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  1. Article ; Online: Ab initio simulations of α- and β-ammonium carbamate (NH

    Howard, Christopher M / Wood, Ian G / Knight, Kevin S / Fortes, A Dominic

    Acta crystallographica Section B, Structural science, crystal engineering and materials

    2022  Volume 78, Issue Pt 3 Pt 2, Page(s) 459–475

    Abstract: Experimental and computational studies of ammonium carbamate have been carried out, with the objective of studying the elastic anisotropy of the framework manifested in (i) the thermal expansion and (ii) the compressibility; furthermore, the relative ... ...

    Abstract Experimental and computational studies of ammonium carbamate have been carried out, with the objective of studying the elastic anisotropy of the framework manifested in (i) the thermal expansion and (ii) the compressibility; furthermore, the relative thermodynamic stability of the two known polymorphs has been evaluated computationally. Using high-resolution neutron powder diffraction data, the crystal structure of α-ammonium carbamate (ND
    MeSH term(s) Carbamates ; Carbon Dioxide ; Neutrons ; Powder Diffraction ; Powders
    Chemical Substances Carbamates ; Powders ; Carbon Dioxide (142M471B3J) ; carbamic acid (O0UC6XOS4H)
    Language English
    Publishing date 2022-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020841-8
    ISSN 2052-5206 ; 1600-5740 ; 1600-8650 ; 2052-5192
    ISSN (online) 2052-5206 ; 1600-5740 ; 1600-8650
    ISSN 2052-5192
    DOI 10.1107/S2052520622002645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A fast ceramic mixed OH

    Zou, Peimiao / Iuga, Dinu / Ling, Sanliang / Brown, Alex J / Chen, Shigang / Zhang, Mengfei / Han, Yisong / Fortes, A Dominic / Howard, Christopher M / Tao, Shanwen

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 909

    Abstract: Low temperature ionic conducting materials such as ... ...

    Abstract Low temperature ionic conducting materials such as OH
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45060-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Glycine zinc sulfate penta-hydrate: redetermination at 10 K from time-of-flight neutron Laue diffraction.

    Fortes, A Dominic / Howard, Christopher M / Wood, Ian G / Gutmann, Matthias J

    Acta crystallographica. Section E, Crystallographic communications

    2016  Volume 72, Issue Pt 10, Page(s) 1438–1445

    Abstract: Single crystals of glycine zinc sulfate penta-hydrate [systematic name: hexa-aqua-zinc tetra-aquadiglycinezinc bis-(sulfate)], [Zn( ... ...

    Abstract Single crystals of glycine zinc sulfate penta-hydrate [systematic name: hexa-aqua-zinc tetra-aquadiglycinezinc bis-(sulfate)], [Zn(H
    Language English
    Publishing date 2016-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989016014304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of ketamine as an adjunct sedative in acute respiratory distress syndrome due to COVID-19 Pneumonia.

    Garner, Orlando / Patterson, Jonathan / Mejia, Julieta Muñoz / Anand, Vijay / Deleija, Juan / Nemeh, Christopher / Vallabh, Meghna / Staggers, Kristen A / Howard, Christopher M / Treviño, Sergio Enrique / Siddique, Muhammad Asim / Morgan, Christopher K

    Respiratory medicine

    2021  Volume 189, Page(s) 106667

    Abstract: Purpose: Deep sedation is sometimes needed in acute respiratory distress syndrome. Ketamine is a sedative that has been shown to have analgesic and sedating properties without having a detrimental impact on hemodynamics. This pharmacological profile ... ...

    Abstract Purpose: Deep sedation is sometimes needed in acute respiratory distress syndrome. Ketamine is a sedative that has been shown to have analgesic and sedating properties without having a detrimental impact on hemodynamics. This pharmacological profile makes ketamine an attractive sedative, potentially reducing the necessity for other sedatives and vasopressors, but there are no studies evaluating its effect on these medications in patients requiring deep sedation for acute respiratory distress syndrome.
    Materials and methods: This is a retrospective, observational study in a single center, quaternary care hospital in southeast Texas. We looked at adults with COVID-19 requiring mechanical ventilation from March 2020 to September 2020.
    Results: We found that patients had less propofol requirements at 72 h after ketamine initiation when compared to 24 h (median 34.2 vs 54.7 mg/kg, p = 0.003). Norepinephrine equivalents were also significantly lower at 48 h than 24 h after ketamine initiation (median 38 vs 62.8 mcg/kg, p = 0.028). There was an increase in hydromorphone infusion rates at all three time points after ketamine was introduced.
    Conclusions: In this cohort of patients with COVID-19 ARDS who required mechanical ventilation receiving ketamine we found propofol sparing effects and vasopressor requirements were reduced, while opioid infusions were not.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid/therapeutic use ; COVID-19/epidemiology ; COVID-19/therapy ; Deep Sedation ; Drug Utilization/statistics & numerical data ; Female ; Humans ; Hydromorphone/therapeutic use ; Hypnotics and Sedatives/administration & dosage ; Ketamine/administration & dosage ; Male ; Middle Aged ; Norepinephrine/therapeutic use ; Propofol/therapeutic use ; Respiration, Artificial ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/therapy ; Retrospective Studies ; Texas/epidemiology
    Chemical Substances Analgesics, Opioid ; Hypnotics and Sedatives ; Ketamine (690G0D6V8H) ; Hydromorphone (Q812464R06) ; Norepinephrine (X4W3ENH1CV) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2021-10-28
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2021.106667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Predictors of failure of high flow nasal cannula failure in acute hypoxemic respiratory failure due to COVID-19.

