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  1. Article ; Online: Turning fat into muscle: can this be an alternative to anti-obesity drugs such as semaglutide?

    Wackerhage, Henning / Hinrichs, Arne / Wolf, Eckhard / Hrabě de Angelis, Martin

    The Journal of physiology

    2024  Volume 602, Issue 8, Page(s) 1655–1658

    MeSH term(s) Humans ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/therapeutic use ; Muscles ; Glucagon-Like Peptides/therapeutic use ; Diabetes Mellitus, Type 2 ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Chemical Substances semaglutide (53AXN4NNHX) ; Anti-Obesity Agents ; Glucagon-Like Peptides (62340-29-8) ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP286430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord

    Caixeta, Fabio / Günther, Sven / Weber, Kathrin / Becker, Lore / Hrabe de Angelis, Martin / Kullander, Klas / Englert, Christoph

    Life science alliance, 1(4):e201800106

    2018  

    Abstract: Locomotion is coordinated by neuronal circuits of the spinal cord. Recently, dI6 neurons were shown to participate in the control of locomotion. A subpopulation of dI6 neurons expresses the Wilms tumor suppressor gene Wt1. However, the function of Wt1 in ...

    Institution Leibniz-Institut für Alternsforschung
    Abstract Locomotion is coordinated by neuronal circuits of the spinal cord. Recently, dI6 neurons were shown to participate in the control of locomotion. A subpopulation of dI6 neurons expresses the Wilms tumor suppressor gene Wt1. However, the function of Wt1 in these cells is not understood. Here, we aimed to identify behavioral changes and cellular alterations in the spinal cord associated with Wt1 deletion. Locomotion analyses of mice with neuron-specific Wt1 deletion revealed a slower walk with a decreased stride frequency and an increased stride length. These mice showed changes in their fore-/hindlimb coordination, which were accompanied by a loss of contralateral projections in the spinal cord. Neonates with Wt1 deletion displayed an increase in uncoordinated hindlimb movements and their motor neuron output was arrhythmic with a decreased frequency. The population size of dI6, V0, and V2a neurons in the developing spinal cord of conditional Wt1 mutants was significantly altered. These results show that the development of particular dI6 neurons depends on Wt1 expression and that loss of Wt1 is associated with alterations in locomotion.
    Keywords Cell Biology ; Development ; Neuroscience
    Language English
    Document type Article
    Database Repository for Life Sciences

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  3. Article: Veranlagung und Lebensstil – die Komplexität des Diabetes mellitus – Langerhans-Medaille 2021 – eine Kurzübersicht über den Preisträger Martin Hrabě de Angelis

    Hrabě de Angelis, Martin

    Diabetologie und Stoffwechsel

    2021  Volume 16, Issue 06, Page(s) 473–475

    Language German
    Publishing date 2021-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/a-1664-5151
    Database Thieme publisher's database

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  4. Book ; Online ; Thesis: Identifying novel genetic determinants of Indirect Genetic Effects

    Tomar, Archana [Verfasser] / Hrabě de Angelis, Martin [Akademischer Betreuer] / Hrabě de Angelis, Martin [Gutachter] / Wolf, Eckhard [Gutachter]

    2023  

    Author's details Archana Tomar ; Gutachter: Martin Hrabě de Angelis, Eckhard Wolf ; Betreuer: Martin Hrabě de Angelis
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  5. Book: Standards of mouse model phenotyping

    Hrabé de Angelis, Martin

    2006  

    Author's details ed. by Martin Hrabě de Angelis
    Keywords Maus ; Tiermodell ; Phänotyp
    Subject Labormaus ; Weiße Maus
    Language English
    Size XXVI, 331 S. : Ill., graph. Darst.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014491210
    ISBN 978-3-527-31031-9 ; 3-527-31031-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 A 3192 order for loan Magazin

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  6. Article ; Online: TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity.

    Tollot-Wegner, Marie / Jessen, Marco / Kim, KyungMok / Sanz-Moreno, Adrián / Spielmann, Nadine / Gailus-Durner, Valerie / Fuchs, Helmut / Hrabe de Angelis, Martin / von Eyss, Björn

    Breast cancer research : BCR

    2024  Volume 26, Issue 1, Page(s) 74

    Abstract: The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is restricted to the luminal population and is critical during puberty and pregnancy. Its function in the resting state remains however ... ...

