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  1. Article ; Online: Development of a synthetic relaxin-3/INSL5 chimeric peptide ligand for NanoBiT complementation binding assays.

    Wu, Hongkang / Hoare, Bradley L / Handley, Thomas N G / Akhter Hossain, Mohammed / Bathgate, Ross A D

    Biochemical pharmacology

    2024  Volume 224, Page(s) 116238

    Abstract: INSL5 and relaxin-3 are relaxin family peptides with important roles in gut and brain function, respectively. They mediate their actions through the class A GPCRs RXFP4 and RXFP3. RXFP4 has been proposed to be a therapeutic target for colon motility ... ...

    Abstract INSL5 and relaxin-3 are relaxin family peptides with important roles in gut and brain function, respectively. They mediate their actions through the class A GPCRs RXFP4 and RXFP3. RXFP4 has been proposed to be a therapeutic target for colon motility disorders whereas RXFP3 targeting could be effective for neurological conditions such as anxiety. Validation of these targets has been limited by the lack of specific ligands and the availability of robust ligand-binding assays for their development. In this study, we have utilized NanoBiT complementation to develop a SmBiT-conjugated tracer for use with LgBiT-fused RXFP3 and RXFP4. The low affinity between LgBiT:SmBiT should result in a low non-specific luminescence signal and enable the quantification of binding without the tedious separation of non-bound ligands. We used solid-phase peptide synthesis to produce a SmBiT-labelled RXFP3/4 agonist, R3/I5, where SmBiT was conjugated to the B-chain N-terminus via a PEG
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116238
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  2. Article ; Online: الإسلام كقوة ناعمة لدولة قطر في تنظيم كأس العالَم 2022

    Hossain Mohammed Naimul Hoque / Latifa Menadi Al-Kaabi

    تجسير, Vol 3, Iss

    2021  Volume 2

    Abstract: يهدف هذا البحث إلى دراسة دور الإسلام في تكوين صورة إيجابية عن دولة قطر، من خلال دراسة العلاقة بين الإسلام – كدين – والقوة الناعمة، والمجالات التي يمكن للإسلام أن يؤدي دوره فيها، والنظرة الإسلامية للرياضة والترفيه، وسبُل تجاوز التحديات التي قد تواجهها ... ...

    Abstract يهدف هذا البحث إلى دراسة دور الإسلام في تكوين صورة إيجابية عن دولة قطر، من خلال دراسة العلاقة بين الإسلام – كدين – والقوة الناعمة، والمجالات التي يمكن للإسلام أن يؤدي دوره فيها، والنظرة الإسلامية للرياضة والترفيه، وسبُل تجاوز التحديات التي قد تواجهها الدولة في مدة استضافة كأس العالم من المنظور الإسلامي. بالإضافة إلى فرصة دولة قطر في تصحيح الصورة الخاطئة عن الإسلام لدى كثير ممن يحضرون فعالياتِ كأس العالم 2022. وقد اعتمد البحث على عدة مناهج علمية، كالمنهج الاستقرائي ومنهج تحليل المحتوى. وتوصَّل إلى نتائج مهمة، منها: إن الإسلام له نظرة إيجابية عن الرياضة والترفيه بضوابطهما الشرعية، وأن هناك علاقة وطيدة بين الإسلام والقوة الناعمة، بحيث يمكنه أن يؤدي دورًا مهمًا في تكوين صورة إيجابية عن دولة قطر، كما يمكن للإسلام أن يحلّ الكثير من التحديات التي قد تواجهها الدولة أثناء تنظيم هذا الحدث العالمي، وأن هذا الحدث يُعدّ فرصة مهمة لدولة قطر في تصحيح الصورة الخاطئة عن الإسلام والمسلمين لدى كثيرين ممن يحضرون هذه الفعالية.
    Keywords القوة الناعمة ; الإسلام ; كأس العالم 2022 ; دولة قطر ; استضافة ; مبادئ الشريعة ; Social Sciences ; H ; General Works ; A
    Language Arabic
    Publishing date 2021-12-01T00:00:00Z
    Publisher Qatar University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The cell cycle, cancer development and therapy.

    Jamasbi, Elaheh / Hamelian, Mona / Hossain, Mohammed Akhter / Varmira, Kambiz

    Molecular biology reports

    2022  Volume 49, Issue 11, Page(s) 10875–10883

    Abstract: The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes during cell division generate changes in chromosome content and ... ...

