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Article ; Online: A Novel Yolk-Shell Fe

Tian, Haina / Zhang, Ruifeng / Li, Jiaqi / Huang, Cailin / Sun, Wen / Hou, Zhenqing / Wang, Peiyuan

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Owing to their good stability and high photothermal conversion efficiency, the development of carbon-based nanoparticles has been intensively investigated, while the limitation of unsatisfactory cellular internalization impedes their further clinical ... ...

Abstract	Owing to their good stability and high photothermal conversion efficiency, the development of carbon-based nanoparticles has been intensively investigated, while the limitation of unsatisfactory cellular internalization impedes their further clinical application. Herein, we report a novel strategy for fabrication of Fe
MeSH term(s)	Animals ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/therapy ; Carbon/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Combined Modality Therapy ; Doxorubicin/administration & dosage ; Doxorubicin/chemistry ; Female ; Magnetic Iron Oxide Nanoparticles/chemistry ; Mice ; Nanostructures ; Particle Size ; Photothermal Therapy ; Treatment Outcome ; Xenograft Model Antitumor Assays
Chemical Substances	Carbon (7440-44-0) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2022-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031623
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Platinum-Coordinated Engineered Nanoreactors with O

Wang, Qiuli / Meng, Jiahao / Huang, Lingling / Wu, Feng / Yi, Xue / Su, Guanghao / Li, Ying / Hou, Zhenqing / Fan, Zhongxiong

ACS applied materials & interfaces

2023 Volume 15, Issue 14, Page(s) 17495–17506

Abstract: How to efficiently synthesize toxic chemo-drugs in the hypoxia tumor microenvironment still faces a huge challenge. Herein, we have tailored engineered vehicle-free nanoreactors by coordination-driven co-assembly of photosensitizer indocyanine green (ICG) ...

Abstract	How to efficiently synthesize toxic chemo-drugs in the hypoxia tumor microenvironment still faces a huge challenge. Herein, we have tailored engineered vehicle-free nanoreactors by coordination-driven co-assembly of photosensitizer indocyanine green (ICG), transition metal platinum (Pt), and nontoxic 1,5-dihydroxynaphthalene (DHN) to self-amplify O
MeSH term(s)	Humans ; Photochemotherapy/methods ; Platinum/therapeutic use ; Hydrogen Peroxide ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Neoplasms/drug therapy ; Hypoxia/drug therapy ; Nanotechnology ; Cell Line, Tumor ; Nanoparticles ; Tumor Microenvironment
Chemical Substances	Platinum (49DFR088MY) ; Hydrogen Peroxide (BBX060AN9V) ; Photosensitizing Agents ; Antineoplastic Agents
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c22153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy.

Li, Jianmin / Wang, Qingluo / Xia, Guoyu / Adilijiang, Nigela / Li, Ying / Hou, Zhenqing / Fan, Zhongxiong / Li, Jinyao

Pharmaceutics

2023 Volume 15, Issue 9

Abstract: Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile, weaken their undesirable side effects on normal cells or tissues. In ...

Abstract	Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile, weaken their undesirable side effects on normal cells or tissues. In this research field, a large number of researchers have achieved significant breakthroughs and advances in oncotherapy. Typically, nanocarriers as a promising drug delivery strategy can effectively deliver drugs to the tumor site through enhanced permeability and retention (EPR) effect-mediated passive targeting and various types of receptor-mediated active targeting, respectively. Herein, we review recent targeted drug delivery strategies and technologies for enhancing oncotherapy. In addition, we also review two mainstream drug delivery strategies, passive and active targeting, based on various nanocarriers for enhancing tumor therapy. Meanwhile, a comparison and combination of passive and active targeting are also carried out. Furthermore, we discuss the associated challenges of passive and active targeted drug delivery strategies and the prospects for further study.
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15092233
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Article ; Online: Bioengineered nanogenerator with sustainable reactive oxygen species storm for self-reinforcing sono-chemodynamic oncotherapy.

Shi, Dao / Wu, Feng / Huang, Lingling / Li, Ying / Ke, Sunkui / Li, Jinyao / Hou, Zhenqing / Fan, Zhongxiong

Journal of colloid and interface science

2023 Volume 646, Page(s) 649–662

Abstract: Oxidative stress-based antitumor modalities derived from reactive oxygen species (ROS) storms have attracted increasing attention. Nevertheless, low delivery efficiency, poor selectivity, hypoxia and overexpressed glutathione (GSH) have severely ... ...

