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  1. Article: Genistein: Therapeutic and Preventive Effects, Mechanisms, and Clinical Application in Digestive Tract Tumor.

    Hou, Shenglin

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 5957378

    Abstract: Genistein is one of the numerous recognized isoflavones that may be found in a variety of soybeans and soy products, including tofu and tofu products. The chemical name for genistein is 4', 5, 7-trihydroxyisoflavone, and it is found in plants. In recent ... ...

    Abstract Genistein is one of the numerous recognized isoflavones that may be found in a variety of soybeans and soy products, including tofu and tofu products. The chemical name for genistein is 4', 5, 7-trihydroxyisoflavone, and it is found in plants. In recent years, the scientific world has become more interested in genistein because of its possible therapeutic effects on many forms of cancer. It has been widely investigated for its anticancer properties. The discovery of genistein's mechanism of action indicates its potential for apoptosis induction and cell cycle arrest in gastrointestinal cancer, especially gastric and colorectal cancer. Genistein's pharmacological activities as determined by the experimental studies presented in this review lend support to its use in the treatment of gastrointestinal cancer; however, additional research is needed in the future to determine its efficacy, safety, and the potential for using nanotechnology to increase bioavailability and therapeutic efficacy.
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/5957378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  2. Article: [Influence of different sphincter-preserving surgeries on postoperative defecation function].

    Hou, S / Ye, Y J

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2022  Volume 25, Issue 6, Page(s) 482–486

    Abstract: Advances in surgical techniques and treatment concept have allowed more patients with low rectal cancer to preserve sphincter without sacrificing survival benefit. However, postoperative dysfunctions such as fecal incontinence, frequency, urgency, and ... ...

    Abstract Advances in surgical techniques and treatment concept have allowed more patients with low rectal cancer to preserve sphincter without sacrificing survival benefit. However, postoperative dysfunctions such as fecal incontinence, frequency, urgency, and clustering often occur in patients with low rectal cancer. The main surgical procedures for low rectal cancer include low anterior rectum resection (LAR), intersphincteric resection (ISR), coloanal anastomosis (Parks) and so on. The incidence of major LARS after LAR is up to 84.6%. The postoperative function of ISR is even worse than LAR. Moreover, the greater the extent of resection ISR surgery, the worse the postoperative function. There are few studies on the function of Parks procedure. Current evidence suggests that the short-term function of Parks procedure is inferior to LAR, but function can gradually recovered over time. Colorectal surgeons have attempted to improve postoperative defecation by modifying bowel reconstructions. Current evidence suggests that J pouch or end-to-side anastomosis during LAR does not reduce the incidence of defecation disorders. Pouch reconstruction during ISR cannot reduce the incidence of severe LARS either. In general, the protection of postoperative defecation function in patients with low rectal cancer still has a long way to go.
    MeSH term(s) Anal Canal/surgery ; Anastomosis, Surgical/adverse effects ; Defecation ; Fecal Incontinence/etiology ; Humans ; Postoperative Complications/epidemiology ; Rectal Neoplasms/complications ; Rectal Neoplasms/surgery
    Language Chinese
    Publishing date 2022-06-27
    Publishing country China
    Document type Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn441530-20220321-00108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The impact of digital transformation and earnings management on ESG performance: evidence from Chinese listed enterprises.

    Wang, Lang / Hou, Sheng

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 783

    Abstract: The improvement of enterprise ESG performance is one of the key driving forces to achieve the goal of economic and social green development. There is a gap between knowledge and practice in the ESG performance of Chinese enterprises, and digital ... ...

    Abstract The improvement of enterprise ESG performance is one of the key driving forces to achieve the goal of economic and social green development. There is a gap between knowledge and practice in the ESG performance of Chinese enterprises, and digital transformation (DT) provides new ideas for ESG development. The research purpose of this paper is to explore the impact mechanism of DT on ESG and the specific path of DT to drive ESG. It provides a reference for listed enterprises to rely on DT to empower their sustainable development capability. This paper takes the panel data of A-share listed enterprises from 2011 to 2021 as the sample and measures the core indicators using the text mining method, modified Jones model, and Roy-Chowdhury model. On this basis, using a combination of econometric models and qualitative comparative analysis, we empirically analyze the impact mechanisms of DT on ESG as well as the specific grouping paths that drive ESG performance. The main conclusions are shown as follows. First, DT can significantly reduce ESG, with an impact coefficient of - 0.013, which is significant at the 5% level. It reflects that the DT of enterprises at this stage has certain deficiencies. There is a matching lag in the enterprise's internal organizational resources. The entry of digital technology will have a certain impact on traditional operations, and the high uncertainty of DT adds some hidden costs to the enterprise. Secondly, there is an indirect suppression effect of accrued earnings management (AEM) in the transmission mechanism of DT affecting ESG. It is verified that DT can reduce information asymmetry and inhibit EM activities, thus reducing the impact on ESG. Finally, a total of six configurations achieved high ESG valuations. High technology practice-low performance manipulation; digital intelligence-low performance manipulation; digital intelligence-digital resources; digital resources-inadequate digital infrastructure.; high technology practice-bottom technology deficiency; digital intelligence-high performance manipulation. Through configuration analysis, the suppression effect of EM is further verified. The lack of AEM is usually the core condition of the high-valuation group. Meanwhile, digital intelligence, digital resources, and digital technology practice can drive the improvement of enterprise ESG. The instrumental variables approach and robustness tests support these findings.
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48636-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Meet the authors: Shouqiao Hou and Daichao Xu.

