LIVIVO - Search results -

Search results

Result 1 - 10 of total 22

Search options

Article ; Online: CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow.

Elias, Shlomo / Sharma, Rahul / Schizas, Michael / Valdez, Izabella / Rampersaud, Sham / Park, Sun-Mi / Gonzalez-Figueroa, Paula / Li, Quan-Zhen / Hoyos, Beatrice / Rudensky, Alexander Y

The Journal of experimental medicine

2022 Volume 219, Issue 7

Abstract: Regulatory T (Treg) cells represent a specialized lineage of suppressive CD4+ T cells whose functionality is critically dependent on their ability to migrate to and dwell in the proximity of cells they control. Here we show that continuous expression of ... ...

Abstract	Regulatory T (Treg) cells represent a specialized lineage of suppressive CD4+ T cells whose functionality is critically dependent on their ability to migrate to and dwell in the proximity of cells they control. Here we show that continuous expression of the chemokine receptor CXCR4 in Treg cells is required for their ability to accumulate in the bone marrow (BM). Induced CXCR4 ablation in Treg cells led to their rapid depletion and consequent increase in mature B cells, foremost the B-1 subset, observed exclusively in the BM without detectable changes in plasma cells or hematopoietic stem cells or any signs of systemic or local immune activation elsewhere. Dysregulation of BM B-1 B cells was associated with a highly specific increase in IgM autoantibodies and total serum IgM levels. Thus, Treg cells control autoreactive B-1 B cells in a CXCR4-dependent manner. These findings have significant implications for understanding the regulation of B cell autoreactivity and malignancies.
MeSH term(s)	B-Lymphocyte Subsets/metabolism ; Bone Marrow/metabolism ; Bone Marrow Cells/metabolism ; Immunoglobulin M/metabolism ; Receptors, CXCR4/metabolism ; T-Lymphocytes, Regulatory
Chemical Substances	Immunoglobulin M ; Receptors, CXCR4
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20220047
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Assembly of a spatial circuit of T-bet-expressing T and B lymphocytes is required for antiviral humoral immunity.

Mendoza, Alejandra / Yewdell, William T / Hoyos, Beatrice / Schizas, Michail / Bou-Puerto, Regina / Michaels, Anthony J / Brown, Chrysothemis C / Chaudhuri, Jayanta / Rudensky, Alexander Y

Science immunology

2021 Volume 6, Issue 60

Abstract: Effective antiviral immunity requires generation of T and B lymphocytes expressing the transcription factor T-bet, a regulator of type 1 inflammatory responses. Using T-bet expression as an endogenous marker for cells participating in a type 1 response, ... ...

Abstract	Effective antiviral immunity requires generation of T and B lymphocytes expressing the transcription factor T-bet, a regulator of type 1 inflammatory responses. Using T-bet expression as an endogenous marker for cells participating in a type 1 response, we report coordinated interactions of T-bet-expressing T and B lymphocytes on the basis of their dynamic colocalization at the T cell zone and B follicle boundary (T-B boundary) and germinal centers (GCs) during lung influenza infection. We demonstrate that the assembly of this circuit takes place in distinct anatomical niches within the draining lymph node, guided by CXCR3 that enables positioning of T
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Communication/immunology ; Disease Models, Animal ; Female ; Germinal Center/cytology ; Germinal Center/metabolism ; Humans ; Immunity, Humoral ; Immunoglobulin Class Switching ; Influenza A virus/immunology ; Influenza, Human/immunology ; Influenza, Human/pathology ; Influenza, Human/virology ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Lung/immunology ; Lung/pathology ; Lung/virology ; Male ; Mice ; Mice, Transgenic ; Nippostrongylus/immunology ; Rats ; Receptors, CXCR3/metabolism ; Strongylida Infections/immunology ; Strongylida Infections/parasitology ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th1 Cells/immunology ; Th1 Cells/metabolism
Chemical Substances	Cxcr3 protein, mouse ; IFNG protein, mouse ; Receptors, CXCR3 ; T-Box Domain Proteins ; T-box transcription factor TBX21 ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abi4710
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.

