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Article ; Online: The role of echinacoside-based cross-linker nanoparticles in the treatment of osteoporosis.

Hu, Dandan / Cheng, Chunan / Bian, Zhen / Xu, Yubo

2024 Volume 12, Page(s) e17229

Abstract: Background: Current drugs for treating osteoporosis may lead to toxic side effects. Echinacoside (ECH) is a natural small molecule drug. This study examined and compared the therapeutic effects of cross-linker (CL)-ECH and ECH-free nanoparticles on ... ...

Abstract	Background: Current drugs for treating osteoporosis may lead to toxic side effects. Echinacoside (ECH) is a natural small molecule drug. This study examined and compared the therapeutic effects of cross-linker (CL)-ECH and ECH-free nanoparticles on osteoporosis. Methods: Echinocandin-based CL-ECH nanoparticles were prepared, and the nanoparticle size and drug loading were optimized and characterized by adjusting the ratio. The antioxidant effect of CL-ECH nanoparticles on bone marrow-derived macrophages (BMDMs) was analyzed using flow cytometry, immunofluorescence staining and quantitative real-time polymerase chain reaction (qRT-PCR). Bone marrow stromal cells (BMSCs)-based detection of bone-producing effects was conducted using alkaline phosphatase (ALP), Alizarin Red S (ARS) and qRT-PCR. TRAP, phalloidin staining, and qRT-PCR was performed to detect osteogenesis-inhibiting effect on BMDMs. CL-ECH nanoparticles were applied to treat an ovariectomized (OVX) mouse model at low doses. Results: Compared to ECH, CL-ECH nanoparticles suppressed oxidative stress in BMDMs by promoting NRF-2 nuclear translocation, which inhibited the production of both reactive oxygen species (ROS) and osteoclast production through downregulating NF- Conclusions: The current discoveries provided a solid theoretical foundation for the development of a new generation of anti-bone resorption drugs and antiosteoporosis drugs.
MeSH term(s)	Animals ; Mice ; Osteoporosis/drug therapy ; Glycosides/pharmacology ; Bone Diseases, Metabolic ; Alkaline Phosphatase
Chemical Substances	echinacoside (I04O1DT48T) ; Glycosides ; Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.17229
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring better stratification methods for individualized treatment of patients with colorectal cancer liver metastases.

Zhang, Deyao / Hu, Dandan

Annals of palliative medicine

2022 Volume 11, Issue 10, Page(s) 3369–3370

MeSH term(s)	Humans ; Liver Neoplasms/pathology ; Hepatectomy ; Colorectal Neoplasms/pathology
Language	English
Publishing date	2022-09-12
Publishing country	China
Document type	Letter
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-22-754
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Article ; Online: PARP10

Wang, Ling / Jiang, Chuang / Hu, Dandan

Aging

2023 Volume 15, Issue 14, Page(s) 6757–6773

Abstract: Acute myeloid leukemia is a heterogeneous disease of the hematopoietic system, which possesses a poor prognosis; thus, the identification of novel molecular markers is urgently needed to better define the risk stratification and optimize treatment ... ...

Abstract	Acute myeloid leukemia is a heterogeneous disease of the hematopoietic system, which possesses a poor prognosis; thus, the identification of novel molecular markers is urgently needed to better define the risk stratification and optimize treatment therapies for this disease. Here, we investigated the roles of the PARP family genes in AML by analyzing their mRNA expression profiles and their association with clinical features using data from TCGA and GSE. Our results showed that
MeSH term(s)	Humans ; Mutation ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Progression-Free Survival ; Multivariate Analysis ; Prognosis ; Hematopoietic Stem Cell Transplantation ; Poly(ADP-ribose) Polymerases/genetics ; Proto-Oncogene Proteins/genetics
Chemical Substances	Biomarkers, Tumor ; PARP10 protein, human (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Proto-Oncogene Proteins
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204832
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Article: [Effect of surface treatment on the three-point bend bonding strength between pure titanium fabricated by selective laser melting and porcelain].

Hu, Dan-Dan / Ren, Can-Xia / Luo, Xiao-Ping

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2023 Volume 32, Issue 3, Page(s) 230–235

Abstract: Purpose: To evaluate the effect of surface treatment on bonding strength between pure titanium formed by selective laser melting and porcelain.: Methods: Pure titanium strips (64) and cobalt-chromium alloy strips (16) were laser machined to meet ISO ... ...