Abstract	Oxidative stress-based antitumor modalities derived from reactive oxygen species (ROS) storms have attracted increasing attention. Nevertheless, low delivery efficiency, poor selectivity, hypoxia and overexpressed glutathione (GSH) have severely restricted the sustainable generation of the ROS storm in tumor cells. Herein, we design a bioengineered nanogenerator by coordination-driven co-assembly of sonosensitizer indocyanine green (ICG), Fenton-like agent copper ion (Cu
MeSH term(s)	Humans ; Reactive Oxygen Species ; Oxidative Stress ; Biomedical Engineering ; Copper/pharmacology ; Drug Liberation ; Glutathione ; Indocyanine Green ; Metformin/pharmacology ; Cell Line, Tumor ; Neoplasms/drug therapy ; Hydrogen Peroxide
Chemical Substances	Reactive Oxygen Species ; Copper (789U1901C5) ; Glutathione (GAN16C9B8O) ; Indocyanine Green (IX6J1063HV) ; Metformin (9100L32L2N) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.081
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Article ; Online: Mechanism of Self-Oxidative Copolymerization and its Application with Polydopamine-pyrrole Nano-copolymers.

He, Yuan / Fan, Zhongxiong / Sun, Pengfei / Jiang, Hairong / Chen, Zhou / Tang, Guo / Hou, Zhenqing / Sun, Yanan / Yi, Yunfeng / Shi, Wei / Ge, Dongtao

Small methods

2024 , Page(s) e2301405

Abstract: Currently, the copolymer of dopamine (DA) and pyrrole (PY) via chemical and electrochemical oxidation usually requires additional oxidants, and lacks flexibility in regulating the size and morphology, thereby limiting the broad applications of DA-PY ... ...

Abstract	Currently, the copolymer of dopamine (DA) and pyrrole (PY) via chemical and electrochemical oxidation usually requires additional oxidants, and lacks flexibility in regulating the size and morphology, thereby limiting the broad applications of DA-PY copolymer in biomedicine. Herein, the semiquinone radicals produced by the self-oxidation of DA is ingeniously utilized as the oxidant to initiate the following copolymerization with PY, and a series of quinone-rich polydopamine-pyrrole copolymers (PDA
Language	English
Publishing date	2024-01-02
Publishing country	Germany
Document type	Journal Article
ISSN	2366-9608
ISSN (online)	2366-9608
DOI	10.1002/smtd.202301405
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Article ; Online: Amino acid-based metallo-supramolecular nanoassemblies capable of regulating cellular redox homeostasis for tumoricidal chemo-/photo-/catalytic combination therapy.

Tu, Li / Chen, Shengqiang / Yuan, Zhikang / Xiong, Yeqi / Luo, Bingkun / Chen, Ying / Hou, Zhenqing / Ke, Sunkui / Lin, Naibo / Li, Chao / Ye, Shefang

Journal of colloid and interface science

2024 Volume 663, Page(s) 810–824

Abstract: Nanozymes, as nanomaterials with natural enzyme activities, have been widely applied to deliver various therapeutic agents to synergistically combat the progression of malignant tumors. However, currently common inorganic nanozyme-based drug delivery ... ...

Abstract	Nanozymes, as nanomaterials with natural enzyme activities, have been widely applied to deliver various therapeutic agents to synergistically combat the progression of malignant tumors. However, currently common inorganic nanozyme-based drug delivery systems still face challenges such as suboptimal biosafety, inadequate stability, and inferior tumor selectivity. Herein, a super-stable amino acid-based metallo-supramolecular nanoassembly (FPIC NPs) with peroxidase (POD)- and glutathione oxidase (GSHOx)-like activities was fabricated via Pt
MeSH term(s)	Humans ; Photochemotherapy ; Amino Acids ; Combined Modality Therapy ; Indocyanine Green/pharmacology ; Neoplasms/drug therapy ; Coloring Agents ; Curcumin ; Oxidation-Reduction ; Cell Line, Tumor ; Nanoparticles
Chemical Substances	Amino Acids ; Indocyanine Green (IX6J1063HV) ; Coloring Agents ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.02.197
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Article: Tumor acidity-responsive carrier-free nanodrugs based on targeting activation via ICG-templated assembly for NIR-II imaging-guided photothermal–chemotherapy [Erratum: February 2021, Vol.9(3), p.1047]

