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Article ; Online: SGK1 Target Genes Involved in Heart and Blood Vessel Functions in PC12 Cells

Yu-He Li / Chia-Cheng Sun / Po-Ming Chen / Hsin-Hung Chen

Cells, Vol 12, Iss 1641, p

2023 Volume 1641

Abstract: Serum and glucocorticoid-regulated kinase 1 (SGK1) is expressed in neuronal cells and involved in the pathogenesis of hypertension and metabolic syndrome, regulation of neuronal function, and depression in the brain. This study aims to identify the ... ...

Abstract	Serum and glucocorticoid-regulated kinase 1 (SGK1) is expressed in neuronal cells and involved in the pathogenesis of hypertension and metabolic syndrome, regulation of neuronal function, and depression in the brain. This study aims to identify the cellular mechanisms and signaling pathways of SGK1 in neuronal cells. In this study, the SGK1 inhibitor GSK650394 is used to suppress SGK1 expression in PC12 cells using an in vitro neuroscience research platform. Comparative transcriptomic analysis was performed to investigate the effects of SGK1 inhibition in nervous cells using mRNA sequencing (RNA-seq), differentially expressed genes (DEGs), and gene enrichment analysis. In total, 12,627 genes were identified, including 675 and 2152 DEGs at 48 and 72 h after treatment with GSK650394 in PC12 cells, respectively. Gene enrichment analysis data indicated that SGK1 inhibition-induced DEGs were enriched in 94 and 173 genes associated with vascular development and functional regulation and were validated using real-time PCR, Western blotting, and GEPIA2. Therefore, this study uses RNA-seq, DEG analysis, and GEPIA2 correlation analysis to identify positive candidate genes and signaling pathways regulated by SGK1 in rat nervous cells, which will enable further exploration of the underlying molecular signaling mechanisms of SGK1 and provide new insights into neuromodulation in cardiovascular diseases.
Keywords	SGK1 ; neuron cells ; PC12 cells ; RNA-seq ; gene enrichment ; Biology (General) ; QH301-705.5
Subject code	572 ; 610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predictive value of motor-evoked potentials for motor recovery in patients with hemiparesis secondary to acute ischemic stroke

Cheng-Chang Yen / Hsin-Hung Chen / Chao-Hsien Lee / Ching-Huang Lin

Annals of Medicine, Vol 55, Iss

2023 Volume 1

Abstract: AbstractBackground Motor recovery following a stroke is related to the initial stroke severity and corticospinal tract integrity. One of the outcomes representing corticospinal tract integrity is the motor evoked potential (MEP). This study aimed to ... ...

Abstract	AbstractBackground Motor recovery following a stroke is related to the initial stroke severity and corticospinal tract integrity. One of the outcomes representing corticospinal tract integrity is the motor evoked potential (MEP). This study aimed to investigate the predictive value of MEP for motor recovery in patients with acute ischemic stroke.Patients and Methods Patients with hemiparesis secondary to initial acute ischemic stroke were enrolled. MEPs of the upper limb were assessed as preserved (MEP+) or absent (MEP-) response ≤10 days post-stroke. Fugl-Meyer assessment (FMA) was performed at baseline and post-stroke at 30 and 90 days. A modified Rankin scale (mRS) was conducted at 90 days post-stroke. Patients were divided into two groups according to the highest FMA score of MEP- patients. Generalized estimating equations and logistic regression were used for our study analysis.Results Sixty-one participants were included in this study. The highest FMA score of MEP- patients ≤10 days after stroke was 38. Among patients with an initial FMA score ≤38, FMA scores at 30 and 90 days post-stroke were significantly higher in MEP + patients than in MEP- patients. Proportional recovery at 30 and 90 days post-stroke was significantly higher in MEP + patients than in MEP- patients. MEP + patients had a higher percentage of good functional outcomes than MEP- patients, without statistical difference. Among patients with initial FMA score >38, FMA scores were 60.4 ± 4.8 and 63.9 ± 2.9 and proportional recovery was 65.2 ± 27.0% and 83.7 ± 24.6% at 30 and 90 days post-stroke, respectively.Conclusions Among patients with moderate-to-severe ischemic stroke, MEP + patients had better motor recoveries (approximately 70%) than MEP– patients at 90 days post-stroke. MEP + patients had better functional outcomes than MEP- patients.
Keywords	Stroke ; motor evoked potential ; paretic limb ; motor recovery ; Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intravascular laser irradiation of blood as novel migraine treatment

