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  1. Article ; Online: Pharmacological management of migraine: current strategies and future directions.

    Pellesi, Lanfranco / Do, Thien Phu / Hougaard, Anders

    Expert opinion on pharmacotherapy

    2024  , Page(s) 1–11

    Abstract: Introduction: Migraine is a complex neurological disorder that affects a significant portion of the global population. As traditional pharmacological approaches often fall short in alleviating symptoms, the development of innovative therapies has ... ...

    Abstract Introduction: Migraine is a complex neurological disorder that affects a significant portion of the global population. As traditional pharmacological approaches often fall short in alleviating symptoms, the development of innovative therapies has garnered significant interest. This text aims to summarize the current pharmacological options for managing migraine and to explore the potential impact of novel therapies.
    Areas covered: We focused on conventional treatments, emerging therapies, and novel compounds in clinical development, including therapies targeting the trigeminovascular system, cannabis-based therapies, hormonal and metabolic therapies, and other options. English peer-reviewed articles were searched in PubMed, Scopus, and ClinicalTrials.gov electronic databases.
    Expert opinion: Several novel treatment options for migraine have become available in recent years. Emerging pharmacological therapies targeting the trigeminovascular system, cannabis-based therapies, hormonal and metabolic interventions, and other emerging treatment modalities, may prove to be valuable for the treatment of migraine. Further research, clinical trials, and substantiated evidence are necessary to validate the efficacy, safety, and long-term outcomes of these therapeutic options.
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2024.2349791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5130: Show issues Location:
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  2. Article ; Online: Risk of Stroke and Myocardial Infarction Among Initiators of Triptans.

    Petersen, Christian Lund / Hougaard, Anders / Gaist, David / Hallas, Jesper

    JAMA neurology

    2024  Volume 81, Issue 3, Page(s) 248–254

    Abstract: Importance: Triptans are contraindicated in patients with ischemic heart disease or previous myocardial infarction, and caution is advised when prescribing these drugs to patients with vascular risk factors. However, controlled observational studies ... ...

    Abstract Importance: Triptans are contraindicated in patients with ischemic heart disease or previous myocardial infarction, and caution is advised when prescribing these drugs to patients with vascular risk factors. However, controlled observational studies have either shown no association or an apparent lower risk, possibly owing to a channeling of triptans to individuals at low risk of cardiovascular outcomes, and it remains unclear whether avoiding triptan treatment for these patients is meaningful.
    Objective: To establish whether an association between triptans and ischemic events could be demonstrated using a self-controlled design because this type of design is robust to the previously mentioned type of confounding.
    Design, setting, and participants: All people in nationwide Danish registries who were initiating triptans and all the ischemic events that they experienced were identified. A case-crossover design was used to estimate odds ratios (OR) for associations between first-ever triptan use and ischemic outcomes, comparing triptan exposure in the 2-week period up to the event with four 2-week reference periods. Data were obtained for the period January 1995 to August 2022. Included from the population of Denmark were individuals redeeming a prescription for any triptan and experiencing at least 1 of 3 predefined ischemic outcomes. No one was excluded.
    Exposure: Initiation of any triptan.
    Main outcomes and measures: Acute myocardial infarction, ischemic stroke, or nonspecified stroke.
    Results: Identified were a total of 429 612 individuals (median [IQR] age, 38 [28-48] years; 325 687 female [75.8%]) who redeemed a first prescription for a triptan in the study period. Of these patients, 11 (0.003%) had a myocardial infarction with the first triptan prescription in either a focal or referent window (odds ratio [OR], 3.3; 95% CI, 1.0-10.9), 18 (0.004%) had ischemic stroke (OR, 3.2; 95% CI, 1.3-8.1), and 35 (0.008%) had ischemic/nonspecified stroke (OR, 3.0; 95% CI, 1.5-5.9). Case patients had a median age of approximately 60 years and had a high-risk cardiovascular profile.
    Conclusions and relevance: Results of this case-crossover study suggest that triptan initiation was associated with higher risk of ischemic stroke and myocardial infarction. For the individual patient with low background cardiovascular risk, the risk of an ischemic event after triptan initiation was very low.
    MeSH term(s) Humans ; Female ; Middle Aged ; Adult ; Tryptamines/adverse effects ; Cross-Over Studies ; Migraine Disorders/drug therapy ; Migraine Disorders/epidemiology ; Myocardial Infarction/chemically induced ; Myocardial Infarction/epidemiology ; Stroke/epidemiology ; Stroke/drug therapy ; Risk Factors ; Serotonin 5-HT1 Receptor Agonists/therapeutic use ; Ischemic Stroke/drug therapy
    Chemical Substances Tryptamines ; Serotonin 5-HT1 Receptor Agonists
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.5549
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  3. Article ; Online: Migraine aura-like episodes following sclerotherapy for varicose veins of the lower extremities-A systematic review.

