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  1. Article ; Online: In Vitro

    Foret-Lucas, Charlotte / Figueroa, Thomas / Coggon, Amelia / Houffschmitt, Alexandre / Dupré, Gabriel / Fusade-Boyer, Maxime / Guérin, Jean-Luc / Delverdier, Maxence / Bessière, Pierre / Volmer, Romain

    Microbiology spectrum

    2023  Volume 11, Issue 1, Page(s) e0422922

    Abstract: H5N8 high-pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4B, which circulated during the 2016 epizootics in Europe, was notable for causing different clinical signs in ducks and chickens. The clinical signs preceding death were predominantly ... ...

    Abstract H5N8 high-pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4B, which circulated during the 2016 epizootics in Europe, was notable for causing different clinical signs in ducks and chickens. The clinical signs preceding death were predominantly neurological in ducks versus respiratory in chickens. To investigate the determinants for the predominant neurological signs observed in ducks, we infected duck and chicken primary cortical neurons. Viral replication was identical in neuronal cultures from both species. In addition, we did not detect any major difference in the immune and inflammatory responses. These results suggest that the predominant neurological involvement of H5N8 HPAIV infection in ducks could not be recapitulated in primary neuronal cultures.
    MeSH term(s) Animals ; Influenza in Birds ; Chickens ; Ducks ; Influenza A Virus, H5N8 Subtype/physiology ; Virulence ; Influenza A virus ; Poultry Diseases ; Respiratory Distress Syndrome
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04229-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Opposite Outcomes of the Within-Host Competition between High- and Low-Pathogenic H5N8 Avian Influenza Viruses in Chickens Compared to Ducks.

    Bessière, Pierre / Figueroa, Thomas / Coggon, Amelia / Foret-Lucas, Charlotte / Houffschmitt, Alexandre / Fusade-Boyer, Maxime / Dupré, Gabriel / Guérin, Jean-Luc / Delverdier, Maxence / Volmer, Romain

    Journal of virology

    2021  Volume 96, Issue 1, Page(s) e0136621

    Abstract: Highly pathogenic avian influenza viruses (HPAIV) emerge from low-pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely ... ...

    Abstract Highly pathogenic avian influenza viruses (HPAIV) emerge from low-pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse genetics-engineered H5N8 viruses differing solely at the HA cleavage, we tested the hypothesis that the interaction between the minority HPAIV and the majority LPAIV could modulate the risk of HPAIV emergence and that the nature of the interaction could depend on the host species. In chickens, we observed that the H5N8
    MeSH term(s) Animals ; Biomarkers ; Biopsy ; Cells, Cultured ; Chickens ; Coinfection ; Disease Susceptibility ; Ducks ; Genotype ; Host-Pathogen Interactions ; Immunohistochemistry ; Influenza A Virus, H5N8 Subtype/physiology ; Influenza in Birds/metabolism ; Influenza in Birds/pathology ; Influenza in Birds/virology ; Poultry Diseases/metabolism ; Poultry Diseases/pathology ; Poultry Diseases/virology ; RNA, Viral ; Species Specificity ; Viral Load ; Virulence ; Virus Replication
    Chemical Substances Biomarkers ; RNA, Viral
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.01366-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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