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  1. Article ; Online: Autophagy modulation changes mechano-chemical sensitivity of T24 bladder cancer cells.

    Jobst, Maximilian / Hossain, Maliha / Kiss, Endre / Bergen, Janice / Marko, Doris / Del Favero, Giorgia

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 170, Page(s) 115942

    Abstract: Bladder cancer cells possess unique adaptive capabilities: shaped by their environment, cells face a complex chemical mixture of metabolites and xenobiotics accompanied by physiological mechanical cues. These responses might translate into resistance to ... ...

    Abstract Bladder cancer cells possess unique adaptive capabilities: shaped by their environment, cells face a complex chemical mixture of metabolites and xenobiotics accompanied by physiological mechanical cues. These responses might translate into resistance to chemotherapeutical regimens and can largely rely on autophagy. Considering molecules capable of rewiring tumor plasticity, compounds of natural origin promise to offer valuable options. Fungal derived metabolites, such as bafilomycin and wortmannin are widely acknowledged as autophagy inhibitors. Here, their potential to tune bladder cancer cells´ adaptability to chemical and physical stimuli was assessed. Additionally, dietary occurring mycotoxins were also investigated, namely deoxynivalenol (DON, 0.1-10 µM) and fusaric acid (FA, 0.1-1 mM). Endowing a Janus' face behavior, DON and FA are on the one side described as toxins with detrimental health effects. Concomitantly, they are also explored experimentally for selective pharmacological applications including anticancer activities. In non-cytotoxic concentrations, bafilomycin (BAFI, 1-10 nM) and wortmannin (WORT, 1 µM) modified cell morphology and reduced cancer cell migration. Application of shear stress and inhibition of mechano-gated PIEZO channels reduced cellular sensitivity to BAFI treatment (1 nM). Similarly, for FA (0.5 mM) PIEZO1 expression and inhibition largely aligned with the modulatory potential on cancer cells motility. Additionally, this study highlighted that the activity profile of compounds with similar cytotoxic potential (e.g. co-incubation DON with BAFI or FA with WORT) can diverge substantially in the regulation of cell mechanotransduction. Considering the interdependence between tumor progression and response to mechanical cues, these data promise to provide a novel viewpoint for the study of chemoresistance and associated pathways.
    MeSH term(s) Humans ; Mechanotransduction, Cellular ; Wortmannin/pharmacology ; Autophagy ; Antineoplastic Agents/pharmacology ; Urinary Bladder Neoplasms/drug therapy ; Ion Channels
    Chemical Substances Wortmannin (XVA4O219QW) ; Antineoplastic Agents ; PIEZO1 protein, human ; Ion Channels
    Language English
    Publishing date 2023-12-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Ultra-Sparse View Reconstruction for Flash X-Ray Imaging using Consensus Equilibrium

    Hossain, Maliha / Paulson, Shane C. / Liao, Hangjie / Chen, Weinong W. / Bouman, Charles A.

    2021  

    Abstract: A growing number of applications require the reconstructionof 3D objects from a very small number of views. In this research, we consider the problem of reconstructing a 3D object from only 4 Flash X-ray CT views taken during the impact of a Kolsky bar. ... ...

    Abstract A growing number of applications require the reconstructionof 3D objects from a very small number of views. In this research, we consider the problem of reconstructing a 3D object from only 4 Flash X-ray CT views taken during the impact of a Kolsky bar. For such ultra-sparse view datasets, even model-based iterative reconstruction (MBIR) methods produce poor quality results. In this paper, we present a framework based on a generalization of Plug-and-Play, known as Multi-Agent Consensus Equilibrium (MACE), for incorporating complex and nonlinear prior information into ultra-sparse CT reconstruction. The MACE method allows any number of agents to simultaneously enforce their own prior constraints on the solution. We apply our method on simulated and real data and demonstrate that MACE reduces artifacts, improves reconstructed image quality, and uncovers image features which were otherwise indiscernible.

    Comment: To be published in Asilomar Conference on Signals, Systems, and Computers 2020
    Keywords Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006
    Publishing date 2021-03-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: High-precision inversion of dynamic radiography using hydrodynamic features.

    Hossain, Maliha / Nadiga, Balasubramanya T / Korobkin, Oleg / Klasky, Marc L / Schei, Jennifer L / Burby, Joshua W / McCann, Michael T / Wilcox, Trevor / De, Soumi / Bouman, Charles A

    Optics express

    2022  Volume 30, Issue 9, Page(s) 14432–14452

    Abstract: While radiography is routinely used to probe complex, evolving density fields in research areas ranging from materials science to shock physics to inertial confinement fusion and other national security applications, complications resulting from noise, ... ...

    Abstract While radiography is routinely used to probe complex, evolving density fields in research areas ranging from materials science to shock physics to inertial confinement fusion and other national security applications, complications resulting from noise, scatter, complex beam dynamics, etc. prevent current methods of reconstructing density from being accurate enough to identify the underlying physics with sufficient confidence. In this work, we show that using only features that are robustly identifiable in radiographs and combining them with the underlying hydrodynamic equations of motion using a machine learning approach of a conditional generative adversarial network (cGAN) provides a new and effective approach to determine density fields from a dynamic sequence of radiographs. In particular, we demonstrate the ability of this method to outperform a traditional, direct radiograph to density reconstruction in the presence of scatter, even when relatively small amounts of scatter are present. Our experiments on synthetic data show that the approach can produce high quality, robust reconstructions. We also show that the distance (in feature space) between a testing radiograph and the training set can serve as a diagnostic of the accuracy of the reconstruction.
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.457497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: High-Precision Inversion of Dynamic Radiography Using Hydrodynamic Features

    Hossain, Maliha / Nadiga, Balasubramanya T. / Korobkin, Oleg / Klasky, Marc L. / Schei, Jennifer L. / Burby, Joshua W. / McCann, Michael T. / Wilcox, Trevor / De, Soumi / Bouman, Charles A.

