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  1. Article ; Online: Modulation of von Willebrand Factor Function by Domain C4 Mutations.

    Hoylaerts, Marc F

    Thrombosis and haemostasis

    2021  Volume 122, Issue 2, Page(s) 176

    MeSH term(s) Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Mutation ; von Willebrand Diseases/genetics ; von Willebrand Factor/genetics
    Chemical Substances von Willebrand Factor
    Language English
    Publishing date 2021-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-1659-0729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  2. Article ; Online: Neutrophil Cathepsin G Enhances Thrombogenicity of Mildly Injured Arteries via ADP-Mediated Platelet Sensitization.

    Nemmar, Abderrahim / Hoylaerts, Marc F

    International journal of molecular sciences

    2022  Volume 23, Issue 2

    Abstract: Inhalation of particulate matter in polluted air causes direct, size-restricted passage in the circulation and pronounced lung inflammation, provoking platelet activation and (non)-fatal cardiovascular complications. To determine potency and mechanism of ...

    Abstract Inhalation of particulate matter in polluted air causes direct, size-restricted passage in the circulation and pronounced lung inflammation, provoking platelet activation and (non)-fatal cardiovascular complications. To determine potency and mechanism of platelet sensitization via neutrophil enzymes, we performed in vitro aggregation studies in washed human platelets and in murine and human blood, in the presence of elastase, cathepsin G and regular platelet agonists, present in damaged arteries. The impact of both enzymes on in vivo thrombogenicity was studied in the same thrombosis mouse model, previously having demonstrated that neutrophil activation enhances peripheral thrombogenicity. At 0.05 U/mL, cathepsin G activated washed human platelets via PAR1, whereas at 0.35 U/mL, aggregation occurred via PAR4. In Swiss mouse platelet-rich plasma no aggregation occurred by cathepsin G at 0.4 U/mL. In human and murine blood, aggregations by 0.05-0.1 U/mL cathepsin G were similar and not PAR-mediated, but platelet aggregation was inhibited by ADP antagonists, advocating cathepsin G-released ADP in blood as the true agonist of sustained platelet activation. In the mouse thrombosis model, cathepsin G and elastase amplified mild thrombogenicity at blood concentrations that activated platelets in vitro. This study shows that cathepsin G and elastase secreted in the circulation during mild air pollution-induced lung inflammation lyse red blood cell membrane proteins, leading to ADP-leakage into plasma, sensitizing platelets and amplifying their contribution to cardiovascular complications of ambient particle inhalation.
    MeSH term(s) Adenosine Diphosphate/metabolism ; Animals ; Arteries/metabolism ; Arteries/pathology ; Biomarkers ; Blood Platelets/metabolism ; Cathepsin G/genetics ; Cathepsin G/metabolism ; Disease Susceptibility ; Humans ; Mice ; Mice, Knockout ; Neutrophil Activation ; Neutrophils/metabolism ; Pancreatic Elastase/metabolism ; Platelet Activation/genetics ; Platelet Aggregation/genetics ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Thrombosis/etiology ; Thrombosis/metabolism ; Thrombosis/pathology
    Chemical Substances Biomarkers ; Adenosine Diphosphate (61D2G4IYVH) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Cathepsin G (EC 3.4.21.20) ; Pancreatic Elastase (EC 3.4.21.36)
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23020744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Modulation of von Willebrand Factor Function by Domain C4 Mutations

    Hoylaerts, Marc F.

    Thrombosis and Haemostasis

    2021  Volume 122, Issue 02, Page(s) 176–176

    Language English
    Publishing date 2021-09-30
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-1659-0729
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: To the heart of the APS puzzle.

    Hoylaerts, Marc F

    Blood

    2010  Volume 116, Issue 16, Page(s) 2867–2869

    Language English
    Publishing date 2010-10-21
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2010-07-297572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  5. Article ; Online: Controlled NO-Release from 3D-Printed Small-Diameter Vascular Grafts Prevents Platelet Activation and Bacterial Infectivity.

