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Article ; Online: Effects of air pollution and green spaces on impaired lung function in children: a case-control study

Zhang, Jingwei / Wang, Yuming / Feng, Lihong / Hou, Changchun / Gu, Qing

Environ Sci Pollut Res. 2022 Feb., v. 29, no. 8 p.11907-11919

2022

Abstract: The occurrences of impaired lung function during childhood could substantially influence the health states of the respiratory system in adults. So, the effects of air pollution and green spaces on impaired lung function in children were investigated in ... ...

Abstract	The occurrences of impaired lung function during childhood could substantially influence the health states of the respiratory system in adults. So, the effects of air pollution and green spaces on impaired lung function in children were investigated in this study. The lung function of each student was tested every year from 2015 to 2017 and the method of case-control study was applied. 2087 students aged from 9 to 11 years old of primary schools in Tianjin were ultimately included in this study. The method of propensity score matching (PSM) was performed to minimize the confounding bias and the conditional logistic regression model was carried out to evaluate the effects of indoor and outdoor environmental risk factors on the occurrences of impaired lung function in children. For every interquartile range (IQR) increase in the mixture of six air pollutants at the lag1, lag2, and lag3 periods, the risks of getting impaired lung function were increased by 53.4%, 34.7%, and 16.9%, respectively. The protective effect of greenness at lag2 period (odds ratios (OR)) = 0.022 (95% confidence interval (CI): 0.008–0.035)) was stronger than that at lag1and lag3 periods, respectively. Separate and combined effects of most air pollutants at different lag periods exerted hazardous effects on the lung function of students. Exposure to greenness had protective effects on the lung health of children.
Keywords	air ; air pollution ; case-control studies ; childhood ; confidence interval ; lung function ; lungs ; protective effect ; regression analysis ; risk ; China
Language	English
Dates of publication	2022-02
Size	p. 11907-11919.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-16554-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Health risks of PM2.5-bound polycyclic aromatic hydrocarbon (PAH) and heavy metals (PPAH&HM) during the replacement of central heating with urban natural gas in Tianjin, China

Zhang, Jingwei / Feng, Lihong / Zhao, Yan / Hou, Changchun / Gu, Qing

Environmental geochemistry and health. 2022 Aug., v. 44, no. 8

2022

Abstract: To investigate the health effects of fine particulate matter (≤ 2.5 μm in aerodynamic diameter; PM₂.₅)-bound heavy metals and polycyclic aromatic hydrocarbons (PAHs) before and after the implementation of the Urban Natural Gas Heating Project (UNGHP), ... ...

Abstract	To investigate the health effects of fine particulate matter (≤ 2.5 μm in aerodynamic diameter; PM₂.₅)-bound heavy metals and polycyclic aromatic hydrocarbons (PAHs) before and after the implementation of the Urban Natural Gas Heating Project (UNGHP), the lifetime cancer risks, hazard quotients (HQs) of heavy metals and PAHs were calculated. Seven kinds of heavy metals (Al, As, Cd, Cr, Mn, Ni and Se) and 12 kinds of PAHs including acenaphthylene (ANY), acenaphthene (ANA), fluoranthene (FLT), pyrene (PYR), chrysene (CHR), benz[a]anthracene (BaA), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), dibenz[a,h]anthracene (DBA), benzo[ghi]perylene (BPE) and indeno[1,2,3-cd]pyrene (IPY) were analyzed and used for the health risk assessments. It was found that HQ of Mn fell from 1.09 in the coal-burning period to 0.72 in the gas-burning period in the suburban area. And lifetime cancer risks of PAHs fell from 35.7 × 10–⁶ in the coal-burning period to 17.22 × 10–⁶ in the gas-burning period in the urban area. It could be concluded that, during the gas-burning period, downward trends were observed for the lifetime cancer risks and HQs of most kinds of heavy metals and PAHs in all regions of Tianjin compared to those during the coal-burning period. The UNGHP was effective, and we should also take other measures to control the pollution.
Keywords	aerodynamics ; anthracenes ; geochemistry ; heat ; natural gas ; particulates ; pollution ; risk ; suburban areas ; urban areas ; China
Language	English
Dates of publication	2022-08
Size	p. 2495-2514.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-021-01040-8
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Article: Moderating Role of TSHR and PTPN22 Gene Polymorphisms in Effects of Excessive Fluoride on Thyroid: a School-Based Cross-Sectional Study