Hsin-Hung Chen / Chun-Yu Lin / Shean-Jen Chen / Wan-Yun Huang / Chien-Wei Kuo / Shin-Tsu Chang

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

an observational study

2023 Volume 8

Abstract: Abstract Background Migraine is one of four major chronic diseases that cause disability. Decreases in regional cerebral blood flow (rCBF) occur during migraine attacks. Laser therapy is extensively employed in treating other vascular diseases; ... ...

Abstract	Abstract Background Migraine is one of four major chronic diseases that cause disability. Decreases in regional cerebral blood flow (rCBF) occur during migraine attacks. Laser therapy is extensively employed in treating other vascular diseases; nevertheless, its effectiveness in migraine management remains largely unknown. Therefore, we evaluated the effect of low-level intravascular laser irradiation of blood (ILIB) therapy in patients with migraine. Methods We performed an observational case–control study in 24 patients suffering from migraine. Patients were divided into an ILIB treatment group and a traditional rehabilitation group. This study performed clinical assessments and single-photon emission computed tomography (SPECT) prior to and after the treatment and 1 month later. Changes in rCBF-SPECT between groups and between timepoints were compared to clinical outcomes. Results Nine patients undergoing rehabilitation and fifteen patients undergoing ILIB were studied from baseline to 1 month follow-up. The ILIB group, visual analog scale for pain (P = 0.001), Montreal Cognitive Assessment (P = 0.003), and Athens Insomnia Scale (P < 0.001) symptom scores significantly improved after treatment. SPECT imaging showed a 1.27 ± 0.27 fold increase in rCBF after ILIB treatment, and no significant differences in the rehabilitation group. Conclusions Low-level ILIB therapy is associated with better clinical and vascular outcomes, and may be a feasible treatment option for migraine. Although our sample size was small, our data provide a starting point for migraine laser therapy research.
Keywords	Migraine ; Rehabilitation ; ILIB ; SPECT ; Cerebral blood flow ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between systemic sclerosis and peripheral arterial disease

Ming-Chia Hsieh / Hsin-Hung Chen / Tzu-Yi Chou / Ta-Wei Su

BMJ Open, Vol 11, Iss

a nationwide observation retrospective claim records cohort study in Taiwan

2021 Volume 9

Keywords	Medicine ; R
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men

Sheng-Kuang Wang / Meng-Chih Lee / Chia-Lien Hung / Hsin-Hung Chen / Chun-Cheng Liao / Yu-Lung Chiu

PLoS ONE, Vol 17, Iss

2022 Volume 3

Abstract: Background Aging-related hypogonadism in men is related to the deterioration of overall health. Those with this disease rarely receive treatment. The hypertriglyceridemic waist (HTGW) phenotype is a tool for predicting abnormalities of cardiovascular ... ...