Abstract	Purpose: To evaluate the effect of surface treatment on bonding strength between pure titanium formed by selective laser melting and porcelain. Methods: Pure titanium strips (64) and cobalt-chromium alloy strips (16) were laser machined to meet ISO 9693 standards. The pure titanium specimens were divided into 4 groups according to the sandblasting pressure and interlayer material. The sandblasting pressure of 0.25 MPa of bonder porcelain group was TB1, the sandblasting pressure of 0.25 MPa of gold coating group was TG1, the sandblasting pressure of 0.45 MPa of bonder porcelain group was TB2, and the sandblasting pressure of 0.45 MPa of the gold coating group was TG2(n=16). After porcelain fusing, half of the specimens in each group were tested for three-point bend bonding strength, and the other half were tested after 10 000 cycles of thermal cycling(n=8). The bonding strength of cobalt-chromium alloy after sandblasting at 0.25 MPa and 0.45 MPa was taken as the control group and recorded as group C1, C2(n=8). The bonding strength was tested using classical three-point bending experiment. The surface roughness of pure titanium was measured by laser scanning confocal microscope(LSCM). Field emission scanning electron microscopy(FE-SEM) was used to observe the interface morphology of titanium-ceramic. The surface morphology of titanium after porcelain stripping was observed with stereomicroscope and fracture modes were analyzed by it. Graphpad Prism 8.0 software package was used for statistical analysis of the data. Results: The bonding strength of group TG2 was (40.16±3.97) MPa and (37.38±2.39) MPa of group TG1, which were significantly higher than that of group TB2 (36.32±1.44) MPa and group TB1 (33.75±2.31) MPa (P＜0.05). The bonding strength of group TB2 with 0.45 MPa sandblasting was significantly higher than that of group TB1 with 0.25 MPa sandblasting (P＜0.05). There was no significant decrease in titanium-ceramic bonding strength before and after thermal cycling. When the sandblasting pressure increased from 0.25 MPa to 0.45 MPa, the roughness increased significantly (P＜0.05). The fracture modes were mixed. Conclusions: Under the conditions of this study, gold coating can significantly improve the bonding strength of Ti22 porcelain and SLM pure titanium than bonder porcelain, and increase of sandblasting pressure can further improve the bonding strength of titanium-porcelain. After 10 000 cycles of thermal cycling, the titanium-porcelain bonding strength did not decrease significantly.
MeSH term(s)	Dental Porcelain ; Titanium ; Dental Bonding ; Materials Testing ; Chromium Alloys ; Lasers ; Gold ; Surface Properties ; Microscopy, Electron, Scanning
Chemical Substances	Dental Porcelain (12001-21-7) ; Titanium (D1JT611TNE) ; Chromium Alloys ; Gold (7440-57-5)
Language	Chinese
Publishing date	2023-09-09
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Maize Methionine Sulfoxide Reductase Genes ZmMSRA2 and ZmMSRA5.1 Involved in the Tolerance to Osmotic or Salinity Stress in Arabidopsis and Maize

Hu, Dandan / Guo, Qiang / Zhang, Yuhua / Chen, Fanguo

Plant Mol Biol Rep. 2023 Mar., v. 41, no. 1 p.118-133

2023

Abstract: Methionine (Met), including the free and protein-bound forms, can easily be oxidized in the presence of excess reactive oxygen species (ROS) under conditions of abiotic stress to form Met sulfoxide (MetO). This reaction can be reversed by MetO reductases ...

