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  1. Artikel ; Online: Association Between Intensity and Timing of Specialty Palliative Care and Hospice Exposure With Quality of End-of-Life Care.

    Wang, Susan E / Gozansky, Wendolyn S / Steiner, Claudia / Lee, Janet S / Nguyen, AnMarie / Shen, Ernest / Martel, Helene / Mangels, Diana B / Sterett, Andrew T / Zalavadia, Ravi / Hou, Nanjiang / Nguyen, Huong Q

    Journal of palliative medicine

    2024  

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2023.0407
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A prospective study of variability in mammographic density during the menstrual cycle.

    Morrow, Monica / Chatterton, Robert T / Rademaker, Alfred W / Hou, Nanjiang / Jordan, V Craig / Hendrick, R Edward / Khan, Seema A

    Breast cancer research and treatment

    2010  Band 121, Heft 3, Seite(n) 565–574

    Abstract: Mammographic breast density has been proposed as a surrogate endpoint in breast cancer prevention studies, but little is known about its variability over time, particularly in relation to menstrual cycle phase. The purpose of this study was to assess ... ...

    Abstract Mammographic breast density has been proposed as a surrogate endpoint in breast cancer prevention studies, but little is known about its variability over time, particularly in relation to menstrual cycle phase. The purpose of this study was to assess variation in breast density on digital mammograms using quantitative and qualitative density measures. Menstrual cycle phase was determined by salivary estradiol and progesterone assays. 73 healthy subjects with regular menses had 1-3 mammograms with paired saliva collection during a 12-month period. The mean difference in density as a percentage of the mean density was calculated for follicular-luteal (n = 50), luteal-luteal (n = 26) and follicular-follicular (n = 23) pairs in the same woman using the same breast. Two density measures (measurement of dense area and BIRADS) were used. The mean luteal density exceeded the mean follicular density by 7.1-9.2%, but density differences between luteal pairs and follicular pairs did not exceed 5%. The intraclass correlation for measurement of dense area was greater than 85% in all phases of the menstrual cycle, but was below 50% for BIRADS for luteal-follicular and follicular-follicular pairs. Our study provides estimates of the amount of variation in mammographic density during the menstrual cycle, and that inherent in repeated density measurement in premenopausal women, and suggests that menstrual phase of mammographic evaluation should be controlled for in intervention studies where density is being used as a surrogate measure.
    Mesh-Begriff(e) Adult ; Breast/anatomy & histology ; Cross-Sectional Studies ; Female ; Humans ; Mammography/methods ; Menstrual Cycle/physiology ; Middle Aged ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2010-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-009-0496-9
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  3. Artikel: A prospective study of variability in mammographic density during the menstrual cycle

    Morrow, Monica / Chatterton, Robert T. Jr / Rademaker, Alfred W / Hou, Nanjiang / Jordan, V. Craig / Hendrick, R. Edward / Khan, Seema A

    Breast cancer research and treatment. 2010 June, v. 121, no. 3

    2010  

    Abstract: Mammographic breast density has been proposed as a surrogate endpoint in breast cancer prevention studies, but little is known about its variability over time, particularly in relation to menstrual cycle phase. The purpose of this study was to assess ... ...

    Abstract Mammographic breast density has been proposed as a surrogate endpoint in breast cancer prevention studies, but little is known about its variability over time, particularly in relation to menstrual cycle phase. The purpose of this study was to assess variation in breast density on digital mammograms using quantitative and qualitative density measures. Menstrual cycle phase was determined by salivary estradiol and progesterone assays. 73 healthy subjects with regular menses had 1-3 mammograms with paired saliva collection during a 12-month period. The mean difference in density as a percentage of the mean density was calculated for follicular-luteal (n = 50), luteal-luteal (n = 26) and follicular-follicular (n = 23) pairs in the same woman using the same breast. Two density measures (measurement of dense area and BIRADS) were used. The mean luteal density exceeded the mean follicular density by 7.1-9.2%, but density differences between luteal pairs and follicular pairs did not exceed 5%. The intraclass correlation for measurement of dense area was greater than 85% in all phases of the menstrual cycle, but was below 50% for BIRADS for luteal-follicular and follicular-follicular pairs. Our study provides estimates of the amount of variation in mammographic density during the menstrual cycle, and that inherent in repeated density measurement in premenopausal women, and suggests that menstrual phase of mammographic evaluation should be controlled for in intervention studies where density is being used as a surrogate measure.
    Schlagwörter menstrual cycle
    Sprache Englisch
    Erscheinungsverlauf 2010-06
    Umfang p. 565-574.
    Verlag Springer US
    Erscheinungsort Boston
    Dokumenttyp Artikel
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-009-0496-9
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  4. Artikel ; Online: Risk of cardiovascular disease from antiretroviral therapy for HIV: a systematic review.

