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  1. Article ; Online: ASO Author Reflections: Tumor Marker Score Based on Conventional Tumor Markers (AFP, CEA, and CA19-9) Predicts Prognosis Well for cHCC-CC Patients After Surgery.

    Hou, Gui-Min / Zeng, Yong

    Annals of surgical oncology

    2021  Volume 28, Issue 12, Page(s) 7661–7662

    MeSH term(s) Biomarkers, Tumor ; CA-19-9 Antigen ; Carcinoembryonic Antigen ; Humans ; Liver Neoplasms ; Prognosis ; alpha-Fetoproteins
    Chemical Substances Biomarkers, Tumor ; CA-19-9 Antigen ; Carcinoembryonic Antigen ; alpha-Fetoproteins
    Language English
    Publishing date 2021-04-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09983-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ectopic thyroid of the pancreatic head: A case report.

    Hou, Gui-Min / Qin, Fang-Yin / He, Yong-Jie / Feng, Xie-Lin

    Asian journal of surgery

    2023  Volume 46, Issue 7, Page(s) 2970–2971

    MeSH term(s) Humans ; Thyroid Dysgenesis/diagnostic imaging ; Thyroid Dysgenesis/surgery
    Language English
    Publishing date 2023-03-09
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.02.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2831: Show issues Location:
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  3. Article ; Online: Sarcopenia predicts an adverse prognosis in patients with combined hepatocellular carcinoma and cholangiocarcinoma after surgery.

    Hou, Gui-Min / Jiang, Chuang / Du, Jin-Peng / Yuan, Ke-Fei

    Cancer medicine

    2021  Volume 11, Issue 2, Page(s) 317–331

    Abstract: Background: The prognostic value of sarcopenia in combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) patients after surgery has not been evaluated, while the efficacy of the available tumor stage for cHCC-CC remains controversial.: ... ...

    Abstract Background: The prognostic value of sarcopenia in combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) patients after surgery has not been evaluated, while the efficacy of the available tumor stage for cHCC-CC remains controversial.
    Methods: All consecutive cHCC-CC patients after surgery were retrieved. The patients were stratified by the sex-specific medians of the psoas muscle index into groups with or without sarcopenia. Prognosis was analyzed using the Kaplan-Meier (K-M) method, and the K-M curves were adjusted by inverse probability weighting (IPW). A nomogram based on Cox regression analysis was established and further compared with primary liver cancer (PLC) stages by internal validation based on bootstrap resampling and k-fold cross-validation.
    Results: A total of 153 patients were stratified into sarcopenia and non-sarcopenia groups. The sarcopenia group revealed statistically worse overall survival (OS) and disease-free survival (DFS) using the K-M method and K-M curves adjusted by IPW. Multivariate Cox regression analyses suggested sarcopenia as an independent risk factor for OS (HR = 1.55; p = 0.040) and DFS (HR = 1.55; p = 0.019). Subgroup analysis based on baseline variables showed sarcopenia as a stable risk factor for the prognosis. Our nomogram outperformed PLC stages in prognostic prediction, as evidenced by the best c-index, area under the curve, and positive improvement of the net reclassification index and integrated discrimination improvement. A fivefold cross-validation revealed consistent results. Decision curve analysis revealed higher net benefits of the nomogram than PLC stages.
    Conclusions: Sarcopenia is an independent and stable risk factor for the prognosis of cHCC-CC patients after surgery. Our nomogram might aid high-risk patient identification and clinical decisions.
    MeSH term(s) Bile Duct Neoplasms/complications ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/pathology ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; China ; Cholangiocarcinoma/complications ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/surgery ; Disease-Free Survival ; Female ; Hepatectomy ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Nomograms ; Retrospective Studies ; Sarcopenia/complications ; Survival Rate
    Language English
    Publishing date 2021-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.4448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prediction of Prognosis for cHCC-CC Patients After Surgery: Comparison of Tumor Marker Score Based on AFP, CEA, CA19-9, and Other Clinical Stages.

    Hou, Gui-Min / Liu, Hai-Ling / Wu, Hong / Zeng, Yong

    Annals of surgical oncology

    2021  Volume 28, Issue 12, Page(s) 7647–7660

    Abstract: Background: The effectiveness of clinical stage as a prognostic factor in combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) patients is controversial.: Patients and methods: Medical records of all pathologically confirmed cHCC-CC ... ...

