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Article ; Online: Maintaining the balance: the critical role of plasmin activity in orthopedic surgery injury response.

Moore-Lotridge, Stephanie N / Hajdu, Katherine S / Hou, Brian Q / Gibson, Breanne H Y / Schoenecker, Jonathan G

Journal of thrombosis and haemostasis : JTH

2023 Volume 21, Issue 10, Page(s) 2653–2665

Abstract: The musculoskeletal system plays vital roles in the body, facilitating movement, protecting vital structures, and regulating hematopoiesis and mineral metabolism. Injuries to this system are common and can cause chronic pain, loss of range of motion, and ...

Abstract	The musculoskeletal system plays vital roles in the body, facilitating movement, protecting vital structures, and regulating hematopoiesis and mineral metabolism. Injuries to this system are common and can cause chronic pain, loss of range of motion, and disability. The acute phase response (APR) is a complex process necessary for surviving and repairing injured musculoskeletal tissue. To conceptualize the APR, it is useful to divide it into 2 distinct phases, survival and repair. During the survival-APR, a "damage matrix" primarily composed of fibrin, via thrombin activity, is produced to contain the zone of injury. Once containment is achieved, the APR transitions to the repair phase, where reparative inflammatory cells use plasmin to systematically remove the damage matrix and replace it with new permanent matrices produced by differentiated mesenchymal stem cells. The timing of thrombin and plasmin activation during their respective APR phases is crucial for appropriate regulation of the damage matrix. This review focuses on evidence indicating that inappropriate exuberant activation of plasmin during the survival-APR can result in an overactive APR, leading to an "immunocoagulopathy" that may cause "immunothrombosis" and death. Conversely, preclinical data suggest that too little plasmin activity during the repair-APR may contribute to failed tissue repair, such as a fracture nonunion, and chronic inflammatory degenerative diseases like osteoporosis. Future clinical studies are required to affirm these findings. Therefore, the temporal-spatial functions of plasmin in response to musculoskeletal injury and its pharmacologic manipulation are intriguing new targets for improving orthopedic care.
MeSH term(s)	Humans ; Fibrinolysin/metabolism ; Fibrinolysis ; Thrombin/metabolism ; Fibrin ; Orthopedic Procedures/adverse effects
Chemical Substances	Fibrinolysin (EC 3.4.21.7) ; Thrombin (EC 3.4.21.5) ; Fibrin (9001-31-4)
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2023.08.002
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Navigating the Enigma of Pediatric Musculoskeletal Infections: A Race Against Time.

Moore-Lotridge, Stephanie N / Hou, Brian Q / Hajdu, Katherine S / Anand, Malini / Hefley, William / Schoenecker, Jonathan G

The Orthopedic clinics of North America

2023 Volume 55, Issue 2, Page(s) 217–232

Abstract: Musculoskeletal infection (MSKI) in children is a critical condition in pediatric orthopedics due to the potential for serious adverse outcomes, including multiorgan dysfunction syndrome, which can lead to death. The diagnosis and treatment of MSKI ... ...

Abstract	Musculoskeletal infection (MSKI) in children is a critical condition in pediatric orthopedics due to the potential for serious adverse outcomes, including multiorgan dysfunction syndrome, which can lead to death. The diagnosis and treatment of MSKI continue to evolve with advancements in infectious organisms, diagnostic technologies, and pharmacologic treatments. It is imperative for pediatric orthopedic surgeons and medical teams to remain up to date with the latest MSKI practices.
MeSH term(s)	Child ; Humans ; Osteomyelitis/diagnosis ; Osteomyelitis/therapy ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/therapy
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417389-2
ISSN	1558-1373 ; 0030-5898
ISSN (online)	1558-1373
ISSN	0030-5898
DOI	10.1016/j.ocl.2023.09.004
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Article ; Online: Symptom resolution following a repeat concussion within the same athlete.

