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  1. Article ; Online: Prognostic Implications of the Acute Lipid Levels in Stroke Patients.

    Hoshino, Takao

    Journal of atherosclerosis and thrombosis

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: My Mentor Howard A. Young.

    Hoshino, Tomoaki

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2022  

    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2022.0074
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1748: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Future directions of lung-protective ventilation strategies in acute respiratory distress syndrome.

    Hoshino, Taiki / Yoshida, Takeshi

    Acute medicine & surgery

    2024  Volume 11, Issue 1, Page(s) e918

    Abstract: Acute respiratory distress syndrome (ARDS) is characterized by the heterogeneous distribution of lung aeration along a gravitational direction due to increased lung density. Therefore, the lung available for ventilation is usually limited to ventral, ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is characterized by the heterogeneous distribution of lung aeration along a gravitational direction due to increased lung density. Therefore, the lung available for ventilation is usually limited to ventral, nondependent lung regions and has been called the "baby" lung. In ARDS, ventilator-induced lung injury is known to occur in nondependent "baby" lungs, as ventilation is shifted to ventral, nondependent lung regions, increasing stress and strain. To protect this nondependent "baby" lung, the clinician targets and limits global parameters such as tidal volume and plateau pressure. In addition, positive end-expiratory pressure (PEEP) is used to prevent dorsal, dependent atelectasis and, if successful, increases the size of the baby lung and lessens its susceptibility to injury from inspiratory stretch. Although many clinical trials have been performed in patients with ARDS over the last two decades, there are few successfully showing benefits on mortality (ie, prone positioning and neuromuscular blocking agents). These disappointing results contrast with other medical disciplines, especially in oncology, where the heterogeneity of diseases is recognized widely and precision medicine has been promoted. Thus, lung-protective ventilation strategies need to take an innovative approach that accounts for the heterogeneity of injured lungs. This article summarizes ventilator-induced lung injury and ARDS and discusses how to implement precision medicine in the field of ARDS. Potentially useful methods to individualize PEEP with esophageal balloon manometry, lung recruitability, and electrical impedance tomography were discussed.
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [2. Quality Control of CT Systems Using Phantom].

    Hoshino, Takashi

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2021  Volume 77, Issue 1, Page(s) 87–93

    MeSH term(s) Phantoms, Imaging ; Quality Control ; Tomography, X-Ray Computed
    Language Japanese
    Publishing date 2021-01-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2021_JSRT_77.1.87
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  5. Article ; Online: Analysis of viscosity measurements obtained using the short back extrusion method. Part 1: Theory of short back extrusion in viscometry.

    Hoshino, Takayoshi

    Journal of texture studies

    2020  Volume 51, Issue 2, Page(s) 201–213

    Abstract: The back extrusion (BE) method is a well-known translational concentric cylinder viscometry that can analyze viscosity from the force-time curve of a cylindrical plunger pushed into a cylindrical cup filled with a sample fluid. It can analyze Newtonian, ... ...

    Abstract The back extrusion (BE) method is a well-known translational concentric cylinder viscometry that can analyze viscosity from the force-time curve of a cylindrical plunger pushed into a cylindrical cup filled with a sample fluid. It can analyze Newtonian, power-law, and Herschel-Bulkley flows. However, the plunger must be moved 100 mm or more from the sample surface toward the cup bottom, any sample fluid adhering to the plunger must be removed. Moreover, given the complexity of the calculation steps, the BE method is not as widely. The short back extrusion (SBE) method proposed in this study is an improved immersed-type BE method. By setting the measurement position inside the sample, the upflow in the annular space is smooth even over a short distance (5-15 mm). Measurement over a short distance decreases the amount of sample adhered to the plunger, mitigating the need to remove any sample from the plunger after each measurement, thereby facilitating repeated measurements. A program automatically determines flow type and, using novel mathematical formulas, it calculates the measured characteristics of the flow. In addition, the greatest advantage of the SBE method is that it can measure samples containing solids. It can be measured in a state in which a person usually eats, because the larger the stress required for the flow, the wider the gap. Moreover, its measurement accuracy is comparable to cone-plate analysis, and the linear region of the analysis area is wide with less destructive movement.
    Language English
    Publishing date 2020-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 242507-5
    ISSN 1745-4603 ; 0022-4901
    ISSN (online) 1745-4603
    ISSN 0022-4901
    DOI 10.1111/jtxs.12501
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    In stock of ZB MED Bonn / Germany

    Z 7672: Show issues

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  6. Article ; Online: Analysis of viscosity measurements obtained using the short back extrusion method. Part 2: Verification of short back extrusion in viscometry.

