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Article ; Online: Association between dietary carbohydrate intake percentage and epilepsy prevalence in the NHANES 2013-2018: a cross-sectional study.

Liu, Yanting / Hu, Guanqun / Zhang, Meiyun / Lin, Jingna

2024 , Page(s) 1–9

Abstract: Background: Epilepsy is a neurological disorder characterized by recurrent seizures. We aimed to investigate the association between the percentage of dietary carbohydrate intake (DCI) and epilepsy prevalence among American adults.: Methods: We ... ...

Abstract	Background: Epilepsy is a neurological disorder characterized by recurrent seizures. We aimed to investigate the association between the percentage of dietary carbohydrate intake (DCI) and epilepsy prevalence among American adults. Methods: We analyzed the data from 9,584 adults aged 20-80 years who participated in the National Health and Nutrition Examination Survey from 2013 to 2018. Logistic regression was applied to explore the association between the percentage of DCI and epilepsy prevalence. Results: A total of 146 (1.5%) individuals with epilepsy were enrolled in this study. The average age of the participants was 56.4 years, and 5,454 (56.9%) individuals were female. A high DCI was associated with an increased prevalence of epilepsy (odds ratio [OR], 4.56; 95% confidence interval [CI], 1.11-18.69; Conclusions: A high percentage of DCI was associated with an increased prevalence of epilepsy. The risk of epilepsy increased 3.5-fold with a 1% increase in DCI. These results suggest an important role of DCI in the dietary management of epilepsy.
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1447449-9
ISSN	1476-8305 ; 1028-415X
ISSN (online)	1476-8305
ISSN	1028-415X
DOI	10.1080/1028415X.2024.2329481
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Article ; Online: Temporal alterations of pituitary adenylate cyclase activating polypeptide and its receptors in a rat model induced by recurrent chemical stimulations: Relevant to chronic migraine.

Wu, Hangfei / Dong, Zhao / Liu, Yinglu / Zhang, Qing / Zhang, Mingjie / Hu, Guanqun / Yu, Shengyuan / Han, Xun

Molecular pain

2023 Volume 19, Page(s) 17448069231152129

Abstract: ... ...

Abstract	Background
MeSH term(s)	Rats ; Male ; Animals ; Pituitary Adenylate Cyclase-Activating Polypeptide/metabolism ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I/metabolism ; Calcitonin Gene-Related Peptide/metabolism ; Rats, Sprague-Dawley ; Stimulation, Chemical ; Migraine Disorders
Chemical Substances	Pituitary Adenylate Cyclase-Activating Polypeptide ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/17448069231152129
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Article ; Online: Cognitive impairment in a classical rat model of chronic migraine may be due to alterations in hippocampal synaptic plasticity and N-methyl-D-aspartate receptor subunits.

Zhang, Mingjie / Liu, Yufei / Hu, Guanqun / Kang, Li / Ran, Ye / Su, Min / Yu, Shengyuan

Molecular pain

2020 Volume 16, Page(s) 1744806920959582

Abstract: Although migraine is a major global public health problem, its impact on cognitive abilities remains controversial. Thus, the present study investigated the effects of repeated administration of inflammatory soup to the dura of rats, over three weeks, on ...

Abstract	Although migraine is a major global public health problem, its impact on cognitive abilities remains controversial. Thus, the present study investigated the effects of repeated administration of inflammatory soup to the dura of rats, over three weeks, on spatial cognition, hippocampal synaptic plasticity, and the expression of N-methyl-D-aspartate receptor subunits. Additionally, low doses of amitriptyline (5 mg/kg) were applied to assess its therapeutic effects. The inflammatory soup group exhibited significant reductions in the cutaneous stimulation threshold, presence of mild cognitive impairment, and decreased long-term potentiation in right hippocampus. However, amitriptyline improved pain behaviors, enhanced cognitive function, and increased synaptic plasticity in the inflammatory soup rats. On the other hand, the administration of amitriptyline to normal rats negatively influenced synaptic plasticity and reduced the expression of N-methyl-D-aspartate receptor subunits. The present results indicate that inflammatory soup-induced dural nociception led to impairments in spatial cognition that could be attributed to reductions in hippocampal long-term potentiation and the decreased expression of N-methyl-D-aspartate receptor subunits.
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/1744806920959582
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Article ; Online: Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine.

