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  1. Article: Interview Dr. Thomas Horvatits: Allgemeinmedizin - der Reiz der Vielseitigkeit

    Horvatits, Thomas

    Arzt & Praxis

    2017  Volume 71, Issue 5, Page(s) 6

    Language German
    Document type Article
    ZDB-ID 1224197-0
    ISSN 0048-5128
    Database Current Contents Medicine

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    Zs.A 868: Show issues Location:
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  2. Article: Higher Risk of HEV Transmission and Exposure among Blood Donors in Europe and Asia in Comparison to North America: A Meta-Analysis.

    Wolski, Annika / Pischke, Sven / Ozga, Ann-Kathrin / Addo, Marylyn M / Horvatits, Thomas

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Background and aims: The increasing number of diagnosed hepatitis E virus (HEV) infections in Europe has led to the implementation of the testing of blood products in various countries. Many nations have not yet implemented such screening. To assess the ...

    Abstract Background and aims: The increasing number of diagnosed hepatitis E virus (HEV) infections in Europe has led to the implementation of the testing of blood products in various countries. Many nations have not yet implemented such screening. To assess the need for HEV screening in blood products worldwide, we conducted a systematic review and meta-analysis assessing HEV RNA positivity and anti-HEV seroprevalence in blood donors.
    Methods: Studies reporting anti-HEV IgG/IgM or HEV RNA positivity rates among blood donors worldwide were identified via predefined search terms in PubMed and Scopus. Estimates were calculated by pooling study data with multivariable linear mixed-effects metaregression analysis.
    Results: A total of 157 (14%) of 1144 studies were included in the final analysis. The estimated HEV PCR positivity rate ranged from 0.01 to 0.14% worldwide, with strikingly higher rates in Asia (0.14%) and Europe (0.10%) in comparison to North America (0.01%). In line with this, anti-HEV IgG seroprevalence in North America (13%) was lower than that in Europe (19%).
    Conclusions: Our data demonstrate large regional differences regarding the risk of HEV exposure and blood-borne HEV transmission. Considering the cost-benefit ratio, this supports blood product screening in high endemic areas, such as Europe and Asia, in contrast to low endemic regions, such as the U.S.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HEV in pregnancy: Understanding the crucial role of steroid hormones.

    Horvatits, Thomas / Pischke, Sven

    Liver international : official journal of the International Association for the Study of the Liver

    2019  Volume 39, Issue 4, Page(s) 621–622

    MeSH term(s) Female ; Hepatitis E ; Hepatitis E virus ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; Steroids
    Chemical Substances Steroids
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13942
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  4. Book ; Online ; Thesis: Prädiktion von Infektionen bei hospitalisierten Patientinnen und Patienten mit Leberzirrhose

    Wittmann, Sebastian Giacomo Verfasser] / [Kluwe, Johannes [Akademischer Betreuer] / Horvatits, Thomas [Akademischer Betreuer]

    2023  

    Author's details Sebastian Giacomo Wittmann ; Johannes Kluwe, Thomas Horvatits
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Extrahepatic manifestations and HEV, the genotype matters.

    Horvatits, Thomas / Pischke, Sven

    EBioMedicine

    2018  Volume 36, Page(s) 3–4

    MeSH term(s) Case-Control Studies ; China ; Genotype ; Hepatitis E ; Hepatitis E virus ; Humans ; Prospective Studies
    Language English
    Publishing date 2018-09-10
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2018.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Liver Injury and Failure in Critical Illness.

    Horvatits, Thomas / Drolz, Andreas / Trauner, Michael / Fuhrmann, Valentin

    Hepatology (Baltimore, Md.)

    2019  Volume 70, Issue 6, Page(s) 2204–2215

    Abstract: The frequency of acquired liver injury and failure in critical illness has been significantly increasing over recent decades. Currently, liver injury and failure are observed in up to 20% of patients in intensive care units and are associated with ... ...

    Abstract The frequency of acquired liver injury and failure in critical illness has been significantly increasing over recent decades. Currently, liver injury and failure are observed in up to 20% of patients in intensive care units and are associated with significantly increased morbidity and mortality. Secondary forms of liver injury in critical illness are divided primarily into cholestatic, hypoxic, or mixed forms. Therefore, sufficient knowledge of underlying alterations (e.g., hemodynamic, inflammatory, or drug induced) is key to a better understanding of clinical manifestations, prognostic implications, as well as diagnostic and therapeutic options of acquired liver injury and failure. This review provides a structured approach for the evaluation and treatment of acquired liver injury and failure in critically ill patients.
    MeSH term(s) Chemical and Drug Induced Liver Injury/therapy ; Cholestasis/diagnosis ; Cholestasis/therapy ; Critical Illness ; Humans ; Hypoxia/complications ; Intensive Care Units ; Liver Failure, Acute/therapy ; Prognosis
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.30824
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    Zs.A 1660: Show issues Location:
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  7. Article ; Online: Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind trial.

