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  1. Article ; Online: Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total Synthesis, and Structural Modification

    Wang, Chao / Wang, Siyuan / Li, Haonan / Hou, Yonglian / Cao, Hao / Hua, Huiming / Li, Dahong

    Mar Drugs. 2023 Mar. 31, v. 21, no. 4

    2023  

    Abstract: Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse biological activities, such as antibacterial, anti-tumor, anti-plasmodium, etc. ...

    Abstract Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse biological activities, such as antibacterial, anti-tumor, anti-plasmodium, etc. Unfortunately, the planar structure of fascaplysin can be inserted into DNA and such interaction also limits the further application of fascaplysin, necessitating its structural modification. In this review, the biological activity, total synthesis and structural modification of fascaplysin will be summarized, which will provide useful information for pharmaceutical researchers interested in the exploration of marine alkaloids and for the betterment of fascaplysin in particular.
    Keywords DNA ; alkaloids ; apoptosis ; medicinal properties
    Language English
    Dates of publication 2023-0331
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040226
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total Synthesis, and Structural Modification.

    Wang, Chao / Wang, Siyuan / Li, Haonan / Hou, Yonglian / Cao, Hao / Hua, Huiming / Li, Dahong

    Marine drugs

    2023  Volume 21, Issue 4

    Abstract: Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse biological activities, such as antibacterial, anti-tumor, anti-plasmodium, etc. ...

    Abstract Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse biological activities, such as antibacterial, anti-tumor, anti-plasmodium, etc. Unfortunately, the planar structure of fascaplysin can be inserted into DNA and such interaction also limits the further application of fascaplysin, necessitating its structural modification. In this review, the biological activity, total synthesis and structural modification of fascaplysin will be summarized, which will provide useful information for pharmaceutical researchers interested in the exploration of marine alkaloids and for the betterment of fascaplysin in particular.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Indoles/pharmacology
    Chemical Substances fascaplysine (114719-57-2) ; Antineoplastic Agents ; Indoles
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A: Design, synthesis and cytotoxicity in MDA-MB-231 human breast cancer cells.

    Wang, Mingying / Sun, Baojia / Ye, Tao / Wang, Yanbing / Hou, Yonglian / Wang, Siyuan / Pan, Huaqi / Hua, Huiming / Li, Dahong

    Bioorganic & medicinal chemistry

    2023  Volume 90, Page(s) 117380

    Abstract: 27 novel 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A were designed and synthesized to make them more conducive to the cancer treatment. The antiproliferative activity of all the target compounds was tested against six human ... ...

    Abstract 27 novel 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A were designed and synthesized to make them more conducive to the cancer treatment. The antiproliferative activity of all the target compounds was tested against six human cancer cell lines and one human normal cell line. Compound 10d exhibited nearly the most potent cytotoxicity with IC
    MeSH term(s) Humans ; Female ; Structure-Activity Relationship ; Cell Line, Tumor ; Brefeldin A/pharmacology ; Breast Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Apoptosis ; Molecular Structure
    Chemical Substances Brefeldin A (20350-15-6) ; 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione ; Antineoplastic Agents
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Anti-breast cancer sinomenine derivatives via mechanisms of apoptosis induction and metastasis reduction.

    Gao, Xiang / Sun, Baojia / Hou, Yonglian / Liu, Lilin / Sun, Jianan / Xu, Fanxing / Li, Dahong / Hua, Huiming

    Journal of enzyme inhibition and medicinal chemistry

    2022  Volume 37, Issue 1, Page(s) 1870–1883

    Abstract: Sinomenine, a morphinane-type isoquinoline-derived alkaloid, was first isolated from stems and roots ... ...

    Abstract Sinomenine, a morphinane-type isoquinoline-derived alkaloid, was first isolated from stems and roots of
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Morphinans/pharmacology ; Triple Negative Breast Neoplasms
    Chemical Substances Antineoplastic Agents ; Morphinans ; sinomenine (63LT81K70N)
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2022.2096020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Stilbenes with potent cytotoxicity from the seedcases of Paeonia suffruticosa Andrews.

    Yang, Meng-Yue / Shao, Zhao-Xiang / Wang, Yue-Tong / Hou, Yong-Lian / Zhu, Ding-Kang / Chen, Sha / Zhang, Ya-Hui / Cao, Fei / Jing, Yong-Kui / Lin, Bin / Li, Zhan-Lin / Li, Da-Hong / Hua, Hui-Ming

    Phytochemistry

    2022  Volume 205, Page(s) 113515

    Abstract: Stilbenes (based on the 1,2-diphenylethylene skeleton) are a class of plant polyphenols with rich structural and bioactive diversity. Twenty-six stilbenes, including five undescribed compounds (7,8-dioxy-4,3',5'-trihydroxystilbene, trans-13'- ... ...

    Abstract Stilbenes (based on the 1,2-diphenylethylene skeleton) are a class of plant polyphenols with rich structural and bioactive diversity. Twenty-six stilbenes, including five undescribed compounds (7,8-dioxy-4,3',5'-trihydroxystilbene, trans-13'-methoxygnetin H, suffruticosol E, paestibenetrimerols A and B), were isolated from the seedcases of Paeonia suffruticosa Andrews. Their structures were elucidated by spectroscopic analyses and comparison with previously reported data. The absolute configurations of trans-13'-methoxygnetin H, suffruticosol E, paestibenetrimerols A and B were assigned from their respective electronic circular dichroism (ECD) spectra. Additionally, the structures of known compounds suffruticosols A, B and rockiol B were revised and the absolute configurations of them, and along with (+)-davidiol A, were also further determined by ECD. The isolated compounds, trans-gnetin H, cis-gnetin H and suffruticosol E, were found to have potent cytotoxicity against the DU-145 and MDA-MB-231 cell lines with IC
    MeSH term(s) Paeonia
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2022.113515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

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