Zhang, Qing / Han, Xun / Wu, Hangfei / Zhang, Mingjie / Hu, Guanqun / Dong, Zhao / Yu, Shengyuan

Molecular pain

2019 Volume 15, Page(s) 1744806918820452

Abstract: Migraine is the seventh most disabling disorder globally, with prevalence of 11.7% worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular system, and calcitonin gene-related peptide (CGRP) is an important therapeutic ... ...

Abstract	Migraine is the seventh most disabling disorder globally, with prevalence of 11.7% worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular system, and calcitonin gene-related peptide (CGRP) is an important therapeutic target for migraine in this system. Recent studies suggested an emerging role of pituitary adenylate cyclase-activating peptide (PACAP) in migraine. However, the relation between CGRP and PACAP and the role of PACAP in migraine remain undefined. In this study, we established a novel repetitive (one, three, and seven days) electrical stimulation model by stimulating dura mater in conscious rats. Then, we determined expression patterns in the trigeminal ganglion and the trigeminal nucleus caudalis of the trigeminovascular system. Electrical stimulation decreased facial mechanical thresholds, and the order of sensitivity was as follows: vibrissal pad >inner canthus >outer canthus (P < 0.001). The electrical stimulation group exhibited head-turning and head-flicks (P < 0.05) nociceptive behaviors. Importantly, electrical stimulation increased the expressions of CGRP, PACAP, and the PACAP-preferring type 1 (PAC1) receptor in both trigeminal ganglion and trigeminal nucleus caudalis (P < 0.05). The expressions of two vasoactive intestinal peptide (VIP)-shared type 2 (VPAC1 and VPAC2) receptors were increased in the trigeminal ganglion, whereas in the trigeminal nucleus caudalis, their increases were peaked on Day 3 and then decreased by Day 7. PACAP was colocalized with NEUronal Nuclei (NeuN), PAC1, and CGRP in both trigeminal ganglion and the trigeminal nucleus caudalis. Our results demonstrate that the repetitive electrical stimulation model can simulate the allodynia during the migraine chronification, and PACAP plays a role in the pathogenesis of migraine potentially via PAC1 receptor.
MeSH term(s)	Animals ; Calcitonin Gene-Related Peptide/metabolism ; Electric Stimulation Therapy/methods ; Female ; Male ; Migraine Disorders/physiopathology ; Migraine Disorders/therapy ; Nociception/drug effects ; Nonlinear Dynamics ; Phosphopyruvate Hydratase/metabolism ; Pituitary Adenylate Cyclase-Activating Polypeptide/metabolism ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide/metabolism ; Statistics, Nonparametric ; Time Factors ; Trigeminal Caudal Nucleus/physiology
Chemical Substances	Pituitary Adenylate Cyclase-Activating Polypeptide ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide ; Phosphopyruvate Hydratase (EC 4.2.1.11) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2019-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/1744806918820452
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Article ; Online: Volumetric abnormalities of the brain in a rat model of recurrent headache.

Jia, Zhihua / Tang, Wenjing / Zhao, Dengfa / Hu, Guanqun / Li, Ruisheng / Yu, Shengyuan

Molecular pain

2018 Volume 14, Page(s) 1744806918756466

Abstract: Voxel-based morphometry is used to detect structural brain changes in patients with migraine. However, the relevance of migraine and structural changes is not clear. This study investigated structural brain abnormalities based on voxel-based morphometry ... ...

