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  1. Article: The role of microglia in the pathogenesis of diabetic-associated cognitive dysfunction.

    Xu, Wenwen / Wang, Xinyu / Hou, Xunyao / Yang, Yan / Ma, Rongrong / Lv, Renjun / Yin, Qingqing

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1246979

    MeSH term(s) Humans ; Microglia ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/pathology ; Diabetes Mellitus/pathology
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1246979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Progress, Challenges, and Opportunities of Geriatric Medicine in China.

    Zhao, Zeyu / Hou, Xunyao / Li, Shangbin / Xu, Wenwen / Yin, Qingqing

    Aging and disease

    2022  Volume 13, Issue 5, Page(s) 1314–1316

    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2022.0128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Internet Use among Older Adults in the Era of COVID-19 in China: Challenges and Opportunities.

    Yin, Qingqing / Wang, Xinyu / Lv, Renjun / Li, Shangbin / Hou, Xunyao / Wang, Jianchun

    Aging and disease

    2023  Volume 14, Issue 3, Page(s) 577–578

    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2022.1006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: China should emphasize understanding and standardized management in diabetic cognitive dysfunction.

    Yin, Qingqing / Gao, Yan / Wang, Xinyu / Li, Shangbin / Hou, Xunyao / Bi, Wenkai

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1195962

    MeSH term(s) Humans ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy ; Dementia ; China/epidemiology ; Diabetes Mellitus/therapy
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1195962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cerebral watershed infarctions as a presentation of idiopathic hypereosinophilic syndrome: a case report.

    Wang, Xinyu / Hou, Xunyao / Lv, Renjun / Chen, Jian / Zhang, Feng / Yin, Qingqing

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 44, Issue 4, Page(s) 1429–1431

    MeSH term(s) Humans ; Cerebral Infarction/complications ; Cerebral Infarction/diagnostic imaging ; Hypereosinophilic Syndrome/complications ; Hypereosinophilic Syndrome/diagnosis
    Language English
    Publishing date 2022-12-01
    Publishing country Italy
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-06532-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer's disease mice.

    Guo, Yunliang / Fan, Zhongyu / Zhao, Shuo / Yu, Wei / Hou, Xunyao / Nie, Shanjing / Xu, Song / Zhao, Cheng / Han, Junting / Liu, Xueping

    Neurological research

    2023  Volume 45, Issue 8, Page(s) 753–764

    Abstract: Objectives: β-Amyloid protein (Aβ) plays pivotal roles in pathogenesis of Alzheimer's disease (AD) and triggers various pathophysiological events. Lycopene is a promising neuroprotector with multiple bioactivities, while its bioavailability is limited. ... ...

    Abstract Objectives: β-Amyloid protein (Aβ) plays pivotal roles in pathogenesis of Alzheimer's disease (AD) and triggers various pathophysiological events. Lycopene is a promising neuroprotector with multiple bioactivities, while its bioavailability is limited. Lycopene-loaded microemulsion (LME) possessing superior bioavailability and brain-targeting efficiency was developed in our previous study. In this investigation, we aimed to comprehensively evaluate its neuroprotective effects and underlying mechanisms using intracerebroventricular (ICV) Aβ
    Methods: Mice were assigned to the Sham, Aβ, Aβ + LME and Aβ + lycopene dissolved in olive oil (LOO) groups. ICV Aβ
    Results: Our findings verified Aβ-induced neurotoxicity on neuroinflammation, oxidative stress, apoptosis, Aβ metabolisms and synaptic plasticity. LME supplementation dramatically attenuated astrocytosis and microgliosis, decreased malondialdehyde production and rescued antioxidant capacities, normalized apoptotic parameters and alleviated neuronal loss, inhibited amyloidogenic processing and activated non-amyloidogenic pathway, together with upregulating synaptic protein expressions and restoring synaptic plasticity. Nevertheless, most of these phenomena were not observed for mice treated with LOO, implying that LME showed significantly higher therapeutic efficacy against Aβ injury.
    Discussion: In summary, brain-targeted LME could exert neuroprotective function via suppressing a series of cascades triggered by Aβ aggregates, thus ameliorating Aβ neurotoxicity and associated abnormalities. Given this, LME may serve as an attractive candidate for AD prevention and treatment, and superiority of brain-targeting delivery is highlighted.
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/toxicity ; Amyloid beta-Peptides/metabolism ; Lycopene/adverse effects ; Lycopene/metabolism ; Neuroinflammatory Diseases ; Oxidative Stress ; Brain/pathology ; Neuronal Plasticity ; Apoptosis ; Disease Models, Animal ; Peptide Fragments/toxicity ; Peptide Fragments/metabolism
    Chemical Substances Amyloid beta-Peptides ; Lycopene (SB0N2N0WV6) ; Peptide Fragments
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 424428-x
    ISSN 1743-1328 ; 0161-6412
    ISSN (online) 1743-1328
    ISSN 0161-6412
    DOI 10.1080/01616412.2023.2203615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1491: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Insidious Attentional Deficits in Patients With Cerebral Small Vessel Disease Revealed by Attention Network Test.

