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  1. Article: [Prognostic factors affecting the success of conversion chemotherapy in patients with unresectable liver metastases from initially colorectal cancer].

    Zhang, W L / Zhou, C / Deng, Y X / Hou, Z L / Zhang, L J / Lin, J Z / Pan, Z Z / Lu, Z H / Peng, J H

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2022  Volume 25, Issue 1, Page(s) 56–62

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/therapeutic use ; Case-Control Studies ; Colorectal Neoplasms/drug therapy ; Fluorouracil/therapeutic use ; Humans ; Leucovorin/therapeutic use ; Liver Neoplasms/drug therapy ; Prognosis ; Retrospective Studies
    Chemical Substances Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
    Language Chinese
    Publishing date 2022-01-23
    Publishing country China
    Document type Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn441530-20210718-00287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expression and clinical significance of the obesity-related gene TNFAIP9 in obese children.

    Gui, L Y / Hu, Y L / Hou, Z L / Wang, P

    Genetics and molecular research : GMR

    2016  Volume 15, Issue 3

    Abstract: To investigate the expression of tumor necrosis factor-alpha inducible protein 9 (TNFAIP9) gene in obese children and its clinical significance, 36 simple obese children and 17 non-obese children were recruited as research subjects. The adipose tissue ... ...

    Abstract To investigate the expression of tumor necrosis factor-alpha inducible protein 9 (TNFAIP9) gene in obese children and its clinical significance, 36 simple obese children and 17 non-obese children were recruited as research subjects. The adipose tissue was obtained by abdominal operation. The expression of TNFAIP9 was detected using real-time fluorescence quantitative polymerase chain reaction and western blot. The relationship between the expression of TNFAIP9 and blood lipid, blood glucose, and obesity indexes was analyzed. The levels of TNFAIP9 mRNA and protein in obese children were significantly lower than those in the control group (P < 0.05). The waist circumference (wc), body mass, body mass index (BMI), fat, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), insulin resistance index (HOMA-IR), and endothelin (ET) in obese children were significantly higher than those in the control group. The level of high-density lipoprotein cholesterol (HDL-C) was significantly lower than that in the control group (P < 0.05). The level of TNFAIP9 protein was negatively correlated with the wc, body mass, BMI, fat, TC, TG, LDL-C, HOMA-IR, and ET (P < 0.05) and was positively correlated with the level of HDL-C (P < 0.05). In conclusion, the expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity.
    MeSH term(s) Adipose Tissue/chemistry ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Adolescent ; Blood Glucose/metabolism ; Body Mass Index ; Child ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Lipids/blood ; Male ; Membrane Proteins/blood ; Membrane Proteins/genetics ; Obesity/blood ; Obesity/genetics ; Oxidoreductases/blood ; Oxidoreductases/genetics ; Triglycerides/blood ; Waist Circumference
    Chemical Substances Blood Glucose ; Insulin ; Lipids ; Membrane Proteins ; Triglycerides ; Oxidoreductases (EC 1.-) ; STEAP4 protein, human (EC 1.16.1.-)
    Language English
    Publishing date 2016-08-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2114039-X
    ISSN 1676-5680 ; 1676-5680
    ISSN (online) 1676-5680
    ISSN 1676-5680
    DOI 10.4238/gmr.15037995
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  3. Article: Effect of systemic morphine on neurons in the lateral reticular nucleus area of the rat.

    Liu, R H / Tang, J S / Hou, Z L

    Brain research bulletin

    1993  Volume 32, Issue 2, Page(s) 179–184

    Abstract: The present study is undertaken to investigate the effect of systemic morphine on neurons in the lateral reticular nucleus (LRN) using extracellular recording techniques. The spontaneous activities of 64 neurons in the LRN area were tested with morphine ( ...