    Bavinger, Clay / Bendavid, Eran / Niehaus, Katherine / Olshen, Richard A / Olkin, Ingram / Sundaram, Vandana / Wein, Nicole / Holodniy, Mark / Hou, Nanjiang / Owens, Douglas K / Desai, Manisha

    PloS one

    2013  Band 8, Heft 3, Seite(n) e59551

    Abstract: Background: Recent studies suggest certain antiretroviral therapy (ART) drugs are associated with increases in cardiovascular disease.: Purpose: We performed a systematic review and meta-analysis to summarize the available evidence, with the goal of ... ...

    Abstract Background: Recent studies suggest certain antiretroviral therapy (ART) drugs are associated with increases in cardiovascular disease.
    Purpose: We performed a systematic review and meta-analysis to summarize the available evidence, with the goal of elucidating whether specific ART drugs are associated with an increased risk of myocardial infarction (MI).
    Data sources: We searched Medline, Web of Science, the Cochrane Library, and abstract archives from the Conference on Retroviruses and Opportunistic Infections and International AIDS Society up to June 2011 to identify published articles and abstracts.
    Study selection: Eligible studies were comparative and included MI, strokes, or other cardiovascular events as outcomes.
    Data extraction: Eligibility screening, data extraction, and quality assessment were performed independently by two investigators.
    Data synthesis: Random effects methods and Fisher's combined probability test were used to summarize evidence.
    Findings: Twenty-seven studies met inclusion criteria, with 8 contributing to a formal meta-analysis. Findings based on two observational studies indicated an increase in risk of MI for patients recently exposed (usually defined as within last 6 months) to abacavir (RR 1.92, 95% CI 1.51-2.42) and protease inhibitors (PI) (RR 2.13, 95% CI 1.06-4.28). Our analysis also suggested an increased risk associated with each additional year of exposure to indinavir (RR 1.11, 95% CI 1.05-1.17) and lopinavir (RR 1.22, 95% CI 1.01-1.47). Our findings of increased cardiovascular risk from abacavir and PIs were in contrast to four published meta-analyses based on secondary analyses of randomized controlled trials, which found no increased risk from cardiovascular disease.
    Conclusion: Although observational studies implicated specific drugs, the evidence is mixed. Further, meta-analyses of randomized trials did not find increased risk from abacavir and PIs. Our findings that implicate specific ARTs in the observational setting provide sufficient evidence to warrant further investigation of this relationship in studies designed for that purpose.
    Mesh-Begriff(e) Anti-HIV Agents/adverse effects ; Cardiovascular Diseases/chemically induced ; Humans ; Protease Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/adverse effects ; Risk
    Chemische Substanzen Anti-HIV Agents ; Protease Inhibitors ; Reverse Transcriptase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2013-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review ; Systematic Review
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0059551
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Ductal lavage is an inefficient method of biomarker measurement in high-risk women.

    Khan, Seema A / Lankes, Heather A / Patil, Deepa B / Bryk, Michele / Hou, Nanjiang / Ivancic, David / Nayar, Ritu / Masood, Shahla / Rademaker, Alfred

    Cancer prevention research (Philadelphia, Pa.)

    2009  Band 2, Heft 3, Seite(n) 265–273

    Abstract: Effective methods of serial epithelial sampling to measure breast-specific biomarkers will aid the rapid evaluation of new preventive interventions. We report here a proof-of-principle phase 2 study to assess the utility of ductal lavage (DL) to measure ... ...