Wang, Yang / Cui, Yushan / Zhang, Dandan / Chen, Chen / Hou, Changchun / Cao, Lichun

Biological trace element research. 2022 Mar., v. 200, no. 3

2022

Abstract: We aimed to investigate the relationship between the effects excessive of fluoride on thyroid health in children and the moderating role of thyroid stimulating hormone receptor (TSHR) or protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene ... ...

Abstract	We aimed to investigate the relationship between the effects excessive of fluoride on thyroid health in children and the moderating role of thyroid stimulating hormone receptor (TSHR) or protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene polymorphisms. Four hundred thirteen children (141 with dental fluorosis and 198 boys) were enrolled from both historical endemic and non-endemic areas of fluorosis in Tianjin, China. The fluoride exposure levels, thyroid health indicators, and TSHR (rs2268458) and PTPN22 (rs3765598) polymorphisms were examined. Multiple logistic models were applied to evaluate the relationship between dental fluorosis and thyroid abnormalities. Children over 9 year old with dental fluorosis have lower FT₄ and TGAb levels and thyroid volume and higher TPOAb levels (all P < 0.05). In overall participants, children with dental fluorosis were more likely to have thyroid antibody single positive issues (adjusted P = 0.039) and less likely to have a goiter according to age or body surface area (age or BSA) (adjusted P = 0.003); In the TSHR (rs2268458) SNP = CC/CT or PTPN22 (rs3765598) SNP = CC subgroup, dental fluorosis may cause thyroid antibody single positive (adjusted P = 0.036; adjusted P = 0.002); in the TSHR (rs2268458) SNP = TT or PTPN22 (rs3765598) SNP = CC subgroup, dental fluorosis may protect children from goiter (age or BSA) (adjusted P = 0.018; adjusted P = 0.013). Excessive fluoride may induce thyroid antibody single positive and reduce goiter in children. Heterogeneity exists in the relationship between excessive fluoride and thyroid antibody single positive or goiter issues across children carrying different TSHR (rs2268458) or PTPN22 (rs3765598) genotypes.
Keywords	antibodies ; cross-sectional studies ; fluorides ; fluorosis ; genes ; goiter ; protein-tyrosine-phosphatase ; research ; surface area ; trace elements ; China
Language	English
Dates of publication	2022-03
Size	p. 1104-1116.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-021-02753-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: How the constituents of fine particulate matter and ozone affect the lung function of children in Tianjin, China.

Zhang, Jingwei / Feng, Lihong / Hou, Changchun / Gu, Qing

Environmental geochemistry and health

2020 Volume 42, Issue 10, Page(s) 3303–3316

Abstract: As the pollution of fine particulate matter (≤ 2.5 μg/ ... ...

Abstract	As the pollution of fine particulate matter (≤ 2.5 μg/m
MeSH term(s)	Adolescent ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Child ; China ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Female ; Humans ; Lung/drug effects ; Male ; Ozone/adverse effects ; Ozone/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Vital Capacity/drug effects
Chemical Substances	Air Pollutants ; Particulate Matter ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00574-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health benefits on cardiocerebrovascular disease of reducing exposure to ambient fine particulate matter in Tianjin, China.

Zhang, Jingwei / Feng, Lihong / Hou, Changchun / Gu, Qing

Environmental science and pollution research international

2020 Volume 27, Issue 12, Page(s) 13261–13275

Abstract: With the development of the industrialization level in China, high concentrations of fine particulate matter (≤ 2.5 μg/ ... ...

Abstract	With the development of the industrialization level in China, high concentrations of fine particulate matter (≤ 2.5 μg/m
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Cardiovascular Diseases ; China ; Humans ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2020-02-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-07910-5
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Article ; Online: Health risks of PM

Zhang, Jingwei / Feng, Lihong / Zhao, Yan / Hou, Changchun / Gu, Qing

Environmental geochemistry and health

2021 Volume 44, Issue 8, Page(s) 2495–2514

Abstract: To investigate the health effects of fine particulate matter (≤ 2.5 μm in aerodynamic diameter; ... ...