Dikiy, Stanislav / Li, Jun / Bai, Lu / Jiang, Menglin / Janke, Laura / Zong, Xinying / Hao, Xiaolei / Hoyos, Beatrice / Wang, Zhong-Min / Xu, Beisi / Fan, Yiping / Rudensky, Alexander Y / Feng, Yongqiang

Immunity

2021 Volume 54, Issue 5, Page(s) 931–946.e11

Abstract: Activation of the STAT5 transcription factor downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the differentiation of regulatory T (Treg) cells. Due to the pleiotropic effects of IL-2R signaling, it is ... ...

Abstract	Activation of the STAT5 transcription factor downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the differentiation of regulatory T (Treg) cells. Due to the pleiotropic effects of IL-2R signaling, it is unclear how STAT5 acts directly on the Foxp3 locus to promote its expression. Here, we report that IL-2 - STAT5 signaling converged on an enhancer (CNS0) during Foxp3 induction. CNS0 facilitated the IL-2 dependent CD25
MeSH term(s)	Animals ; Autoimmunity/immunology ; Cell Differentiation/immunology ; Cell Lineage/immunology ; Enhancer Elements, Genetic/immunology ; Female ; Forkhead Transcription Factors/immunology ; Humans ; Immune Tolerance/immunology ; Interleukin-2/immunology ; Interleukin-2 Receptor alpha Subunit/immunology ; Male ; Mice ; Receptors, Interleukin-2/immunology ; STAT5 Transcription Factor/immunology ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Forkhead Transcription Factors ; Foxp3 protein, mouse ; Interleukin-2 ; Interleukin-2 Receptor alpha Subunit ; Receptors, Interleukin-2 ; STAT5 Transcription Factor
Language	English
Publishing date	2021-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2021.03.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.

Hu, Wei / Wang, Zhong-Min / Feng, Yongqiang / Schizas, Michail / Hoyos, Beatrice E / van der Veeken, Joris / Verter, Jacob G / Bou-Puerto, Regina / Rudensky, Alexander Y

Nature immunology

2021 Volume 22, Issue 9, Page(s) 1163–1174

Abstract: The immunosuppressive function of regulatory T ( ... ...

Abstract	The immunosuppressive function of regulatory T (T
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; Autoimmunity/genetics ; Autoimmunity/immunology ; Cell Differentiation/immunology ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation/genetics ; Homeostasis/immunology ; Inflammation Mediators/metabolism ; Lymphocyte Activation/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/pathology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Forkhead Transcription Factors ; Foxp3 protein, mouse ; Inflammation Mediators
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-021-01001-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Retinol as a cofactor for PKCδ-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity.

Shabrova, Elena / Hoyos, Beatrice / Vinogradov, Valerie / Kim, Youn-Kyung / Wassef, Lesley / Leitges, Michael / Quadro, Loredana / Hammerling, Ulrich

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2016 Volume 30, Issue 3, Page(s) 1339–1355

Abstract: We previously defined that the mitochondria-localized PKCδ signaling complex stimulates the conversion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex. We demonstrated in vitro and ex vivo that retinol supplementation enhances ATP ... ...

Abstract	We previously defined that the mitochondria-localized PKCδ signaling complex stimulates the conversion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex. We demonstrated in vitro and ex vivo that retinol supplementation enhances ATP synthesis in the presence of the PKCδ signalosome. Here, we tested in vivo if a persistent oversupply of retinol would further impair glucose metabolism in a mouse model of diet-induced insulin resistance. We crossed mice overexpressing human retinol-binding protein (hRBP) under the muscle creatine kinase (MCK) promoter (MCKhRBP) with the PKCδ(-/-) strain to generate mice with a different status of the PKCδ signalosome and retinoid levels. Mice with a functional PKCδ signalosome and elevated retinoid levels (PKCδ(+/+)hRBP) developed the most advanced stage of insulin resistance. In contrast, elevation of retinoid levels in mice with inactive PKCδ did not affect remarkably their metabolism, resulting in phenotypic similarity between PKCδ(-/-)hRBP and PKCδ(-/-) mice. Therefore, in addition to the well-defined role of PKCδ in the etiology of metabolic syndrome, we present a novel PKCδ signaling pathway that requires retinol as a metabolic cofactor and is involved in the regulation of fuel utilization in mitochondria. The distinct role in whole-body energy homeostasis establishes the PKCδ signalosome as a promising target for therapeutic intervention in metabolic disorders.
MeSH term(s)	Animals ; Diet/adverse effects ; Disease Models, Animal ; Glucose/metabolism ; Homeostasis/physiology ; Humans ; Insulin Resistance/physiology ; Male ; Metabolic Syndrome/metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Obesity/metabolism ; Promoter Regions, Genetic/physiology ; Protein Kinase C-delta/metabolism ; Pyruvate Dehydrogenase Complex/metabolism ; Retinoids/metabolism ; Retinol-Binding Proteins/metabolism ; Signal Transduction/physiology ; Vitamin A/metabolism
Chemical Substances	Pyruvate Dehydrogenase Complex ; Retinoids ; Retinol-Binding Proteins ; Vitamin A (11103-57-4) ; Prkcd protein, mouse (EC 2.7.1.-) ; Protein Kinase C-delta (EC 2.7.11.13) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.15-281543
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