    Abstract The present study is undertaken to investigate the effect of systemic morphine on neurons in the lateral reticular nucleus (LRN) using extracellular recording techniques. The spontaneous activities of 64 neurons in the LRN area were tested with morphine (3-5 mg/kg, IV). Morphine excited 23 and inhibited 28 neurons tested, and 13 neurons were not affected. Of the 28 neurons inhibited, 20 were identified as nociceptive and the remaining 6 were nonnociceptive. Of the 23 neurons excited by morphine, 18 were nociceptive and 5 were nonociceptive. Systemic naloxone (0.3-0.5 mg/kg) significantly reversed the morphine effect in 15 out of 19 neurons excited and 19 out of 20 neurons inhibited by morphine. Thirteen out of 64 neurons were further identified as reticulospinal neurons, of which four were excited and four were inhibited by morphine. The remaining five were not affected. The results demonstrate that a similar proportion of neurons in the LRN area were either excited or inhibited by systemic morphine, and the majority of them are nociceptive neurons. It is suggested that different types of neurons in the LRN area may have different functions in morphine analgesia.
    MeSH term(s) Animals ; Catheterization, Central Venous ; Male ; Medulla Oblongata/cytology ; Medulla Oblongata/drug effects ; Morphine/administration & dosage ; Naloxone/administration & dosage ; Neurons/drug effects ; Pain/physiopathology ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Naloxone (36B82AMQ7N) ; Morphine (76I7G6D29C)
    Language English
    Publishing date 1993
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/0361-9230(93)90072-j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1243: Show issues Location:
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  4. Article: Role of the deep mesencephalic nucleus in the antinociception induced by stimulation of the anterior pretectal nucleus in rats.

    Wang, X M / Yuan, B / Hou, Z L

    Brain research

    1992  Volume 577, Issue 2, Page(s) 321–325

    Abstract: The present study showed that the inhibitory effect on the tail-flick reflex (TF) of stimulating the deep mesencephalic nucleus (DpMe) was very similar to that produced by stimulation of the anterior pretectal nucleus (APtN). An electrolytic lesion of ... ...

    Abstract The present study showed that the inhibitory effect on the tail-flick reflex (TF) of stimulating the deep mesencephalic nucleus (DpMe) was very similar to that produced by stimulation of the anterior pretectal nucleus (APtN). An electrolytic lesion of the ipsilateral DpMe greatly reduced the inhibitory effect of APtN stimulation on the TF. Furthermore, activating the neuronal cell bodies in DpMe but not the fibers of passage by microinjection of L-glutamate into this area was also shown to elicit inhibition of TF. On the other hand, inhibiting the neuronal cells in DpMe by microinjection of gamma-aminobutyric acid produced a marked reduction in the APtN-induced inhibition of TF, which was comparable to that produced by DpMe lesions. It is suggested that the APtN-induced antinociception is, at least in part, mediated via a relay through the DpMe.
    MeSH term(s) Animals ; Electric Stimulation ; Glutamates/pharmacology ; Glutamic Acid ; Mesencephalon/drug effects ; Mesencephalon/physiology ; Microinjections ; Pain/physiopathology ; Rats ; Rats, Inbred Strains ; Reflex/physiology ; Tail/physiology ; gamma-Aminobutyric Acid/pharmacology
    Chemical Substances Glutamates ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 1992-04-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/0006-8993(92)90291-g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Electrophysiological identification of spinally projecting neurons in the lateral reticular nucleus of the rat.

    Liu, R H / Tang, J S / Hou, Z L

    Brain research

    1989  Volume 481, Issue 2, Page(s) 350–355

    Abstract: Eighty-four neurons in the caudal ventrolateral medullary reticular formation were antidromically activated by the stimulation of the dorsolateral funiculus in 49 urethane-anesthetized rats. Of 76 neurons, 37 had no spontaneous discharge. Of the neurons ... ...

    Abstract Eighty-four neurons in the caudal ventrolateral medullary reticular formation were antidromically activated by the stimulation of the dorsolateral funiculus in 49 urethane-anesthetized rats. Of 76 neurons, 37 had no spontaneous discharge. Of the neurons that had spontaneous discharges, 80% had firing rates between 0.1 and 15 Hz. The average conduction velocity, determined among 70 neurons, was 15.20 +/- 1.23 m/s, and 87% had conduction velocities within the range of 2-30 m/s. This study further confirms the existence of spinally-projecting neurons in the lateral reticular nucleus (LRN) of the caudal medulla, and some of them are probably responsible for the descending controls of nociception from the LRN.
    MeSH term(s) Action Potentials ; Animals ; Efferent Pathways/physiology ; Electric Stimulation ; Male ; Medulla Oblongata/physiology ; Neural Conduction ; Rats ; Rats, Inbred Strains ; Spinal Cord/physiology
    Language English
    Publishing date 1989-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/0006-8993(89)90813-5
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  6. Article: The effect of acupuncture manipulation to the discharges of needling sensation receptors.