Abstract	To investigate the health effects of fine particulate matter (≤ 2.5 μm in aerodynamic diameter; PM
MeSH term(s)	Anthracenes ; Coal/analysis ; Environmental Monitoring ; Heating ; Metals, Heavy ; Natural Gas ; Particulate Matter/analysis ; Polycyclic Aromatic Hydrocarbons/analysis ; Pyrenes
Chemical Substances	Anthracenes ; Coal ; Metals, Heavy ; Natural Gas ; Particulate Matter ; Polycyclic Aromatic Hydrocarbons ; Pyrenes
Language	English
Publishing date	2021-07-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-021-01040-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of air pollution and green spaces on impaired lung function in children: a case-control study.

Zhang, Jingwei / Wang, Yuming / Feng, Lihong / Hou, Changchun / Gu, Qing

Environmental science and pollution research international

2021 Volume 29, Issue 8, Page(s) 11907–11919

Abstract	The occurrences of impaired lung function during childhood could substantially influence the health states of the respiratory system in adults. So, the effects of air pollution and green spaces on impaired lung function in children were investigated in this study. The lung function of each student was tested every year from 2015 to 2017 and the method of case-control study was applied. 2087 students aged from 9 to 11 years old of primary schools in Tianjin were ultimately included in this study. The method of propensity score matching (PSM) was performed to minimize the confounding bias and the conditional logistic regression model was carried out to evaluate the effects of indoor and outdoor environmental risk factors on the occurrences of impaired lung function in children. For every interquartile range (IQR) increase in the mixture of six air pollutants at the lag1, lag2, and lag3 periods, the risks of getting impaired lung function were increased by 53.4%, 34.7%, and 16.9%, respectively. The protective effect of greenness at lag2 period (odds ratios (OR)) = 0.022 (95% confidence interval (CI): 0.008-0.035)) was stronger than that at lag1and lag3 periods, respectively. Separate and combined effects of most air pollutants at different lag periods exerted hazardous effects on the lung function of students. Exposure to greenness had protective effects on the lung health of children.
MeSH term(s)	Adult ; Air Pollutants/analysis ; Air Pollution/analysis ; Air Pollution/statistics & numerical data ; Case-Control Studies ; Child ; Environmental Exposure/analysis ; Environmental Exposure/statistics & numerical data ; Humans ; Lung/chemistry ; Parks, Recreational ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2021-09-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-16554-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: How the constituents of fine particulate matter and ozone affect the lung function of children in Tianjin, China

Zhang, Jingwei / Feng, Lihong / Hou, Changchun / Gu, Qing

Environmental geochemistry and health. 2020 Oct., v. 42, no. 10

2020

Abstract: As the pollution of fine particulate matter (≤ 2.5 μg/m³ in aerodynamic diameter; PM₂.₅) and ozone (O₃) is becoming more and more serious in developing countries, we, hereby, investigated the effects of PM₂.₅, constituents of PM₂.₅ and O₃ on the lung ... ...

Abstract	As the pollution of fine particulate matter (≤ 2.5 μg/m³ in aerodynamic diameter; PM₂.₅) and ozone (O₃) is becoming more and more serious in developing countries, we, hereby, investigated the effects of PM₂.₅, constituents of PM₂.₅ and O₃ on the lung function of children in Tianjin, China. The lung functions of 198 pupils from nine primary schools in Tianjin were examined (repeated five times) during the months of October to December in 2016, 2017 and 2018, respectively. And the mixed-effect models were used to evaluate the effects of air pollutants. A 10 μg/m³ increase in PM₂.₅ and O₃-8h might lead to reductions of forced vital capacity (FVC) in 1.03% (− 1.87 to − 0.19%) and 21.09% (− 25.54 to − 16.58%), respectively, while a 10 ng/m³ increment in ANY might account for the 166.44% (− 221.32 to − 112.31%) decreases in FVC. PM₂.₅ and O₃-8h might be more harmful to the lung functions of female students and participants with PS exposure at home. And the main sources of pollution resulting in the decrease in pulmonary function might be traffic pollution and coal combustion.
Keywords	aerodynamics ; air ; coal ; combustion ; females ; geochemistry ; lung function ; lungs ; ozone ; particulates ; traffic ; China
Language	English
Dates of publication	2020-10
Size	p. 3303-3316.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00574-7
Database	NAL-Catalogue (AGRICOLA)

