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  1. Article: Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac Ca

    Hovey, Liam / Guo, Xiaoyun / Chen, Yi / Liu, Qinghang / Catterall, William A

    Frontiers in physiology

    2023  Volume 14, Page(s) 1049611

    Abstract: The cardiac calcium channel ... ...

    Abstract The cardiac calcium channel Ca
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1049611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Convergent regulation of Ca

    Hovey, Liam / Gamal El-Din, Tamer M / Catterall, William A

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 42, Page(s) e2208533119

    Abstract: The L-type calcium currents conducted by the cardiac ... ...

    Abstract The L-type calcium currents conducted by the cardiac Ca
    MeSH term(s) Adrenergic Agents ; Calcium/metabolism ; Calcium Channels, L-Type/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Guanosine/metabolism ; Monomeric GTP-Binding Proteins/metabolism ; Phosphorylation
    Chemical Substances Adrenergic Agents ; Calcium Channels, L-Type ; Guanosine (12133JR80S) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Monomeric GTP-Binding Proteins (EC 3.6.5.2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2208533119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vascular Surgery In-Training Examination performance following implementation of the Vascular Surgical Council on Resident Education curriculum.

    Hovey, Liam / Quiroga, Elina / Singh, Niten / Zettervall, Sara / Smith, Matthew / Abularrage, Christopher J / Chow, Warren B

    Journal of vascular surgery

    2023  Volume 78, Issue 2, Page(s) 534–538

    Abstract: Objective: The Vascular Surgery Surgical Council on Resident Education (VSCORE) program is a standardized curriculum intended to prepare Vascular Surgery trainees for the annual Vascular Surgery In-Training Examination (VSITE). This study evaluated the ... ...

    Abstract Objective: The Vascular Surgery Surgical Council on Resident Education (VSCORE) program is a standardized curriculum intended to prepare Vascular Surgery trainees for the annual Vascular Surgery In-Training Examination (VSITE). This study evaluated the performance of 0+5 and 5+2 Vascular Surgery trainees on the VSITE prior to and following implementation of the VSCORE curriculum.
    Methods: VSITE scores, measured as percentage of questions correct, were collected for Vascular Surgery trainees at a United States academic medical center between 2015 and 2022. The VSITE scores were compared for the periods prior to (2015-2021) and following (2022) implementation of the VSCORE curriculum.
    Results: Fifty-seven VSITE scores were evaluated, including 46 examinations completed prior to and 11 after the implementation of the VSCORE curriculum. The mean VSITE score across all training levels (post-graduate year [PGY] 1-7) increased significantly from 68.4% ± 1.5% prior to implementation of VSCORE curriculum to 76.5% ± 3.1% following implementation (P = .03). Two-way analysis of variance identified pre- and post-VSCORE implementation as a statistically significant categorical variable when residents were stratified into junior (PGY 1-2), senior (PGY 3-5), and fellow (PGY 6-7) training levels (P < .001). The mean change in score between consecutive years also increased following VSCORE implementation (14.1% ± 2.3%) compared with the pre-VSCORE era (5.7% ± 1.7%; P = .002) CONCLUSIONS: The implementation of the VSCORE curriculum at an academic medical center improved VSITE scores across vascular surgery trainees at all levels.
    MeSH term(s) Humans ; United States ; Internship and Residency ; Education, Medical, Graduate ; Educational Measurement ; Clinical Competence ; Curriculum ; Vascular Surgical Procedures/education ; General Surgery/education
    Language English
    Publishing date 2023-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2023.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Na

    Mahling, Ryan / Hovey, Liam / Isbell, Holly M / Marx, Dagan C / Miller, Mark S / Kilpatrick, Adina M / Weaver, Lisa D / Yoder, Jesse B / Kim, Elaine H / Andresen, Corinne N J / Li, Shuxiang / Shea, Madeline A

    Structure (London, England : 1993)

    2021  Volume 29, Issue 12, Page(s) 1339–1356.e7

    Abstract: Neuronal voltage-gated sodium channel ... ...

    Abstract Neuronal voltage-gated sodium channel Na
    MeSH term(s) Calcium/metabolism ; Calcium Signaling/physiology ; Calmodulin/genetics ; Calmodulin/metabolism ; Humans ; Mutation ; NAV1.2 Voltage-Gated Sodium Channel/genetics ; NAV1.2 Voltage-Gated Sodium Channel/metabolism ; Protein Binding
    Chemical Substances Calmodulin ; NAV1.2 Voltage-Gated Sodium Channel ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2021.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel Na

    Hovey, Liam / Fowler, C Andrew / Mahling, Ryan / Lin, Zesen / Miller, Mark Stephen / Marx, Dagan C / Yoder, Jesse B / Kim, Elaine H / Tefft, Kristin M / Waite, Brett C / Feldkamp, Michael D / Yu, Liping / Shea, Madeline A

    Biophysical chemistry

    2017  Volume 224, Page(s) 1–19

    Abstract: Several members of the voltage-gated sodium channel family are regulated by calmodulin (CaM) and ionic calcium. The neuronal voltage-gated sodium channel ... ...

    Abstract Several members of the voltage-gated sodium channel family are regulated by calmodulin (CaM) and ionic calcium. The neuronal voltage-gated sodium channel Na
    MeSH term(s) Amino Acid Motifs ; Animals ; Binding Sites ; Calcium/metabolism ; Calcium/pharmacology ; Calmodulin/metabolism ; NAV1.2 Voltage-Gated Sodium Channel/chemistry ; Nerve Tissue Proteins/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Rats
    Chemical Substances Calmodulin ; NAV1.2 Voltage-Gated Sodium Channel ; Nerve Tissue Proteins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-03-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2017.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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