    Bahtiri, Lionesa / Thomsen, Andreas Vinther / Ashina, Messoud / Hougaard, Anders

    Headache

    2023  Volume 63, Issue 1, Page(s) 40–50

    Abstract: Objective: This systematic review provides a summary and evaluation of cases of migraine aura-like episodes elicited by sclerotherapy of veins of the lower extremities and discusses possible underlying mechanisms.: Background: Sclerotherapy is a ... ...

    Abstract Objective: This systematic review provides a summary and evaluation of cases of migraine aura-like episodes elicited by sclerotherapy of veins of the lower extremities and discusses possible underlying mechanisms.
    Background: Sclerotherapy is a commonly used treatment for varicose veins. Symptoms resembling migraine aura have been reported during and following sclerotherapy of the lower extremities, suggesting that sclerotherapy may elicit migraine aura.
    Methods: We searched PubMed for articles reporting neurological complications that were transient and fully reversible following sclerotherapy treatment for varicose veins in the lower limbs. There were no restrictions regarding article language or publication date. Only original studies and case reports were included. Two authors independently reviewed included articles in detail. Data were extracted from each article, including details on symptoms, previous migraine history, sclerotherapy method, and the presence of a right-to-left cardiac shunt in patients. We evaluated whether episodes fulfilled modified International Classification of Headache Disorders, 3rd edition, criteria for 1.2 Migraine with aura or 1.5.2 Probable migraine with aura.
    Results: The search yielded 777 articles, 28 of which were included. Twenty-six articles reported 119 episodes of transient neurological symptoms in 34,500 sclerotherapy sessions. Two additional articles reported six episodes of transient neurological symptoms with no specification of the number of sessions. Of the 125 episodes, 119 involved transient visual disturbances, and eight met the modified criteria for Probable migraine with aura. In most episodes (98%), clinical information was insufficient to determine if the criteria were fulfilled.
    Conclusions: Symptoms that are clinically indistinguishable from migraine with aura attacks may occur following sclerotherapy, although this likely is rare. Microembolization through a right-to-left shunt triggering cortical spreading depolarization is a possible mechanism. Our findings are limited by infrequent specific assessments for neurological complications and a low level of detail in the description of symptoms in the available literature. Future prospective studies are needed to determine this phenomenon's incidence and underlying mechanisms.
    MeSH term(s) Humans ; Sclerotherapy/adverse effects ; Sclerotherapy/methods ; Migraine with Aura/therapy ; Migraine with Aura/complications ; Varicose Veins/therapy ; Migraine Disorders/etiology ; Epilepsy ; Lower Extremity
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14448
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  4. Article ; Online: Investigations of functional and structural changes in migraine with aura by magnetic resonance imaging.

    Hougaard, Anders

    Danish medical journal

    2015  Volume 62, Issue 8, Page(s) B5129

    Abstract: Migraine sufferers with aura often report visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of ... ...