    Hou, Shouqiao / Xu, Daichao

    Molecular cell

    2024  Volume 84, Issue 5, Page(s) 811–813

    Abstract: Molecular Cell speaks with first author Shouqiao Hou and corresponding author Daichao Xu about the scientific journey toward their paper, "PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis" (in this issue of Molecular Cell), the ... ...

    Abstract Molecular Cell speaks with first author Shouqiao Hou and corresponding author Daichao Xu about the scientific journey toward their paper, "PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis" (in this issue of Molecular Cell), the challenges they faced, and interesting remaining questions for the field.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2024.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ethylene insensitive 2 (EIN2) destiny shaper: The post-translational modification.

    Su, Meifei / Hou, Suiwen

    Journal of plant physiology

    2024  Volume 295, Page(s) 154190

    Abstract: PTMs (Post-Translational Modifications) of proteins facilitate rapid modulation of protein function in response to various environmental stimuli. The EIN2 (Ethylene Insensitive 2) protein is a core regulatory of the ethylene signaling pathway. Recent ... ...

    Abstract PTMs (Post-Translational Modifications) of proteins facilitate rapid modulation of protein function in response to various environmental stimuli. The EIN2 (Ethylene Insensitive 2) protein is a core regulatory of the ethylene signaling pathway. Recent findings have demonstrated that PTMs, including protein phosphorylation, ubiquitination, and glycosylation, govern EIN2 trafficking, subcellular localization, stability, and physiological roles. The cognition of multiple PTMs in EIN2 underscores the stringent regulation of protein. Consequently, a thorough review of the regulatory role of PTMs in EIN2 functions will improve our profound comprehension of the regulation mechanism and various physiological processes of EIN2-mediated signaling pathways. This review discusses the evolution, functions, structure and characteristics of EIN2 protein in plants. Additionally, this review sheds light on the progress of protein ubiquitination, phosphorylation, O-Glycosylation in the regulation of EIN2 functions, and the unresolved questions and future perspectives.
    MeSH term(s) Arabidopsis Proteins/metabolism ; Arabidopsis/metabolism ; Ethylenes/metabolism ; Protein Processing, Post-Translational ; Phosphorylation ; Receptors, Cell Surface/genetics
    Chemical Substances Arabidopsis Proteins ; ethylene (91GW059KN7) ; Ethylenes ; EIN2 protein, Arabidopsis ; Receptors, Cell Surface
    Language English
    Publishing date 2024-02-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2024.154190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Recent progress in the effect of magnetic iron oxide nanoparticles on cells and extracellular vesicles.

    Chen, Yuling / Hou, Shike

    Cell death discovery

    2023  Volume 9, Issue 1, Page(s) 195

    Abstract: At present, iron oxide nanoparticles (IONPs) are widely used in the biomedical field. They have unique advantages in targeted drug delivery, imaging and disease treatment. However, there are many things to pay attention to. In this paper, we reviewed the ...

    Abstract At present, iron oxide nanoparticles (IONPs) are widely used in the biomedical field. They have unique advantages in targeted drug delivery, imaging and disease treatment. However, there are many things to pay attention to. In this paper, we reviewed the fate of IONPs in different cells and the influence on the production, separation, delivery and treatment of extracellular vesicles. It aims to provide cutting-edge knowledge related to iron oxide nanoparticles. Only by ensuring the safety and effectiveness of IONPs can their application in biomedical research and clinic be further improved.
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-023-01490-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Core techniques and values of full-endoscopic spine surgery via transforaminal approach].

    Li, Z Z / Hou, S X

    Zhonghua wai ke za zhi [Chinese journal of surgery

    2023  Volume 61, Issue 8, Page(s) 650–655

    Abstract: Full-endoscopic spinal surgery via transforaminal approach (TF-FESS) originated from the minimally invasive techniques of percutaneous interventional treatment of intervertebral disc diseases through posterolateral approach.Thanks to the continuous ... ...

