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  1. Article: The Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma: A Systematic Review and Meta-analysis.

    Kanakopoulos, Dimitrios / Lacey, Hester / Payne, Anna / Houlihan, Maria / Riyat, Harjoat / Wheelan, Rhys / Cubitt, Jonathan / Totty, Joshua P

    Plastic and reconstructive surgery. Global open

    2024  Volume 12, Issue 4, Page(s) e5760

    Abstract: Background: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with high metastatic potential. Sentinel lymph node biopsy (SLNB) is used to assess locoregional spread, facilitate staging, and inform prognosis. Positive nodal status is associated ...

    Abstract Background: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with high metastatic potential. Sentinel lymph node biopsy (SLNB) is used to assess locoregional spread, facilitate staging, and inform prognosis. Positive nodal status is associated with higher recurrence rates and reduced overall survival.
    Methods: A systematic search was conducted. Eligible articles included patients diagnosed with MCC, who would be candidates for or who had SLNB. The Covidence tool was used for screening and data extraction, including additional treatments, disease-free survival, overall survival, and recurrence. Methodological quality was assessed using the Newcastle-Ottowa Scale criteria.
    Results: SLNB was associated with increased likelihood of completion lymphadenectomy (223 versus 41), regional radiotherapy (2167 versus 808), and systemic chemotherapy (138 versus 31). Overall survival for patients undergoing SLNB was 81% at 2 years, 75% at 3 years, and 72% at 5 years (odds ratio: 0.79). Hazard ratio for positive SLNB versus negative was 3.36 (
    Conclusions: Lymph node metastases are associated with reduced overall survival and increased recurrence of MCC. Determining nodal status early can inform prognosis, facilitate staging, and determine need for adjuvant treatment. Adjuvant treatments are associated with reduced mortality and improved overall survival; SLNB is an important influencer of their use. Early prophylactic intervention should be considered in MCC in both positive and negative nodal status to improve overall outcomes. Widespread use of SLNB will allow more accurate assessment of the role of nodal status on adjuvant treatment and long-term outcomes.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A new wound in an old burn scar: a guide to Marjolin's ulcers for primary care.

    Houlihan, Maria / Patel, Krupali / Wilson, Yvonne T / Rajput, Vijay / Chipp, Elizabeth

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2021  Volume 71, Issue 703, Page(s) 92–93

    MeSH term(s) Burns ; Carcinoma, Squamous Cell ; Cicatrix/pathology ; Humans ; Primary Health Care ; Skin Neoplasms ; Skin Ulcer ; Ulcer
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp21X714893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 100: Show issues

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  3. Article ; Online: Diameter Criteria Have Limited Value for Prediction of Functional Dialysis Use of Arteriovenous Fistulas.

    Wilmink, Teun / Corte-Real Houlihan, Maria

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2018  Volume 56, Issue 4, Page(s) 572–581

    Abstract: Objective: To determine the value of diameter measurements for prediction of functional dialysis use (FDU) of arteriovenous fistulas (AVF).: Methods: Review of access operations and dialysis databases from January 1, 2007 to August 1, 2015. Follow up ...

    Abstract Objective: To determine the value of diameter measurements for prediction of functional dialysis use (FDU) of arteriovenous fistulas (AVF).
    Methods: Review of access operations and dialysis databases from January 1, 2007 to August 1, 2015. Follow up until July 1, 2016. FDU defined as six consecutive dialysis sessions with two needles on the AVF. Artery and vein diameters measured by portable ultrasound in access clinic. Contribution of diameter to predict FDU assessed with logistic regression. Diagnostic accuracy assessed by sensitivity, specificity, positive and negative predictive values (PPV and NPV).
    Results: 803 AVF operations were analysed: 507 (63%) radiocephalic fistulas (RCAVF), 237 (30%) brachiocephalic fistulas (BCAVF), and 59 (7%) brachiobasilic fistulas (BBAVF). Women had lower FDU in RCAVF (0.65, 95% CI 0.58-0.72 vs. 0.86, 95% CI 0.81-0.89; p < .0001), but not in BCAVF (0.83, 95% CI 0.75-0.89 vs. 0.81, 95% CI 0.73-0.88; p = .75). Female gender was an independent negative predictor of FDU in RCAVF (OR 0.31; 95% CI 0.20-0.49). Vascular kidney disease was an independent negative predictor for FDU in RCAVF (OR 0.33; 95% CI 0.17-0.64) and BCAVF (OR 0.22; 95% CI 0.09-0.57) in multivariable analysis. Artery and vein diameter did not improve the model for RCAVF. Vein diameter as categorical variable improved the model for BCAVF. Diameter cut off of radial artery ≥ 2 mm has 96% sensitivity, 86% PPV, 9% specificity, and 29% NPV in men. Radial artery diameter ≥2 mm had 96% sensitivity, 67% PPV but 13% specificity and 62% NPV in women.
    Conclusions: Diameter is a poor predictor of FDU of AVF. Arterial diameter measurements add no diagnostic value for BCAVF. Poor specificity suggests a diameter under 2 mm at the wrist should not preclude AVF formation. Vascular kidney disease is an independent negative predictor for FDU in all AVF.
    MeSH term(s) Arteries/diagnostic imaging ; Arteries/pathology ; Arteriovenous Shunt, Surgical/methods ; Databases, Factual/statistics & numerical data ; Dimensional Measurement Accuracy ; Female ; Humans ; Male ; Middle Aged ; Organ Size ; Predictive Value of Tests ; Preoperative Care/methods ; Renal Dialysis/methods ; Renal Dialysis/standards ; Treatment Outcome ; Ultrasonography/methods ; United Kingdom ; Veins/diagnostic imaging ; Veins/pathology
    Language English
    Publishing date 2018-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2018.06.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 381: Show issues

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  4. Article: Early multicentre experience of pre-pectoral implant based immediate breast reconstruction using Braxon

    Jafferbhoy, Sadaf / Chandarana, Mihir / Houlihan, Maria / Parmeshwar, Rishikesh / Narayanan, Sankaran / Soumian, Soni / Harries, Simon / Jones, Lucie / Clarke, Dayalan

    Gland surgery

    2017  Volume 6, Issue 6, Page(s) 682–688

    Abstract: Background: The last two decades have seen significant changes in surgical management of breast cancer. The offer of immediate breast reconstruction (IBR) following mastectomy is currently standard practice. Skin sparing and nipple sparing mastectomy ... ...

    Abstract Background: The last two decades have seen significant changes in surgical management of breast cancer. The offer of immediate breast reconstruction (IBR) following mastectomy is currently standard practice. Skin sparing and nipple sparing mastectomy with implant-based IBR have emerged as oncologically safe treatment options. Prepectoral implant placement and complete coverage of implant with acellular dermal matrix (ADM) eliminates the need to detach the muscle from underlying chest wall in contrast to the subpectoral technique. We report short-term outcomes of a multicentre study from the United Kingdom (UK) using Braxon
    Methods: A prospective study was conducted from December 2015 to October 2016 and included all patients from three breast units in the UK who underwent a mastectomy and an implant-based IBR using Braxon
    Results: Seventy-eight IBRs were included in the analysis with a median follow-up of 9.98 months. Mean age of the cohort was 50 years with a mean body mass index of 25.7 kg/m
    Conclusions: Our early experience with this novel prepectoral technique using Braxon
    Language English
    Publishing date 2017-11-17
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs.2017.07.07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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