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Article ; Online: Evaluating the factors influencing sun protection factors (SPF): Pooling data from multiple studies involving two reference ISO 24444:2019 sunscreen products (P2 and P8).

Granger, Corinne / Trullàs, Carles / Sokeechand, Nusayha Bibi / Jourdan, Eric / Krutmann, Jean / Francois-Newton, Veronique / Hosenally, Muzzammil

Photodermatology, photoimmunology & photomedicine

2024 Volume 40, Issue 1, Page(s) e12942

Abstract: Background: Standardized methods for sun protection factor (SPF) testing are still beset with endpoint and method-driven issues, and can be influenced by multiple factors. The purpose of this analysis is to explore the factors influencing the results of ...

Abstract	Background: Standardized methods for sun protection factor (SPF) testing are still beset with endpoint and method-driven issues, and can be influenced by multiple factors. The purpose of this analysis is to explore the factors influencing the results of sun protection factor (SPF) testing in human subjects according to the ISO 24444:2019 standard. Intrinsic factors, such as baseline skin color, age and gender, the minimal erythemal dose on an unprotected area (MEDu), as well as environmental factors such as season/weather influences, are considered for analysis. Methods: Datasets generated for two reference products (P2 and P8) during the conduct of 50 such studies using the ISO standard 24444:2019 for the testing of SPF products, from a single testing center located in Bucharest, Romania between April 2021 and December 2022, were retrieved and compiled. Overall, the data for 334 subjects was available, with 276 observations for the reference P8, and 171 for P2. Results: No effects due to gender or age were detected. Seasonal changes, the individual typology angle (ITA°) and MEDu were found to have an influence on the outcome of the SPF values. Conclusions: This study adds new original data about the impact of intrinsic and extrinsic factors on SPF variations pertaining to ISO reference sunscreen P8 (SPF 50+). The findings suggest that some factors will inevitably impact the results between two SPF experiments for the same product and SPF testing laboratory. The interconnections between the sources of this variation are discussed. The findings of this research help to identify and characterize factors that contribute to SPF testing variability.
MeSH term(s)	Humans ; Sunscreening Agents ; Sun Protection Factor ; Sunlight/adverse effects ; Ultraviolet Rays/adverse effects ; Weather
Chemical Substances	Sunscreening Agents
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1028855-7
ISSN	1600-0781 ; 0108-9684 ; 0905-4383
ISSN (online)	1600-0781
ISSN	0108-9684 ; 0905-4383
DOI	10.1111/phpp.12942
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Article: Evaluation of a Sunscreen Product Compared with Reference Standards P3, P5 and P8 in Outdoor Conditions: a Randomized, Double-Blinded, Intra-individual Study in Healthy Subjects.

Granger, Corinne / Petkar, Gitanjali / Hosenally, Muzzammil / Bustos, Javier / Trullàs, Carles / Passeron, Thierry / Krutmann, Jean

Dermatology and therapy

2022 Volume 12, Issue 11, Page(s) 2531–2546

Abstract: Introduction: The shortcomings of standardized sunscreen testing have been discussed in recent years, noting differences between how sunscreens perform in indoor clinical (in vivo) laboratory testing compared with real-life conditions. We previously ... ...

Abstract	Introduction: The shortcomings of standardized sunscreen testing have been discussed in recent years, noting differences between how sunscreens perform in indoor clinical (in vivo) laboratory testing compared with real-life conditions. We previously developed an outdoor clinical method for ranking sunscreens by performance level. We used this method to test the performance of a new broad-spectrum sunscreen against International Organization for Standardization (ISO) reference products P3, P5 and P8. Methods: Sixty-five healthy volunteers with individual typology angle (ITA) ≥ 28° (light to intermediate skin colour) participated in an outdoor study in Mauritius. Test areas were marked on their backs, which were treated with the different products: one commercially available broad-spectrum sun protection factor (SPF) 50 sunscreen [investigational product (IP)] and the three reference products P3 (SPF 15), P5 (SPF 30) and P8 (SPF 50+) from ISO norm 24444:2019 for SPF testing. The test areas were exposed for 2-3 h, depending on the baseline skin colour. They were also compared with an unprotected positive control area and a non-exposed negative control area. Clinical and colorimetry assessment of erythema and pigmentation were performed at 24 h and 8 days, respectively. Results: Overall, according to this outdoor clinical testing method, the sunscreens' efficacy was ranked in an appropriate order given their established SPF levels, with higher SPFs giving greater protection against erythema and pigmentation. Between the different levels of SPF, the differences were statistically significant, for both clinical and colorimetry assessments. The new broad-spectrum SPF 50 IP performed similarly to the SPF 50+ (P8) reference product. Even the highest SPF products, SPF 50 and SPF 50+, had some instances of photoprotection failure. Conclusion: These findings confirm the feasibility of this outdoor clinical testing method in ranking sunscreens and provide further evidence, in addition to standardized SPF and UVA protection factor (UVAPF) testing, on how this new broad-spectrum SPF 50 sunscreen performs in extreme outdoor solar exposure: in line with reference product P8 (SPF 50+). Trial registration no: ISRCTN95394014.
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680284-3
ISSN	2190-9172 ; 2193-8210
ISSN (online)	2190-9172
ISSN	2193-8210
DOI	10.1007/s13555-022-00815-w
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Article ; Online: Outdoor clinical testing with reference sunscreens to determine differences in skin response between populations of different ethnicity: A combined data analysis from 128 subjects.

