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  1. Article: Piperonyl formulations as horse fly repellents.

    HOWELL, D E

    Journal of economic entomology

    2007  Volume 42, Issue 2, Page(s) 401

    MeSH term(s) Animals ; Chemistry, Pharmaceutical ; Diptera ; Insecticides
    Chemical Substances Insecticides
    Language English
    Publishing date 2007-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 3031-4
    ISSN 0022-0493
    ISSN 0022-0493
    DOI 10.1093/jee/42.2.401
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  2. Article: Inhibition of lipopolysaccharide-induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guinea pigs.

    Howell, R E / Jenkins, L P / Howell, D E

    The Journal of pharmacology and experimental therapeutics

    1995  Volume 275, Issue 2, Page(s) 703–709

    Abstract: There is a need for pharmacological agents for the treatment of pulmonary edema associated with the adult respiratory distress syndrome. Therefore, we examined the effects of isozyme-selective cyclic AMP phosphodiesterase (cAMP PDE) inhibitors, as well ... ...

    Abstract There is a need for pharmacological agents for the treatment of pulmonary edema associated with the adult respiratory distress syndrome. Therefore, we examined the effects of isozyme-selective cyclic AMP phosphodiesterase (cAMP PDE) inhibitors, as well as aminophylline and dexamethasone, on the pulmonary edema, protein leakage into the airways and airway neutrophilia induced by aerosolized lipopolysaccharide (LPS) in intact guinea pigs. Twenty-four hours after LPS exposure lung wet/dry weight ratios increased from 4.9 +/- 0.004 to 5.8 +/- 0.02. Rolipram (PDE4 selective), CI-930 (PDE3 selective), aminophylline and dexamethasone (given p.o. 1 hr before and 4 hr after LPS exposure) inhibited pulmonary edema formation with ED50 values of 1.7, 0.5, 31 and 2.8 mg/kg, respectively. Maximum inhibition occurred with rolipram at 10 mg/kg (70 +/- 17%), CI-930 at 10 mg/kg (101 +/- 4%), aminophylline at 50 mg/kg (88 +/- 14%) and dexamethasone at 3 mg/kg (64 +/- 6%). Denbufylline and milrinone also inhibited pulmonary edema formation at 10 mg/kg i.p., supporting the inhibition of PDE4 and PDE3 as the mechanisms of action of rolipram and CI-930, respectively. Rolipram, CI-930, aminophylline and dexamethasone (at maximum doses for inhibiting pulmonary edema) inhibited the 3-fold increase in bronchoalveolar lavage albumin concentration 24 hr after LPS exposure (42 +/- 14%, 98 +/- 2%, 70 +/- 9% and 53 +/- 13%, respectively). However, none of these compounds (at maximum doses for inhibiting pulmonary edema) inhibited the corresponding 400-fold increase in lavage neutrophil counts.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Aerosols ; Aminophylline/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Bronchoalveolar Lavage Fluid/chemistry ; Dexamethasone/pharmacology ; Disease Models, Animal ; Guinea Pigs ; Lipopolysaccharides/administration & dosage ; Male ; Phosphodiesterase Inhibitors/pharmacology ; Pulmonary Edema/drug therapy ; Pulmonary Edema/prevention & control ; Pyridazines/pharmacology ; Pyrrolidinones/pharmacology ; Respiratory Distress Syndrome, Adult/drug therapy ; Rolipram
    Chemical Substances Aerosols ; Anti-Inflammatory Agents ; Lipopolysaccharides ; Phosphodiesterase Inhibitors ; Pyridazines ; Pyrrolidinones ; Aminophylline (27Y3KJK423) ; Dexamethasone (7S5I7G3JQL) ; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone (86798-59-6) ; Rolipram (K676NL63N7)
    Language English
    Publishing date 1995-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
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  5. Article: The venomous hair structure, venom and life cycle of Lagoa crispata, a puss caterpillar of Oklahoma.

    Lamdin, J M / Howell, D E / Kocan, K M / Murphey, D R / Arnold, D C / Fenton, A W / Odell, G V / Ownby, C L

    Toxicon : official journal of the International Society on Toxinology

    2000  Volume 38, Issue 9, Page(s) 1163–1189

    Abstract: The presence of a unique population of Lagoa crispata, puss caterpillar, in western Oklahoma is reported. A detailed microscopic examination shows the structure of the L. crispata spines resemble the type 4 spines described by [Kawamoto, F., Kumada, N., ... ...

