Article ; Online: Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice.
Free radical biology & medicine
2024
Abstract: Apart from dopaminergic neurotoxicity, exposure to rotenone, a commonly used insecticide in agriculture, also adversely affects hippocampal and cortical neurons, resulting in cognitive impairments in mice. We recently established a role of microglia- ... ...
Abstract | Apart from dopaminergic neurotoxicity, exposure to rotenone, a commonly used insecticide in agriculture, also adversely affects hippocampal and cortical neurons, resulting in cognitive impairments in mice. We recently established a role of microglia-mediated neuroinflammation in rotenone-elicited deficits of cognition, yet the mechanisms remain elusive. Here, we investigated the involvement of NADPH oxidase 2 (NOX2) catalytic subunit gp91 |
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Language | English |
Publishing date | 2024-04-30 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 807032-5 |
ISSN | 1873-4596 ; 0891-5849 |
ISSN (online) | 1873-4596 |
ISSN | 0891-5849 |
DOI | 10.1016/j.freeradbiomed.2024.04.240 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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