    Kabirian, Fatemeh / Ditkowski, Bartosz / Zamanian, Ali / Hoylaerts, Marc F / Mozafari, Masoud / Heying, Ruth

    ACS biomaterials science & engineering

    2019  Volume 5, Issue 5, Page(s) 2284–2296

    Abstract: Thrombogenicity and bacterial infectiveness are the most common complications for foreign blood contacting surfaces associated with functional failure of small-diameter vascular grafts (SDVGs). In this work, novel bactericidal and nonthrombogenic SDVGs ... ...

    Abstract Thrombogenicity and bacterial infectiveness are the most common complications for foreign blood contacting surfaces associated with functional failure of small-diameter vascular grafts (SDVGs). In this work, novel bactericidal and nonthrombogenic SDVGs were manufactured via 3D-printing technology, thus producing a controlled nitric oxide (NO) release coating.
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.9b00220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Platelet receptors.

    Kauskot, Alexandre / Hoylaerts, Marc F

    Handbook of experimental pharmacology

    2012  , Issue 210, Page(s) 23–57

    Abstract: Well-understood functions for "traditional" platelet receptors are described, but "newer" receptors are equally discussed. Receptors are described biochemically (structure, ligand(s), protein partners, and function) and whenever possible, their clinical ... ...

    Abstract Well-understood functions for "traditional" platelet receptors are described, but "newer" receptors are equally discussed. Receptors are described biochemically (structure, ligand(s), protein partners, and function) and whenever possible, their clinical importance (mutations, polymorphisms, syndrome) are highlighted.
    MeSH term(s) Animals ; Blood Platelets/chemistry ; Humans ; Integrins/analysis ; Platelet Adhesiveness ; Platelet Aggregation ; Platelet Glycoprotein GPIb-IX Complex/analysis ; Receptors, Cell Surface/analysis ; Receptors, Cell Surface/physiology ; Receptors, Collagen/analysis ; Receptors, Prostaglandin E/analysis
    Chemical Substances Integrins ; Platelet Glycoprotein GPIb-IX Complex ; Receptors, Cell Surface ; Receptors, Collagen ; Receptors, Prostaglandin E ; glycoprotein receptor GPIb-IX
    Language English
    Publishing date 2012
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/978-3-642-29423-5_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  7. Article ; Online: Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.

    Izzi, Benedetta / Tirozzi, Alfonsina / Cerletti, Chiara / Donati, Maria Benedetta / de Gaetano, Giovanni / Hoylaerts, Marc F / Iacoviello, Licia / Gialluisi, Alessandro

    International journal of molecular sciences

    2020  Volume 21, Issue 22

    Abstract: Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the ... ...

    Abstract Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.
    MeSH term(s) Biomarkers/blood ; Hemostasis/genetics ; Humans ; Neurodegenerative Diseases/blood ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/genetics ; Neurodevelopmental Disorders/blood ; Neurodevelopmental Disorders/epidemiology ; Neurodevelopmental Disorders/genetics ; Neurons/metabolism ; Neurons/pathology ; Thrombosis/blood ; Thrombosis/epidemiology ; Thrombosis/genetics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21228817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells.

    Bolean, Maytê / Izzi, Benedetta / van Kerckhoven, Soetkin / Bottini, Massimo / Ramos, Ana Paula / Millán, José Luis / Hoylaerts, Marc F / Ciancaglini, Pietro

    Biochimica et biophysica acta. General subjects

    2020  Volume 1864, Issue 8, Page(s) 129629

    Abstract: Backgound: Vascular smooth muscle cells (VSMCs) transdifferentiated ectopically trigger vascular calcifications, contributing to clinical cardiovascular disease in the aging population. AnxA5 and TNAP play a crucial role in (patho)physiological ... ...