    Abstract Effective methods of serial epithelial sampling to measure breast-specific biomarkers will aid the rapid evaluation of new preventive interventions. We report here a proof-of-principle phase 2 study to assess the utility of ductal lavage (DL) to measure biomarkers of tamoxifen action. We enrolled women with a 5-year breast cancer risk estimate >1.6% or the unaffected breast of women with T1a or T1b breast cancer. After entry DL, participants chose tamoxifen or observation and underwent repeat DL 6 months later. Samples were processed for cytology and immunohistochemistry for estrogen receptor alpha, Ki-67, and cyclooxygenase-2. Of 182 women recruited, 115 (63%) underwent entry and repeat DL; 85 (47%) had sufficient cells for analysis from > or =1 duct at both time points; in 78 (43%), cells were sufficient from > or =1 matched ducts. Forty-six women chose observation and 39 chose tamoxifen. We observed greater reductions in the tamoxifen group than in the observation group for Ki-67 (adjusted P = 0.03) and estrogen receptor alpha (adjusted P = 0.07), but not in cyclooxygenase-2 (adjusted P = 0.4) labeling. Cytologic findings showed a trend toward improvement in the tamoxifen group compared with the observation group. Interobserver variability for cytologic diagnosis between two observers showed good agreement (kappa = 0.44). Using DL, we observed the expected changes in tamoxifen-related biomarkers; however, poor reproducibility of biomarkers in the observation group, the 53% attrition rate of subjects from recruitment to biomarker analyses, and the expense of DL are significant barriers to the use of this procedure for biomarker assessment over time.
    Mesh-Begriff(e) Adult ; Biomarkers/analysis ; Biomarkers/blood ; Biomarkers, Tumor/biosynthesis ; Breast Neoplasms/blood ; Breast Neoplasms/diagnosis ; Cytological Techniques ; Female ; Humans ; Immunohistochemistry/methods ; Middle Aged ; Neoplasm Recurrence, Local/prevention & control ; Observer Variation ; Risk ; Tamoxifen/therapeutic use ; Therapeutic Irrigation ; Treatment Outcome
    Chemische Substanzen Biomarkers ; Biomarkers, Tumor ; Tamoxifen (094ZI81Y45)
    Sprache Englisch
    Erscheinungsdatum 2009-02-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-08-0119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Acceptance of tamoxifen chemoprevention by physicians and women at risk.

    Tchou, Julia / Hou, Nanjiang / Rademaker, Alfred / Jordan, V Craig / Morrow, Monica

    Cancer

    2004  Band 100, Heft 9, Seite(n) 1800–1806

    Abstract: Background: In the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 trial, tamoxifen was shown to reduce breast carcinoma risk by 49% in high-risk women. The purpose of the current study was to identify factors associated with being ... ...

    Abstract Background: In the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 trial, tamoxifen was shown to reduce breast carcinoma risk by 49% in high-risk women. The purpose of the current study was to identify factors associated with being offered, and accepting, tamoxifen chemoprevention.
    Methods: The records of 219 women who sought risk evaluation after the publication of the NSABP P-1 trial between September 1998 and October 2002 were reviewed. Risk was calculated using the model of either Gail et al. or Claus et al. The impact of individual risk factors on the offering and acceptance of tamoxifen was compared using the Fisher exact test and logistic regression analysis.
    Results: Tamoxifen was offered to 137 women (63%) in the current study. The magnitude of Gail risk, age, menopausal status, hysterectomy, and history of lobular carcinoma in situ (LCIS) or atypical hyperplasia (AH) were all found to be significant predictors of a patient being offered tamoxifen. On multivariate analysis, only a history of AH or LCIS and hysterectomy were found to be significant, with odds ratios of 20.3 and 3.4, respectively. Fifty-seven of the women who were offered tamoxifen (42%) took the drug. Only a history of LCIS or AH and older age were found to be predictive of tamoxifen acceptance.
    Conclusions: In the current study, risk due to AH or LCIS was found to be the main predictor of being offered and accepting tamoxifen chemoprevention.
    Mesh-Begriff(e) Adult ; Aged ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/pathology ; Breast Neoplasms/prevention & control ; Chemoprevention ; Cohort Studies ; Female ; Humans ; Logistic Models ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Patient Acceptance of Health Care ; Probability ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Management ; Statistics, Nonparametric ; Tamoxifen/adverse effects ; Tamoxifen/therapeutic use ; Treatment Outcome
    Chemische Substanzen Antineoplastic Agents, Hormonal ; Tamoxifen (094ZI81Y45)
    Sprache Englisch
    Erscheinungsdatum 2004-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.20205
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Reproducibility of ductal lavage cytology and cellularity over a six month interval in high risk women.

    Patil, Deepa B / Lankes, Heather A / Nayar, Ritu / Masood, Shahla / Bryk, Michelle / Hou, Nanjiang / Rademaker, Alfred / Khan, Seema A

    Breast cancer research and treatment

    2008  Band 112, Heft 2, Seite(n) 327–333

    Abstract: Background: Ductal lavage (DL) allows repeat sampling of breast epithelium for serial observation in a chemoprevention setting; however, the reproducibility of duct cannulation, cell yield and cytology has not been addressed.: Methods: We conducted a ...