    Abstract Migraine sufferers with aura often report visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. A useful technology to study these features of migraine with aura (MA) is functional magnetic resonance imaging (fMRI), which has the potential not only to detect, but also to localize hypersensitive cortex. The main objective of this thesis was to investigate the cortical responsivity of patients with MA during visual stimulation using fMRI. To optimize sensitivity, we applied a within-patient design by assessing functional interhemispheric differences in patients consistently experiencing visual aura in the same visual hemifield. To validate our data analysis methods, we initially studied healthy volunteers using single hemifield visual stimulation and compared the "stimulated" hemispheres (i.e. hemispheres contralateral to the visual stimulation) to the "non-stimulated" hemispheres. We then applied this validated method of interhemispheric comparison of fMRI-blood oxygenation level dependent (BOLD) activation to compare left versus right hemisphere responses to symmetric full-field visual stimulation in 54 healthy subjects (study I). This study concluded that, a) the applied visual stimulation is effective in activating large expanses of visual cortex, b) interhemispheric differences in fMRI-BOLD activation can be determined using the proposed method, and c) visual responses to symmetric full-field visual stimulation are asymmetrically distributed between the cerebral hemispheres. We investigated the effects of migraine aura, by including 20 patients with frequent side-fixed visual aura attacks, i.e. ≥= 90% of auras occurring in the same visual hemifield (study II). To circumvent bias relating to differences between right and left hemispheres (e.g. caused by physiological left/right bias, asymmetry of the visual stimulation or magnetic field inhomogeneity of the scanner), we included an equal number of patients with right- and left-sided symptoms. Further, we included 20 individually matched healthy controls with no history (including family history) of migraine. We compared the fMRI-BOLD responses to visual stimulation between symptomatic and asymptomatic hemispheres during the interictal phase and between migraine patients and controls. BOLD responses were selectively increased in the symptomatic hemispheres and localized in the inferior parietal lobule, the inferior frontal gyrus and the superior parietal lobule. The affected cortical areas comprise a visually driven functional network involved in oculomotor control, guidance of movement, motion perception, visual attention, and visual spatial memory. The patients also had significantly increased response in the same cortical areas when compared to controls. Since these findings theoretically could depend on aura-related differences in brain structure, we performed additional analyses (study III) to determine the relation between migraine aura and structural, cortical and subcortical, grey matter abnormalities. We analyzed structural MRI data from the same 20 patients and applied voxel-based morphometry and surface-based morphometry on a whole-hemisphere level and for specific anatomical regions of interest. Within-subject comparisons were made with regard to aura symptoms (N = 20 vs 20) and with regard to headache (N = 13 vs 13). We found no differences in grey matter structure with regard to aura symptoms in MA patients. Comparing the typical migraine headache side of the patients to the contralateral side revealed a difference in cortical thickness in the inferior frontal gyrus, which correlated significantly with the migraine attack frequency. In conclusion, we validated a method of interhemispheric comparison of fMRI-BOLD responses to visual stimulation. By using this method we discovered a lateralized alteration of a visually driven functional network in patients with side-fixed aura. These findings suggest a hyperexcitability of the visual system in the interictal phase of migraine with visual aura. Further, this abnormal function is not dependent on lateralized abnormalities of gray matter structure. However, alteration of the inferior frontal cortex related to headache lateralization could indicate structural reorganization of pain inhibitory circuits in response to the repeated intense nociceptive input due to the headache attacks.
    MeSH term(s) Academic Dissertations as Topic ; Adult ; Brain/anatomy & histology ; Brain/physiopathology ; Case-Control Studies ; Cerebrum/physiopathology ; Female ; Healthy Volunteers ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/statistics & numerical data ; Male ; Middle Aged ; Migraine with Aura/physiopathology ; Photic Stimulation/methods ; Young Adult
    Language English
    Publishing date 2015-08
    Publishing country Denmark
    Document type Journal Article ; Validation Studies
    ZDB-ID 2648771-8
    ISSN 2245-1919 ; 2245-1919
    ISSN (online) 2245-1919
    ISSN 2245-1919
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  5. Article ; Online: Investigations of the migraine-provoking effect of levcromakalim in patients with migraine with aura.