    Abstract Backgound: Vascular smooth muscle cells (VSMCs) transdifferentiated ectopically trigger vascular calcifications, contributing to clinical cardiovascular disease in the aging population. AnxA5 and TNAP play a crucial role in (patho)physiological mineralization.
    Methods: We performed affinity studies between DPPC and 9:1 DPPC:DPPS-proteoliposomes carrying AnxA5 and/or TNAP and different types of collagen matrix: type I, II, I + III and native collagenous extracellular matrix (ECM) produced from VSMCs with or without differentiation, to simulate ectopic calcification conditions.
    Results: AnxA5-proteoliposomes had the highest affinity for collagens, specially for type II. TNAP-proteoliposomes bound poorly and the simultaneous presence of TNAP in the AnxA5-proteoliposomes disturbed interactions between AnxA5 and collagen. DPPC AnxA5-proteoliposomes affinities for ECM from transdifferentiating cells went up 2-fold compared to that from native VSMCs. The affinities of DPPC:DPPS-proteoliposomes were high for ECM from VSMCs with or without differentiation, underscoring a synergistic effect between AnxA5 and DPPS. Co-localization studies uncovered binding of proteoliposomes harboring AnxA5 or TNAP+AnxA5 to various regions of the ECM, not limited to type II collagen.
    Conclusion: AnxA5-proteoliposomes showed the highest affinities for type II collagen, deposited during chondrocyte mineralization in joint cartilage. TNAP in the lipid/protein microenvironment disturbs interactions between AnxA5 and collagen. These findings support the hypothesis that TNAP is cleaved from the MVs membrane just before ECM binding, such facilitating MV anchoring to ECM via AnxA5 interaction.
    General significance: Proteoliposomes as MV biomimetics are useful in the understanding of mechanisms that regulate the mineralization process and may be essential for the development of novel therapeutic strategies to prevent or inhibit ectopic mineralization.
    MeSH term(s) Annexin A5/metabolism ; Binding Sites ; Biomimetic Materials/metabolism ; Carrier Proteins/metabolism ; Cell Differentiation ; Collagen/metabolism ; Extracellular Matrix/metabolism ; Humans ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; Proteolipids/metabolism
    Chemical Substances ANXA5 protein, human ; Annexin A5 ; Carrier Proteins ; Proteolipids ; proteoliposomes ; Collagen (9007-34-5) ; ALPL protein, human (EC 3.1.3.1)
    Language English
    Publishing date 2020-04-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2020.129629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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  9. Article ; Online: Hemostasis and inflammation

    Hoylaerts Marc F / Verhamme Peter

    Thrombosis Journal, Vol 7, Iss 1, p

    two of a kind?

    2009  Volume 15

    Abstract: Abstract Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the coagulation cascade, tightly controlled by natural anticoagulants and the fibrinolytic system. ...

    Abstract Abstract Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the coagulation cascade, tightly controlled by natural anticoagulants and the fibrinolytic system.
    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2009-11-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.

    Izzi, Benedetta / Noro, Fabrizia / Cludts, Katrien / Freson, Kathleen / Hoylaerts, Marc F

    International journal of molecular sciences

    2018  Volume 19, Issue 4

    Abstract: Chromosomal interactions connect distant enhancers and promoters on the same chromosome, activating or repressing gene expression. ...

    Abstract Chromosomal interactions connect distant enhancers and promoters on the same chromosome, activating or repressing gene expression.
    MeSH term(s) Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; CpG Islands ; DNA Methylation ; Exodeoxyribonucleases/genetics ; Exodeoxyribonucleases/metabolism ; Heparin-binding EGF-like Growth Factor/genetics ; Heparin-binding EGF-like Growth Factor/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Promoter Regions, Genetic ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism
    Chemical Substances Cell Cycle Proteins ; Heparin-binding EGF-like Growth Factor ; Neoplasm Proteins ; PEAR1 protein, human ; PRCC protein, human ; Receptors, Cell Surface ; AEN protein, human (EC 3.1.-) ; Exodeoxyribonucleases (EC 3.1.-)
    Language English
    Publishing date 2018-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19041069
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