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Article: Health benefits on cardiocerebrovascular disease of reducing exposure to ambient fine particulate matter in Tianjin, China

Zhang, Jingwei / Feng, Lihong / Hou, Changchun / Gu, Qing

Environmental science and pollution research international. 2020 Apr., v. 27, no. 12

2020

Abstract: With the development of the industrialization level in China, high concentrations of fine particulate matter (≤ 2.5 μg/m3 in aerodynamic diameter (PM2.5)) could have a great impact on the health of the population. Our study is to quantify the health ... ...

Abstract	With the development of the industrialization level in China, high concentrations of fine particulate matter (≤ 2.5 μg/m3 in aerodynamic diameter (PM2.5)) could have a great impact on the health of the population. Our study is to quantify the health benefits on cardiocerebrovascular disease of reducing exposure to PM2.5 in Tianjin, China. We obtained the data on cardiovascular disease (CVD), ischemic heart disease (IHD), and cerebrovascular disease (CD) mortalities to quantify the association between CVD, CD, and IHD mortalities and PM2.5 and calculate health and economic benefits when the annual average concentration of PM2.5 was reduced to National Ambient Air Quality Standard (NAAQS) and World Health Organization (WHO) guidelines by using our concentration response (C-R) functions. There were 435.22 (95% CI 253.86 to 616.57) all-cause, 130.22 (95% CI 66.34 to194.09) IHD, and 204.07 (95% CI 111.66 to 296.47) CD deaths attributed to PM2.5 and the economic benefits obtained by preventing all-cause, IHD, and CD mortalities were equivalent to be 2.79%, 0.83%, and 1.31% of Baodi’s GDP in Tianjin in 2017, respectively. PM2.5 concentration was positive with all-cause, IHD, and CD mortalities in rural, suburban, and urban area of Tianjin, China. Meanwhile, the number of avoidable deaths and economic cost of reducing PM2.5 concentrations to NAAQS and WHO guidelines was highest in the rural area.
Keywords	World Health Organization ; aerodynamics ; air quality ; cerebrovascular disorders ; economic costs ; financial economics ; guidelines ; industrialization ; mortality ; myocardial ischemia ; particulates ; rural areas ; suburban areas ; urban areas ; China
Language	English
Dates of publication	2020-04
Size	p. 13261-13275.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-07910-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Predicting Hospital Readmissions in Patients Receiving Novel-Dose Sacubitril/Valsartan Therapy: A Competing-Risk, Causal Mediation Analysis.

Hou, Changchun / Hao, Xinxin / Sun, Ning / Luo, Xiaolin / Gao, Zhichun / Chen, Ling / Liu, Xi / Qin, Zhexue

Journal of cardiovascular pharmacology and therapeutics

2023 Volume 28, Page(s) 10742484231219603

Abstract: Backgrounds: ...

Abstract	Backgrounds:
MeSH term(s)	Humans ; Patient Readmission ; Mediation Analysis ; Tetrazoles/adverse effects ; Stroke Volume ; Treatment Outcome ; Angiotensin Receptor Antagonists/adverse effects ; Valsartan/adverse effects ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Drug Combinations ; Ventricular Function, Left
Chemical Substances	sacubitril (17ERJ0MKGI) ; Tetrazoles ; Angiotensin Receptor Antagonists ; Valsartan (80M03YXJ7I) ; Drug Combinations
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329372-2
ISSN	1940-4034 ; 1074-2484
ISSN (online)	1940-4034
ISSN	1074-2484
DOI	10.1177/10742484231219603
Database	MEDical Literature Analysis and Retrieval System OnLINE

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