Tang, Alan R / Williams, Kristen L / Davis, Philip J / Grusky, Alan Z / Hou, Brian Q / Hajdu, Katherine S / Yengo-Kahn, Aaron M / Zuckerman, Scott L / Terry, Douglas P

Brain injury

2024 Volume 38, Issue 4, Page(s) 295–303

Abstract: Introduction: Repeat sport-related concussion (SRC) is anecdotally associated with prolonged recovery. Few studies have examined repeat concussion within the same athlete. We sought to explore differences in symptom burden and recovery outcomes in an ... ...

Abstract	Introduction: Repeat sport-related concussion (SRC) is anecdotally associated with prolonged recovery. Few studies have examined repeat concussion within the same athlete. We sought to explore differences in symptom burden and recovery outcomes in an individual athlete's initial and repeat SRC. Methods: A retrospective within-subject cohort study of athletes aged 12-23 years diagnosed with two separate SRCs from 11/2017-10/2020 was conducted. Primary outcomes were initial symptom severity and time-to-symptom-resolution. Secondary outcomes included return-to-learn (RTL) and return-to-play (RTP) duration. Results: Of 868 athletes seen, 47 athletes presented with repeat concussions. Median time between concussions was 244 days (IQR 136-395). Comparing initial to repeat concussion, no differences were observed in time-to-clinic (4.3 ± 7.3vs.3.7 ± 4.6 days, Conclusion: No significant differences in symptom duration and RTP/RTL were seen between initial/repeat concussion.
MeSH term(s)	Humans ; Athletic Injuries/complications ; Athletic Injuries/diagnosis ; Cohort Studies ; Retrospective Studies ; Brain Concussion/diagnosis ; Brain Concussion/complications ; Athletes
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699052.2024.2311341
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Zs.A 2242: Show issues

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Article ; Online: Racial and Socioeconomic Disparities in Laminoplasty Versus Laminectomy With Fusion in Patients With Cervical Spondylosis.

Hou, Brian Q / Croft, Andrew J / Vaughan, Wilson E / Davidson, Claudia / Pennings, Jacquelyn S / Bowers, Mitchell F / Vickery, Justin W / Abtahi, Amir M / Gardocki, Raymond J / Lugo-Pico, Julian G / Zuckerman, Scott L / Stephens, Byron F

Spine

2024 Volume 49, Issue 10, Page(s) 694–700

Abstract: Study design: A retrospective cohort study using prospectively collected data.: Objective: The aim of this study was to investigate preoperative differences in racial and socioeconomic factors in patients undergoing laminoplasty (LP) versus ... ...

Abstract	Study design: A retrospective cohort study using prospectively collected data. Objective: The aim of this study was to investigate preoperative differences in racial and socioeconomic factors in patients undergoing laminoplasty (LP) versus laminectomy and fusion (LF) for degenerative cervical myelopathy (DCM). Summary of background data: DCM is prevalent in the United States, requiring surgical intervention to prevent neurological degeneration. While LF is utilized more frequently, LP is an emerging alternative. Previous studies have demonstrated similar neurological outcomes for both procedures. However, treatment selection is primarily at the discretion of the surgeon and may be influenced by social determinants of health that impact surgical outcomes. Materials and methods: The Quality Outcome Database (QOD), a national spine registry, was queried for adult patients who underwent either LP or LF for the management of DCM. Covariates associated with socioeconomic status, pain and disability, and demographic and medical history were collected. Multivariate logistic regression was performed to assess patient factors associated with undergoing LP versus LF. Results: Of 1673 DCM patients, 157 (9.4%) underwent LP and 1516 (90.6%) underwent LF. A significantly greater proportion of LP patients had private insurance (P<0.001), a greater than high school level education (P<0.001), were employed (P<0.001), and underwent primary surgery (P<0.001). LP patients reported significantly lower baseline neck/arm pain and Neck Disability Index (P<0.001). In the multivariate regression model, lower baseline neck pain [odds ratio (OR)=0.915, P=0.001], identifying as non-Caucasian (OR=2.082, P<0.032), being employed (OR=1.592, P=0.023), and having a greater than high school level education (OR=1.845, P<0.001) were associated with undergoing LP rather than LF. Conclusions: In DCM patients undergoing surgery, factors associated with patients undergoing LP versus LF included lower baseline neck pain, non-Caucasian race, higher education, and employment. While symptomatology may influence the decision to choose LP over LF, there may also be socioeconomic factors at play. The trend of more educated and employed patients undergoing LP warrants further investigation.
MeSH term(s)	Humans ; Male ; Female ; Laminoplasty/methods ; Laminectomy/methods ; Middle Aged ; Spondylosis/surgery ; Cervical Vertebrae/surgery ; Spinal Fusion/methods ; Retrospective Studies ; Aged ; Socioeconomic Factors ; Adult ; Treatment Outcome ; Healthcare Disparities/ethnology ; Socioeconomic Disparities in Health
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article ; Comparative Study
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000004793
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Zs.A 1305: Show issues

