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  1. Book: British Thoracic Society guideline for the initial outpatient management of pulmonary embolism

    Howard, Luke S.

    (Thorax ; volume 73, supplement 2 (July 2018))

    2018  

    Institution British Thoracic Society
    Author's details British Thoracic Society Outpatient Management of Pulmonary Embolism Guideline Development Group ; Dr Luke Howard (chair) [und 16 weitere]
    Series title Thorax ; volume 73, supplement 2 (July 2018)
    Collection
    Language English
    Size ii29 Seiten
    Publisher BMJ
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019854013
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui III Zs 83 -73,Suppl.2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Systematic pulmonary embolism follow-up: why we should all do it!

    Howard, Luke S / Price, Laura C

    The European respiratory journal

    2024  Volume 63, Issue 3

    MeSH term(s) Humans ; Follow-Up Studies ; Hypertension, Pulmonary ; Pulmonary Embolism/diagnosis ; Registries
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00253-2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  3. Article ; Online: Acute pulmonary embolism.

    Howard, Luke

    Clinical medicine (London, England)

    2019  Volume 19, Issue 3, Page(s) 243–247

    Abstract: Pulmonary embolism, despite being common, often remains elusive as a diagnosis, and clinical suspicion needs to remain high when seeing a patient with cardiopulmonary symptoms. Once suspected, diagnosis is usually straightforward; however, optimal ... ...

    Abstract Pulmonary embolism, despite being common, often remains elusive as a diagnosis, and clinical suspicion needs to remain high when seeing a patient with cardiopulmonary symptoms. Once suspected, diagnosis is usually straightforward; however, optimal treatment can be difficult. Risk stratification with clinical scores, biomarkers and imaging helps to refine the best treatment strategy, but the position of thrombolysis in intermediate risk (submassive) pulmonary embolism remains a grey area. Pulmonary embolism response teams are on the increase to provide advice in such cases. Direct oral anticoagulants have been a major advance in treatment this decade, but are not appropriate for all patients. Follow-up of patients with pulmonary embolism should be mandatory to determine duration of anticoagulation and to assess for serious long-term complications.
    MeSH term(s) Acute Disease ; Anticoagulants/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Humans ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/therapy ; Thrombolytic Therapy
    Chemical Substances Anticoagulants ; Fibrinolytic Agents
    Language English
    Publishing date 2019-05-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.19-3-247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Erratum: Acute pulmonary embolism.

    Howard, Luke

    Clinical medicine (London, England)

    2019  Volume 19, Issue 4, Page(s) 359

    Language English
    Publishing date 2019-07-15
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.19-4-359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Thrombolysis for PE: less is more?

    Howard, Luke S

    Thorax

    2018  Volume 73, Issue 5, Page(s) 412–413

    MeSH term(s) Fibrinolysis ; Fibrinolytic Agents ; Humans ; Network Meta-Analysis ; Pulmonary Embolism ; Thrombolytic Therapy
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2018-01-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2017-211141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Non-vitamin K antagonist oral anticoagulants for pulmonary embolism: who, where and for how long?

    Howard, Luke S

    Expert review of respiratory medicine

    2018  Volume 12, Issue 5, Page(s) 387–402

    Abstract: Introduction: Acute pulmonary embolism (PE) is a relatively common cardiopulmonary emergency that is a major cause of hospitalization and morbidity and is the primary cause of mortality associated with venous thromboembolism (VTE). During the last ... ...

    Abstract Introduction: Acute pulmonary embolism (PE) is a relatively common cardiopulmonary emergency that is a major cause of hospitalization and morbidity and is the primary cause of mortality associated with venous thromboembolism (VTE). During the last decade, one of the biggest changes in the management of PE has been the approval of four non-vitamin K antagonist oral anticoagulants (NOACs; apixaban, dabigatran, edoxaban and rivaroxaban) for the treatment of PE and deep vein thrombosis and secondary prevention of VTE. Areas covered: This article reviews the evolving management of PE in the NOAC era and addresses three fundamental questions: who should receive NOACs over conventional heparin/vitamin K antagonist regimens for the treatment of acute PE; should patients be treated as inpatients or outpatients; and how long should patients be treated to reduce the risk of recurrence? Expert commentary: The management of PE is changing. NOACs provide new anticoagulant treatment options for patients with PE, based on Phase III clinical study results. The consistent efficacy and safety profile of NOACs across many PE patient subgroups, including the elderly, fragile patients, those with active cancer and high-risk (right ventricular dysfunction) patients, suggests NOAC use will increase among these patients.
    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Dabigatran/administration & dosage ; Dabigatran/therapeutic use ; Humans ; Pulmonary Embolism/drug therapy ; Pyrazoles/administration & dosage ; Pyrazoles/therapeutic use ; Pyridines/administration & dosage ; Pyridines/therapeutic use ; Pyridones/administration & dosage ; Pyridones/therapeutic use ; Rivaroxaban/administration & dosage ; Rivaroxaban/therapeutic use ; Secondary Prevention ; Thiazoles/administration & dosage ; Thiazoles/therapeutic use ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Pyrazoles ; Pyridines ; Pyridones ; Thiazoles ; apixaban (3Z9Y7UWC1J) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC) ; edoxaban (NDU3J18APO)
    Language English
    Publishing date 2018-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2018.1452614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6963: Show issues Location:
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  7. Article ; Online: Is right heart catheterisation still a fundamental part of the follow-up assessment of pulmonary arterial hypertension? The argument against.