Order via subito

Details ▾

Article ; Online: β-apo-10'-carotenoids support normal embryonic development during vitamin A deficiency.

Spiegler, Elizabeth / Kim, Youn-Kyung / Hoyos, Beatrice / Narayanasamy, Sureshbabu / Jiang, Hongfeng / Savio, Nicole / Curley, Robert W / Harrison, Earl H / Hammerling, Ulrich / Quadro, Loredana

Scientific reports

2018 Volume 8, Issue 1, Page(s) 8834

Abstract: Vitamin A deficiency is still a public health concern affecting millions of pregnant women and children. Retinoic acid, the active form of vitamin A, is critical for proper mammalian embryonic development. Embryos can generate retinoic acid from maternal ...

Abstract	Vitamin A deficiency is still a public health concern affecting millions of pregnant women and children. Retinoic acid, the active form of vitamin A, is critical for proper mammalian embryonic development. Embryos can generate retinoic acid from maternal circulating β-carotene upon oxidation of retinaldehyde produced via the symmetric cleavage enzyme β-carotene 15,15'-oxygenase (BCO1). Another cleavage enzyme, β-carotene 9',10'-oxygenase (BCO2), asymmetrically cleaves β-carotene in adult tissues to prevent its mitochondrial toxicity, generating β-apo-10'-carotenal, which can be converted to retinoids (vitamin A and its metabolites) by BCO1. However, the role of BCO2 during mammalian embryogenesis is unknown. We found that mice lacking BCO2 on a vitamin A deficiency-susceptible genetic background (Rbp4
MeSH term(s)	Animals ; Carotenoids/metabolism ; Dioxygenases/deficiency ; Dioxygenases/metabolism ; Embryonic Development ; Mice, Inbred C57BL ; Mice, Knockout ; Retinoids/metabolism ; Retinol-Binding Proteins, Plasma/deficiency ; Retinol-Binding Proteins, Plasma/metabolism ; Vitamin A Deficiency/complications ; Vitamin A Deficiency/physiopathology ; beta-Carotene 15,15'-Monooxygenase/deficiency ; beta-Carotene 15,15'-Monooxygenase/metabolism
Chemical Substances	Rbp4 protein, mouse ; Retinoids ; Retinol-Binding Proteins, Plasma ; beta-apo-10'-carotenal ; Carotenoids (36-88-4) ; Dioxygenases (EC 1.13.11.-) ; Bco1 protein, mouse (EC 1.13.11.63) ; Bco2 protein, mouse (EC 1.14.99.-) ; beta-Carotene 15,15'-Monooxygenase (EC 1.14.99.36)
Language	English
Publishing date	2018-06-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-27071-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

Campbell, Clarissa / Dikiy, Stanislav / Bhattarai, Shakti K / Chinen, Takatoshi / Matheis, Fanny / Calafiore, Marco / Hoyos, Beatrice / Hanash, Alan / Mucida, Daniel / Bucci, Vanni / Rudensky, Alexander Y

Immunity

2018 Volume 48, Issue 6, Page(s) 1245–1257.e9

Abstract: The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, ... ...