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Article ; Online: Health Care Navigation of Black and White Adolescents After Sport-Related Concussion: A Path Toward Health Equity.

Wallace, Jessica / Hou, Brian Q / Hajdu, Katherine / Tang, Alan R / Grusky, Alan Z / Lee, Timothy / Zuckerman, Scott L / Yengo-Kahn, Aaron M

Journal of athletic training

2022 Volume 57, Issue 4, Page(s) 352–359

Abstract: Context: Care-seeking behaviors for sport-related concussion (SRC) are not consistent across demographic subgroups. Not only may these differences stem from health inequities, but they can perpetuate disparities in care for SRCs.: Objective: To ... ...

Abstract	Context: Care-seeking behaviors for sport-related concussion (SRC) are not consistent across demographic subgroups. Not only may these differences stem from health inequities, but they can perpetuate disparities in care for SRCs. Objective: To determine whether racial differences existed in the care pathway from injury to SRC clinic of adolescent athletes. Design: Retrospective cohort study. Setting: Regional SRC center. Patients or other participants: Of 582 total athletes, 96 (16.5%) Black and 486 (83.5%) White adolescent athletes were diagnosed with SRC and evaluated within 3 months at the SRC clinic. Main outcome measure(s): Race was the defined exposure, dichotomized as Black or White. The 4 primary outcomes were (1) location of the first health system contact, (2) time from injury to the first health system contact, (3) time to the in-person SRC clinic visit, and (4) whether the athlete established care (>1 visit), was released immediately to an athletic trainer, or was lost to follow-up. Results: Black and White athletes mostly presented directly to the SRC clinic (61.5% versus 62.3%) at a median (interquartile range) of 3 (1-5) and 4 (1-8) days, respectively (P = .821). Similar proportions of Black and White athletes also first presented to the emergency department (30.2% and 27.2%) at a median of 0 (0-1) versus 0 (0-1) days, respectively (P = .941). Black athletes more frequently had care transferred to their athletic trainer than White athletes (39.6% versus 29.6%) and less frequently established care (56.3% versus 64.0%), respectively; however, these differences were not statistically significant (P = .138). Loss to follow-up was uncommon among Black (4.2%) and White (6.4%) athletes alike. Conclusions: Within an established SRC referral network and multidisciplinary clinic, no racial disparities were observed in how athletes were initially managed or ultimately presented to the SRC clinic despite racial differences in school type and insurance coverage. The SRC center assimilation and affiliation with school systems may be helpful in improving access and providing equitable care across diverse patient demographics.
MeSH term(s)	Adolescent ; Athletes ; Athletic Injuries/diagnosis ; Brain Concussion/diagnosis ; Health Equity ; Humans ; Retrospective Studies ; Sports
Language	English
Publishing date	2022-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2070051-9
ISSN	1938-162X ; 1062-6050
ISSN (online)	1938-162X
ISSN	1062-6050
DOI	10.4085/1062-6050-0330.21
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Article ; Online: Factors Associated With Additional Clinic Visits in the Treatment of Sports-Related Concussion.