    Garner, Orlando / Dongarwar, Deepa / Salihu, Hamisu M / Barrantes Perez, Jairo H / Abraham, Jocelyn / McBride, Cameron / Mathew, Sindhu / Antony, Preethi / Collins, Keegan / Richards, Katherine L / Howard, Christopher M

    Respiratory medicine

    2021  Volume 185, Page(s) 106474

    Abstract: Hypoxemic respiratory failure is a common manifestation of COVID-19 pneumonia. Early in the COVID-19 pandemic, patients with hypoxemic respiratory failure were, at times, being intubated earlier than normal; in part because the options of heated ... ...

    Abstract Hypoxemic respiratory failure is a common manifestation of COVID-19 pneumonia. Early in the COVID-19 pandemic, patients with hypoxemic respiratory failure were, at times, being intubated earlier than normal; in part because the options of heated humidified high flow nasal cannula (HFNC) and non-invasive ventilation (NIV) were considered potentially inadequate and to increase risk of virus aerosolization. To understand the benefits and factors that predict success and failure of HFNC in this population, we evaluated data from the first 30 sequential patients admitted with COVID-19 pneumonia to our center who were managed with HFNC. We conducted Cox Proportional Hazards regression models to evaluate the factors associated with high flow nasal cannula failure (outcome variable), using time to intubation (censoring variable), while adjusting for comorbidities and immunosuppression. In the majority of our patients (76.7%), the use of HFNC failed and the patients were ultimately placed on mechanical ventilation. Those at increased risk of failure had a higher sequential organ failure assessment score, and at least one comorbidity or history of immunosuppression. Our data suggest that high flow nasal cannula may have a role in some patients with COVID-19 presenting with hypoxemic respiratory failure, but careful patient selection is the likely key to its success.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; Cannula/adverse effects ; Equipment Failure ; Female ; Humans ; Male ; Middle Aged ; Noninvasive Ventilation/adverse effects ; Noninvasive Ventilation/instrumentation ; Oxygen Inhalation Therapy/adverse effects ; Oxygen Inhalation Therapy/instrumentation ; Pandemics ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2021.106474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Investigation of high-pressure planetary ices by cryo-recovery. II. High-pressure apparatus, examples and a new high-pressure phase of MgSO

    Wang, Weiwei / Fortes, A Dominic / Dobson, David P / Howard, Christopher M / Bowles, John / Hughes, Neil J / Wood, Ian G

    Journal of applied crystallography

    2018  Volume 51, Issue Pt 3, Page(s) 692–705

    Abstract: An apparatus is described for the compression of samples to ∼2 GPa at temperatures from 80 to 300 K, rapid chilling to 80 K whilst under load and subsequent recovery into liquid nitro-gen after the load is released. In this way, a variety of quenchable ... ...

    Abstract An apparatus is described for the compression of samples to ∼2 GPa at temperatures from 80 to 300 K, rapid chilling to 80 K whilst under load and subsequent recovery into liquid nitro-gen after the load is released. In this way, a variety of quenchable high-pressure phases of many materials may be preserved for examination outside the high-pressure sample environment, with the principal benefit being the ability to obtain high-resolution powder diffraction data for phase identification and structure solution. The use of this apparatus, in combination with a newly developed cold-loadable low-temperature stage for X-ray powder diffraction (the PheniX-FL), is illustrated using ice VI (a high-pressure polymorph of ordinary water ice that is thermodynamically stable only above ∼0.6 GPa) as an example. A second example using synthetic epsomite (MgSO
    Language English
    Publishing date 2018-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020879-0
    ISSN 1600-5767 ; 0021-8898
    ISSN (online) 1600-5767
    ISSN 0021-8898
    DOI 10.1107/S1600576718003977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Challenges in providing critical care for patients with anti-N-methyl-D-aspartate receptor encephalitis.

    Howard, Christopher M / Kass, Joseph S / Bandi, Venkata D P / Guntupalli, Kalpalatha K

    Chest

    2014  Volume 145, Issue 5, Page(s) 1143–1147

    Abstract: Anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is characterized by a constellation of psychiatric, neurologic, autonomic, and cardiopulmonary manifestations. Although patients typically recover with appropriate treatment, they commonly require ... ...

