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  1. Article ; Online: Clinical and radiographic assessment and restoration of maxillary sinus function in relation to oro-antral fistula closure: a systematic review.

    Bell, Garmon / Howard, Laura / Lamont, Thomas

    Oral surgery, oral medicine, oral pathology and oral radiology

    2022  Volume 134, Issue 4, Page(s) 432–441

    Abstract: Background: The purpose of this study was to determine current practice in assessment of maxillary sinus health during oro-antral fistula closure.: Method: A systematic review using specific MeSH headings between 1990 and September 2021 on Medline, ... ...

    Abstract Background: The purpose of this study was to determine current practice in assessment of maxillary sinus health during oro-antral fistula closure.
    Method: A systematic review using specific MeSH headings between 1990 and September 2021 on Medline, Ovid, and PubMed was performed. The inclusion criterion was closure of oro-antral fistula in adult patients. Exclusion criteria were oro-antral fistula arising in children; or from trauma, malignancy, or developmental abnormality; or any osteonecrotic lesion of bone. Risk of bias for individual papers was not assessed. Oxford Centre for Evidence Based Medicine levels of evidence were recorded.
    Results: 4309 papers were identified, and 119 were eligible for review. Nineteen were from otolaryngology (16%), 25 from combined ear, nose, and throat (ENT) and oral/oral and maxillofacial (OS/OMF) surgery (21%), and 75 from OS/OMF surgery (63%). Preoperative rhinoscopy and cross-sectional imaging were reported in 33 papers (28%), reflecting the role of ENT with or without OS/OMFS. Sixty-eight did not record any formal assessment of maxillary sinus health (57%), of which 60 were from OS/OMF surgery (50%). Use of computed tomography was reported in 58 papers (49%), and use of cone beam computed tomography was reported in 8 papers (7%) but did not correlate with assessment of sinus health.
    Discussion: Most surgery for oro-antral fistual closure was undertaken without objective assessment of maxillary sinus health, pre- or postoperatively. The involvement of ENT was associated with formal assessment of maxillary sinus health.
    MeSH term(s) Adult ; Child ; Cone-Beam Computed Tomography ; Endoscopy/methods ; Humans ; Maxillary Sinus/diagnostic imaging ; Maxillary Sinus/surgery ; Oroantral Fistula/complications ; Oroantral Fistula/diagnostic imaging ; Oroantral Fistula/surgery ; Rhinoplasty
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2022.02.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bbvac: A Live Vaccine Candidate That Provides Long-Lasting Anamnestic and Th17-Mediated Immunity against the Three Classical

    Gestal, Monica C / Howard, Laura K / Dewan, Kalyan K / Harvill, Eric T

    mSphere

    2022  Volume 7, Issue 1, Page(s) e0089221

    Abstract: Acute pathogens such as Bordetella pertussis can cause severe disease but are ultimately cleared by the immune response. This has led to the accepted paradigm that convalescent immunity is optimal and therefore broadly accepted as the "gold standard" ... ...

    Abstract Acute pathogens such as Bordetella pertussis can cause severe disease but are ultimately cleared by the immune response. This has led to the accepted paradigm that convalescent immunity is optimal and therefore broadly accepted as the "gold standard" against which vaccine candidates should be compared. However, successful pathogens like B. pertussis have evolved multiple mechanisms for suppressing and evading host immunity, raising the possibility that disruption of these mechanisms could result in substantially stronger or better immunity. Current acellular B. pertussis vaccines, delivered in a 5-dose regimen, induce only short-term immunity against disease and even less against colonization and transmission. Importantly, they provide modest protection against other
    MeSH term(s) Animals ; Bordetella pertussis ; Disease Models, Animal ; Mice ; Pertussis Vaccine ; Vaccines, Attenuated ; Whooping Cough/microbiology ; Whooping Cough/prevention & control
    Chemical Substances Pertussis Vaccine ; Vaccines, Attenuated
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00892-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: BET 2: Is keeping the eyes shut while fitting predictive of a psychogenic cause for seizures?