    Thomsen, Andreas Vinther / Al-Karagholi, Mohammad Al-Mahdi / Hougaard, Anders / Ostrowski, Sisse Rye / Pedersen, Ole Birger / Hansen, Thomas Folkmann / Ashina, Messoud

    Cephalalgia : an international journal of headache

    2024  Volume 44, Issue 3, Page(s) 3331024241237247

    Abstract: Background/hypothesis: Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim to further explore ... ...

    Abstract Background/hypothesis: Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim to further explore the migraine aura-inducing potential of levcromakalim.
    Methods: In a double-blind, randomized, placebo-controlled cross-over study, 27 adult participants with migraine with aura received intravenous infusions of levcromakalim and saline. Headache, aura and associated symptoms were evaluated for 24 hours following administration of the study drug. The primary endpoint was occurrence of migraine-like attacks with or without aura in the 24-hour observation period.
    Results: Thirteen participants developed migraine-like attacks on the active day only (P = 0.0098), and four participants developed aura on the active day only (P = 0.68). The median time to onset of migraine-like headache was three hours, and the median time to onset of aura was 27.5 minutes.
    Conclusion/interpretation: Our findings affirm the potent migraine-inducing effect of levcromakalim. We observed a lower induction-rate of migraine aura than previously reported. Further studies are warranted to identify predictors of migraine aura following levcromakalim.
    Clinicaltrials.gov identifier: NCT04905654.
    MeSH term(s) Adult ; Humans ; Cromakalim ; Migraine with Aura ; Cross-Over Studies ; Migraine Disorders/drug therapy ; Headache ; Double-Blind Method ; Epilepsy
    Chemical Substances Cromakalim (0G4X367WA3)
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/03331024241237247
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  6. Article ; Online: The depiction of migraine visual aura on the internet.

    Viana, Michele / Hougaard, Anders / Do, Thien Phu

    Cephalalgia : an international journal of headache

    2020  Volume 40, Issue 10, Page(s) 1113–1118

    Abstract: Introduction: The most common and multifaceted migraine aura symptoms are visual disturbances. Health information is one of the most popular topics on the internet but the quality and reliability of publicized information is unknown. The aim of this ... ...

    Abstract Introduction: The most common and multifaceted migraine aura symptoms are visual disturbances. Health information is one of the most popular topics on the internet but the quality and reliability of publicized information is unknown. The aim of this study was to analyze images of migraine aura on Google to determine the frequency of correct presentations of visual aura and distribution of visual aura phenotypes.
    Methods: Two authors screened the 100 highest indexed migraine aura related images on Google. The content of the images was categorized into elementary visual symptoms.
    Results: Forty out of 100 images were accurate representations of visual migraine aura. Such images included 31 different visual aura phenotypes. The majority had more than one elementary visual symptom (median 2, IQR 1-3), most commonly "bean-like" forms (45%), zigzag lines (40%), and foggy/blurred vision (33%).
    Discussion: Forty percent of images were accurate portrayals of visual migraine aura symptoms, but these presented limited phenotypes. The information derived from the internet photos may hinder the effective recognition of aura symptoms. Thus, there is a need to provide a more comprehensive representation of visual migraine aura symptoms on the internet.
    MeSH term(s) Humans ; Internet ; Migraine with Aura
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102420927027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Symptomatic migraine: A systematic review to establish a clinically important diagnostic entity.

    Thomsen, Andreas Vinther / Sørensen, Morten Togo / Ashina, Messoud / Hougaard, Anders

    Headache

    2021  Volume 61, Issue 8, Page(s) 1180–1193

    Abstract: Objective: To determine if a clinical presentation indistinguishable from migraine can occur due to an underlying condition or pathology, that is, "symptomatic migraine.": Background: It is currently not clear whether migraine truly can be caused by ... ...