    Abstract Background: Ductal lavage (DL) allows repeat sampling of breast epithelium for serial observation in a chemoprevention setting; however, the reproducibility of duct cannulation, cell yield and cytology has not been addressed.
    Methods: We conducted a Phase 2 trial, wherein high risk women chose tamoxifen treatment or observation following an entry DL procedure. We present data from the non-intervention arm of our study to assess the reproducibility of cannulation, cell yield, and cytologic diagnosis from DL of the same duct at two time-points. Inter-observer variability was assessed by a blinded review of Papanicoloau-stained slides by two cytopathologists.
    Results: Sixty-five women had a successful lavage of 187 ducts at baseline and chose observation; 63/65 (97%) had a successful lavage 6 months later. Successful recannulation of the same duct was accomplished in 63 women (97%) and162 ducts (87%). Total epithelial cell yields >or=100 were obtained from 57/65 women (88%) and 129/187 ducts (69%) at baseline, and 46/63 women (73%) and 80/162 ducts (49%) at both time-points. Cytologic diagnosis was reproducible in 27/63 (43%) women and 77/162 (48%) ducts. Inter-observer variability for cytologic diagnosis between two observers showed good agreement (kappa = 0.62).
    Conclusions: Recannulation and lavage of the same duct after a 6 month interval can be achieved with high frequency; however, reproducibility of cell yield and cytologic findings from the same duct is sub-optimal, leading to significant attrition of evaluable subjects. The utility of DL for the serial monitoring of breast epithelium is therefore limited.
    Mesh-Begriff(e) Adult ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/therapy ; Cytological Techniques/methods ; Female ; Hormone Replacement Therapy ; Humans ; Mammary Glands, Human/pathology ; Middle Aged ; Nipples/cytology ; Nipples/pathology ; Observer Variation ; Reproducibility of Results ; Risk ; Tamoxifen/therapeutic use ; Therapeutic Irrigation/methods
    Chemische Substanzen Antineoplastic Agents, Hormonal ; Tamoxifen (094ZI81Y45)
    Sprache Englisch
    Erscheinungsdatum 2008-11
    Erscheinungsland Netherlands
    Dokumenttyp Clinical Trial, Phase II ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-007-9861-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Tamoxifen use in patients with ductal carcinoma in situ and T1a/b N0 invasive carcinoma.

    Nakhlis, Faina / Lazarus, Laura / Hou, Nanjiang / Acharya, Simbi / Khan, Seema A / Staradub, Valerie L / Rademaker, Alfred W / Morrow, Monica

    Journal of the American College of Surgeons

    2005  Band 201, Heft 5, Seite(n) 688–694

    Abstract: Background: The purpose of this study was to determine how often patients with ductal carcinoma in situ and T1a/b N0 cancer are offered and accept tamoxifen for secondary chemoprevention.: Study design: A retrospective review of 284 patients with T1a/ ...

    Abstract Background: The purpose of this study was to determine how often patients with ductal carcinoma in situ and T1a/b N0 cancer are offered and accept tamoxifen for secondary chemoprevention.
    Study design: A retrospective review of 284 patients with T1a/b N0 invasive cancer treated between February 1995 and December 2001 and 129 patients with DCIS treated after September 1998 was carried out. Patient and tumor characteristics associated with being offered and accepting tamoxifen were compared.
    Results: Tamoxifen was offered to 67% of the invasive cancer patients and accepted by 76% (51% of the entire group). Hormone receptor status was the only significant predictor of being offered tamoxifen (p = 0.004). Older age (p = 0.04), Caucasian race (p = 0.01), and parity (p = 0.04) in premenopausal women were significant predictors of tamoxifen acceptance on univariate analysis. After the publication of the National Surgical Adjuvant Breast and Bowel Project P-1 trial, significantly more patients were offered tamoxifen (p = 0.02), but acceptance rates did not change. Tamoxifen was offered to 91% of the ductal carcinoma in situ patients and accepted by 73% (67% overall). Lumpectomy was associated with significantly higher rates of being offered (p = 0.02) and accepting tamoxifen (p = 0.002) on univariate analysis.
    Conclusions: Factors associated with tamoxifen risks and benefits correlate poorly with the use of the drug.
    Mesh-Begriff(e) Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/drug therapy ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Intraductal, Noninfiltrating/drug therapy ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Female ; Humans ; Mastectomy ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Tamoxifen/therapeutic use
    Chemische Substanzen Antineoplastic Agents, Hormonal ; Tamoxifen (094ZI81Y45)
    Sprache Englisch
    Erscheinungsdatum 2005-11
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2005.06.195
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women.