Granger, Corinne / Passeron, Thierry / Trullas, Carles / Hosenally, Muzzammil / Sokeechand, Bibi Nusayha / Krutmann, Jean / Lim, Henry W

Photodermatology, photoimmunology & photomedicine

2023 Volume 39, Issue 5, Page(s) 419–427

Abstract: Background: Two previously published clinical studies by our group assessed erythema and pigmentation responses in outdoor conditions with three reference sunscreens, comparing their effectiveness under the full spectrum of natural sunlight. These ... ...

Abstract	Background: Two previously published clinical studies by our group assessed erythema and pigmentation responses in outdoor conditions with three reference sunscreens, comparing their effectiveness under the full spectrum of natural sunlight. These studies followed an almost identical protocol but were conducted in two different locations and in two ethnic groups: broadly, Chinese (Singapore) and White European (Mauritius). We analysed the data from these two study populations to compare differences in skin response according to ethnicity. Methods: The analysis included 128 subjects (53 were Chinese from Singapore and 75 were White European from Mauritius and Singapore). Products used were the reference sunscreens P3 (sun protection factor [SPF] 15), P5 (SPF 30) and P8 (SPF 50+) from ISO norm 24444:2019. Participants were exposed to outdoor sunlight for 2-3 h, depending on baseline ITA. Endpoints were erythema at 24 h: clinical score and colorimetry (Δa) and pigmentation at 1 week based on colorimetry (ΔL and ΔITA). Results: Among those with baseline ITA > 41, there were differences in erythemal response between the Chinese and White European groups, the White European group being more erythematous and also having a higher rate of photoprotection failure particularly at SPFs 15 and 30. Conclusion: Differences in skin response to sun influenced by ethnicity should be taken into account when making recommendations on sun safety.
MeSH term(s)	Humans ; Sunscreening Agents/therapeutic use ; Ethnicity ; Ultraviolet Rays/adverse effects ; Sun Protection Factor ; Erythema/prevention & control ; Skin
Chemical Substances	Sunscreening Agents
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1028855-7
ISSN	1600-0781 ; 0108-9684 ; 0905-4383
ISSN (online)	1600-0781
ISSN	0108-9684 ; 0905-4383
DOI	10.1111/phpp.12871
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Article ; Online: Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences.

Mahomoodally, Mohamad Fawzi / Coodian, Kaisavadee / Hosenally, Muzzammil / Zengin, Gokhan / Shariati, Mohammad Ali / Abdalla, Ashraf N / Alhazmi, Hassan A / Khuwaja, Gulrana / Mohan, Syam / Khalid, Asaad

Phytotherapy research : PTR

2024

Abstract: Gout, or hyperuricemia is a multifactorial and multi-faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and ... ...

Abstract	Gout, or hyperuricemia is a multifactorial and multi-faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8211
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Article ; Online: Nutritional, medicinal and functional properties of different parts of the date palm and its fruit (

Mahomoodally, Mohamad Fawzi / Khadaroo, Shahana Khatoon / Hosenally, Muzzammil / Zengin, Gokhan / Rebezov, Maksim / Ali Shariati, Mohammad / Khalid, Asaad / Abdalla, Ashraf N / Algarni, Alanood S / Simal-Gandara, Jesus

Critical reviews in food science and nutrition

2023 , Page(s) 1–56

Abstract: Appraised for being one of the oldest staple nutritive foods mainly in the Arabian Peninsula, the date palm tree ( ...