    Abstract Objective: To determine if a clinical presentation indistinguishable from migraine can occur due to an underlying condition or pathology, that is, "symptomatic migraine."
    Background: It is currently not clear whether migraine truly can be caused by an underlying condition or pathology. Characterization of the etiology and clinical features of possible symptomatic migraine is of significant clinical importance and further may help elucidate the pathophysiology of migraine.
    Methods: We devised operational diagnostic criteria for "symptomatic migraine" and "possible symptomatic migraine" requiring strong evidence for a causal relation between underlying cause and migraine symptoms adhering strictly to diagnostic criteria. PubMed was searched for case reports of symptomatic migraine from inception to March 2020. Only articles published in English or German were included. No restrictions were placed on study design. Relevant references in the articles were also included. Papers were systematically reviewed by two independent reviewers for detailed clinical features of migraine as well as the proposed underlying conditions and the effects of treatment of these conditions.
    Results: Our search retrieved 1726 items. After screening, 109 papers comprising 504 cases were reviewed in detail. Eleven patients with migraine with aura (MWA) fulfilled our working criteria for symptomatic migraine, and 39 patients fulfilled our criteria for possible symptomatic migraine. The most common etiologies of symptomatic migraine were arteriovenous malformations, carotid stenosis, dissection or aneurysm, brain infarctions, meningioma, and various intra-axial tumors.
    Conclusions: Symptomatic MWA, indistinguishable from idiopathic MWA, may occur due to cortical lesions or microembolization. We found no clear evidence supporting the existence of symptomatic migraine without aura although we did identify possible cases. Our findings are limited by the available literature, and we suggest that prospective studies are needed.
    MeSH term(s) Brain Neoplasms/complications ; Cerebrovascular Disorders/complications ; Humans ; Migraine Disorders/diagnosis ; Migraine Disorders/etiology ; Migraine Disorders/physiopathology ; Migraine with Aura/diagnosis ; Migraine with Aura/etiology ; Migraine with Aura/physiopathology
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14187
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  8. Article ; Online: Is calcitonin gene-related peptide a reliable biochemical marker of migraine?

    Tesfay, Betel / Karlsson, William Kristian / Moreno, Rogelio Dominguez / Hay, Debbie L / Hougaard, Anders

    Current opinion in neurology

    2022  Volume 35, Issue 3, Page(s) 343–352

    Abstract: Purpose of review: The aim of this study was to provide an overview of clinical studies on calcitonin gene-related peptide (CGRP) measurements in body fluids of migraine patients and to discuss the validity of CGRP measurement as a clinical biomarker of ...

    Abstract Purpose of review: The aim of this study was to provide an overview of clinical studies on calcitonin gene-related peptide (CGRP) measurements in body fluids of migraine patients and to discuss the validity of CGRP measurement as a clinical biomarker of migraine.
    Recent findings: Several studies have reported increased CGRP levels in venous blood, saliva and tear fluid of migraine patients compared with healthy controls and in migraine patients during attacks compared with the interictal state, suggesting that CGRP may be a feasible biomarker of migraine. However, the findings of studies investigating CGRP levels in migraine patients are generally conflicting and measurements of CGRP levels are challenged by several methodological issues. Reported differences in CGRP levels between patients with chronic migraine relative to episodic migraine have also been inconsistent. There is also a well documented involvement of CGRP in several nonmigraine pain disorders, including cluster headache and common pain conditions such as osteoarthritis.
    Summary: Current evidence does not justify the usage of CGRP levels as a biomarker for diagnosing migraine or for determining the severity of the disease in individual patients. However, CGRP measurements could prove useful in the future as clinically relevant biomarkers for predicting the response to therapy, including anti-CGRP migraine drugs.
    MeSH term(s) Biomarkers ; Calcitonin Gene-Related Peptide ; Cluster Headache ; Humans ; Migraine Disorders/drug therapy ; Pain
    Chemical Substances Biomarkers ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2022-06-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001053
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  9. Article ; Online: Investigations of the subarachnoid space as a potential link between aura and headache in migraine: A case-control MRI study.

    Thomsen, Andreas Vinther / Puonti, Oula / Gaist, David / Kyvik, Kirsten Ohm / Madsen, Kristoffer / Thielscher, Axel / Siebner, Hartwig Roman / Ashina, Messoud / Hougaard, Anders

    Cephalalgia : an international journal of headache

    2023  Volume 43, Issue 6, Page(s) 3331024231170541

    Abstract: Background: The connection between migraine aura and headache is poorly understood. Some patients experience migraine aura without headache, and patients with migraine aura with headache commonly experience milder headaches with age. The distance ... ...