    Chatterton, Robert T / Mateo, Esnar T / Hou, Nanjiang / Rademaker, Alfred W / Acharya, Simbi / Jordan, V Craig / Morrow, Monica

    The Journal of endocrinology

    2005  Band 186, Heft 1, Seite(n) 77–84

    Abstract: The objective of the study was to characterize salivary sex steroid levels in 56 women undergoing annual mammography who were participating in a breast density study at the Lynn Sage Breast Center of Northwestern Memorial Hospital, and to determine the ... ...

    Abstract The objective of the study was to characterize salivary sex steroid levels in 56 women undergoing annual mammography who were participating in a breast density study at the Lynn Sage Breast Center of Northwestern Memorial Hospital, and to determine the predictability of the patterns within women. Saliva was collected daily by the women at home for one complete menstrual cycle and then again at approximately 6-month intervals. The occurrence of sporadic anovulatory cycles was identified in 12 subjects, and persistent oestradiol (OE2) elevation in all three cycles without significant progesterone levels occurred in another five subjects. In addition, both OE2 and progesterone were significantly lower in initial menstrual cycles than in subsequent cycles, suggestive of an effect of participation in the study on hormone levels. Initial salivary OE2 levels were not good predictors of corresponding levels in either follicular or luteal phases of the menstrual cycles at the 6-month intervals. However, after the initial cycle, progesterone levels were highly predictable within individuals over a period of 6 months (r=0.78, P<0.001). The study emphasizes the natural variation among and within women in the absence of any intervention, and indicates the need for properly controlled studies before attributing changes in hormonal levels to therapy. In addition, it emphasizes the importance of sampling at multiple time points when examining the relationship between hormones and risk.
    Mesh-Begriff(e) Adult ; Analysis of Variance ; Biomarkers/blood ; Body Mass Index ; Estradiol/analysis ; Female ; Humans ; Middle Aged ; Models, Statistical ; Ovulation ; Premenopause/blood ; Progesterone/analysis ; Reference Values ; Saliva/chemistry
    Chemische Substanzen Biomarkers ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
    Sprache Englisch
    Erscheinungsdatum 2005-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1677/joe.1.06025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: A predictive model for the development of hormone-responsive breast cancer.

    Gorla, Seema Rao / Hou, Nanjiang / Acharya, Simbi / Rademaker, Alfred / Khan, Seema / Staradub, Valerie / Morrow, Monica

    Annals of surgical oncology

    2005  Band 12, Heft 1, Seite(n) 48–56

    Abstract: Background: Effective therapies to reduce the risk of hormone-sensitive breast cancers (ER or PR positive) exist. Available models predict the risk of breast cancer without addressing hormone receptor status. The purpose of this study was to identify ... ...

    Abstract Background: Effective therapies to reduce the risk of hormone-sensitive breast cancers (ER or PR positive) exist. Available models predict the risk of breast cancer without addressing hormone receptor status. The purpose of this study was to identify risk factors predictive of the development of hormone-sensitive cancers.
    Methods: A total of 1285 invasive breast cancers in 1263 women were identified from a prospectively maintained database. Risk factors were compared for ER+ and ER- cancers by using Fisher's exact test.
    Results: Models were developed for premenopausal and postmenopausal women. In premenopausal women, white race, age at menarche < 12 years, and nulliparity or age at first birth > 20 years were used. The risk of ER+ cancer increased from 67.7% with 0 variables to 83.8% with all three (P = .013). In postmenopausal women, white race and a history of estrogen therapy were used. With none of the variables present, the incidence of ER+ cancer was 70.0%; it was 77.6% with one variable and 85.4% with both variables (P = .002). In postmenopausal women, variables predicted significant differences in hormone sensitivity only for those aged < or = 60 years. In the subset of women with information on alcohol use, adding this variable to the model improved the prediction of hormonal status.
    Conclusions: Our findings, if prospectively validated, may help identify those who would obtain the greatest benefit from hormonal chemoprevention strategies for breast cancer risk reduction.
    Mesh-Begriff(e) Adult ; Age Factors ; Aged ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Chemoprevention ; Continental Population Groups ; Female ; Forecasting ; Humans ; Menarche ; Middle Aged ; Models, Theoretical ; Neoplasm Invasiveness ; Parity ; Prognosis ; Prospective Studies ; Receptors, Estrogen/analysis ; Risk Factors
    Chemische Substanzen Antineoplastic Agents, Hormonal ; Receptors, Estrogen
    Sprache Englisch
    Erscheinungsdatum 2005-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1007/s10434-004-1170-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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