Hou, Brian Q / Yengo-Kahn, Aaron M / Hajdu, Katherine / Tang, Alan R / Grusky, Alan Z / Zuckerman, Scott L / Terry, Douglas P

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

2022 Volume 32, Issue 6, Page(s) 588–594

Abstract: Objective: To evaluate the variables associated with additional concussion clinic visits before discharge to athletic trainer (AT).: Design: Retrospective cohort study.: Setting: Multidisciplinary Sports Concussion Center.: Patients: Patients ... ...

Abstract	Objective: To evaluate the variables associated with additional concussion clinic visits before discharge to athletic trainer (AT). Design: Retrospective cohort study. Setting: Multidisciplinary Sports Concussion Center. Patients: Patients ages 12 to 23 years presenting with a sport-related concussion between January 11, 2017, and January 10, 2020, and were discharged to an AT. Methodology: Our main outcome variable was being discharged to AT after the initial clinic visit versus those who attended additional clinic visits before AT discharge. We examined the influence of age, sex, initial visit symptom score, family and personal history of psychiatric disorders and migraines, history of prior concussions, and other variables on this outcome. Results: Of 524 patients, 236 were discharged to AT after the initial clinic visit, while 288 patients required additional clinic visits. The additional visit group had higher initial visit symptom scores ( P = 0.002), head imaging performed more frequently ( P < 0.02), a family history of psychiatric disorders and/or migraines ( P < 0.001, P < 0.001), more often reported a prior concussion ( P = 0.02), and was younger ( P = 0.014) compared with the one visit group. In a multiple variable model, the family history of psychiatric disorders [odds ratio (OR), 3.12 (95% CI, 1.531-6.343), P = 0.002], prior concussions [OR, 1.39 (95% CI, 1.020-1.892), P = 0.037], greater initial symptom score [OR, 1.05 (95% CI, 1.031-1.058), P < 0.001], and younger age [OR, 0.87 (95% CI, 0.773-0.979), P = 0.021] were strongly associated with additional visits. Conclusions: Among athletes treated at a regional sports concussion center, family history of psychiatric disorders, increased symptom score at initial visit, prior concussions, and younger age were each uniquely associated with needing additional clinic visits at the time of initial assessment. Understanding these variables may guide treatment protocols for optimal care.
MeSH term(s)	Humans ; Child ; Adolescent ; Young Adult ; Adult ; Athletic Injuries/diagnosis ; Retrospective Studies ; Brain Concussion/diagnosis ; Brain Concussion/therapy ; Brain Concussion/complications ; Sports ; Athletes ; Migraine Disorders/complications ; Ambulatory Care
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062530-6
ISSN	1536-3724 ; 1050-642X
ISSN (online)	1536-3724
ISSN	1050-642X
DOI	10.1097/JSM.0000000000001057
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Article ; Online: Predicting early versus late recovery from sport-related concussion using decision tree analysis.

Allen, Jackson H / Tang, Alan R / Hajdu, Katherine S / Hou, Brian Q / Grusky, Alan Z / Chen, Heidi / Bonfield, Christopher M / Zuckerman, Scott L / Terry, Douglas P / Yengo-Kahn, Aaron M

Journal of neurosurgery. Pediatrics

2023 Volume 32, Issue 1, Page(s) 9–18

Abstract: Objective: Accurately predicting early (≤ 14 days) versus typical (15-27 days) or delayed (≥ 28 days) recovery from sport-related concussion (SRC) may allow for improved resource utilization and precision in planning and carrying out rehabilitation. In ... ...