    Abstract The presence of a unique population of Lagoa crispata, puss caterpillar, in western Oklahoma is reported. A detailed microscopic examination shows the structure of the L. crispata spines resemble the type 4 spines described by [Kawamoto, F., Kumada, N., 1984. Biology and venoms of lepidoptera. In: Tu, A.T. (Ed.), Handbook of Natural Toxins, Insect Poisons, Allergens and other invertebrate venoms, vol. 2, pp. 291-332 (ch. 9)]. The major food source of L. crispata are the leaves of oak (shin oak). The high tannin content of this food source results in spine extracts high in oak tannins. These extracts have activity but enzyme and toxin activity is lost with time. The gel filtration protein fractions are colored from brown to yellow and are inactive as enzymes or toxins. No hyaluronidase, protease or phosphohydrolase activity is detected in these protein fractions. The life cycle shows these caterpillars have 6 instars. Characterizations and annual emerging times of each instar are included.
    MeSH term(s) Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/isolation & purification ; Amino Acids/analysis ; Animals ; Arthropod Venoms/chemistry ; Arthropod Venoms/enzymology ; Arthropod Venoms/toxicity ; Electrophoresis, Disc ; Endopeptidases/chemistry ; Endopeptidases/isolation & purification ; Female ; Hair/chemistry ; Hair/enzymology ; Hyaluronoglucosaminidase/chemistry ; Hyaluronoglucosaminidase/isolation & purification ; Insecta/chemistry ; Larva ; Life Cycle Stages ; Male ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Oklahoma ; Rabbits ; Rats ; Tissue Fixation
    Chemical Substances Amino Acids ; Arthropod Venoms ; Hyaluronoglucosaminidase (EC 3.2.1.35) ; Endopeptidases (EC 3.4.-) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2000-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/s0041-0101(99)00195-6
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  6. Article: The venomous hair structure, venom and life cycle of Lagoa crispata, a puss caterpillar of Oklahoma

    Lamdin, J.M / Howell, D.E / Kocan, K.M / Murphey, D.R / Arnold, D.C / Fenton, A.W / Odell, G.V / Ownby, C.L

    Toxicon. Sept 2000. v. 38 (9)

    2000  

    Keywords life cycle (organisms) ; Lepidoptera ; anatomy and morphology ; ultrastructure ; biological development ; venoms ; chemical composition ; hyaluronoglucosaminidase ; adenosinetriphosphatase ; proteinases ; toxicity ; bioassays ; mice ; Oklahoma
    Language English
    Dates of publication 2000-09
    Size p. 1163-1189.
    Document type Article
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
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  7. Article: RESISTANCE OF THE HOUSE FLY TO BACILLUS THURINGIENSIS BERLINER.

    HARVEY, T L / HOWELL, D E

    Journal of invertebrate pathology

    1965  Volume 20, Page(s) 92–100

    MeSH term(s) Animals ; Bacillus ; Bacillus thuringiensis ; Houseflies ; Insecta ; Metamorphosis, Biological ; Research
    Language English
    Publishing date 1965-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390885-9
    ISSN 1096-0805 ; 0022-2011
    ISSN (online) 1096-0805
    ISSN 0022-2011
    DOI 10.1016/0022-2011(65)90160-6
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  8. Article: A USEFUL METHOD FOR MOUNTING INSECTS.

    Howell, D E

    Science (New York, N.Y.)

    1938  Volume 87, Issue 2250, Page(s) 146

    Language English
    Publishing date 1938-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.87.2250.146
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    Zs.MG 77: Show issues

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  9. Book: The Transmission of anaplasmosis by horseflies (Tabanidae)

    Howell, D. E

    (Technical bulletin ; no. T-11)

    1941  

    Author's details by D.E. Howell ... [et al.]
    Series title Technical bulletin ; no. T-11
    Keywords Anaplasmosis/Transmission. ; Horseflies. ; Flies as carriers of disease.
    Language English
    Size 23 p. ;, 22 cm.
    Publisher Oklahoma Agricultural and Mechanical College, Agricultural Experiment Station
    Publishing place Stillwater, Okla
    Document type Book
    Database NAL-Catalogue (AGRICOLA)

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  10. Book: Fly control in Oklahoma

    Howell, D. E

    (Bulletin B ; 385)

    1952  

    Author's details by D.E. Howell
    Series title Bulletin B ; 385
    Keywords Flies/Control/Oklahoma.
    Language English
    Size 18 p. :, ill. ;, 22 cm.
    Publisher Oklahoma Agricultural Experiment Station
    Publishing place Stillwater, Okla
    Document type Book
    Note Cover title.
    Database NAL-Catalogue (AGRICOLA)

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