Abstract	Methionine (Met), including the free and protein-bound forms, can easily be oxidized in the presence of excess reactive oxygen species (ROS) under conditions of abiotic stress to form Met sulfoxide (MetO). This reaction can be reversed by MetO reductases (MSRs), which are known to be involved in a variety of stress response mechanisms in plants, but the functions of their maize MSRA homologs have not been reported to date. Cytoplasmic ZmMSRA2 and secretary ZmMSRA5.1, previously shown to be induced under salinity or drought stress, belong to the MSRA subfamily. In the present study, their constitutive expression in Arabidopsis resulted in notable increases in MSR enzymatic activity; virus-induced gene silencing (VIGS) analysis in maize indicated that the silencing expression of ZmMSRA2 or ZmMSRA5.1 decreased the tolerance of seedlings to osmotic or salinity, respectively; the ectopic expression of ZmMSRA2 in Arabidopsis increased the tolerance of seedlings to mannitol, H₂O₂, and ABA, and that of ZmMSRA5.1 enhanced the tolerance to NaCl and H₂O₂. Compared with that of the wild-type, the germination rates of seeds overexpressing ZmMSRA2 or ZmMSRA5.1 were higher under osmotic or salinity stress, respectively. The effect of active ZmMSRA2 in Arabidopsis was the suppression of ROS accumulation and the increase in intracellular proline content; ZmMSRA5.1 led to improved ion transport and decreased ROS content. The expression of the maize MSRA homologs in Arabidopsis resulted in no observed changes in the transcription of Arabidopsis MSRA subfamily members, while genes of the MSRB subfamily were downregulated overall. Together, our findings suggest that ZmMSRA2 participates in osmotic stress tolerance by decreasing the ROS content, and enhancing the proline and ABA pathways, whereas ZmMSRA5.1 is involved in tolerance to salinity by reducing ROS accumulation and modifying ion transportation. Characterization of these two genes contributes to the understanding of redox metabolism in maize.
Keywords	Arabidopsis ; corn ; enzyme activity ; gene expression ; genes ; germination ; ion transport ; mannitol ; metabolism ; methionine ; osmotic stress ; oxidoreductases ; proline ; reactive oxygen species ; salinity ; salt stress ; salt tolerance ; stress response ; stress tolerance ; sulfoxides ; water stress
Language	English
Dates of publication	2023-03
Size	p. 118-133.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	2018592-3
ISSN	1572-9818 ; 0735-9640
ISSN (online)	1572-9818
ISSN	0735-9640
DOI	10.1007/s11105-022-01354-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of heat treatment on the bonding strength of pure titanium processed via selective laser melting and porcelain

HU Dandan / LUO Xiaoping / REN Canxia

口腔疾病防治, Vol 30, Iss 8, Pp 549-

2022 Volume 555

Abstract: Objective To evaluate the effect of heat treatment on the bonding strength of pure titanium formed by selective laser melting (SLM) and porcelain. Methods Ninety-six pure titanium specimens were laser machined to meet ISO 9693 standards. The specimens ... ...

Abstract	Objective To evaluate the effect of heat treatment on the bonding strength of pure titanium formed by selective laser melting (SLM) and porcelain. Methods Ninety-six pure titanium specimens were laser machined to meet ISO 9693 standards. The specimens were divided into a heat treated group (A) and a nonheat treated group (B). According to the porcelain type, the specimens in groups A and B were divided into Super Ti22 (a), Titankeramik (b), and Triceram (c) groups. Then, according to sandblasting pressures of 0.25 MPa (1) and 0.45 MPa (2), they were further divided into Aa1, Aa2, Ab1, Ab2, Ac1, Ac2, Ba1, Ba2, Bb1, Bb2, Bc1, and Bc2 groups. The surface morphology and roughness of the sandblasted specimens were assessed using a laser scanning confocal microscope. After the porcelain was fused, the three-point bending titanium-porcelain bonding strength was tested. A stereomicroscope was used to characterize the titanium-porcelain interfaces and determine the mode of failure. Results The Vickers hardness of group A specimens (188.21 ± 11.94) was significantly lower than that of group B specimens (204.48 ± 6.32) HV (P<0.05). The roughness value in group A1 (2.90 ± 0.32) μm was significantly lower than that in group A2 (3.43 ± 0.43) μm (P<0.05). Specimens in group B1 (2.62 ± 0.08) μm were significantly smaller than those in group B2 (3.01 ± 0.06) μm (P<0.05). The bonding strength in group Aa1 was (33.75 ± 2.31) MPa, group Aa2 was (36.32 ± 1.44) MPa, group Ab1 was (39.82 ± 2.28) MPa, group Ab2 was (33.74 ± 1.53) MPa and group Ac2 was (38.63 ± 1.36) MPa, which was significantly higher than that in the corresponding groups Ba1 (29.65 ± 1.10) MPa, Ba2 (27.17 ± 2.24) MPa, Bb1 (27.29 ± 1.61) MPa, Bb2 (23.85 ± 0.97) MPa, and Bc2 (35.75 ± 1.93) MPa (P<0.05). With increasing sandblasting pressure, the bonding strength of the titanium ceramic in group Aa2 was significantly higher than in group Aa1, while that in group Ab2 was significantly lower than that in group Ab1 (P<0.05). In groups A, Bc1 and Bc2, the ...
Keywords	selective laser melting， ; fixed prosthesis， ; pure titanium， ; porcelain， ; heat treatment， ; sandblasting， ; titanium-porcelain bonding， ; bonding strength， ; roughness， ; vickers hardness， ; three-point bending， ; fracture mode， ; Medicine ; R
Subject code	796
Language	Chinese
Publishing date	2022-08-01T00:00:00Z
Publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk of hepatitis B virus reactivation and its effect on survival in advanced hepatocellular carcinoma patients treated with hepatic arterial infusion chemotherapy and lenvatinib plus programmed death receptor-1 inhibitors.