Abstract	Background Aging-related hypogonadism in men is related to the deterioration of overall health. Those with this disease rarely receive treatment. The hypertriglyceridemic waist (HTGW) phenotype is a tool for predicting abnormalities of cardiovascular metabolism. However, the relationship between the HTGW phenotype and hypogonadism remains undetermined. This study aimed to determine the association between HTGW phenotype and hypogonadism in different age groups. Methods Data of this cross-sectional study were obtained from MJ Health Screening Center in Taiwan from 2007 to 2016. The HTGW phenotype was divided into four categories based on whether the waist circumference (WC) and triglyceride levels were normal. WC of <90 cm and triglyceride level of <150 mg/dL were defined as normal. Hypogonadism was defined as a testosterone level of <300 ng/dL. Results Overall, 6442 male participants were divided into three age groups: <50, 50–64, and ≥65 years (n = 4135, 1958, and 349; age groups 1, 2, and 3, respectively). The overall prevalence of hypogonadism was 10.6%. In group 1, participants with HTGW (odds ratio, 1.98; 95% confidence interval (CI), 1.354–2.896) had a higher risk of hypogonadism than those with normal WC and normal triglyceride levels after adjustment for body mass index and fasting blood glucose level. In group 2, participants with HTGW (odds ratio, 1.873; 95% CI, 1.099–3.193) had an increased risk of hypogonadism after adjustment for body mass index, fasting blood glucose level, Cholesterol levels, high-density lipoprotein (HDL) levels, low-density lipoprptein (LDL) levels and smoking status. However, no relationship was observed between HTGW phenotype and hypogonadism in group 3. Conclusion HTGW phenotype was highly associated with hypogonadism in Taiwanese adult men. More attention should be paid to men aged <50 years with HTGW.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men.

Sheng-Kuang Wang / Meng-Chih Lee / Chia-Lien Hung / Hsin-Hung Chen / Chun-Cheng Liao / Yu-Lung Chiu

PLoS ONE, Vol 17, Iss 3, p e

2022 Volume 0265629

Abstract	Background Aging-related hypogonadism in men is related to the deterioration of overall health. Those with this disease rarely receive treatment. The hypertriglyceridemic waist (HTGW) phenotype is a tool for predicting abnormalities of cardiovascular metabolism. However, the relationship between the HTGW phenotype and hypogonadism remains undetermined. This study aimed to determine the association between HTGW phenotype and hypogonadism in different age groups. Methods Data of this cross-sectional study were obtained from MJ Health Screening Center in Taiwan from 2007 to 2016. The HTGW phenotype was divided into four categories based on whether the waist circumference (WC) and triglyceride levels were normal. WC of <90 cm and triglyceride level of <150 mg/dL were defined as normal. Hypogonadism was defined as a testosterone level of <300 ng/dL. Results Overall, 6442 male participants were divided into three age groups: <50, 50-64, and ≥65 years (n = 4135, 1958, and 349; age groups 1, 2, and 3, respectively). The overall prevalence of hypogonadism was 10.6%. In group 1, participants with HTGW (odds ratio, 1.98; 95% confidence interval (CI), 1.354-2.896) had a higher risk of hypogonadism than those with normal WC and normal triglyceride levels after adjustment for body mass index and fasting blood glucose level. In group 2, participants with HTGW (odds ratio, 1.873; 95% CI, 1.099-3.193) had an increased risk of hypogonadism after adjustment for body mass index, fasting blood glucose level, Cholesterol levels, high-density lipoprotein (HDL) levels, low-density lipoprptein (LDL) levels and smoking status. However, no relationship was observed between HTGW phenotype and hypogonadism in group 3. Conclusion HTGW phenotype was highly associated with hypogonadism in Taiwanese adult men. More attention should be paid to men aged <50 years with HTGW.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Kidney transplantation waiting times and risk of cardiovascular events and mortality

Pei-Ling Tang / Chih-Yang Hsu / Hsin-Hung Chen / Yahn-Bor Chern / Chi-Cheng Lai

BMJ Open, Vol 12, Iss

a retrospective observational cohort study in Taiwan

2022 Volume 5

Keywords	Medicine ; R
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Statistical Modeling and Simulation of Online Shopping Customer Loyalty Based on Machine Learning and Big Data Analysis

Jui-Chan Huang / Po-Chang Ko / Cher-Min Fong / Sn-Man Lai / Hsin-Hung Chen / Ching-Tang Hsieh

Security and Communication Networks, Vol

2021 Volume 2021

Abstract: With the increase in the number of online shopping users, customer loyalty is directly related to product sales. This research mainly explores the statistical modeling and simulation of online shopping customer loyalty based on machine learning and big ... ...