    Abstract The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is restricted to the luminal population and is critical during puberty and pregnancy. Its function in the resting state remains however unclear. To evaluate whether it could be a target for cancer therapy, we investigated TRPS1 function in the healthy adult mammary gland using a conditional ubiquitous depletion mouse model where long-term depletion does not affect fitness. Using transcriptomic approaches, flow cytometry and functional assays, we show that TRPS1 activity is essential to maintain a functional luminal progenitor compartment. This requires the repression of both YAP/TAZ and SRF/MRTF activities. TRPS1 represses SRF/MRTF activity indirectly by modulating RhoA activity. Our work uncovers a hitherto undisclosed function of TRPS1 in luminal progenitors intrinsically linked to mechanotransduction in the mammary gland. It may also provide new insights into the oncogenic functions of TRPS1 as luminal progenitors are likely the cells of origin of many breast cancers.
    MeSH term(s) Animals ; Female ; Mice ; Mammary Glands, Animal/metabolism ; Mammary Glands, Animal/cytology ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Stem Cells/metabolism ; Repressor Proteins/metabolism ; Repressor Proteins/genetics ; Serum Response Factor/metabolism ; Serum Response Factor/genetics ; Humans ; Trans-Activators/metabolism ; Trans-Activators/genetics
    Chemical Substances Transcription Factors ; Repressor Proteins ; Trps1 protein, mouse ; Serum Response Factor ; TRPS1 protein, human ; Trans-Activators
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-024-01824-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5494: Show issues Location:
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  7. Book ; Online ; Thesis: In-depth characterization of mouse models for monogenic diabetes and gene therapy of Hnf4a-KI mice

    Amend, Anna-Lena Verfasser] / [Hrabé de Angelis, Martin [Akademischer Betreuer] / Hrabé de Angelis, Martin [Gutachter] / Schnieke, Angelika [Gutachter]

    2022  

    Author's details Anna-Lena Amend ; Gutachter: Martin Hrabě de Angelis, Angelika Schnieke ; Betreuer: Martin Hrabě de Angelis
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Book: Schlussbericht IG German Mouse Clinic

    Hrabé de Angelis, Martin

    program of medical genome research ; [Schlussbericht 2008 - 2013]

    2013  

    Title variant Schlussbericht Deutsche Mausklinik GMC
    Institution German Mouse Clinic
    Institut für Experimentelle Genetik
    Author's details [Institut für Experimentelle Genetik, Helmholtz Zentrum München]. Coordinator: [M.] Hrabě de Angelis
    Language German
    Size 217, [26] S., Ill., graph. Darst.
    Publishing place München
    Document type Book
    Note Förderkennzeichen BMBF 01GS0850-01GS0854 - 01GS0868 - 01GS0869. - Verbund-Nr. 01064291 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online: Schlussbericht IG German Mouse Clinic

    Hrabé de Angelis, Martin

    program of medical genome research ; Schlussbericht 2008 - 2013

    2013  

    Title variant Schlussbericht Deutsche Mausklinik GMC
    Institution German Mouse Clinic
    Institut für Experimentelle Genetik
    Author's details Institut für Experimentelle Genetik, Helmholtz Zentrum München. Coordinator: [M.] Hrabě de Angelis
    Language German
    Size Online-Ressource (243 S., 2,29 MB), Ill., graph. Darst.
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek
    Publishing place Hannover ; München
    Document type Book ; Online
    Note Förderkennzeichen BMBF 01GS0850-01GS0854 - 01GS0868 - 01GS0869. - Verbund-Nr. 01064291 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes

    Beckers, Johannes / Hrabě de Angelis, Martin / Schürmann, Annette

    Diabetes aktuell

    2021  Volume 19, Issue 02, Page(s) 62–65

    Abstract: Genetische Prädisposition, Ernährung und körperliche Aktivität sind Faktoren, die das Auftreten eines Typ-2-Diabetes beeinflussen. In dem Forschungsschwerpunkt (Academy) „Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes“ suchen ... ...

    Abstract Genetische Prädisposition, Ernährung und körperliche Aktivität sind Faktoren, die das Auftreten eines Typ-2-Diabetes beeinflussen. In dem Forschungsschwerpunkt (Academy) „Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes“ suchen Forschende des DZD (Deutsches Zentrum für Diabetesforschung) nach Genen, die für den Stoffwechsel wichtig sind. Ist die Wirkung dieser Gene aufgrund von Mutationen gestört, so kann dies zu einem erhöhten Diabetes-Risiko führen. Doch nicht nur der genetische Code selbst beeinflusst das Diabetes-Risiko. Auch der Lebensstil kann Einfluss darauf nehmen, in welchem Ausmaß bestimmte Gene abgelesen werden (Epigenetik). Aktuelle Untersuchungen zeigen, dass sich bereits einige Jahre vor der Diagnose eines Typ-2-Diabetes bei den Betroffenen epigenetische Veränderungen in Blutzellen und in den Langerhans-Inseln der Bauchspeicheldrüse feststellen lassen.
    Language German
    Publishing date 2021-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2225026-8
    ISSN 1864-1733 ; 1861-6089 ; 1617-0482
    ISSN (online) 1864-1733
    ISSN 1861-6089 ; 1617-0482
    DOI 10.1055/a-1410-3746
    Database Thieme publisher's database

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