Yang, Zhenyun / Guan, Renguo / Fu, Yizhen / Hu, Dandan / Zhou, Zhongguo / Chen, Minshan / Zhang, Yaojun

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1336619

Abstract: Background: Hepatitis B virus (HBV) reactivation is a common complication in hepatocellular carcinoma (HCC) patients treated with chemotherapy or immunotherapy. This study aimed to evaluate the risk of HBV reactivation and its effect on survival in HCC ... ...

Abstract	Background: Hepatitis B virus (HBV) reactivation is a common complication in hepatocellular carcinoma (HCC) patients treated with chemotherapy or immunotherapy. This study aimed to evaluate the risk of HBV reactivation and its effect on survival in HCC patients treated with HAIC and lenvatinib plus PD1s. Methods: We retrospectively collected the data of 213 HBV-related HCC patients who underwent HAIC and lenvatinib plus PD1s treatment between June 2019 to June 2022 at Sun Yat-sen University, China. The primary outcome was the risk of HBV reactivation. The secondary outcomes were overall survival (OS), progression-free survival (PFS), and treatment-related adverse events. Results: Sixteen patients (7.5%) occurred HBV reactivation in our study. The incidence of HBV reactivation was 5% in patients with antiviral prophylaxis and 21.9% in patients without antiviral prophylaxis, respectively. The logistic regression model indicated that for HBV reactivation, lack of antiviral prophylaxis ( Conclusion: HBV reactivation may occur in HCC patients treated with HAIC and lenvatinib plus PD1s. Patients with HBV reactivation had shorter survival time compared with non-reactivation. Therefore, HBV-related HCC patients should undergo antiviral therapy and HBV-DNA monitoring before and during the combination treatment.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/drug therapy ; Hepatitis B virus/physiology ; Liver Neoplasms/drug therapy ; Retrospective Studies ; Antiviral Agents/therapeutic use ; Receptors, Death Domain ; Phenylurea Compounds ; Quinolines
Chemical Substances	lenvatinib (EE083865G2) ; Antiviral Agents ; Receptors, Death Domain ; Phenylurea Compounds ; Quinolines
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1336619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Unraveling the spatial-temporal distribution patterns of soil abundant and rare bacterial communities in China's subtropical mountain forest.

Wu, Panpan / Hu, Dandan / Guo, Jiaheng / Li, Jinlong / Zhong, Quanlin / Cheng, Dongliang

Frontiers in microbiology

2024 Volume 15, Page(s) 1323887

Abstract: Introduction: The pivotal roles of both abundant and rare bacteria in ecosystem function are widely acknowledged. Despite this, the diversity elevational patterns of these two bacterial taxa in different seasons and influencing factors remains ... ...