    Hoshino, Takayoshi

    Journal of texture studies

    2020  Volume 51, Issue 2, Page(s) 214–224

    Abstract: The short back extrusion (SBE) method of the translational concentric cylinder viscometer improves upon the back extrusion (BE) method by starting from an immersed position and acting over a short distance. According to this improvement, the SBE method ... ...

    Abstract The short back extrusion (SBE) method of the translational concentric cylinder viscometer improves upon the back extrusion (BE) method by starting from an immersed position and acting over a short distance. According to this improvement, the SBE method can measure the flow behavior consecutively in short distance movement. Also using novel mathematical formulas, the analysis program automatic determines between Newtonian, power law, and Herschel-Bulkley flow and can be presented to the constitutive equation and the graph of the flow behavior. In the first part, the theory and mathematical analyses were presented; in this second part, the verification is presented to prove the accuracy of the SBE method using viscosity standard for Newtonian flow, locust bean gum solution for power-law flow, and commercial mayonnaise for Herschel-Bulkley flow. There are no viscosity standards in the non-Newtonian fluid, so the SBE method analysis was compared with the cone-plate viscometry. In special, the viscosity measurement of Herschel-Bulkley fluids using conventional cone-plate viscometry is very difficult because of the destruction of the sample structure by the rotational measurement. The yield stress of truly starting to flow cannot be measured and only the viscosity in the destroyed state can be measured. There is no other viscometry that can easily determine the characteristics of a fluid and display constitutive equations and graphs. Recently, the oscillatory shear testing has conducted replacing cone-plate viscometry but the SBE method can regain the right to measure viscosity of Herschel-Bulkley fluids.
    Language English
    Publishing date 2020-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 242507-5
    ISSN 1745-4603 ; 0022-4901
    ISSN (online) 1745-4603
    ISSN 0022-4901
    DOI 10.1111/jtxs.12510
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    In stock of ZB MED Bonn / Germany

    Z 7672: Show issues

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  7. Article ; Online: Extracellular Histones Promote Calcium Phosphate-Dependent Calcification in Mouse Vascular Smooth Muscle Cells.

    Hoshino, Tomonori / Kharaghani, Davood / Kohno, Shohei

    Journal of biochemistry

    2024  

    Abstract: Vascular calcification, a major risk factor for cardiovascular events, is associated with a poor prognosis in chronic kidney disease (CKD) patients. This process is often associated with the transformation of vascular smooth muscle cells (VSMCs) into ... ...

    Abstract Vascular calcification, a major risk factor for cardiovascular events, is associated with a poor prognosis in chronic kidney disease (CKD) patients. This process is often associated with the transformation of vascular smooth muscle cells (VSMCs) into cells with osteoblast-like characteristics. Damage-associated molecular patterns (DAMPs), such as extracellular histones released from damaged or dying cells, are suspected to accumulate at calcification sites. To investigate the potential involvement of DAMPs in vascular calcification, we assessed the impact of externally added histones (extracellular histones) on calcium and inorganic phosphate-induced calcification in mouse VSMCs. Our study found that extracellular histones intensified calcification. We also observed that the histones decreased the expression of VSMC marker genes, while simultaneously increasing the expression of osteoblast marker genes. Additionally, histones treated with DNase I, which degrades dsDNA, attenuated this calcification, compared with the non-treated histones, suggesting a potential involvement of dsDNA in this process. Elevated levels of dsDNA were also detected in the serum of CKD model mice, underlining its potential role in vascular calcification in CKD. Our findings suggest that extracellular histones could play a pivotal role in the vascular calcification observed in CKD.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvae011
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.202: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The copy number of the eukaryotic rRNA gene can be counted comprehensively.

    Yabuki, Akinori / Hoshino, Tatsuhiko / Nakamura, Tamiko / Mizuno, Keiko

    MicrobiologyOpen

    2024  Volume 13, Issue 2, Page(s) e1399

    Abstract: Gene sequence has been widely used in molecular ecology. For instance, the ribosomal RNA (rRNA) gene has been widely used as a biological marker to understand microbial communities. The variety of the detected rRNA gene sequences reflects the diversity ... ...