Abstract	The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-deficient and -sufficient mice. pTreg cell deficiency led to heightened type 2 immune responses triggered by microbial exposure, which disrupted the niche of border-dwelling bacteria early during colonization. Moreover, impaired pTreg cell generation led to pervasive changes in metabolite profiles, altered features of the intestinal epithelium, and reduced body weight in the presence of commensal microbes. Absence of a single species of bacteria depleted in pTreg cell-deficient animals, Mucispirillum schaedleri, partially accounted for the sequelae of pTreg cell deficiency. These observations suggest that pTreg cells modulate the metabolic function of the intestinal microbiota by restraining immune defense mechanisms that may disrupt a particular bacterial niche.
MeSH term(s)	Animals ; Gastrointestinal Microbiome/immunology ; Host Microbial Interactions/immunology ; Immunity, Mucosal/immunology ; Intestinal Mucosa/immunology ; Mice ; T-Lymphocytes, Regulatory/immunology
Language	English
Publishing date	2018-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2018.04.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Hiding in plain sight: uncovering a new function of vitamin A in redox signaling.

Hoyos, Beatrice / Acin-Perez, Rebeca / Fischman, Donald A / Manfredi, Giovanni / Hammerling, Ulrich

Biochimica et biophysica acta

2011 Volume 1821, Issue 1, Page(s) 241–247

Abstract: The protein kinase Cδ signalosome modulates the generation of acetyl-Coenzyme A from glycolytic sources. This module is composed of four interlinked components: PKCδ, the signal adapter p66Shc, cytochrome c, and vitamin A. It resides in the intermembrane ...

Abstract	The protein kinase Cδ signalosome modulates the generation of acetyl-Coenzyme A from glycolytic sources. This module is composed of four interlinked components: PKCδ, the signal adapter p66Shc, cytochrome c, and vitamin A. It resides in the intermembrane space of mitochondria, and is at the center of a feedback loop that senses upstream the redox balance between oxidized and reduced cytochrome c as a measure of the workload of the respiratory chain, and transmits a forward signal to the pyruvate dehydrogenase complex to adjust the flux of fuel entering the tricarboxylic acid cycle. The novel role of vitamin A as co-activator and potential electron carrier, required for redox activation of PKCδ, is discussed. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.
MeSH term(s)	Acetyl Coenzyme A/metabolism ; Animals ; Citric Acid Cycle/physiology ; Cytochromes c/metabolism ; Electron Transport/physiology ; Humans ; Mitochondria/metabolism ; Oxidation-Reduction ; Oxidative Phosphorylation ; Protein Kinase C-delta/metabolism ; Pyruvate Dehydrogenase Complex/metabolism ; Signal Transduction ; Vitamin A/analogs & derivatives ; Vitamin A/metabolism
Chemical Substances	Pyruvate Dehydrogenase Complex ; Vitamin A (11103-57-4) ; anhydrovitamin A (235BBF3K97) ; Acetyl Coenzyme A (72-89-9) ; Cytochromes c (9007-43-6) ; Protein Kinase C-delta (EC 2.7.11.13)
Language	English
Publishing date	2011-06-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbalip.2011.06.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet.

Levine, Andrew G / Mendoza, Alejandra / Hemmers, Saskia / Moltedo, Bruno / Niec, Rachel E / Schizas, Michail / Hoyos, Beatrice E / Putintseva, Ekaterina V / Chaudhry, Ashutosh / Dikiy, Stanislav / Fujisawa, Sho / Chudakov, Dmitriy M / Treuting, Piper M / Rudensky, Alexander Y

Nature

2017 Volume 550, Issue 7674, Page(s) 142

Abstract: This corrects the article DOI: 10.1038/nature22360. ...

Abstract	This corrects the article DOI: 10.1038/nature22360.
Language	English
Publishing date	2017-09-29
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature24013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Stability and function of regulatory T cells expressing the transcription factor T-bet.

Nature

2017 Volume 546, Issue 7658, Page(s) 421–425

Abstract: Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 ( ... ...

Abstract	Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (T
MeSH term(s)	Animals ; Autoimmunity/immunology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Separation ; Female ; Immune Tolerance/immunology ; Lymphocyte Activation ; Male ; Mice ; T-Box Domain Proteins/metabolism ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th1 Cells/cytology ; Th1 Cells/immunology ; Th17 Cells/cytology ; Th17 Cells/immunology ; Th2 Cells/cytology ; Th2 Cells/immunology
Chemical Substances	T-Box Domain Proteins ; T-box transcription factor TBX21
Language	English
Publishing date	2017-06-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature22360
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito