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Article ; Online: Management of Anterior Urethral Stricture: A Survey of Contemporary Practice of Iranian Urologists.

Hosseini, Jalil / Khannejad, Samin / Attar, Armin / Goudarzikarim, Ali

2024

Abstract: Purpose: To evaluate Iranian urologists' approach to urethral stricture and assess how often they select open urethroplasty over minimally invasive procedures.: Material and methods: This cross-sectional observational study was conducted via www.: ... ...

Abstract	Purpose: To evaluate Iranian urologists' approach to urethral stricture and assess how often they select open urethroplasty over minimally invasive procedures. Material and methods: This cross-sectional observational study was conducted via www. Survey: porsline.ir among members of the Iranian urologists' community. The urologists were contacted via email and social media applications (e.g., WhatsApp, Telegram), and data, including their demographic information and years of practice, as well as questions related to their attitude towards the management of urethral stricture, were collected. Results: A total number of 376 patients were included in the current survey. The specialty of reconstructive urology was selected by less than 2% (n=5) as their field of interest. Only 6.64% (n=25) of the urologists stated that they received adequate training for management of urethral stricture. Only about 5% (n=19), believed that according to scientific resources, chose open urethroplasty as the initial management. Almost 94% (n=353) did not perform any urethroplasties during the past year and about 0.2% (n=2) performed more than 20 open urethroplasties. For diagnosing urethral stricture, almost 99% of them chose RUG+VCUG, 72% chose urethrocystoscopy, and 69% chose uroflowmetry in the third place. For evaluation of urethroplasty postoperative outcomes, 76% (n=269) used RUG+VCUG, 15% (n=56) used Rigid Cystoscopy, and 8% (n=29) used Flexible Cystoscopy, Conclusion: Iranian urologists prefer minimally invasive procedures for treating urethral stricture, similar to other countries. This lack of urologists' interest in open urethroplasty is greatly due to poor training during the residency years and little experience with urethral strictures. Therefore, further considerations in order to improve urologists' knowledge and expertise for management of urethral stricture is recommended.
Language	English
Publishing date	2024-03-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v20i.7886
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mothers' Perceptions About Childbirth Preparation Classes: A Qualitative Study.

Kashiha, Mina / Hosseini, Jalil / Samadaee Gelehkolaee, Keshvar

International journal of community based nursing and midwifery

2023 Volume 11, Issue 4, Page(s) 278–286

Abstract: Background: Childbirth preparation classes are designed for better adaptation of couples to physiological and psychological changes related to pregnancy and childbirth. Therefore, we aimed to explore the mothers' perceptions about childbirth preparation ...

Abstract	Background: Childbirth preparation classes are designed for better adaptation of couples to physiological and psychological changes related to pregnancy and childbirth. Therefore, we aimed to explore the mothers' perceptions about childbirth preparation classes. Methods: A qualitative study was conducted using the conventional qualitative content analysis method from May to August 2022. Eighteen women who had given birth in the last six months in one of the hospitals in Tehran and at least 20 days had passed since their delivery were included in the study; also, five husbands, two midwives, and two obstetricians were interviewed. The participants were purposefully selected according to the inclusion criteria. Sampling continued until data saturation. Data were collected through individual, in-depth, and semi-structured interviews and analyzed by the MAXQDA version 10 software. Results: Mothers' age ranged from 17 to 37 years. 128 primary codes, 7 sub-sub themes, 3 sub-themes, and one theme were extracted. The sub-themes included satisfaction from the choice (perception forming for better choices, common consent), making the wait pleasant (dignity-oriented professional care, adaptation to change, feeling of empowerment), and good termination (free and conscious choice for birth mode, self-control during delivery process). Finally, a theme called "making motherhood pleasant" was extracted. Conclusion: Making motherhood pleasant can be a meaningful achievement of childbirth preparation classes. Paying more attention to improving the quality of these classes can help improve family health. Therefore, policymakers should implement strategies to facilitate women's access to these classes.
MeSH term(s)	Pregnancy ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Iran ; Mothers/psychology ; Prenatal Care ; Midwifery/methods ; Qualitative Research
Language	English
Publishing date	2023-10-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2760489-5
ISSN	2322-4835 ; 2322-4835
ISSN (online)	2322-4835
ISSN	2322-4835
DOI	10.30476/IJCBNM.2023.98607.2247
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Article ; Online: Ventral-Onlay Buccal Mucosal Graft Urethroplasty of a Perineal Fistula in a 26-Year-Old Patient With 46 XX Male Syndrome: A Case Report.

Hosseini, Jalil / Zamani Hajiabadi, Arshia / Mirjalili, Ali Mohammad

American journal of men's health

2023 Volume 17, Issue 2, Page(s) 15579883231156663

Abstract: Substitution urethroplasty with either a flap or graft is the gold standard for treating long segment urethral strictures. In 1992, Burger and colleagues rediscovered and popularized buccal mucosal graft (BMG). After that El-Kassaby and colleagues, in ... ...

Abstract	Substitution urethroplasty with either a flap or graft is the gold standard for treating long segment urethral strictures. In 1992, Burger and colleagues rediscovered and popularized buccal mucosal graft (BMG). After that El-Kassaby and colleagues, in 1993, used BMG to repair anterior urethral stricture. De la Chapelle syndrome or 46 XX male syndrome is a rare genetic disorder found in 1 in 20,000-25,000 men. This condition described as a presentation of male phenotype along a 46 xx karyotype. In this case report, we report a reconstructive surgery of a 46 XX male syndrome with ambiguous genitalia who presented with the chief complaint of bulbar urethral fistula opened in the perineal space. In this case, we used a buccal mucous graft with the ventral-onlay urethroplasty technique for reconstructing the failed bulbar urethra and closure of the fistula.
MeSH term(s)	Male ; Humans ; Urethra/surgery ; 46, XX Testicular Disorders of Sex Development/complications ; Mouth Mucosa/transplantation ; Urethral Stricture/surgery ; Fistula/surgery ; Fistula/complications ; Treatment Outcome
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883231156663
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Article ; Online: Tele-Urology in the Era of COVID-19: an Experience of the Reconstructive Urology Department in Iran.

Hosseini, Jalil / Eslami, Amir Hossein / Nematollahi, Shahrzad / Sharifian, Rayka / Sheikh Milani, Arezoo / Fatemi, Alireza

Urology journal

2024

Abstract: Introduction: The outbreak of coronavirus has put additional pressure on the health care systems of many countries; but telemedicine can be an important way to deal with it, especially for people whose health has been affected by the virus. The present ... ...

Abstract	Introduction: The outbreak of coronavirus has put additional pressure on the health care systems of many countries; but telemedicine can be an important way to deal with it, especially for people whose health has been affected by the virus. The present study aims to investigate the Implementation of a Tele-urology Program for Reconstructive Urologic Referrals: Initial Results and Patient Satisfaction. Material and methods: All patients with a history of a urethral reconstructive surgery during last year was entered to our study and two nurses collected data of demographic and past medical history of patients by existed. Telephone visits:Fellowship of reconstructive urology was connected to patients during a phone call and filled the USS-PROM and COVID-19 questionnaires. Face to face visits: All patients were asked to answer the questionnaire about recent exposure and infection by corona virus, recent travel and other risk factors of COVID-19. Results: Mean of USSPROM scale was calculated as 1.65 (+2.91) with a range of 0-15. Based on categorization for USSPROM scale, 74 patients (94.8%) had mild symptoms while 4 patients (5.1%) had moderate symptoms and needed further medical attention. Four patients with moderate USSPROM score were required to cystoscopic evaluation, which one patient with moderate USSPROM score had severe stricture and candidate for redo urethroplasty. Two other patients need for urethral stricture dilatation. Cost was calculated based on taxi-service fee. Accordingly, the average (+SD) cost for in-person visits to the physician was estimated as 4.80 + 4.32 million Rials. In terms of distance, the average distance for receiving medical services according to the patient`s residence area was 373.2 +348.79 kilometres.In terms of the patient`s opinion regarding virtual examination, inappropriateness of virtual visits for physical examination, and patient`s inability to explain the problem correctly, patient`s condition at the time of the virtual visit were the main challenges reported by the respondent. Conclusion: Considering that the present COVID-19 emergency will likely last for months, telehealth could be the safest way to deliver urological care for a large percentage of the patients, such as those who are more at risk of unfavorable outcomes of COVID-19.
Language	English
Publishing date	2024-03-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v20i.8096
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Article ; Online: Missed urethral duplication associated with hypospadias, post-hypospadias repair urethral stenosis, and recurrent urinary tract infections in an adult: a case report.