    Wehmeyer, Malte H / Horvatits, Thomas / Buchholz, Anika / Krause, Linda / Walter, Sarah / Zapf, Antonia / Lohse, Ansgar W / Kluwe, Johannes

    Trials

    2022  Volume 23, Issue 1, Page(s) 302

    Abstract: Background: Proton-pump inhibitors (PPI) are liberally prescribed in patients with liver cirrhosis. Observational studies link PPI therapy in cirrhotic patients with an increased risk for infectious complications, hepatic encephalopathy and an increased ...

    Abstract Background: Proton-pump inhibitors (PPI) are liberally prescribed in patients with liver cirrhosis. Observational studies link PPI therapy in cirrhotic patients with an increased risk for infectious complications, hepatic encephalopathy and an increased risk for hospitalization and mortality. However, patients with liver cirrhosis are also considered to be at risk for peptic ulcer bleeding. The STOPPIT trial evaluates if discontinuation of a pre-existing PPI treatment delays a composite endpoint of re-hospitalization and/or death in patients (recently) hospitalized with liver cirrhosis compared to patients on continued PPI medication.
    Methods: The STOPPIT-trial is a prospective, multicentre, randomized, double-blinded, placebo-controlled, parallel-group trial. In total, 476 patients with complicated liver cirrhosis who already receive long-term PPI therapy without evidence-based indication are 1:1 randomized to receive either esomeprazole 20 mg (control group) or placebo (intervention group) for 360 days. Patients with an indication for PPI therapy (such as a recent diagnosis of peptic ulcers, severe reflux esophagitis, severe hemorrhagic gastritis, recent endoscopic therapy for oesophageal varices) are excluded. The primary composite endpoint is the time-to re-hospitalization and/or death. Secondary endpoints include rates of re-hospitalization, mortality, occurrence of infections, hepatic decompensation and acute-on-chronic liver failure. The safety endpoint is defined as manifestation of an evidence-based indication for PPI re-therapy. The impact of PPI continuation or discontinuation on the intestinal microbiota will be studied. The recruitment will take place at 18 study sites throughout Germany. Recruitment has started in April 2021.
    Discussion: The STOPPIT trial is the first clinical trial to study the effects of PPI withdrawal on relevant outcome variables in patients with complicated liver cirrhosis. If the hypothesis that PPI withdrawal improves clinical outcomes of cirrhosis patients is confirmed, this would argue for a strong restriction of the currently liberal prescription practice of PPIs in this population. If, on the other hand, the trial demonstrates an increased risk of gastrointestinal bleeding events in patients after PPI withdrawal, this could create a rationale for a more liberal, prophylactic PPI treatment in patients with liver cirrhosis.
    Trial registration: EU clinical trials register EudraCT 2019-005008-16 (registered December 27, 2019).
    Clinicaltrials: gov NCT04448028 (registered June 25, 2020). German Clinical Trials Register DRKS00021290 (registered March 10, 2021).
    MeSH term(s) COVID-19 ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Multicenter Studies as Topic ; Prospective Studies ; Proton Pump Inhibitors/adverse effects ; Randomized Controlled Trials as Topic ; SARS-CoV-2
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06232-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Microplastics detected in cirrhotic liver tissue.

    Horvatits, Thomas / Tamminga, Matthias / Liu, Beibei / Sebode, Marcial / Carambia, Antonella / Fischer, Lutz / Püschel, Klaus / Huber, Samuel / Fischer, Elke Kerstin

    EBioMedicine

    2022  Volume 82, Page(s) 104147

    Abstract: Background: The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently in human blood, stool and placenta. However, two aspects remain unclear: whether MPs accumulate ...