    Abstract Full-endoscopic spinal surgery via transforaminal approach (TF-FESS) originated from the minimally invasive techniques of percutaneous interventional treatment of intervertebral disc diseases through posterolateral approach.Thanks to the continuous development and improvement of full-endoscopic equipment alongside surgical instruments and techniques, a developed technical system has been established in discectomy, spinal canal decompression, interbody fusion, etc. The combination of these basic techniques can treat relatively complex degenerative spinal diseases. The core techniques of TF-FESS include percutaneous puncture, foraminoplasty, spinal canal decompression, discectomy, annulus fibrosus suture, interbody fusion. This paper elaborates on the key points of the core techniques, indications, advantages, disadvantages, and prospects of the TF-FESS.
    Language Chinese
    Publishing date 2023-07-03
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604573-x
    ISSN 0529-5815
    ISSN 0529-5815
    DOI 10.3760/cma.j.cn112139-20230321-00118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2469: Show issues Location:
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    Zs.MO 218: Show issues

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  8. Article ; Online: Bacteria manipulate host cells with channel-forming effectors.

    Liu, Yukun / Hou, Shuguo

    Trends in microbiology

    2023  Volume 32, Issue 1, Page(s) 8–9

    Abstract: Bacterial pathogens deliver effectors into host cells mostly to manipulate signaling and metabolic molecules, thereby subverting host immunity. A recent study by Nomura et al. demonstrates that certain effectors create membrane channels in host cells, ... ...

    Abstract Bacterial pathogens deliver effectors into host cells mostly to manipulate signaling and metabolic molecules, thereby subverting host immunity. A recent study by Nomura et al. demonstrates that certain effectors create membrane channels in host cells, enabling bacteria to access water and solutes for multiplication.
    MeSH term(s) Bacterial Proteins/metabolism ; Bacteria/genetics ; Bacteria/metabolism ; Plant Diseases/microbiology
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2023.10.013
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    Zs.A 3738: Show issues Location:
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  9. Article ; Online: PCB defect detection algorithm based on CDI-YOLO.

    Xiao, Gaoshang / Hou, Shuling / Zhou, Huiying

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7351

    Abstract: During the manufacturing process of printed circuit boards (PCBs), quality defects can occur, which can affect the performance and reliability of PCBs. Existing deep learning-based PCB defect detection methods are difficult to simultaneously achieve the ... ...

    Abstract During the manufacturing process of printed circuit boards (PCBs), quality defects can occur, which can affect the performance and reliability of PCBs. Existing deep learning-based PCB defect detection methods are difficult to simultaneously achieve the goals of high detection accuracy, fast detection speed, and small number of parameters. Therefore, this paper proposes a PCB defect detection algorithm based on CDI-YOLO. Firstly, the coordinate attention mechanism (CA) is introduced to improve the backbone and neck network of YOLOv7-tiny, enhance the feature extraction capability of the model, and thus improve the accuracy of model detection. Secondly, DSConv is used to replace part of the common convolution in YOLOv7-tiny to achieve lower computing costs and faster detection speed. Finally, Inner-CIoU is used as the bounding box regression loss function of CDI-YOLO to speed up the bounding box regression process. The experimental results show that the method achieves 98.3% mAP on the PCB defect dataset, the detection speed is 128 frames per second (FPS), the parameters is 5.8 M, and the giga floating-point operations per second (GFLOPs) is 12.6 G. Compared with the existing methods, the comprehensive performance of this method has advantages.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57491-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: DGK5 phosphorylation finetunes PA homeostasis in plant immunity.

    Wang, Lijun / Liu, Yukun / Hou, Shuguo

    Trends in plant science

    2024  

    Abstract: Phosphatidic acid (PA) as a universal second messenger is transiently and rapidly produced upon immune activation in plants. A recent study by Kong et al. elucidated a mechanism for maintaining PA homeostasis via two uncoupled phosphorylation events of ... ...

    Abstract Phosphatidic acid (PA) as a universal second messenger is transiently and rapidly produced upon immune activation in plants. A recent study by Kong et al. elucidated a mechanism for maintaining PA homeostasis via two uncoupled phosphorylation events of DIACYLGLYCEROL KINASE 5 (DGK5) at different phosphorylation sites by two distinct kinases.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1305448-x
    ISSN 1878-4372 ; 1360-1385
    ISSN (online) 1878-4372
    ISSN 1360-1385
    DOI 10.1016/j.tplants.2024.03.017
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