Hosseini, Jalil / Abouei, Saeid / Mirjalili, Alimohammad

Journal of medical case reports

2022 Volume 16, Issue 1, Page(s) 355

Abstract: Background: Duplication of urethra is a very rare congenital disorder. Several types of this anomaly have been reported around the world, and are also discussed in this report. However, the mechanism of this anomaly is still unclear.: Case: A 45-year- ...

Abstract	Background: Duplication of urethra is a very rare congenital disorder. Several types of this anomaly have been reported around the world, and are also discussed in this report. However, the mechanism of this anomaly is still unclear. Case: A 45-year-old Persian man with a complaint of recurrent urinary tract infection was referred to our clinic. He had a history of repairing penoscrotal hypospadias in childhood along with obstructive and irritating symptoms in adolescence. On his last voiding cystourethrogram and retrograde urethrogram, stenosis was observed in the proximal bulbar urethra along with a double urethra in the dorsal region of the main urethra. The double urethra was removed with operation, and he was followed for 1 month after surgery. He had no complaints of recurrence or urinary incontinence. Conclusions: This report shows the different classification systems, types of double urethra, and approach and management, which mainly involves surgery; however, surgical management should be done according to the anatomical findings of the abnormality.
MeSH term(s)	Adolescent ; Adult ; Constriction, Pathologic/complications ; Humans ; Hypospadias/complications ; Hypospadias/surgery ; Male ; Middle Aged ; Urethra/abnormalities ; Urethra/diagnostic imaging ; Urethra/surgery ; Urethral Stricture/diagnostic imaging ; Urethral Stricture/etiology ; Urethral Stricture/surgery ; Urinary Tract Infections/complications
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-022-03580-8
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Article: Male urethral diverticulum without having urethral stricture: A rare case.

Hosseini, Jalil / Karim, Ali Goudarzi / Abedi, Amir Reza

Urology case reports

2022 Volume 45, Page(s) 102272

Abstract: A rare case of male urethral diverticulum presents in this article. A 34-year-old man was referred to our clinic because of post-void dribbling. The retrograde cystogram and cystoscopy confirmed a 3 cm urethral diverticulum in the penile urethra without ... ...

Abstract	A rare case of male urethral diverticulum presents in this article. A 34-year-old man was referred to our clinic because of post-void dribbling. The retrograde cystogram and cystoscopy confirmed a 3 cm urethral diverticulum in the penile urethra without having urethra stricture. Open surgical repair was scheduled to excise urethral diverticulum and restore urethral continuity. Corpus spongiosum and dartus fascia was used to reinforce the repair.
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2022.102272
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Article ; Online: Outcomes of HUD Versus CIC in Patients With Urethral Strictures.

Hosseini, Jalil / Mirjalili, Ali Mohammad / Sharifian, Rayka / Abouei, Saeid / Tajamolian, Roya / Samadaee Gelehkolaee, Keshvar

American journal of men's health

2023 Volume 17, Issue 5, Page(s) 15579883231202714

Abstract: Treatment of urethral stricture is a complex reconstructive urology treatment. Previous surgery in the treatment of urethral stricture increases the risk of urinary incontinence. Therefore, this study aimed to assess the outcome of comparing two ... ...