    Guo, Yunliang / Zhao, Shuo / Hou, Xunyao / Nie, Shanjing / Xu, Song / Hong, Yan / Chen, Yali / Guo, Shougang / Liu, Xueping / Xia, Zhangyong

    Frontiers in neurology

    2022  Volume 13, Page(s) 865307

    Abstract: Background: Several reports have indicated potential cognitive decline for cerebral small vessel disease (CSVD), especially in attention domain, whereas the attentional function at network level is still elusive. In this study, we used the attention ... ...

    Abstract Background: Several reports have indicated potential cognitive decline for cerebral small vessel disease (CSVD), especially in attention domain, whereas the attentional function at network level is still elusive. In this study, we used the attention network test (ANT) paradigm to characterize the efficiency of the alerting, orienting, and executive control networks in patients with CSVD and explore possible correlations between attention network efficiencies and obtained CSVD total score.
    Methods: A total of 31 patients with CSVD and 30 healthy controls matched for age, gender, and education level were recruited. After neuropsychological and anxiety/depression/somatization assessments, an original version of ANT containing different cue conditions and target stimuli was used to investigate independent attentional components, and then, behavioral performance (accuracy and reaction time) and network efficacy were recorded and analyzed.
    Results: Assessed by traditional neuropsychological scale (MoCA), we did not find difference between groups on general cognition. Nevertheless, the overall reaction time to targets of ANT was markedly prolonged in patients with CSVD, and similar phenomenon was observed for overall accuracy on ANT. Moreover, patients showed significantly lower orienting and executive control network efficiencies compared with controls, while not for alerting network. These impairments were correlated with total CSVD burdens, but not with anxiety, depression, or somatization.
    Conclusions: Although general and almost all individual cognitive function evaluated by MoCA seemed to remain intact, the orienting and executive control function was impaired in individuals with CSVD, which was modulated by lesion grades. Our observations implied insidious attentional deficits regarding CSVD. Given this, considering its simplicity and sensitivity, ANT could serve as an attractive tool for early diagnosis of cognitive dysfunction. Further investigations on the availability of ANT detection for CSVD are warranted.
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.865307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin-3 level.

    Ma, Shizhan / Li, Shangbin / Lv, Renjun / Hou, Xunyao / Nie, Shanjing / Yin, Qingqing

    Journal of diabetes investigation

    2020  Volume 11, Issue 5, Page(s) 1295–1302

    Abstract: Aims/introduction: Galectin-3 (Gal3) contributes to insulin resistance, inflammation and obesity, the three risk factors for mild cognitive impairment (MCI) in type 2 diabetes mellitus patients.: Materials and methods: A total of 134 hospitalized ... ...

    Abstract Aims/introduction: Galectin-3 (Gal3) contributes to insulin resistance, inflammation and obesity, the three risk factors for mild cognitive impairment (MCI) in type 2 diabetes mellitus patients.
    Materials and methods: A total of 134 hospitalized type 2 diabetes mellitus patients were assessed by the Montreal Cognitive Assessment method, and divided into 65 MCI and 69 controls. Levels of variables, Gal3 and Aβ42, were investigated in relation with cognitive function in both type 2 diabetes mellitus patients with MCI and high-fat diet/streptozotocin induced type 2 diabetes mellitus rats.
    Results: Significantly higher levels of serum Gal3 and lower levels of plasma Aβ42 (all P < 0.05) were found in the MCI type 2 diabetes mellitus group as compared with the non-MCI type 2 diabetes mellitus control. Partial correlation analysis showed that Gal3 is negatively correlated with both MMSE score (r = -0.51, P < 0.01) and Montreal Cognitive Assessment score (r = -0.47, P < 0.001) after adjustment for glycated hemoglobin, homoeostasis model assessment of insulin resistance and Aβ42 in all type 2 diabetes mellitus patients, with a stronger effect seen in the MCI type 2 diabetes mellitus group after further analysis with MCI strata. A simple logistic regression model showed that Gal3 and Aβ42 are significantly associated with MCI type 2 diabetes mellitus patients after adjustment with the covariates sex, age, body mass index, glycated hemoglobin, homoeostasis model assessment of insulin resistance and antidiabetic drugs. Serum and brain Gal3 levels were significantly increased in high-fat diet/streptozotocin diabetic rats, which correlate to the impairment of learning and memory ability. Gal3 inhibitor modified citrus pectin decreased serum and brain Gal3 levels in diabetic rats, accompanied by the amelioration of learning and memory impairment.
    Conclusions: Gal3 might be associated with cognitive impairment in type 2 diabetes mellitus, and serum Gal3 level might be a new risk factor of MCI in type 2 diabetes mellitus patients.
    MeSH term(s) Aged ; Animals ; Biomarkers/blood ; Blood Glucose/analysis ; Blood Proteins ; Body Mass Index ; Case-Control Studies ; China/epidemiology ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Type 2/complications ; Female ; Follow-Up Studies ; Galectins/blood ; Humans ; Male ; Neuropsychological Tests ; Prevalence ; Prognosis ; Rats ; Rats, Wistar
    Chemical Substances Biomarkers ; Blood Glucose ; Blood Proteins ; Galectins ; LGALS3 protein, human
    Language English
    Publishing date 2020-04-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13256
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6920: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Selective Impairment of Processing Task-Irrelevant Emotional Faces in Cerebral Small Vessel Disease Patients.