Abstract	Voxel-based morphometry is used to detect structural brain changes in patients with migraine. However, the relevance of migraine and structural changes is not clear. This study investigated structural brain abnormalities based on voxel-based morphometry using a rat model of recurrent headache. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious male rats. Rats were subgrouped according to the frequency and duration of the inflammatory soup infusion. Tactile sensory testing was conducted prior to infusion of the inflammatory soup or saline. The periorbital tactile thresholds in the high-frequency inflammatory soup stimulation group declined persistently from day 5. Increased white matter volume was observed in the rats three weeks after inflammatory soup stimulation, brainstem in the in the low-frequency inflammatory soup-infusion group and cortex in the high-frequency inflammatory soup-infusion group. After six weeks' stimulation, rats showed gray matter volume changes. The brain structural abnormalities recovered after the stimulation was stopped in the low-frequency inflammatory soup-infused rats and persisted even after the high-frequency inflammatory soup stimulus stopped. The changes of voxel-based morphometry in migraineurs may be the result of recurrent headache. Cognition, memory, and learning may play an important role in the chronification of migraines. Reducing migraine attacks has the promise of preventing chronicity of migraine.
MeSH term(s)	Animals ; Brain/abnormalities ; Brain/pathology ; Disease Models, Animal ; Gray Matter/pathology ; Headache/pathology ; Magnetic Resonance Imaging ; Male ; Organ Size ; Rats, Sprague-Dawley ; Recurrence ; Sensory Thresholds ; Touch ; White Matter/pathology
Language	English
Publishing date	2018-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/1744806918756466
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Article ; Online: Novel gap junction protein beta-1 gene mutation associated with a stroke-like syndrome and central nervous system involvement in patients with X-linked Charcot-Marie-Tooth Type 1: A case report and literature review.

Hu, Guanqun / Zhang, Lvming / Zhang, Mingjie / Yang, Chunxiao / Nie, Xiting / Xiang, Feng / Chen, Li / Dong, Zhao / Yu, Shengyuan

Clinical neurology and neurosurgery

2019 Volume 180, Page(s) 68–73

Abstract: Gap junction protein beta-1 (GJB1) gene mutations lead to X-linked Charcot-Marie-Tooth Type 1 (CMTX1). We studied a Chinese family with CMTX1 and identiﬁed a novel GJB1 point mutation. Our patient had a transient stroke-like clinical manifestations and ... ...

Abstract	Gap junction protein beta-1 (GJB1) gene mutations lead to X-linked Charcot-Marie-Tooth Type 1 (CMTX1). We studied a Chinese family with CMTX1 and identiﬁed a novel GJB1 point mutation. Our patient had a transient stroke-like clinical manifestations and magnetic resonance imaging (MRI) changes. An analysis of the genomic DNA of the proband showed a T to C hemizygous mutation in the GJB1 gene at nucleotide position 380, causing a predicted amino acid change from isoleucine to threonine at codon 127, which predicted structural alterations disrupting the function of the GJB1 protein. This novel point mutation expanded the spectrum of GJB1 mutations known to be associated with CMTX1. We performed a PubMed review of CMTX cases with central nervous system involvement in the English-language literature from the past 20 years, and summarized the demographic data, nucleotide and amino acid changes, clinical characteristics, clinical manifestations, and neuroimaging features.
MeSH term(s)	Amino Acid Substitution ; Asian People ; Charcot-Marie-Tooth Disease/complications ; Charcot-Marie-Tooth Disease/diagnostic imaging ; Charcot-Marie-Tooth Disease/genetics ; Connexins/genetics ; DNA/genetics ; Electrodiagnosis ; Electroencephalography ; Humans ; Magnetic Resonance Imaging ; Male ; Point Mutation/genetics ; Stroke/genetics ; Syndrome ; Treatment Outcome ; Young Adult ; Gap Junction beta-1 Protein
Chemical Substances	Connexins ; DNA (9007-49-2)
Language	English
Publishing date	2019-03-28
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2019.03.018
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Article ; Online: Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine.

Su, Min / Ran, Ye / He, Zizi / Zhang, Mingjie / Hu, Guanqun / Tang, Wenjing / Zhao, Dengfa / Yu, Shengyuan

Molecular pain

2018 Volume 14, Page(s) 1744806918754612

Abstract: Objective Although nociceptive sensitisation is an important pathophysiological process in migraine and migraine chronification, its underlying mechanisms remain unclear. Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has a critical role in ...