    Rn, Anna Mackway-Jones / Howard, Laura

    Emergency medicine journal : EMJ

    2019  Volume 37, Issue 1, Page(s) 46–47

    MeSH term(s) Eye ; Female ; Humans ; Mental Disorders/complications ; Mental Disorders/diagnosis ; Predictive Value of Tests ; Seizures/diagnosis ; Seizures/etiology ; Young Adult
    Language English
    Publishing date 2019-12-15
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2019-209314.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: BET 1: The role of topical phenylephrine in non-traumatic epistaxis.

    Howard, Laura / Baombe, Janos

    Emergency medicine journal : EMJ

    2019  Volume 36, Issue 9, Page(s) 572–573

    Abstract: A short cut review of the literature was carried out to establish whether topical phenylephrine was an effective treatment for non-traumatic epistaxis. A single paper looked at this modality comparing it to another topical treatment. The author, date and ...

    Abstract A short cut review of the literature was carried out to establish whether topical phenylephrine was an effective treatment for non-traumatic epistaxis. A single paper looked at this modality comparing it to another topical treatment. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses are tabulated. It is concluded that further more robust studies are needed to answer this question.
    MeSH term(s) Administration, Topical ; Epistaxis/drug therapy ; Evidence-Based Emergency Medicine/methods ; Humans ; Phenylephrine/administration & dosage ; Treatment Outcome ; Vasoconstrictor Agents/administration & dosage
    Chemical Substances Vasoconstrictor Agents ; Phenylephrine (1WS297W6MV)
    Language English
    Publishing date 2019-08-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2019-208927.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neuregulin-4 contributes to the establishment of cutaneous sensory innervation.

    Howard, Laura / Wyatt, Sean / Davies, Alun M

    Developmental neurobiology

    2021  Volume 81, Issue 2, Page(s) 139–148

    Abstract: Recent work has shown that neuregulin-4 (NRG4) is a physiological regulator of the growth of sympathetic axons and CNS dendrites in the developing nervous system. Here, we have investigated whether NRG4 plays a role in sensory axon growth and the ... ...

    Abstract Recent work has shown that neuregulin-4 (NRG4) is a physiological regulator of the growth of sympathetic axons and CNS dendrites in the developing nervous system. Here, we have investigated whether NRG4 plays a role in sensory axon growth and the establishment of cutaneous sensory innervation. Imaging early nerve fibers in the well-characterized cutaneous trigeminal territory, the brachial plexus, and thorax revealed very marked and highly significant decreases in nerve fiber length and branching density in Nrg4
    MeSH term(s) Axons/physiology ; Nerve Growth Factors ; Neuregulins/chemistry ; Neuregulins/metabolism ; Neuregulins/physiology ; Neurons/physiology ; Neurons, Afferent/physiology
    Chemical Substances Nerve Growth Factors ; Neuregulins ; neuregulin-4
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gastrointestinal conditions related to tooth wear.

    Howard, John P / Howard, Laura J / Geraghty, Joe / Leven, A Johanna / Ashley, Martin

    British dental journal

    2023  Volume 234, Issue 6, Page(s) 451–454

    Abstract: Gastro-oesophageal reflux disease (GORD) is a relatively common condition that occurs in adults and less commonly in children. It develops when the reflux of stomach contents into the oesophagus causes troublesome symptoms and/or complications. Signs and ...

    Abstract Gastro-oesophageal reflux disease (GORD) is a relatively common condition that occurs in adults and less commonly in children. It develops when the reflux of stomach contents into the oesophagus causes troublesome symptoms and/or complications. Signs and symptoms include heartburn, retrosternal discomfort, epigastric pain and hoarseness, dental erosion, chronic cough, burning mouth syndrome, halitosis and laryngitis. A proportion of patients will, however, have silent reflux. Strongly associated risk factors include family history, age, hiatus hernia, obesity and neurological conditions, such as cerebral palsy. There are different treatment options which may be considered for GORD, consisting of conservative, medical and surgical therapy. Dentists should be aware of the symptoms of GORD and dental signs of intrinsic erosion indicative of possible GORD so that they can question patients about this and, if appropriate, initiate a referral to a general medical practitioner.
    MeSH term(s) Adult ; Child ; Humans ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/diagnosis ; Tooth Wear/diagnosis ; Tooth Wear/etiology ; Tooth Wear/therapy ; Risk Factors ; Tooth Attrition
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-5677-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: BET 2: Hydroxychloroquine in the treatment of COVID-19.