Abstract	Introduction: The pivotal roles of both abundant and rare bacteria in ecosystem function are widely acknowledged. Despite this, the diversity elevational patterns of these two bacterial taxa in different seasons and influencing factors remains underexplored, especially in the case of rare bacteria. Methods: Here, a metabarcoding approach was employed to investigate elevational patterns of these two bacterial communities in different seasons and tested the roles of soil physico-chemical properties in structuring these abundant and rare bacterial community. Results and discussion: Our findings revealed that variation in elevation and season exerted notably effects on the rare bacterial diversity. Despite the reactions of abundant and rare communities to the elevational gradient exhibited similarities during both summer and winter, distinct elevational patterns were observed in their respective diversity. Specifically, abundant bacterial diversity exhibited a roughly U-shaped pattern along the elevation gradient, while rare bacterial diversity increased with the elevational gradient. Soil moisture and N:P were the dominant factor leading to the pronounced divergence in elevational distributions in summer. Soil temperature and pH were the key factors in winter. The network analysis revealed the bacteria are better able to adapt to environmental fluctuations during the summer season. Additionally, compared to abundant bacteria, the taxonomy of rare bacteria displayed a higher degree of complexity. Our discovery contributes to advancing our comprehension of intricate dynamic diversity patterns in abundant and rare bacteria in the context of environmental gradients and seasonal fluctuations.
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1323887
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Article: Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens.

Hou, Yue / Han, Bo / Lin, Zehua / Liu, Qizheng / Liu, Zhenhe / Si, Hongbin / Hu, Dandan

Microorganisms

2024 Volume 12, Issue 3

Abstract: Chicken coccidiosis costs the poultry industry over GBP 10 billion per year. The main method of preventing and controlling coccidiosis in chickens continues to be the use of drugs. Unfortunately, the prevalence of drug resistance in the field reduces or ... ...

Abstract	Chicken coccidiosis costs the poultry industry over GBP 10 billion per year. The main method of preventing and controlling coccidiosis in chickens continues to be the use of drugs. Unfortunately, the prevalence of drug resistance in the field reduces or even eliminates the effectiveness of drugs, and drug residues in the food supply chain can also can be harmful to humans. Therefore, safe and effective anticoccidial drugs are urgently needed. Natural products have many advantages such as being safe, effective and inexpensive and are a sustainable way to control coccidiosis. In this study, the anticoccidial effects of six natural compounds were tested by
Language	English
Publishing date	2024-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12030601
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Article ; Online: Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction.

Wang, Peipei / Ouyang, Jing / Zhou, Kaiqian / Hu, Dandan / Zhang, Shengnan / Zhang, Aihua / Yang, Yunwen

Biomedical journal

2024 , Page(s) 100730

Abstract: Background: Mitochondrial dysfunction is a critical factor in the pathogenesis of acute kidney injury (AKI). Agents that ameliorate mitochondrial dysfunction hold potential for AKI treatment. The objective of this study was to investigate the impact of ... ...

Abstract	Background: Mitochondrial dysfunction is a critical factor in the pathogenesis of acute kidney injury (AKI). Agents that ameliorate mitochondrial dysfunction hold potential for AKI treatment. The objective of this study was to investigate the impact of olesoxime, a novel mitochondrial-targeted agent, on cisplatin-induced AKI. Methods: In vivo, a cisplatin-induced AKI mouse model was established by administering a single intraperitoneal dose of cisplatin (25 mg/kg) to male C57BL/6 mice for 72 hours, followed by gavage of either olesoxime or a control solution. In vitro, human proximal tubular HK2 cells were cultured and subjected to treatments with cisplatin, either in the presence or absence of olesoxime. Results: In vivo, our findings demonstrated that olesoxime administration significantly mitigated the nephrotoxic effects of cisplatin in mice, as evidenced by reduced blood urea nitrogen (BUN) and serum creatinine (SCr) levels, improved renal histopathology, and decreased expression of renal tubular injury markers such as kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Furthermore, olesoxime administration markedly reduced cisplatin-induced apoptosis, inflammation, and oxidative stress in the kidneys of AKI mice. Additionally, olesoxime treatment effectively restored mitochondrial function in the kidneys of AKI mice. In vitro, our results indicated that olesoxime treatment protected against cisplatin-induced apoptosis and mitochondrial dysfunction in cultured HK2 cells. Notably, cisplatin's anticancer effects were unaffected by olesoxime treatment in human cancer cells. Conclusion: The results of this study suggest that olesoxime is a viable and efficient therapeutic agent in the treatment of cisplatin-induced acute kidney injury presumably by alleviating mitochondrial dysfunction.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2320-2890
ISSN (online)	2320-2890
ISSN	2320-2890
DOI	10.1016/j.bj.2024.100730
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