ; Fatty Acid-Binding Proteins ; Genotype ; Humans ; Middle Aged ; Obesity, Morbid/epidemiology ; Obesity, Morbid/genetics ; Obesity, Morbid/surgery ; Prospective Studies ; Receptors, Leptin ; Weight Loss/genetics
    Chemical Substances FABP2 protein, human ; Fatty Acid-Binding Proteins ; LEPR protein, human ; Receptors, Leptin ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
    Language English
    Publishing date 2018-04-22
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-018-3213-0
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  9. Article ; Online: Anthropometric and lipid profile of individuals with severe obesity carrying the fatty acid-binding protein-2 Thr54 allele.

    Kops, Natalia Luiza / Correia Horvath, Jaqueline D / de Castro, Mariana L Dias / Friedman, Rogério

    Nutrition (Burbank, Los Angeles County, Calif.)

    2017  Volume 41, Page(s) 45–50

    Abstract: Objective: The aim of this study was to evaluate the anthropometric and lipid profiles of individuals being considered for bariatric surgery, taking into account the presence of the Thr54 allele of the fatty acid-binding protein-2 (FABP-2) gene ( ... ...

    Abstract Objective: The aim of this study was to evaluate the anthropometric and lipid profiles of individuals being considered for bariatric surgery, taking into account the presence of the Thr54 allele of the fatty acid-binding protein-2 (FABP-2) gene (rs1799883), and dietary intake.
    Methods: In a cross-sectional study, 120 participants being evaluated for bariatric surgery were asked to keep 24-h dietary records (R24 h) for 3 d, and to collect a 24-h urine sample for measurement of urea (as an assessment of the adequacy of food records) during day 3 of the diet record; a fasting blood sample for laboratory and genetic evaluations was collected.
    Results: When considering the whole sample, no significant differences were found; however, those who complied with the R24 h (n = 43) had more years of schooling and higher saturated fat intake, but lower weight and body mass index (BMI). When analyzing only the completers, the Thr54 allele carriers showed higher body weight (P = 0.02), BMI (P = 0.03), hip circumference (P = 0.02), basal metabolic rate (P = 0.02), and homeostatic model assessment-β (P = 0.04) compared with those who were homozygous for Ala54.
    Conclusion: When the participants complied with the R24 h, Thr54 carriers were shown to have higher anthropometric parameters and higher homeostatic model assessment-β values than those with the wild genotype, but the lipid profile resulted similar in both carriers and noncarriers.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2017.01.013
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  10. Article ; Online: Behavioral factors associated with multiple-type HPV genital infections: data from a cross-sectional study in young women in Brazil.

    Kops, Natália Luiza / Caierão, Juliana / Bessel, Marina / Horvath, Jaqueline Driemeyer Correia / Domingues, Carla Magda / Benzaken, Adele Schwartz / Villa, Luisa Lina / de Souza, Flávia Moreno Alves / Pereira, Gerson Fernando Mendes / Wendland, Eliana Marcia

    Reproductive health

    2021  Volume 18, Issue 1, Page(s) 201

    Abstract: Objectives: To investigate the pattern of multiple human papillomavirus (HPV) infections and associated factors in young women who access the Brazilian public health care system to better understand the characteristics of multiple HPV infections, a ... ...

    Abstract Objectives: To investigate the pattern of multiple human papillomavirus (HPV) infections and associated factors in young women who access the Brazilian public health care system to better understand the characteristics of multiple HPV infections, a critical issue in this era of multivalent vaccines.
    Methods: This was a cross-sectional, multicenter study with sexually active unvaccinated women (16-25 years old) from 119 primary Brazilian healthcare centers between September 2016 and November 2017. Cervical samples were collected by trained health professionals, and HPV detection was performed in a central laboratory by Linear Array.
    Results: Of the 5268 women, 33.00% (95% CI 31.07-34.92) had multiple infections. At least one type of high-risk HPV was present in 85.50% of all multiple infections. All HPV types were detected more frequently in association with other types than alone. Young individuals who were single or in a casual relationship and those who had more than one sexual partner in the past year were more likely to have multiple infections.
    Conclusions: In this work, a high rate of multiple HPV infections among unvaccinated young adults tended to increase due to certain risk factors. Such data can provide insight for decision makers in the development of public policies regarding HPV prevention.
    MeSH term(s) Adolescent ; Adult ; Brazil/epidemiology ; Cervix Uteri ; Cross-Sectional Studies ; Female ; Humans ; Papillomavirus Infections/epidemiology ; Prevalence ; Young Adult
    Language English
    Publishing date 2021-10-10
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ISSN 1742-4755
    ISSN (online) 1742-4755
    DOI 10.1186/s12978-021-01244-2
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