    Howard, Luke S

    The European respiratory journal

    2018  Volume 52, Issue 1

    MeSH term(s) Cardiac Catheterization/methods ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Predictive Value of Tests ; Risk Assessment/methods ; Vascular Resistance
    Language English
    Publishing date 2018-07-04
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00996-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  8. Article ; Online: Pulmonary Embolism (PE) to Chronic Thromboembolic Pulmonary Disease (CTEPD): Findings from a Survey of UK Physicians.

    Pepke-Zaba, Joanna / Howard, Luke / Kiely, David G / Sweeney, Shruti / Johnson, Martin

    Advances in respiratory medicine

    2024  Volume 92, Issue 1, Page(s) 45–57

    Abstract: Chronic thromboembolic pulmonary disease (CTEPD) is a complication of pulmonary embolism (PE). We conducted an online survey of UK PE-treating physicians to understand practices in the follow-up of PE and awareness of CTEPD. The physicians surveyed ( ...

    Abstract Chronic thromboembolic pulmonary disease (CTEPD) is a complication of pulmonary embolism (PE). We conducted an online survey of UK PE-treating physicians to understand practices in the follow-up of PE and awareness of CTEPD. The physicians surveyed (
    MeSH term(s) Humans ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/therapy ; Physicians ; Cardiology ; Internal Medicine ; United Kingdom
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.3390/arm92010007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Polyphenolic profiles of a variety of wild berries from the Pacific Northwest region of North America.

    Higbee, Jerome / Brownmiller, Cindi / Solverson, Patrick / Howard, Luke / Carbonero, Franck

    Current research in food science

    2023  Volume 7, Page(s) 100564

    Abstract: Polyphenols have been extensively profiled and quantified in commercially grown berries, but similar information is sparsely available for wild berries. Because polyphenolic contents are inherently associated with berries health benefits, determining ... ...

    Abstract Polyphenols have been extensively profiled and quantified in commercially grown berries, but similar information is sparsely available for wild berries. Because polyphenolic contents are inherently associated with berries health benefits, determining phenolic profiles is an important step for strategizing potential uses by the industry and for health and nutrition outcomes. Here, we profiled phenolic compounds in wild berries commonly encountered and harvested in the Pacific Northwest region of North America. Huckleberries (
    Language English
    Publishing date 2023-08-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9271
    ISSN (online) 2665-9271
    DOI 10.1016/j.crfs.2023.100564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Chemical Composition of Volatile Extracts from Black Raspberries, Blueberries, and Blackberries and Their Antiproliferative Effect on A549 Non-Small-Cell Lung Cancer Cells.

    Gu, Inah / Brownmiller, Cindi / Howard, Luke / Lee, Sun-Ok

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Berry volatiles are responsible for the berry aroma but there is limited information available on the health-promoting activities of berry volatiles. The objectives of this study were to evaluate the chemical composition of volatile extracts from black ... ...

    Abstract Berry volatiles are responsible for the berry aroma but there is limited information available on the health-promoting activities of berry volatiles. The objectives of this study were to evaluate the chemical composition of volatile extracts from black raspberries, blueberries, and blackberries and investigate their antiproliferative effect and apoptotic mechanisms on A549 lung cancer cells. The chemical composition of three berry volatile extracts (BVEs) was identified by using gas chromatography-mass spectrometry. Cells were treated with different dilutions of three BVEs for 48 h and determined for cell proliferation and apoptosis. Total volatiles in BVEs were 1.6−3.2 mg/L. Two-fold diluted BVEs significantly inhibited cell proliferation after 48 h, inducing apoptosis (p < 0.05). Blackberry volatile extract significantly reduced the inactive form of apoptotic proteins, including poly adenosine diphosphate-ribose polymerase (PARP), procaspase-9, and procaspase-3 compared to the control (p < 0.05). Blueberry volatile extract showed higher apoptotic cell death (p < 0.05) with a slightly higher cell population in G0/G1 phase than other berries. These results showed that volatile extracts from three berries have the antiproliferative effect on human lung adenocarcinoma cells partially via apoptosis, suggesting that volatiles from three berries may have potential anti-cancer activity through apoptosis in lung cancer.
    Language English
    Publishing date 2022-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12122056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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