    Zhao, Y / Shi, W C / Hou, Z L

    Zhen ci yan jiu = Acupuncture research

    1988  Volume 13, Issue 3, Page(s) 221–225

    MeSH term(s) Acupuncture Therapy ; Animals ; Cats ; Electric Stimulation Therapy ; Electrophysiology ; Mechanoreceptors/physiology ; Perception/physiology ; Sensation/physiology
    Language English
    Publishing date 1988
    Publishing country China
    Document type Journal Article
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
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  7. Article: [Effects of electroacupuncture stimulation (EAS) of different frequencies on the excitability of fibers of various groups].

    Tang, J S / Shi, W C / Hou, Z L

    Zhen ci yan jiu = Acupuncture research

    1987  Volume 12, Issue 1, Page(s) 68–72

    MeSH term(s) Action Potentials ; Acupuncture Therapy ; Animals ; Electric Stimulation ; Female ; Male ; Nerve Fibers/physiology ; Peroneal Nerve/physiology ; Rabbits ; Refractory Period, Electrophysiological
    Language Chinese
    Publishing date 1987
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
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  8. Article: [The observation on the general properties of the acupoint muscle action potential].

    Yan, J Q / Wang, K M / Hou, Z L

    Zhen ci yan jiu = Acupuncture research

    1987  Volume 12, Issue 2, Page(s) 144–5, 138

    MeSH term(s) Action Potentials ; Acupuncture Therapy ; Female ; Humans ; Male ; Muscles/physiology ; Myography
    Language Chinese
    Publishing date 1987
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
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  9. Article: Responses of reticulospinal neurons in the lateral reticular nucleus area of the rat to cutaneous noxious and non-noxious stimulation.

    Liu, R H / Tang, J S / Hou, Z L / Jia, H

    Neuroscience letters

    1990  Volume 109, Issue 1-2, Page(s) 92–96

    Abstract: Response properties of reticulospinal neurons in the lateral reticular nucleus (LRN) area to natural cutaneous stimulation were investigated systematically in 45 urethane-anesthetized rats by using extracellular recording techniques. A total of 64 ... ...

    Abstract Response properties of reticulospinal neurons in the lateral reticular nucleus (LRN) area to natural cutaneous stimulation were investigated systematically in 45 urethane-anesthetized rats by using extracellular recording techniques. A total of 64 neurons were tested with peripheral stimuli, of which 19 were responsive only to noxious stimuli; 7 responsive to both noxious and non-noxious stimuli; 4 responsive only to non-noxious stimuli; and 34 not responsive to any cutaneous stimuli. Both the noxious and non-noxious receptive fields were large and bilateral. Among the neurons responding to noxious stimuli, the majority (72%) was excited. This study provides evidence that some reticulospinal neurons in the rat LRN area are involved in the mechanisms of nociception.
    MeSH term(s) Action Potentials ; Afferent Pathways/physiology ; Animals ; Electric Stimulation ; Male ; Medulla Oblongata/physiology ; Medulla Oblongata/physiopathology ; Neurons, Afferent/physiology ; Nociceptors/physiology ; Physical Stimulation ; Rats ; Rats, Inbred Strains ; Skin/innervation
    Language English
    Publishing date 1990-02-05
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/0304-3940(90)90543-i
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    Zs.A 1166: Show issues Location:
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  10. Article: A study on the receptive field of acupoints and the relationship between characteristics of needling sensation and groups of afferent fibres.

    Wang, K M / Yao, S M / Xian, Y L / Hou, Z L

    Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences

    1985  Volume 28, Issue 9, Page(s) 963–971

    Abstract: We have recorded the afferent unit discharges and using it as an index, measured the locations and the volumes of nine acupoints, such as Neiguan and Shaoshang, which are innervated by median nerve. We have also investigated the relationships between ... ...

    Abstract We have recorded the afferent unit discharges and using it as an index, measured the locations and the volumes of nine acupoints, such as Neiguan and Shaoshang, which are innervated by median nerve. We have also investigated the relationships between electric needling sensations and afferent fibres of different groups as well as manual needling sensations by means of analysing power-spectrum of the unit discharges with FFT. It has been found that the fibres of Group II and Group IV convey numbness and soreness, respectively. The fibres of Group III relates to the conduction of heaviness and distention closely.
    MeSH term(s) Action Potentials ; Acupuncture Therapy ; Afferent Pathways/physiology ; Electric Stimulation ; Humans ; Median Nerve/physiology ; Nerve Fibers/physiology ; Paralysis/physiopathology ; Sensation/physiology ; Synaptic Transmission
    Language English
    Publishing date 1985-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 406604-2
    ISSN 0253-5823
    ISSN 0253-5823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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