Xue, Kaihang / Wei, Feng / Lin, Jinyan / Tian, Haina / Zhu, Fukai / Li, Yang / Hou, Zhenqing

Biomaterials science. 2021 Feb. 9, v. 9, no. 3

2021

Abstract: Carrier-free nanodrugs composed of photosensitizers and chemotherapeutic drugs show great potential in synergistic photothermal–chemotherapy. However, the targeting specificity to tumor cells is still a major obstacle for carrier-free nanodrugs. ... ...

Abstract	Carrier-free nanodrugs composed of photosensitizers and chemotherapeutic drugs show great potential in synergistic photothermal–chemotherapy. However, the targeting specificity to tumor cells is still a major obstacle for carrier-free nanodrugs. Meanwhile, almost all exogenous tumor-targeting ligands show no therapeutic effect by themselves. Here, a tumor microenvironment-driven self-targeting supramolecular nanodrug was successfully constructed via an indocyanine green (ICG)-templated small-molecule self-assembly strategy with methotrexate (MTX, folic acid-like antitumor drug) followed by post-insertion of weak acidity-responsive PEG for synergistic photothermal–chemotherapy. Interestingly, the size and morphology could be adjusted by changing the ICG-to-MTX ratio. Notably, the dynamic introduction of PEG not only could temporarily shield self-targeting function in blood to prolong the circulation time, but also could trigger the activation of self-targeting via re-exposing MTX ligands within the tumor microenvironment to enhance cellular uptake. Furthermore, the dePEGylated nanodrug would be disassembled to release MTX on-demand for chemotherapy via both stimuli of stronger lysosomal acidity and an external NIR laser. Moreover, the elimination of tumors could be realized through NIR-II fluorescence/PA imaging-guided synergistic photothermal–chemotherapy. The tumor microenvironment-driven carrier-free nanodrug based on self-targeting activation via ICG-templated assembly might provide a brand-new idea for synergistic photothermal–chemotherapy.
Keywords	acidity ; biocompatible materials ; blood ; drug therapy ; fluorescence ; ligands ; methotrexate ; neoplasms
Language	English
Dates of publication	2021-0209
Size	p. 1008-1019.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d0bm01864c
Database	NAL-Catalogue (AGRICOLA)

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Article: Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy

Fan, Zhongxiong / Shi, Dao / Zuo, Wenbao / Feng, Juan / Ge, Dongtao / Su, Guanghao / Yang, Lichao / Hou, Zhenqing

ACS applied materials & interfaces. 2022 Jan. 20, v. 14, no. 4

2022

Abstract: Although nanotheranostics have displayed striking potential toward precise nanomedicine, their targeting delivery and tumor penetration capacities are still impeded by several biological barriers. Besides, the current antitumor strategies mainly focus on ...

Abstract	Although nanotheranostics have displayed striking potential toward precise nanomedicine, their targeting delivery and tumor penetration capacities are still impeded by several biological barriers. Besides, the current antitumor strategies mainly focus on killing tumor cells rather than antiangiogenesis. Enlightened by the fact that the smart transformable self-targeting nanotheranostics can enhance their targeting efficiency, tumor penetration, and cellular uptake, we herein report carrier-free Trojan-horse diameter-reducible metal–organic nanotheranostics by the coordination-driven supramolecular sequential co-assembly of the chemo-drug pemetrexed (PEM), transition-metal ions (Feᴵᴵᴵ), and antiangiogenesis pseudolaric acid B. Such nanotheranostics with both a high dual-drug payload efficiency and outstanding physiological stability are responsively decomposed into numerous ultra-small-diameter nanotheranostics under stimuli of the moderate acidic tumor microenvironment and then internalized into tumor cells through tumor-receptor-mediated self-targeting, synergistically enhancing tumor penetration and cellular uptake. Besides, such nanotheranostics enable visualization of self-targeting capacity under the macroscopic monitor of computed tomography/magnetic resonance imaging, thereby realizing efficient oncotherapy. Moreover, tumor microvessels are precisely monitored by optical coherence tomography angiography/laser speckle imaging during chemo-antiangiogenic therapy in vivo, visually verifying that such nanotheranostics possess an excellent antiangiogenic effect. Our work will provide a promising strategy for further tumor diagnosis and targeted therapy.
Keywords	angiography ; computed tomography ; magnetism ; microvessels ; nanomedicine ; neoplasms ; therapeutics
Language	English
Dates of publication	2022-0120
Size	p. 5033-5052.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c22350
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβ clearance.