Abstract	With the increase in the number of online shopping users, customer loyalty is directly related to product sales. This research mainly explores the statistical modeling and simulation of online shopping customer loyalty based on machine learning and big data analysis. This research mainly uses machine learning clustering algorithm to simulate customer loyalty. Call the k-means interactive mining algorithm based on the Hash structure to perform data mining on the multidimensional hierarchical tree of corporate credit risk, continuously adjust the support thresholds for different levels of data mining according to specific requirements and select effective association rules until satisfactory results are obtained. After conducting credit risk assessment and early warning modeling for the enterprise, the initial preselected model is obtained. The information to be collected is first obtained by the web crawler from the target website to the temporary web page database, where it will go through a series of preprocessing steps such as completion, deduplication, analysis, and extraction to ensure that the crawled web page is correctly analyzed, to avoid incorrect data due to network errors during the crawling process. The correctly parsed data will be stored for the next step of data cleaning or data analysis. For writing a Java program to parse HTML documents, first set the subject keyword and URL and parse the HTML from the obtained file or string by analyzing the structure of the website. Secondly, use the CSS selector to find the web page list information, retrieve the data, and store it in Elements. In the overall fit test of the model, the root mean square error approximation (RMSEA) value is 0.053, between 0.05 and 0.08. The results show that the model designed in this study achieves a relatively good fitting effect and strengthens customers’ perception of shopping websites, and relationship trust plays a greater role in maintaining customer loyalty.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	650 ; 006
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan

Hsin-Hung Chen / Chien-Tung Wu / Yueh-Ting Tsai / Chun-Wei Ho / Ming-Chia Hsieh / Jung-Nien Lai

Evidence-Based Complementary and Alternative Medicine, Vol

A Nationwide Study

2021 Volume 2021

Abstract: Introduction. Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), ...

Abstract	Introduction. Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. Materials and Methods. This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. Results. In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56–0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82–0.90) and presented a dose-dependent effect. Conclusion. The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Seafloor characterization in the southernmost Okinawa Trough from underwater optical imagery

Yu-Cheng Chou / Chau-Chang Wang / Hsin-Hung Chen / Yuan-He Lin

Terrestrial, Atmospheric and Oceanic Sciences, Vol 30, Iss 5, Pp 717-

2019 Volume 737

Abstract: This paper presents the seafloor survey results obtained in 2016 and 2017 using four deep-towed vehicles, developed by the Institute of Undersea Technology at National Sun Yat-sen University, for investigating mineral resource potential offshore ... ...

Abstract	This paper presents the seafloor survey results obtained in 2016 and 2017 using four deep-towed vehicles, developed by the Institute of Undersea Technology at National Sun Yat-sen University, for investigating mineral resource potential offshore northeastern Taiwan. The deep-towed vehicles include the Abyss Twist-pair Imaging System (ATIS), the Video-guided Multi-corer (V-Corer), the TV-guided Grabber (TVG), and the Fiber-optical Instrumentation Towed System (FITS). The seafloor video surveys and sampling were conducted at five survey sites in the southern Okinawa Trough through five survey cruises. A total of 82.69 km of seafloor survey tracks were accomplished and plenty of seafloor characteristics and ecological phenomena were observed through the four deep-towed vehicles. The seafloor survey results, including the video data and the samples of animals, sediments, and mounds, have been provided to different scientific teams for conducting research on marine geophysics, marine geology, marine geochemistry, and marine ecology. The video data can be cross-checked and used as the supporting evidence for the analysis results from the scientific researchers.
Keywords	Geography (General) ; G1-922 ; Geology ; QE1-996.5
Subject code	333
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Chinese Geoscience Union
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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