Abstract	Objective: Accurately predicting early (≤ 14 days) versus typical (15-27 days) or delayed (≥ 28 days) recovery from sport-related concussion (SRC) may allow for improved resource utilization and precision in planning and carrying out rehabilitation. In this study, the authors sought to develop an algorithm that enables accurate differentiation of recovery periods and duration after SRC. The authors hypothesized that data regarding initial symptom burden as quantified by a Post-Concussion Symptom Scale (PCSS) score, time to presentation, and number of prior concussions would be the most useful for analyzing predictive factors for concussion recovery duration. Methods: A retrospective case-control study was conducted to assess the primary outcome of days to clinical recovery following SRC in pediatric patients. Data from patients 12-18 years old presenting within 28 days of injury to an SRC clinic between November 11, 2017, and October 10, 2020, were analyzed. Patients with positive evidence of injury on head imaging or incomplete records were excluded. The primary outcome was duration of clinical recovery, grouped as early (≤ 14 days), typical (15-27 days), or delayed (≥ 28 days). Recovery was defined as follows: 1) symptom resolution or return to baseline, or 2) initiation of graduated return to play. CHAID (chi-square automatic interaction detection) analysis was used to optimize a decision tree based on 16 input factors, including age, sex, initial PCSS score, time to clinic presentation, number of prior concussions, and presence of defined symptom clusters. The cohort was randomized into training (70%) and test (30%) samples for algorithm validation. Results: A total of 493 patients met the inclusion criteria (mean age 15.7 ± 1.5 years, 68.2% male, 70.0% White). The median time to presentation was 5 days (IQR 2-10 days). Most patients (52.3%) recovered within 14 days of injury, 21.5% recovered within 15-27 days, and 26.2% had a recovery period of 28 days or longer. The variables most predictive of recovery were initial PCSS score (cutoffs ≤ 6, 7-28, or ≥ 29), time to presentation (≤ 7 vs > 7 days), or prior concussions (0 vs ≥ 1). The model accurately discriminated between early versus typical or delayed recovery duration groupings (area under the curve 0.80, Youden index 0.44), and correctly classified > 90% of patients who recovered early. Conclusions: This novel three-factor predictive tool enabled accurate discrimination of early versus typical or delayed SRC recovery to better allocate resources, counsel patients, and make timely referrals.
MeSH term(s)	Humans ; Child ; Adolescent ; Retrospective Studies ; Athletic Injuries/diagnosis ; Case-Control Studies ; Brain Concussion/diagnosis ; Post-Concussion Syndrome/diagnosis ; Decision Trees
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2023.2.PEDS2330
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Uk I Zs.135 -Pediatrics-: Show issues

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Article ; Online: Investigation of Factors Contributing to Racial Differences in Sport-Related Concussion Outcomes.

Tang, Alan R / Wallace, Jessica / Grusky, Alan Z / Hou, Brian Q / Hajdu, Katherine S / Bonfield, Christopher M / Zuckerman, Scott L / Yengo-Kahn, Aaron M

World neurosurgery

2023 Volume 173, Page(s) e755–e765

Abstract: Objective: Following sport-related concussion (SRC), early studies have demonstrated racial differences in time to clinical recovery; however, these differences have not been fully explained. We sought to further explore these associations by ... ...