    Howard, Laura / Baombe, Janos / Reynard, Charles

    Emergency medicine journal : EMJ

    2020  Volume 37, Issue 7, Page(s) 451–453

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Male ; Middle Aged ; Observational Studies as Topic ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; RNA, Viral/isolation & purification ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances RNA, Viral ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2020-210221.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: BET 1: is the patient's perception of shortness of breath a useful triage tool in exacerbations of COPD?

    Anna Mackway-Jones, R N / Howard, Laura

    Emergency medicine journal : EMJ

    2020  Volume 37, Issue 2, Page(s) 112–113

    Abstract: A shortcut review was carried out to establish whether the degree of breathlessness in patients with an acute exacerbation of COPD is indicative of the severity of the exacerbation. Three hundred and forty-seven papers were found using the reported ... ...

    Abstract A shortcut review was carried out to establish whether the degree of breathlessness in patients with an acute exacerbation of COPD is indicative of the severity of the exacerbation. Three hundred and forty-seven papers were found using the reported searches, of which five presented the best available evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these five papers are tabulated. It is concluded that increased shortness of breath is associated with a worse prognosis in patients with acute exacerbations of COPD. Dyspnoea assessment should be included in the triage process.
    MeSH term(s) Dyspnea/etiology ; Dyspnea/physiopathology ; Humans ; Patients/psychology ; Patients/statistics & numerical data ; Perception ; Pulmonary Disease, Chronic Obstructive/complications ; Triage/methods ; Triage/standards ; Triage/statistics & numerical data
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2019-209390.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: BET 1: Lidocaine with propofol to reduce pain on injection.

    Baombe, Janos P / Howard, Laura

    Emergency medicine journal : EMJ

    2017  Volume 34, Issue 8, Page(s) 551–552

    Abstract: A short review was carried out to see if mixing lidocaine with propofol is a safe and effective method in reducing the commonly reported pain at the injection site. Four relevant papers were found using the described search strategy. The author, date and ...

    Abstract A short review was carried out to see if mixing lidocaine with propofol is a safe and effective method in reducing the commonly reported pain at the injection site. Four relevant papers were found using the described search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. Although a promising idea, a paucity of good quality evidence suggests further needed research.
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2017-206976.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: BET 1: IN PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME, DOES WELLENS' SIGN ON THE ELECTROCARDIOGRAPH IDENTIFY CRITICAL LEFT ANTERIOR DESCENDING ARTERY STENOSIS?

    Morris, Niall / Howard, Laura

    Emergency medicine journal : EMJ

    2017  Volume 34, Issue 4, Page(s) 264–266

    Abstract: Wellens' syndrome consists of a history suggestive of an acute coronary syndrome and biphasic or deeply inverted T waves in ECG leads V2-V3. A shortcut review was carried out to establish whether this ECG pattern identifies patients with a critical left ... ...

    Abstract Wellens' syndrome consists of a history suggestive of an acute coronary syndrome and biphasic or deeply inverted T waves in ECG leads V2-V3. A shortcut review was carried out to establish whether this ECG pattern identifies patients with a critical left anterior descending artery stenosis. Six relevant papers were found. The clinical bottom line is that biphasic T-wave inversion in lead V2-V3 should alert the clinician to a probable critical stenosis of the left anterior descending artery.
    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/etiology ; Adult ; Coronary Stenosis/complications ; Coronary Stenosis/diagnosis ; Diagnosis, Differential ; Electrocardiography/classification ; Electrocardiography/methods ; Humans ; Male ; Myocardial Infarction/diagnosis
    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2017-206665.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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