Abstract	Treatment of urethral stricture is a complex reconstructive urology treatment. Previous surgery in the treatment of urethral stricture increases the risk of urinary incontinence. Therefore, this study aimed to assess the outcome of comparing two preservative or nonsurgical methods, clean intermittent catheterization (CIC) or hydraulic urethral dilatation (HUD). Forty-eight patients diagnosed with symptomatic urethral stricture were enrolled in the study. Patients were randomly divided into two groups: Nelaton-based dilatation and HUD treatment. Patients were assessed using patient-reported outcome measure for urethral stricture surgery (USS-PROM) through direct clinical interview and were followed up for 12 months. The rate of urinary infection, the need for surgical intervention, and the patient's quality of life were considered as outcomes of the interventions. SPSS software, version 20.0, was used for statistical analysis. Overall, 23 (47.9%) patients underwent HUD of stricture and Nelaton-based dilatation of stricture was done in 25 (52.1%) patients. We found that surgical intervention was required in four patients in the HUD group, but 15 patients in the CIC group required surgical intervention. Also, the need for surgical intervention and urinary tract infection (UTI) was significantly greater in the CIC group compared with the HUD group. With respect to the patient-reported outcomes, the mean Peeling's voiding picture (Q8) and EQ-VAS score (Q16) in the HUD group (
MeSH term(s)	Humans ; Urethral Stricture/surgery ; Constriction, Pathologic ; Dilatation/methods ; Quality of Life ; Urethra/surgery ; Treatment Outcome
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883231202714
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Article: Female anterior wall onlay urethroplasty with lower lip buccal mucosal graft: Importance of the laterally extended incision.

Emami, Maryam / Shadpour, Pejman / Kamali, Koosha / Narimani, Nima / Hosseini, Jalil

Asian journal of urology

2022 Volume 10, Issue 1, Page(s) 33–38

Abstract: Objective: To describe the outcome of female anterior wall (pubic side) onlay urethroplasty with buccal mucosal graft using laterally extended surgical dissection in patients with previously failed minimally invasive techniques.: Methods: From ... ...

Abstract	Objective: To describe the outcome of female anterior wall (pubic side) onlay urethroplasty with buccal mucosal graft using laterally extended surgical dissection in patients with previously failed minimally invasive techniques. Methods: From January 2016 to April 2018, 17 symptomatic patients with previously failed minimally invasive procedures were enrolled in the study. The diagnosis of urethral stricture was confirmed based on a combination of patients' symptoms, post-void residual urine, video-urodynamics, and cystoscopy. Urethroplasty with lower lip mucosal graft was performed using the modified laterally extended dissection. Patients were evaluated pre-operatively and 12-month post-operatively with the American Urological Association symptom score, post-void residual urine, and maximum flow rate. Results: Despite the previously failed minimally invasive procedures, urethroplasty with lower lip buccal graft and laterally extended dissection resulted in favorable outcomes (success rate=94%). The mean±standard deviation of American urological association symptom score improved from pre-operative levels at the 12-month post-operative follow-up (25.82±3.97 to 10.88±5.57); so did postvoid residual urine (71.12±74.98 mL to 15.00±28.30 mL), and maximum flow rate (7.88±1.72 mL/s to 25.82±5.59 mL/s) with all statistically significant ( Conclusion: The current study showed that female urethroplasty with buccal graft could be highly successful in experienced hands. An anterior approach could be superior to the posterior one due to higher mechanical support and lower sacculation rate. A laterally extended incision may improve visualization and better graft placement by providing wider working space. The results should be evaluated in the future studies with larger sample size.
Language	English
Publishing date	2022-04-11
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2831144-9
ISSN	2214-3882
ISSN	2214-3882
DOI	10.1016/j.ajur.2022.04.002
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Article ; Online: MiR-106b-5p Regulates the Reprogramming of Spermatogonial Stem Cells into iPSC (Induced Pluripotent Stem Cell)-Like Cells

Hasani Fard, Amir Hossein / Valizadeh, Mahmoud / Mazaheri, Zohreh / Hosseini, Jalil

Iranian biomedical journal

2022 Volume 26, Issue 4, Page(s) 291–300

Abstract: Background: Recent years have brought notable progress in raising the efficiency of the reprogramming technique so that approaches have evolved from known transgenic factors to only a few miRNAs. Nevertheless, there is a poor understanding of both the ... ...