    Abstract Anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) is characterized by a constellation of psychiatric, neurologic, autonomic, and cardiopulmonary manifestations. Although patients typically recover with appropriate treatment, they commonly require weeks to months of inpatient care, including prolonged stays in critical care units. This case series not only advocates for consideration of the disease in the appropriate context but also specifically highlights the distinct challenges intensivists encounter caring for patients with NMDARE. With a greater knowledge of the nuances and sequelae of NMDARE, critical care specialists will be better equipped to anticipate and manage the potentially life-threatening complications of the disease.
    MeSH term(s) Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy ; Cerebrospinal Fluid/chemistry ; Cognitive Therapy/methods ; Critical Care/standards ; Critical Care/trends ; Dose-Response Relationship, Drug ; Female ; Glucocorticoids/administration & dosage ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Immunologic Factors/administration & dosage ; Injections, Intravenous ; Plasma Exchange/methods ; Receptors, N-Methyl-D-Aspartate/immunology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Respiration, Artificial/methods ; Young Adult
    Chemical Substances Glucocorticoids ; Immunoglobulins, Intravenous ; Immunologic Factors ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.13-1490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel risk factors associated with hepatitis E virus infection in a large outbreak in northern Uganda: results from a case-control study and environmental analysis.

    Howard, Christopher M / Handzel, Thomas / Hill, Vincent R / Grytdal, Scott P / Blanton, Curtis / Kamili, Saleem / Drobeniuc, Jan / Hu, Dale / Teshale, Eyasu

    The American journal of tropical medicine and hygiene

    2010  Volume 83, Issue 5, Page(s) 1170–1173

    Abstract: An outbreak of hepatitis E virus (HEV) began in October 2007 in northern Uganda. To determine risk factors and sources for ongoing transmission, we conducted both a case-control study and an environmental investigation. A case patient was defined as ... ...

    Abstract An outbreak of hepatitis E virus (HEV) began in October 2007 in northern Uganda. To determine risk factors and sources for ongoing transmission, we conducted both a case-control study and an environmental investigation. A case patient was defined as having serologic evidence of HEV infection, whereas controls were seronegative. We identified risk factors for infection by univariable and multivariable analyses using conditional logistic regression. Several water sources were tested for HEV RNA. Among 112 cases and 145 controls, storage of drinking water in large-mouthed vessels (adjusted odds ratios [AOR] = 2.83; 95% confidence interval [CI] = 1.16-6.94) and washing hands in a group basin (AOR = 1.90; 95% CI = 1.07-3.38) were associated with HEV infection. HEV RNA was detected from communal hand-rinse and surface-water samples. The epidemiologic and environmental water-testing results suggest that household-level factors played an important role in the transmission of HEV-modalities that have been previously underappreciated.
    MeSH term(s) Adolescent ; Adult ; Case-Control Studies ; Child ; Child, Preschool ; Disease Outbreaks ; Hepatitis E/epidemiology ; Hepatitis E virus/genetics ; Hepatitis E virus/immunology ; Hepatitis E virus/isolation & purification ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Odds Ratio ; RNA, Viral/isolation & purification ; Risk Factors ; Uganda/epidemiology ; Water Microbiology ; Young Adult
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2010-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.2010.10-0384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hepatitis E epidemic, Uganda.

    Teshale, Eyasu H / Howard, Christopher M / Grytdal, Scott P / Handzel, Thomas R / Barry, Vaughn / Kamili, Saleem / Drobeniuc, Jan / Okware, Samuel / Downing, Robert / Tappero, Jordan W / Bakamutumaho, Barnabas / Teo, Chong Gee / Ward, John W / Holmberg, Scott D / Hu, Dale J

    Emerging infectious diseases

    2009  Volume 16, Issue 1, Page(s) 126–129

    Abstract: In October 2007, an epidemic of hepatitis E was suspected in Kitgum District of northern Uganda where no previous epidemics had been documented. This outbreak has progressed to become one of the largest hepatitis E outbreaks in the world. By June 2009, ... ...

    Abstract In October 2007, an epidemic of hepatitis E was suspected in Kitgum District of northern Uganda where no previous epidemics had been documented. This outbreak has progressed to become one of the largest hepatitis E outbreaks in the world. By June 2009, the epidemic had caused illness in >10,196 persons and 160 deaths.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Disease Outbreaks ; Female ; Hepatitis E/epidemiology ; Hepatitis E/virology ; Hepatitis E virus/genetics ; Humans ; Infant ; Male ; Middle Aged ; Pregnancy ; Uganda/epidemiology ; Young Adult
    Language English
    Publishing date 2009-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid1601.090764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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