    Abstract Background: The connection between migraine aura and headache is poorly understood. Some patients experience migraine aura without headache, and patients with migraine aura with headache commonly experience milder headaches with age. The distance between the cerebral cortex and the overlying dura mater has been hypothesized to influence development of headache following aura. We tested this hypothesis by comparing approximated distances between visual cortical areas and overlying dura mater between female patients with migraine aura without headache and female patients with migraine aura with headache.
    Methods: Twelve cases with migraine aura without headache and 45 age-matched controls with migraine aura with headache underwent 3.0 T MRI. We calculated average distances between the occipital lobes, between the calcarine sulci, and between the skull and visual areas V1, V2 and V3a. We also measured volumes of corticospinal fluid between the occipital lobes, between the calcarine sulci, and overlying visual areas V2 and V3a. We investigated the relationship between headache status, distances and corticospinal fluid volumes using conditional logistic regression.
    Results: Distances between the occipital lobes, calcarine sulci and between the skull and V1, V2 and V3a did not differ between patients with migraine aura with headache and patients with migraine aura without headache. We found no differences in corticospinal fluid volumes between groups.
    Conclusion: We found no indication for a connection between visual migraine aura and headache based on cortico-cortical, cortex-to-skull distances, or corticospinal fluid volumes overlying visual cortical areas. Longitudinal studies with imaging sequences optimized for measuring the cortico-dural distance and a larger sample of patients are needed to further investigate the hypothesis.
    MeSH term(s) Humans ; Female ; Migraine with Aura/diagnostic imaging ; Migraine Disorders ; Headache ; Epilepsy ; Subarachnoid Space ; Magnetic Resonance Imaging/methods ; Case-Control Studies
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/03331024231170541
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  10. Article ; Online: Lack of reproducibility of resting-state functional MRI findings in migraine with aura.

    Hougaard, Anders / Gaist, David / Garde, Ellen / Iversen, Pernille / Madsen, Camilla G / Kyvik, Kirsten O / Ashina, Messoud / Siebner, Hartwig R / Madsen, Kristoffer H

    Cephalalgia : an international journal of headache

    2023  Volume 43, Issue 11, Page(s) 3331024231212574

    Abstract: Background: Several studies have applied resting-state functional MRI to examine whether functional brain connectivity is altered in migraine with aura patients. These studies had multiple limitations, including small sample sizes, and reported ... ...

    Abstract Background: Several studies have applied resting-state functional MRI to examine whether functional brain connectivity is altered in migraine with aura patients. These studies had multiple limitations, including small sample sizes, and reported conflicting results. Here, we performed a large, cross-sectional brain imaging study to reproduce previous findings.
    Methods: We recruited women aged 30-60 years from the nationwide Danish Twin Registry. Resting-state functional MRI of women with migraine with aura, their co-twins, and unrelated migraine-free twins was performed at a single centre. We carried out an extensive series of brain connectivity data analyses. Patients were compared to migraine-free controls and to co-twins.
    Results: Comparisons were based on data from 160 patients, 30 co-twins, and 136 controls. Patients were similar to controls with regard to age, and several lifestyle characteristics. We replicated clear effects of age on resting-state networks. In contrast, we failed to detect any differences, and to replicate previously reported differences, in functional connectivity between migraine patients with aura and non-migraine controls or their co-twins in any of the analyses.
    Conclusion: Given the large sample size and the unbiased population-based design of our study, we conclude that women with migraine with aura have normal resting-state brain connectivity outside of migraine attacks.
    MeSH term(s) Female ; Humans ; Brain/diagnostic imaging ; Cross-Sectional Studies ; Epilepsy ; Magnetic Resonance Imaging/methods ; Migraine with Aura/diagnostic imaging ; Migraine without Aura/diagnostic imaging ; Reproducibility of Results
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article ; Twin Study
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/03331024231212574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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