    Abstract Background: The effectiveness of clinical stage as a prognostic factor in combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) patients is controversial.
    Patients and methods: Medical records of all pathologically confirmed cHCC-CC patients from 2000 to 2017 at West China Hospital were retrieved. Tumor marker score (TMS) was determined from optimal AFP, CEA, and CA19-9 cutoff values. Interaction and subgroup analysis were conducted according to potential confounders. Prognostic value of TMS and other prognostic models were evaluated by Kaplan-Meier (K-M) analysis, c-index, and time-dependent receiver operating curves (td-ROC).
    Results: Optimal cutoff values for preoperative AFP, CEA, and CA19-9 were 10.76 ng/mL, 5.24 ng/mL, and 31.54 U/mL, respectively. Among 128 patients, 24, 58, and 46 were classified into TMS 0, TMS 1, and TMS ≥ 2, respectively. TMS could stratify our series into groups of statistically different prognosis. Subgroup analysis according to potential confounders and test for interactions showed that TMS 1 and TMS ≥ 2 were stable risk factors relative to TMS 0. Univariate (HR: TMS1 = 2.30, p = 0.014; TMS ≥ 2 = 5.1, p < 0.001) and multivariate Cox regression analyses (HR: TMS1 = 1.72, p = 0.124; TMS ≥ 2 = 4.15, p < 0.001) identified TMS as an independent prognostic risk factor. TMS had good discrimination (c-index 0.666, 95% CI 0.619-0.714), and calibration plots revealed favorable consistency. Area under the curve (AUC) value of td-ROC for TMS and integrated AUC was higher than for other clinical stages at any month within 5 years postoperation.
    Conclusion: TMS exhibited optimal prognostic value over other widely used clinical stages for cHCC-CC after surgery and may guide clinicians in prognostic prediction.
    MeSH term(s) Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Biomarkers, Tumor ; CA-19-9 Antigen ; Carcinoembryonic Antigen ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/surgery ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/surgery ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/surgery ; Prognosis ; alpha-Fetoproteins
    Chemical Substances Biomarkers, Tumor ; CA-19-9 Antigen ; Carcinoembryonic Antigen ; alpha-Fetoproteins
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09949-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Nomogram Models for Predicting Risk and Prognosis of Newly Diagnosed Ovarian Cancer Patients with Liver Metastases - A Large Population-Based Real-World Study.

    Hou, Gui-Min / Jiang, Chuang / Du, Jin-Peng / Liu, Chang / Chen, Xiang-Zheng / Yuan, Ke-Fei / Wu, Hong / Zeng, Yong

    Journal of Cancer

    2021  Volume 12, Issue 24, Page(s) 7255–7265

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-10-25
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.64255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Interference of Lumican Regulates the Invasion and Migration of Liver Cancer Cells].

    Mu, Qi-Ming / He, Wei / Hou, Gui-Min / Liang, Yong / Wang, Gang / Li, Chun-Lin / Liao, Bo / Liu, Xin / Ye, Zhi / Lu, Jian-Li / Wang, Wen-Tao

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2018  Volume 49, Issue 3, Page(s) 358–363

    Abstract: Objective: To explore the effect of silencing lumican on the invasion and migration of liver cancer cells.: Methods: Lumican was silenced by shRNA in liver cancer cells (HepG2 and MHCC97H). The mRNA levels of lumican were detected by qRT-PCR. Cell ... ...

    Abstract Objective: To explore the effect of silencing lumican on the invasion and migration of liver cancer cells.
    Methods: Lumican was silenced by shRNA in liver cancer cells (HepG2 and MHCC97H). The mRNA levels of lumican were detected by qRT-PCR. Cell invasion was measured by Transwell. Cell migration was tested via wound healing. The protein levels of lumican,MMP-9,VEGF,ERK1,JNK,p-ERK1 and p-JNK were measured by Western blot.
    Results: Liver cancer cells (HepG2 and MHCC97H) had higher levels of mRNA and protein of lumican compared with normal hepatocyte L02 (
    Conclusion: Silencing lumican by shRNA attenuates the invasion and migration of liver cancer cells via inhibiting the activation of ERK1/JNK pathway.
    MeSH term(s) Cell Line, Tumor ; Cell Movement ; Gene Silencing ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Lumican/genetics ; Lumican/metabolism ; MAP Kinase Kinase 4/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Neoplasm Invasiveness ; RNA, Small Interfering ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Lumican ; RNA, Small Interfering ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; MAP Kinase Kinase 4 (EC 2.7.12.2) ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language Chinese
    Publishing date 2018-07-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2708: Show issues Location:
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