    Fan, Zhongyu / Guo, Yunliang / Hou, Xunyao / Lv, Renjun / Nie, Shanjing / Xu, Song / Chen, Jian / Hong, Yan / Zhao, Shuo / Liu, Xueping

    Neuropsychiatric disease and treatment

    2021  Volume 17, Page(s) 3693–3703

    Abstract: Background: Few reports have implied electrophysiological alterations and neurocognitive abnormalities in patients with cerebral small vessel disease (CSVD), while no investigation is available regarding emotional processing. In the present study, pre- ... ...

    Abstract Background: Few reports have implied electrophysiological alterations and neurocognitive abnormalities in patients with cerebral small vessel disease (CSVD), while no investigation is available regarding emotional processing. In the present study, pre-attentive processing of facial expressions was compared between CSVD sufferers and healthy controls using expression-related visual mismatch negativity (EMMN) as the indicator.
    Methods: A total of 22 CSVD patients (12 males) and 21 age-matched healthy controls (12 males) were recruited for neuropsychological and emotional assessments, as well as electroencephalogram recording and analysis. We employed an expression-related oddball paradigm to investigate automatic emotional processing, and a series of schematic emotional faces (neutral, happy, sad) unrelated to subject's task were present in the test to avoid low-level processing of facial features.
    Results: Although the distinctions of neuropsychological (MoCA and MMSE), emotional (GAD-7 and PHQ-9) and behavioral parameters (reaction time to target stimuli and response accuracy) did not reach significant levels, mean amplitudes of sad EMMN in time intervals of 150-250 ms and 250-350 ms were remarkably reduced in CSVD patients compared with healthy controls, but not for happy EMMN. Furthermore, in the control group, sad EMMN was demonstrated to be larger (more negative) than happy EMMN, while this interesting phenomenon disappeared in the CSVD group.
    Conclusion: Our findings confirmed selective impairment of processing expressions which were task-irrelevant in CSVD patients, without the existence of negative bias (sad superiority) effect. The efficacy of EMMN as an electrophysiological evaluation marker of CSVD should be taken into account in future investigations.
    Language English
    Publishing date 2021-12-16
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S340680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6068: Show issues Location:
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  10. Article: Preliminary Findings on Visual Event-Related Potential P3 in Asymptomatic Patients with Cerebral Small Vessel Disease.

    Nie, Shanjing / Shen, Chao / Guo, Yunliang / Hou, Xunyao / Hong, Yan / Xu, Song / Lv, Renjun / Liu, Xueping

    Neuropsychiatric disease and treatment

    2021  Volume 17, Page(s) 3379–3394

    Abstract: Background: Cerebral small vessel disease is the primary cause of cognitive impairment. Therefore, early recognition is of great significance. Some studies have shown that asymptomatic cerebral small vessel disease (aCSVD) patients have abnormal ... ...

    Abstract Background: Cerebral small vessel disease is the primary cause of cognitive impairment. Therefore, early recognition is of great significance. Some studies have shown that asymptomatic cerebral small vessel disease (aCSVD) patients have abnormal neurocognitive function, but this is not readily apparent at the initial stage. The objective of this paper was to assess visual spatial attention by event-related potential (ERP) examination and to analyze the relationship between ERP data and clinical characteristics in patients with aCSVD.
    Methods: We selected 25 aCSVD patients and enrolled 23 age-matched normal subjects as the control group. We measured the latency and amplitude of original/corresponding differential ERP components using the modified visual oddball paradigm, which included a standard stimulus, target stimulus, and new stimulus. Additionally, we selected aberrant ERP components to study the correlations between the ERP data and clinical characteristics of the patients with aCSVD.
    Results: We found not only lower amplitude but also significantly longer P3 latency in the aCSVD patients. The above results were further verified by analyzing the different components (target minus standard and novel minus standard) of P3. Furthermore, abnormal ERPs in the aCSVD patients were closely related to the changes observed with imaging.
    Conclusion: It was demonstrated that the speed and capability of processing visual spatial information was impaired in aCSVD patients compared with healthy controls. Thus, ERP examination could detect the presence of attentional deficits and might become a rapid and sensitive method for the early diagnosis of aCSVD. However, its availability needs further investigation.
    Language English
    Publishing date 2021-11-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S338717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6068: Show issues Location:
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