    Abstract The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes during cell division generate changes in chromosome content and alter the balances of chromosomes number. Any defects in expression of TIF1 family proteins, SAC proteins network, mitotic checkpoint proteins involved in chromosome mis-segregation and cancer development. Here we discuss the function of organelles deal with the chromosome segregation machinery, proteins and correction mechanisms involved in the accurate chromosome segregation during mitosis.
    MeSH term(s) Humans ; Chromosome Segregation ; Mitosis/genetics ; Cell Cycle/genetics ; M Phase Cell Cycle Checkpoints ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/therapy ; Kinetochores/metabolism
    Chemical Substances Cell Cycle Proteins
    Language English
    Publishing date 2022-08-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07788-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The Chemical Synthesis of Insulin: An Enduring Challenge.

    Karas, John A / Wade, John D / Hossain, Mohammed Akhter

    Chemical reviews

    2021  Volume 121, Issue 8, Page(s) 4531–4560

    Abstract: The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly, type 2 diabetes. With a worsening global diabetes epidemic and ... ...

    Abstract The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly, type 2 diabetes. With a worsening global diabetes epidemic and its significant health budget imposition, there is a great demand for new analogues possessing improved physical and functional properties. However, the chemical synthesis of insulin's intricate 51-amino acid, two-chain, three-disulfide bond structure, together with the poor physicochemical properties of both the individual chains and the hormone itself, has long represented a major challenge to organic chemists. This review provides a timely overview of the past efforts to chemically assemble this fascinating hormone using an array of strategies to enable both correct folding of the two chains and selective formation of disulfide bonds. These methods not only have contributed to general peptide synthesis chemistry and enabled access to the greatly growing numbers of insulin-like and cystine-rich peptides but also, today, enable the production of insulin at the synthetic efficiency levels of recombinant DNA expression methods. They have led to the production of a myriad of novel analogues with optimized structural and functional features and of the feasibility for their industrial manufacture.
    MeSH term(s) Amino Acid Sequence ; Animals ; Chemistry Techniques, Synthetic/methods ; Humans ; Insulin/analogs & derivatives ; Insulin/chemical synthesis ; Insulin/chemistry ; Protein Conformation
    Chemical Substances Insulin
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.0c01251
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  5. Article: Chemical Glycosylation and Its Application to Glucose Homeostasis-Regulating Peptides.

    Chandrashekar, Chaitra / Hossain, Mohammed Akhter / Wade, John D

    Frontiers in chemistry

    2021  Volume 9, Page(s) 650025

    Abstract: Peptides and proteins are attractive targets for therapeutic drug development due to their exquisite target specificity and low toxicity profiles. However, their complex structures give rise to several challenges including solubility, stability, ... ...

    Abstract Peptides and proteins are attractive targets for therapeutic drug development due to their exquisite target specificity and low toxicity profiles. However, their complex structures give rise to several challenges including solubility, stability, aggregation, low bioavailability, and poor pharmacokinetics. Numerous chemical strategies to address these have been developed including the introduction of several natural and non-natural modifications such as glycosylation, lipidation, cyclization and PEGylation. Glycosylation is considered to be one of the most useful modifications as it is known to contribute to increasing the stability, to improve solubility, and increase the circulating half-lifves of these biomolecules. However, cellular glycosylation is a highly complex process that generally results in heterogenous glycan structures which confounds quality control and chemical and biological assays. For this reason, much effort has been expended on the development of chemical methods, including by solid phase peptide synthesis or chemoenzymatic processes, to enable the acquisition of homogenous glycopeptides to greatly expand possibilities in drug development. In this mini-review, we highlight the importance of such chemical glycosylation methods for improving the biophysical properties of naturally non-glycosylated peptides as applied to the therapeutically essential insulin and related peptides that are used in the treatment of diabetes.
    Language English
    Publishing date 2021-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2021.650025
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  6. Article: Gray death: a powerful opioid combination leading to rapid fatality - correspondence.

    Hasan, Tanvir / Sami, Saad A / Barmon, Jaytirmoy / Hossain, Mohammed K / Emran, Talha B

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 4, Page(s) 1308–1309

    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000310
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  7. Article: Hydro-chemical characteristics and groundwater quality evaluation in south-western region of Bangladesh: A GIS-based approach and multivariate analyses.

    Hossain, Mohammed Sadid / Nahar, Nazneen / Shaibur, Molla Rahman / Bhuiyan, Md Tareq / Siddique, Abu Bakar / Al Maruf, Abdullah / Khan, Abu Shamim

    Heliyon

    2024  Volume 10, Issue 1, Page(s) e24011

    Abstract: The study focuses on the chemistry of groundwater and if it is suitable for drinking and for use in agriculture using water quality indices, GIS mapping, and multivariate analyses in Sharsa Upazila, Jashore district, Bangladesh. In this study, the ... ...