    Abstract Background: The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently in human blood, stool and placenta. However, two aspects remain unclear: whether MPs accumulate in peripheral organs, specifically in the liver, and if liver cirrhosis favours this process. We aimed to examine human liver tissue samples to determine whether MPs accumulate in the liver.
    Methods: This proof-of-concept case series, conducted in Germany, Europe, analyzed tissue samples of 6 patients with liver cirrhosis and 5 individuals without underlying liver disease. A total of 17 samples (11 liver, 3 kidney and 3 spleen samples) were analyzed according to the final protocol. A reliable method for detection of MP particles from 4 to 30 µm in human tissue was developed. Chemical digestion of tissue samples, staining with Nile red, subsequent fluorescent microscopy and Raman spectroscopy were performed. Morphology, size and composition of MP polymers were assessed.
    Findings: Considering the limit of detection, all liver, kidney and spleen samples from patients without underlying liver disease tested negative for MPs. In contrast, MP concentrations in cirrhotic liver tissues tested positive and showed significantly higher concentrations compared to liver samples of individuals without underlying liver disease. Six different microplastic polymers ranging from 4 to 30 µm in size were detected.
    Interpretation: This proof-of-concept case series assessed the presence of MPs in human liver tissue and found six different MP polymers in the liver of individuals with liver cirrhosis, but not in those without underlying liver disease. Future studies are needed to evaluate whether hepatic MP accumulation represents a potential cause in the pathogenesis of fibrosis, or a consequence of cirrhosis and portal hypertension.
    Funding: No funding was received for conducting this investigator driven study.
    MeSH term(s) Animals ; Ecosystem ; Environmental Monitoring ; Humans ; Liver Cirrhosis ; Mice ; Microplastics ; Plastics/chemistry ; Polymers ; Water Pollutants, Chemical/analysis
    Chemical Substances Microplastics ; Plastics ; Polymers ; Water Pollutants, Chemical
    Language English
    Publishing date 2022-07-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104147
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  9. Article ; Online: Therapeutic options in pulmonary hepatic vascular diseases.

    Horvatits, Thomas / Fuhrmann, Valentin

    Expert review of clinical pharmacology

    2014  Volume 7, Issue 1, Page(s) 31–42

    Abstract: Pulmonary-hepatic vascular disorders are frequent complications in patients with portal hypertension and cirrhosis. Both hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) are associated with increased morbidity and mortality. The ... ...

    Abstract Pulmonary-hepatic vascular disorders are frequent complications in patients with portal hypertension and cirrhosis. Both hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) are associated with increased morbidity and mortality. The diagnosis of HPS should be confirmed early by arterial blood gas analysis and contrast enhanced echocardiography whereas POPH is finally diagnosed by presence of pulmonary arterial hypertension evaluated via right heart catheterization and presence of portal hypertension. Therapeutic options are initiation of long term oxygen therapy and liver transplantation in patients with severe HPS. Patients with POPH should receive targeted medical therapies with endothelin receptor antagonists, phosphodiesterase-5 inhibitors and/or prostanoids. In contrast, β-blockers should be avoided. It is unclear whether liver transplantation cures POPH or not. This review summarizes current knowledge of underlying conditions and focuses on therapeutic options in patients with pulmonary-hepatic vascular disorders.
    MeSH term(s) Animals ; Blood Gas Analysis ; Cardiac Catheterization/methods ; Contrast Media ; Echocardiography/methods ; Familial Primary Pulmonary Hypertension ; Hepatopulmonary Syndrome/diagnosis ; Hepatopulmonary Syndrome/physiopathology ; Hepatopulmonary Syndrome/therapy ; Humans ; Hypertension, Portal/diagnosis ; Hypertension, Portal/physiopathology ; Hypertension, Portal/therapy ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/therapy ; Liver Cirrhosis/complications ; Liver Transplantation/methods ; Oxygen/administration & dosage
    Chemical Substances Contrast Media ; Oxygen (S88TT14065)
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1586/17512433.2014.857598
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  10. Article ; Online: Muscle quality determined by computed tomography predicts short-term and long-term survival after liver transplantation.

    Molwitz, Isabel / Recklies, Franziska / Stark, Maria / Horvatits, Thomas / Salamon, Johannes / Huber, Samuel / Fischer, Lutz / Adam, Gerhard / Lohse, Ansgar W / Sterneck, Martina / Horvatits, Karoline

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7631

    Abstract: Sarcopenia, the loss of muscle mass and quality, contributes to worse clinical outcome in patients with end-stage liver disease, but its impact on short- and long-term survival remains insufficiently understood. The aim of this study was to evaluate the ... ...

    Abstract Sarcopenia, the loss of muscle mass and quality, contributes to worse clinical outcome in patients with end-stage liver disease, but its impact on short- and long-term survival remains insufficiently understood. The aim of this study was to evaluate the development of computed tomography (CT) muscle parameters and their impact on short-term and long-term survival after liver transplantation. This retrospective study included patients with liver transplantation between 2011 and 2015 and a pre-transplant CT scan. Clinical characteristics, CT muscle mass and density were assessed pre-transplant, and in available CT scans at short-term (11 months) and long-term follow-up (56 months). Overall, 93/152 (61%) patients (109 male, 55 ± 10 years) suffered from sarcopenia pre-transplant. In short- (n = 50) and long-term follow-up (n = 52) the muscle mass (- 2.65 cm
    MeSH term(s) Humans ; Male ; Liver Transplantation/adverse effects ; Sarcopenia/etiology ; Retrospective Studies ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Tomography, X-Ray Computed ; Muscular Diseases/pathology
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33349-y
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