    2021  

    Abstract: Radiography is often used to probe complex, evolving density fields in dynamic systems and in so doing gain insight into the underlying physics. This technique has been used in numerous fields including materials science, shock physics, inertial ... ...

    Abstract Radiography is often used to probe complex, evolving density fields in dynamic systems and in so doing gain insight into the underlying physics. This technique has been used in numerous fields including materials science, shock physics, inertial confinement fusion, and other national security applications. In many of these applications, however, complications resulting from noise, scatter, complex beam dynamics, etc. prevent the reconstruction of density from being accurate enough to identify the underlying physics with sufficient confidence. As such, density reconstruction from static/dynamic radiography has typically been limited to identifying discontinuous features such as cracks and voids in a number of these applications. In this work, we propose a fundamentally new approach to reconstructing density from a temporal sequence of radiographic images. Using only the robust features identifiable in radiographs, we combine them with the underlying hydrodynamic equations of motion using a machine learning approach, namely, conditional generative adversarial networks (cGAN), to determine the density fields from a dynamic sequence of radiographs. Next, we seek to further enhance the hydrodynamic consistency of the ML-based density reconstruction through a process of parameter estimation and projection onto a hydrodynamic manifold. In this context, we note that the distance from the hydrodynamic manifold given by the training data to the test data in the parameter space considered both serves as a diagnostic of the robustness of the predictions and serves to augment the training database, with the expectation that the latter will further reduce future density reconstruction errors. Finally, we demonstrate the ability of this method to outperform a traditional radiographic reconstruction in capturing allowable hydrodynamic paths even when relatively small amounts of scatter are present.

    Comment: Submitted to Optics Express
    Keywords Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2021-12-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Del Nido Cardioplegia can be safely administered in high-risk coronary artery bypass grafting surgery after acute myocardial infarction: a propensity matched comparison.

    Yerebakan, Halit / Sorabella, Robert A / Najjar, Marc / Castillero, Estibaliz / Mongero, Linda / Beck, James / Hossain, Maliha / Takayama, Hiroo / Williams, Mathew R / Naka, Yoshifumi / Argenziano, Michael / Bacha, Emile / Smith, Craig R / George, Isaac

    Journal of cardiothoracic surgery

    2014  Volume 9, Page(s) 141

    Abstract: Objective: Del Nido (DN) cardioplegia solution provides a depolarized hyperkalemic arrest lasting up to 60 minutes, and the addition of lidocaine may limit intracellular calcium influx. Single-dose DN cardioplegia solution may offer an alternative ... ...

    Abstract Objective: Del Nido (DN) cardioplegia solution provides a depolarized hyperkalemic arrest lasting up to 60 minutes, and the addition of lidocaine may limit intracellular calcium influx. Single-dose DN cardioplegia solution may offer an alternative myocardial protection strategy to multi-dose cold whole blood (WB) cardioplegia following acute myocardial infarction (AMI).
    Methods: We retrospectively reviewed 88 consecutive patients with AMI undergoing coronary artery bypass (CABG) surgery with cardioplegic arrest between June 2010 to June 2012. Patients exclusively received WB (n = 40, June 2010-July 2011) or DN (n = 48, August 2011-June 2012) cardioplegia. Preoperative and postoperative data were retrospectively reviewed and compared using propensity scoring.
    Results: No significant difference in age, maximum preoperative serum troponin level, ejection fraction, and STS score was present between DN and WB. A single cardioplegia dose was given in 41 DN vs. 0 WB patients (p < 0.001), and retrograde cardioplegia was used 10 DN vs. 31 WB patients (p < 0.001). Mean cardiopulmonary bypass and cross clamp times were significantly shorter in the DN group versus WB group. Transfusion rate, length of stay, intra-aortic balloon pump requirement, post-operative inotropic support, and 30-day mortality was no different between groups. One patient in the WB group required a mechanical support due to profound cardiogenic shock.
    Conclusions: DN cardioplegia may provide equivalent myocardial protection to existing cardioplegia without negative inotropic effects in the setting of acute myocardial infarction.
    MeSH term(s) Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Anterior Wall Myocardial Infarction/surgery ; Blood Transfusion ; Cardioplegic Solutions/administration & dosage ; Cardiopulmonary Bypass ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Drug Administration Schedule ; Female ; Heart Arrest, Induced/adverse effects ; Heart Arrest, Induced/methods ; Humans ; Intra-Aortic Balloon Pumping ; Male ; Middle Aged ; Postoperative Period ; Retrospective Studies ; Safety ; Shock, Cardiogenic/etiology ; Troponin/blood
    Chemical Substances Cardioplegic Solutions ; Troponin
    Language English
    Publishing date 2014-10-30
    Publishing country England
    Document type Journal Article
    ISSN 1749-8090
    ISSN (online) 1749-8090
    DOI 10.1186/s13019-014-0141-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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