Abstract	Background: Recent years have brought notable progress in raising the efficiency of the reprogramming technique so that approaches have evolved from known transgenic factors to only a few miRNAs. Nevertheless, there is a poor understanding of both the key factors and biological networks underlying this reprogramming. The present study aimed to investigate the potential of miR-106b-5p in regulating spermatogonial stem cells (SSCs) to induced pluripotent stem cell (iPSC)-like cells. Methods: We used SSCs because pluripotency is inducible in SSCs under defined culture conditions, and they have a few issues compared to other adult stem cells. As both signaling and post-transcriptional gene controls are critical for pluripotency regulation, we traced the expression of Oct-4, Sox-2, Klf-4, c-Myc, and Nanog (OSKMN). Besides, we considered miR-106b-5p targets using bioinformatic methods. Results: Our results showed that transfected SSCs with miR-106b-5p increased the expression of the OSKMN factors, which was significantly more than negative control groups. Moreover, using the functional miRNA enrichment analysis, online tools, and databases, we predicted that miR-106b-5p targeted a signaling pathway gene named MAPK1/ERK2, related to regulating stem cell pluripotency. Conclusion: Together, our data suggest that miR-106b-5p regulates the reprogramming of SSCs into iPSC-like cells. Furthermore, noteworthy progress in the in vitro development of SSCs indicates promise reservoirs and opportunities for future clinical trials.
MeSH term(s)	Induced Pluripotent Stem Cells ; MicroRNAs ; Signal Transduction
Chemical Substances	MicroRNAs
Language	English
Publishing date	2022-07-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2489282-8
ISSN	2008-823X ; 1028-852X
ISSN (online)	2008-823X
ISSN	1028-852X
DOI	10.52547/ibj.3594
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Article ; Online: Elevated angiopoietin-like protein 3 serum levels in diabetic nephropathy patients and its association with renal function and lipid profile.

Azadi, Samaneh Mohassel / Fadaei, Reza / Omid-Shafaat, Ramtin / Hosseini, Jalil / Moradi, Nariman

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 172

Abstract: Background: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease that has life-threatening consequences like micro and macrovascular complication. Diabetic nephropathy (DN) is one of the common consequences of T2DM which is related to secretory ...

Abstract	Background: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease that has life-threatening consequences like micro and macrovascular complication. Diabetic nephropathy (DN) is one of the common consequences of T2DM which is related to secretory factors like hepatokines. Angiopoietin-Like Protein 3 (ANGPTL3) is a hepatokine that is perturbated in cardiometabolic diseases and experimental studies showed its effect on renal functions and lipid metabolism. For the first time, ANGPTL3 was measured in patients with T2DM and DN in the present study. Methods: Serum levels of ANGPTL3, IL-6, and TNF-α were measured in 60 healthy control, 60 T2DM patients, and 61 DN patients. Results: Serum levels of ANGPTL3 increased in T2DM (252.39 ± 66.01) and DN (284.59 ± 69.27) patients compared to controls (160.22 ± 48.96), and DN patients compared with T2DM patients. Urinary albumin excretion (UAE) was higher in the DN group compared to T2DM and control groups. Moreover, serum levels of IL-6 and TNF-α were elevated in both patient groups compared to controls. Moreover, ANGPTL3 represented a positive correlation with triglycerides, creatinine, and UAE in patients with both T2DM and DN groups and showed an inverse correlation with eGFR in patients with DN. Moreover, this hepatokine had a good potential to differentiate patients from controls, especially, DN patients. Conclusions: these findings provide invivo evidence for the relation of ANGPTL3 with renal dysfunction and hypertriglyceridemia in patients with DN which is in line with experimental findings and suggested a potential role for this hepatokine in DN pathogenesis.
MeSH term(s)	Humans ; Angiopoietin-Like Protein 3 ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/etiology ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Albumins ; Triglycerides ; Kidney/physiology
Chemical Substances	Angiopoietin-Like Protein 3 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Albumins ; Triglycerides ; ANGPTL3 protein, human
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03214-1
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