    Abstract Gene sequence has been widely used in molecular ecology. For instance, the ribosomal RNA (rRNA) gene has been widely used as a biological marker to understand microbial communities. The variety of the detected rRNA gene sequences reflects the diversity of the microorganisms existing in the analyzed sample. Their biomass can also be estimated by applying quantitative sequencing with information on rRNA gene copy numbers in genomes; however, information on rRNA gene copy numbers is still limited. Especially, the copy number in microbial eukaryotes is much less understood than that of prokaryotes, possibly because of the large and complex structure of eukaryotic genomes. In this study, we report an alternative approach that is more appropriate than the existing method of quantitative sequencing and demonstrate that the copy number of eukaryotic rRNA can be measured efficiently and comprehensively. By applying this approach widely, information on the eukaryotic rRNA copy number can be determined, and their community structures can be depicted and compared more efficiently.
    MeSH term(s) DNA Copy Number Variations ; Genes, rRNA ; Biomass ; Gene Dosage ; Microbiota ; RNA, Ribosomal/genetics
    Chemical Substances RNA, Ribosomal
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2661368-2
    ISSN 2045-8827 ; 2045-8827
    ISSN (online) 2045-8827
    ISSN 2045-8827
    DOI 10.1002/mbo3.1399
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  9. Article ; Online: Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers.

    Okayama, Ayumi / Hoshino, Tatsuya / Wada, Kohei / Takahashi, Hiroshi

    Chemistry and physics of lipids

    2024  Volume 259, Page(s) 105376

    Abstract: Membrane sterols contribute to the function of biomembranes by regulating the physical properties of the lipid bilayers. Cholesterol, a typical mammalian sterol, is biosynthesized by oxidation of lanosterol. From a molecular evolutionary perspective, ... ...

    Abstract Membrane sterols contribute to the function of biomembranes by regulating the physical properties of the lipid bilayers. Cholesterol, a typical mammalian sterol, is biosynthesized by oxidation of lanosterol. From a molecular evolutionary perspective, lanosterol is considered the ancestral molecule of cholesterol. Here, we studied whether cholesterol is superior to lanosterol in regulating the physical properties of the lipid bilayer in terms of the structural effect on model biomembranes composed of a phospholipid. For comparison, oxysterol, which is formed by oxidation of cholesterol, was also studied. The phospholipid used was 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), which is abundantly found in mammalian biomembranes, and 7β-hydroxycholesterol, which is highly cytotoxic, was used as the oxysterol. The apparent molecular volume was calculated from the mass density determined by the flotation method using H
    MeSH term(s) Phospholipids/chemistry ; Lanosterol/chemistry ; Lipid Bilayers/chemistry ; Oxysterols ; Cholesterol/chemistry ; Phosphatidylcholines/chemistry ; Sterols
    Chemical Substances Phospholipids ; Lanosterol (1J05Z83K3M) ; Lipid Bilayers ; Oxysterols ; Cholesterol (97C5T2UQ7J) ; Phosphatidylcholines ; Sterols
    Language English
    Publishing date 2024-02-06
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 213869-4
    ISSN 1873-2941 ; 0009-3084
    ISSN (online) 1873-2941
    ISSN 0009-3084
    DOI 10.1016/j.chemphyslip.2024.105376
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    Zs.A 804: Show issues Location:
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  10. Article: Molecular architecture of primate specific neural circuit formation.

    Shimogori, Tomomi / Onishi, Kohei / Hoshino, Takafumi / Nakanishi, Moe

    Research square

    2024  

    Abstract: The mammalian cortex is a highly evolved brain region, but we still lack a comprehensive understanding of the molecular mechanisms underlying primate-specific neural circuits formation. In this study, we employed spatial transcriptomics to assess gene ... ...

    Abstract The mammalian cortex is a highly evolved brain region, but we still lack a comprehensive understanding of the molecular mechanisms underlying primate-specific neural circuits formation. In this study, we employed spatial transcriptomics to assess gene expression dynamics in the marmoset cortex during development, focusing on key regions and time points. Spatial transcriptomics identified genes that are sexually, spatially, and temporally differentially expressed in the developing marmoset cortex. Our detailed analysis of the visual cortex unveiled dynamic changes in gene expression across layers with distinct projections and functions. Notably, we discovered numerous axon guidance molecules with spatiotemporal expression patterns unique to the developing marmoset prefrontal cortex (PFC), which control PFC neuronal circuits. Among these molecules,
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4082064/v1
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