Abstract	Objective: Following sport-related concussion (SRC), early studies have demonstrated racial differences in time to clinical recovery; however, these differences have not been fully explained. We sought to further explore these associations by considering possible mediating/moderating factors. Methods: Data from patients aged 12-18 years diagnosed with SRC from November 2017 to October 2020 were analyzed. Those missing key data, lost to follow-up, or missing race were excluded. The exposure of interest was race, dichotomized as Black/White. The primary outcome was time to clinical recovery (days from injury until the patient was either deemed recovered by an SRC provider or symptom score returned to baseline or zero.) RESULTS: A total of 389 (82%) White and 87 (18%) Black athletes with SRC were included. Black athletes more frequently reported no SRC history (83% vs. 67%, P = 0.006) and lower symptom burden at presentation (median total Post-Concussion Symptom Scale 11 vs. 23, P < 0.001) than White athletes. Black athletes achieved earlier clinical recovery (hazard ratio [HR] = 1.35, 95% CI 1.03-1.77, P = 0.030), which remained significant (HR = 1.32, 95% CI 1.002-1.73, P = 0.048) after adjusting for confounders associated with recovery but not race. A third model adding the initial Post-Concussion Symptom Scale score nullified the association between race/recovery (HR = 1.12, 95% CI 0.85-1.48, P = 0.410). Adding prior concussion history further reduced the association between race/recovery (HR = 1.01, 95% CI 0.77-1.34, P = 0.925). Conclusions: Overall, Black athletes initially presented with fewer concussion symptoms than White athletes, despite no difference in time to clinic. Black athletes achieved earlier clinical recovery following SRC, a difference explained by differences in initial symptom burden and self-reported concussion history. These crucial differences may stem from cultural/psychologic/organic factors.
MeSH term(s)	Humans ; Post-Concussion Syndrome/complications ; Athletic Injuries/complications ; Race Factors ; Brain Concussion/complications ; Sports ; Athletes
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.03.009
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Zs.A 1159: Show issues

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Article ; Online: Use of acute cognitive symptom cluster to predict return-to-learn duration following a sport-related concussion.

Tang, Alan R / Davis, Philip J / Williams, Kristen L / Grusky, Alan Z / Hajdu, Katherine S / Hou, Brian Q / Yengo-Kahn, Aaron M / Zuckerman, Scott L / Terry, Douglas P

Journal of neurosurgery. Pediatrics

2022 Volume 30, Issue 4, Page(s) 378–385

Abstract: Objective: Adolescents sustaining sport-related concussion often experience difficulties with the return-to-learn (RTL) process. Whereas the initial symptom burden has predicted prolonged RTL, no studies have established a relationship between acute ... ...

Abstract	Objective: Adolescents sustaining sport-related concussion often experience difficulties with the return-to-learn (RTL) process. Whereas the initial symptom burden has predicted prolonged RTL, no studies have established a relationship between acute cognitive symptoms and RTL duration. The authors sought to evaluate the relationship between initial cognitive symptoms and RTL duration. Methods: A retrospective single-institution cohort study of adolescent athletes aged 12-23 years who were evaluated within 5 days of a diagnosed sport-related concussion between November 2017 and October 2020 was conducted. Athletes missing cognitive symptom ratings and RTL data were excluded. The primary exposure variable was the Cognitive Symptom Ratio (CSR), defined as total cognitive symptom cluster score divided by total Post-Concussion Symptom Scale (PCSS) score from the initial clinic visit. Primary and secondary outcomes were time to RTL and total length of care, respectively. Multivariable Cox proportional hazards modeling was used to assess the effect of CSR on RTL duration. Results: Of 653 athletes evaluated within 5 days of injury, 346 patients were included in the final cohort. Athletes reported a median initial PCSS score of 21 (interquartile range [IQR] 6-37) and a median cognitive symptom score of 4 (IQR 0-9). Most patients endorsed some degree of difficulty concentrating (n = 212, 61.3%). The median CSR was 0.18 (IQR 0.00-0.27). On multivariable regression analysis, a higher CSR was associated with prolonged RTL duration (HR 0.30, 95% CI 0.13-0.69, p = 0.004). When initial PCSS score was added to the model, the previously significant association between CSR and RTL was no longer significant (HR 0.67, 95% CI 0.29-1.59, p = 0.367). When dichotomized based on frequency distribution, a higher proportion of patients with low CSR achieved RTL by 7 days postinjury (82.2% vs 69.9%, p = 0.007), a difference not seen at 14 days (92.2% vs 87.3%, p = 0.133). Conclusions: An acute ratio of cognitive symptoms may predict patients at increased risk for prolonged RTL and those with normal PCSS scores who may experience difficulties once resuming school activities.
Language	English
Publishing date	2022-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2022.6.PEDS22182
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