    Abstract The study focuses on the chemistry of groundwater and if it is suitable for drinking and for use in agriculture using water quality indices, GIS mapping, and multivariate analyses in Sharsa Upazila, Jashore district, Bangladesh. In this study, the concentration of NH
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24011
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  8. Article: Anti-oxidant and neuro-modulatory effects of bioactive

    Jyoti, Mifta Ahmed / Shah, Md Shahin / Uddin, Mohammad Najim / Hossain, Mohammed Kamrul / Han, Aixia / Geng, Peiwu / Islam, Mohammad Nazmul / Mamun, Abdullah Al

    Frontiers in chemistry

    2024  Volume 12, Page(s) 1341308

    Abstract: Byttneria ... ...

    Abstract Byttneria pilosa
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2024.1341308
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  9. Article ; Online: Total Chemical Synthesis of Aggregation-Prone Disulfide-Rich Starfish Peptides.

    Wu, Hongkang / Praveen, Praveen / Handley, Thomas Ng / Chandrashekar, Chaitra / Cummins, Scott F / Bathgate, Ross A D / Hossain, Mohammed Akhter

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e202400933

    Abstract: A relaxin-like gonad-stimulating peptide (RGP), Aso-RGP, featuring six cysteine residues, was identified in the Crown-of-Thorns Starfish (COTS, Acanthaster cf. solaris) and initially produced through recombinant yeast expression. This method yielded a ... ...

    Abstract : A relaxin-like gonad-stimulating peptide (RGP), Aso-RGP, featuring six cysteine residues, was identified in the Crown-of-Thorns Starfish (COTS, Acanthaster cf. solaris) and initially produced through recombinant yeast expression. This method yielded a single-chain peptide with an uncleaved C-peptide (His Tag) and suboptimal purity. Our objective was to chemically synthesize Aso-RGP in its mature form, comprising two chains (A and B) and three disulfide bridges, omitting the C-peptide. Furthermore, we aimed to synthesize a newly identified relaxin-like peptide, Aso-RLP2, from COTS, which had not been previously synthesized. This paper report the first total chemical synthesis of Aso-RGP and Aso-RLP2. Aso-RGP synthesis proceeded without major issues, whereas the A-chain of Aso-RLP2, in its reduced and unfolded state with two free thiols, presented considerable challenges. These were initially marked by "messy" RP-HPLC profiles, typically indicative of synthesis failure. Surprisingly, oxidizing the A-chain significantly improved the RP-HPLC profile, revealing the main issue was not synthesis failure but the peptide's aggregation tendency, which initially obscured analysis. This discovery highlights the critical need to account for aggregation in peptide synthesis and analysis. Ultimately, our efforts led to the successful synthesis of both peptides with purities exceeding 95%.
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400933
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  10. Article: Examination of power relations in fishers' resilience: Evidences from wetland fisheries in Bangladesh

    Hossain, Mohammed Anwar / Selamat, Nor Hafizah

    Indian journal of ecology. 2021 Apr., v. 48, no. 2

    2021  

    Abstract: Social relations of power influence fishers' access to wetland fisheries and their resilience to social-ecological disturbances to comanage fisheries in Bangladesh. This study deploys a survey and in-depth interviews to examine power relations and their ... ...

    Abstract Social relations of power influence fishers' access to wetland fisheries and their resilience to social-ecological disturbances to comanage fisheries in Bangladesh. This study deploys a survey and in-depth interviews to examine power relations and their effects on fishers' resilience drawing lessons from Boishgoan fishery of the northeastern wetland areas in Bangladesh. The results reveal that the sharing of power is characterized by disparities and inequities in fisheries co-management. Although co-management devolves fishing rights to fishers, the rich and powerful lease the fishery with the help of government officials (Department of Fisheries (DoF) and Local Government) and political leaders. The lack of political affiliations and resources mainly impede fishers' access to the fishery and their resilience to social-ecological disturbances in fisheries co-management. The existing power structure strengthens powerful persons' and hinders fishers' access to fisheries. The exclusion from benefits and management leads to fishers' marginalization and failure in co-management. Without reversing power asymmetries and inequalities, it is hardly possible to establish fishers' rights and resilience in co-management.
    Keywords collaborative management ; ecology ; fisheries ; local government ; politics ; surveys ; wetlands ; Bangladesh
    Language English
    Dates of publication 2021-04
    Size p. 530-535.
    Publishing place Indian Ecological Society
    Document type Article
    ZDB-ID 193796-0
    ISSN 0304-5250
    ISSN 0304-5250
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7625: Show issues

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