Abstract	Objective Although nociceptive sensitisation is an important pathophysiological process in migraine and migraine chronification, its underlying mechanisms remain unclear. Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has a critical role in both neuropathic pain and morphine tolerance. The present study examined whether elements of the TLR4 pathway contribute to hyperalgesia induced by dural inflammation in rats. Methods A rat model of migraine was established by infusing a dural inflammatory soup. A group pretreated with TAK-242 was used to inhibit the activation of TLR4. The protein levels of TLR4 and its downstream molecules in the trigeminal pathway were examined by Western blot and immunofluorescence. The expression of activated microglia and astrocytes was also analysed. Levels of interleukin-1 beta, tumour necrosis factor-alpha, and brain-derived neurotrophic factor were measured by enzyme-linked immunosorbent assay. Results Acute inflammatory soup infusion induced time-dependent facial mechanical hyperalgesia, which was blocked by TAK-242 pretreatment. The inflammatory soup stimulus increased the production of TLR4 downstream molecules and interleukin-1 beta. Higher levels of microglia activation and brain-derived neurotrophic factor release were observed following the administration of the inflammatory soup but were alleviated by TAK-242. Conclusions These data suggest that the TLR4 signalling pathway promotes hyperalgesia induced by acute inflammatory soup delivery by stimulating the production of proinflammatory cytokines and activating microglia.
MeSH term(s)	Acute Disease ; Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Calcium-Binding Proteins/metabolism ; Disease Models, Animal ; Dura Mater/pathology ; Glial Fibrillary Acidic Protein/metabolism ; Hyperalgesia/complications ; Hyperalgesia/drug therapy ; Hyperalgesia/pathology ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/pathology ; Interleukin-1beta/metabolism ; Male ; Microfilament Proteins/metabolism ; Microglia/drug effects ; Microglia/metabolism ; Migraine Disorders/complications ; Migraine Disorders/drug therapy ; Migraine Disorders/pathology ; NF-kappa B/metabolism ; Nociception/drug effects ; Pain Threshold/drug effects ; Proto-Oncogene Proteins c-fos/metabolism ; Rats, Sprague-Dawley ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Aif1 protein, rat ; Brain-Derived Neurotrophic Factor ; Calcium-Binding Proteins ; Glial Fibrillary Acidic Protein ; Interleukin-1beta ; Microfilament Proteins ; NF-kappa B ; Proto-Oncogene Proteins c-fos ; Sulfonamides ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha ; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
Language	English
Publishing date	2018-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/1744806918754612
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Article ; Online: Wider range of allodynia in a rat model of repeated dural nociception compared with infraorbital nerve chronic constriction injury.

Hu, Guanqun / Zhang, Mingjie / Su, Min / Zhang, Qing / Wu, Hangfei / Wang, Xiaolin / Dong, Zhao / Yu, Shengyuan

Neuroscience letters

2017 Volume 666, Page(s) 120–126

Abstract: Background: To identify differences in allodynia and grooming behaviours between rat models of either repeated dural nociception with inflammatory soup (IS) or infraorbital nerve chronic constriction injury (IoN-CCI).: Methods: Repeated dural ... ...

Abstract	Background: To identify differences in allodynia and grooming behaviours between rat models of either repeated dural nociception with inflammatory soup (IS) or infraorbital nerve chronic constriction injury (IoN-CCI). Methods: Repeated dural nociception was induced via the application of IS to the dural meninges and IoN-CCI was applied to model neuropathic pain. All surgeries were performed on the right side and a sham operation was performed on the control group. Mechanical and thermal withdrawal thresholds were tested on different facial areas and hindpaw during the interictal period and grooming behaviours were recorded. Results: A significant decreases was found in the mechanical withdrawal thresholds of the bilateral vibrissa pad and right periorbital area in both the IS and the IoN-CCI groups, but only in the left periorbital area of the IS group. Hindpaw thermal allodynia was evident only in the IS group. Ipsilateral hindpaw grooming behaviour increased in the IS group and facial grooming behaviour increased in the IoN-CCI group. Conclusions: Repeated dural nociception induced by IS and IoN-CCI in rats effectively simulated chronic migraine (CM) and trigeminal neuralgia (TN), respectively. The IS group exhibited a wider range of allodynia than the IoN-CCI group, but further studies are necessary to determine underlying mechanisms.
MeSH term(s)	Animals ; Constriction ; Disease Models, Animal ; Hyperalgesia/physiopathology ; Male ; Maxillary Nerve/physiopathology ; Migraine Disorders/physiopathology ; Neuralgia/physiopathology ; Nociception/physiology ; Rats, Wistar
Language	English
Publishing date	2017-12-23
Publishing country	Ireland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2017.12.048
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