Fan, Zhongxiong / Ren, Tong / Wang, Youjun / Jin, Hao / Shi, Dao / Tan, Xiaofeng / Ge, Dongtao / Hou, Zhenqing / Jin, Xin / Yang, Lichao

Biomaterials

2022 Volume 283, Page(s) 121452

Abstract: Here, inspired by the concept of supramolecular inclusion complex, we successfully fabricate metformin (Met)-based supramolecular nanodrugs with the Aβ-responsive on-demand drug release for synergistic Alzheimer's disease (AD) therapy via enhancing ... ...

Abstract	Here, inspired by the concept of supramolecular inclusion complex, we successfully fabricate metformin (Met)-based supramolecular nanodrugs with the Aβ-responsive on-demand drug release for synergistic Alzheimer's disease (AD) therapy via enhancing microglial Aβ clearance. Interestingly, the introduction of low-dosage Met (1.1 mg/kg) can not only significantly improve the structural stability of nanodrugs but also exert a synergistic anti-dementia effect with donepezil (Don). Besides, such nanodrugs with outstanding physiological stability can selectively penetrate the blood-brain barrier (BBB), target brain, increase efficient uptake of microglia and neurons, and then achieve simultaneous spatiotemporal on-demand drug release under stimuli of the overexpressed amyloid-beta (Aβ). Furthermore, Met and Don released from nanodrugs exhibit a superior synergistic anti-dementia effect by enhancing microglial phagocytosis and Aβ clearance through the lysosomal pathway. Taken together, we report a synergistic strategy based on Aβ-responsive supramolecular nanodrugs for AD therapy, which can be expected to provide a novel clinical therapeutic idea for ameliorating central nervous system disease.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Humans ; Metformin/metabolism ; Metformin/pharmacology ; Metformin/therapeutic use ; Microglia ; Nanoparticles/therapeutic use
Chemical Substances	Amyloid beta-Peptides ; Metformin (9100L32L2N)
Language	English
Publishing date	2022-03-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121452
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Article ; Online: Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy.

Fan, Zhongxiong / Shi, Dao / Zuo, Wenbao / Feng, Juan / Ge, Dongtao / Su, Guanghao / Yang, Lichao / Hou, Zhenqing

ACS applied materials & interfaces

2022 Volume 14, Issue 4, Page(s) 5033–5052

Abstract	Although nanotheranostics have displayed striking potential toward precise nanomedicine, their targeting delivery and tumor penetration capacities are still impeded by several biological barriers. Besides, the current antitumor strategies mainly focus on killing tumor cells rather than antiangiogenesis. Enlightened by the fact that the smart transformable self-targeting nanotheranostics can enhance their targeting efficiency, tumor penetration, and cellular uptake, we herein report carrier-free Trojan-horse diameter-reducible metal-organic nanotheranostics by the coordination-driven supramolecular sequential co-assembly of the chemo-drug pemetrexed (PEM), transition-metal ions (Fe
MeSH term(s)	Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Materials Testing ; Metal-Organic Frameworks/chemistry ; Metal-Organic Frameworks/pharmacology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; Particle Size ; Pemetrexed/chemistry ; Pemetrexed/pharmacology ; Surface Properties ; Theranostic Nanomedicine
Chemical Substances	Angiogenesis Inhibitors ; Antineoplastic Agents ; Biocompatible Materials ; Diterpenes ; Metal-Organic Frameworks ; Pemetrexed (04Q9AIZ7NO) ; pseudolaric acid B (82508-31-4)
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c22350
Database	MEDical Literature Analysis and Retrieval System OnLINE

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