Abstract	Appraised for being one of the oldest staple nutritive foods mainly in the Arabian Peninsula, the date palm tree (
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Systematic Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2023.2191285
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Article ; Online: Prevalence, Genomic Characterization, and Risk Assessment of Human Pathogenic Vibrio Species in Seafood.

Neetoo, Hudaa / Reega, Keshnee / Manoga, Zishaan Sheik / Nazurally, Nadeem / Bhoyroo, Vishwakalyan / Allam, Mushal / Jaufeerally-Fakim, Yasmina / Ghoorah, Anisah Wahed / Jaumdally, Wasseem / Hossen, Aicha Malleck / Mayghun, Farheen / Ismail, Arshad / Hosenally, Muzzammil

Journal of food protection

2022 Volume 85, Issue 11, Page(s) 1553–1565

MeSH term(s)	Animals ; Humans ; Hemolysin Proteins ; Prevalence ; Vibrio parahaemolyticus ; Vibrio Infections/epidemiology ; Seafood ; Ostreidae ; Anti-Bacterial Agents ; Genomics ; Risk Assessment ; beta-Lactams ; Penicillins ; Quinolones ; Tetracyclines
Chemical Substances	Hemolysin Proteins ; Anti-Bacterial Agents ; beta-Lactams ; Penicillins ; Quinolones ; Tetracyclines
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/JFP-22-064
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Article ; Online: The protective effect of a novel sunscreen against blue light.

Francois-Newton, Veronique / Kolanthan, Vimi Lutchmanen / Mandary, Madiiha Bibi / Philibert, Evans Georges / Soobramaney, Vitisha / Petkar, Gitanjali / Sokeechand, Bibi Nusayha / Hosenally, Muzzammil / Cavagnino, Andrea / Baraibar, Martin Andres / Ng, Sue Phay

International journal of cosmetic science

2022 Volume 44, Issue 4, Page(s) 464–476

Abstract: Background and objective: Premature skin ageing, and skin hyperpigmentation are influenced by exogenous factors, such as ultraviolet radiation and blue light. In this study, we assess the protective effect of a sunscreen (TDF: Methodology: The ... ...

Abstract	Background and objective: Premature skin ageing, and skin hyperpigmentation are influenced by exogenous factors, such as ultraviolet radiation and blue light. In this study, we assess the protective effect of a sunscreen (TDF Methodology: The protective effect of the test product against blue light was first evaluated ex vivo on human skin explants. The treated and non-treated explants were exposed to 14 J/cm Results: Human skin explants treated with test product showed significantly lower levels of accumulated carbonylated proteins, with a protection of 82%, following exposure to blue light 460 nm. Findings of the in vivo studies also indicated that the test product presented significantly better protective efficacy against immediate and persistent pigmentation induced by blue light 415 nm. Conclusion: Hence, it can be concluded that the test product can protect against the oxidative stress as well as the immediate and persistent pigmentation induced by blue light.
MeSH term(s)	Humans ; Hyperpigmentation ; Light ; Skin/radiation effects ; Skin Pigmentation ; Sunscreening Agents/pharmacology ; Ultraviolet Rays
Chemical Substances	Sunscreening Agents
Language	English
Publishing date	2022-08-01
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	198917-0
ISSN	1468-2494 ; 0142-5463
ISSN (online)	1468-2494
ISSN	0142-5463
DOI	10.1111/ics.12794
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Article: Essential oils from tropical medicinal herbs and food plants inhibit biofilm formation in vitro and are non-cytotoxic to human cells

Aumeeruddy-Elalfi, Zaahira / Ismaël, Ismaël Saïd / Hosenally, Muzzammil / Zengin, Gokhan / Mahomoodally, Mohamad Fawzi

3 Biotech. 2018 Sept., v. 8, no. 9

2018

Abstract: The biofilm inhibition and eradication potential of essential oils (EOs) extracted from six tropical medicinal herbs and food plants [Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), Citrus reticulata (CR), and ... ...

Abstract	The biofilm inhibition and eradication potential of essential oils (EOs) extracted from six tropical medicinal herbs and food plants [Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), Citrus reticulata (CR), and Cinnamomum zeylanicum (CZ)] were assessed. The mechanism of inhibition was studied via quenching of efflux pump. Cytotoxicity was evaluated using Artemia salina assay and cell lines [human cervix carcinoma (HeLa), human lung fibroblast (MRC-5), and murine melanoma (B16F10)]. EOs of CH, CR, PA, and PT were found to be prospective antibiofilm agents (IC50 of 0.29, 0.59, 0.22, and 0.11 mg/mL against Staphylococcus epidermidis; 0.39, 0.54, 0.09, and 0.13 mg/mL against Escherichia coli; and 0.54, 0.90, 0.44 and 0.51 mg/mL against Candida albicans for CH, CR, PA, and PT, respectively). The simultaneous actions of the EOs and efflux pump inhibitor impacted on the resistance of the biofilms. LC50 of the EOs ranged from 223 to 583 μg/mL against A. salina. The non-cytotoxic concentration of the EOs varied from 200 to 300 μg/mL (HeLa and MRC-5), and 150–200 μg/mL (B16F10). EOs from these tropical medicinal herbs and food plants are useful sources of new antimicrobials with low cytotoxicity which could open new horizons in the drug development process.
Keywords	Artemia salina ; Candida albicans ; Cinnamomum verum ; Citrus hystrix ; Citrus maxima ; Citrus reticulata ; Escherichia coli ; Psiadia ; Staphylococcus epidermidis ; anti-infective agents ; biofilm ; carcinoma ; cell lines ; cervix ; cytotoxicity ; drugs ; essential oils ; fibroblasts ; food plants ; humans ; inhibitory concentration 50 ; lethal concentration 50 ; lungs ; medicinal plants ; melanoma ; mice ; transporters
Language	English
Dates of publication	2018-09
Size	p. 395.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-018-1413-x
Database	NAL-Catalogue (AGRICOLA)

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Article: Essential oils from tropical medicinal herbs and food plants inhibit biofilm formation in vitro and are non-cytotoxic to human cells.

Aumeeruddy-Elalfi, Zaahira / Ismaël, Ismaël Saïd / Hosenally, Muzzammil / Zengin, Gokhan / Mahomoodally, Mohamad Fawzi

3 Biotech

2018 Volume 8, Issue 9, Page(s) 395

Abstract: The biofilm inhibition and eradication potential of essential oils (EOs) extracted from six tropical medicinal herbs and food plants [ ...

Abstract	The biofilm inhibition and eradication potential of essential oils (EOs) extracted from six tropical medicinal herbs and food plants [
Language	English
Publishing date	2018-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-018-1413-x
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Article ; Online: Outdoor sunscreen testing with high-intensity solar exposure in a Chinese and Caucasian population.

Granger, Corinne / Ong, Gavin / Andres, Philippe / Trullàs, Carles / Hosenally, Muzzammil / Lai, Wei / Liu, Wei / Krutmann, Jean / Passeron, Thierry / Lim, Henry W

Photodermatology, photoimmunology & photomedicine

2021 Volume 38, Issue 1, Page(s) 19–28

Abstract: Background: Currently, sunscreens' sun protection factor (SPF) and ultraviolet (UV) A protection are tested separately under indoor conditions, without considering external conditions that may affect performance. Studies are often conducted in Caucasian ...

Abstract	Background: Currently, sunscreens' sun protection factor (SPF) and ultraviolet (UV) A protection are tested separately under indoor conditions, without considering external conditions that may affect performance. Studies are often conducted in Caucasian individuals; other racial groups may respond differently. Methods: An outdoor, double-blind, intra-individual study was performed in 63 healthy Chinese and Caucasian volunteers in Singapore. Subjects underwent one outdoor sun exposure lasting 2-3 hours. ISO reference products P3 (SPF 15), P5 (SPF 30), and P8 (SPF 50+) applied at 2 mg/cm Results: Clinical erythema and pigmentation scores were statistically significantly different among the three sunscreens, with the highest SPF product providing the highest protection, confirming the discriminatory capacity of the model used. Colorimetric assessment correlated well with clinical evaluation. Conclusion: This study confirmed the feasibility of ranking sunscreens (at 2 mg/cm
MeSH term(s)	China ; Double-Blind Method ; Erythema/etiology ; Erythema/prevention & control ; Humans ; Sun Protection Factor ; Sunburn ; Sunscreening Agents/therapeutic use ; Ultraviolet Rays/adverse effects
Chemical Substances	Sunscreening Agents
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1028855-7
ISSN	1600-0781 ; 0108-9684 ; 0905-4383
ISSN (online)	1600-0781
ISSN	0108-9684 ; 0905-4383
DOI	10.1111/phpp.12710
Database	MEDical Literature Analysis and Retrieval System OnLINE

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