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Article: Shenfu injection: a review of pharmacological effects on cardiovascular diseases.

Xu, Fei-Fei / Xie, Xiao-Fang / Hu, Hai-Yan / Tong, Rong-Sheng / Peng, Cheng

2024 Volume 15, Page(s) 1279584

Abstract: Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Shenfu Decoction created more than 700 years ago. SFI has been widely used in China for over 30 years for treating ... ...

Abstract	Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Shenfu Decoction created more than 700 years ago. SFI has been widely used in China for over 30 years for treating cardiovascular diseases. The main components in it include ginsenosides and aconitum alkaloids. In recent years, the role of SFI in the treatment of cardiovascular diseases has attracted much attention. The pharmacological effects and therapeutic applications of SFI in cardiovascular diseases are summarized here, highlighting pharmacological features and potential mechanisms developments, confirming that SFI can play a role in multiple ways and is a promising drug for treating cardiovascular diseases.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1279584
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Article: Ultrasonographic assessment of cardiac function and disease severity in coronary heart disease.

Zhang, Jing-Fang / Du, Yin-Hui / Hu, Hai-Yan / Han, Xiu-Qing

World journal of clinical cases

2021 Volume 9, Issue 28, Page(s) 8366–8373

Abstract: Background: Coronary heart disease (CHD) causes many adverse cardiovascular events and poses a threat to the patient's health and quality of life.: Aim: To evaluate ultrasonography for evaluation of cardiac function and lesion degree in patients with ...

Abstract	Background: Coronary heart disease (CHD) causes many adverse cardiovascular events and poses a threat to the patient's health and quality of life. Aim: To evaluate ultrasonography for evaluation of cardiac function and lesion degree in patients with CHD. Methods: A total of 106 patients with CHD (study group) and 106 healthy individuals (control group) in our hospital from March 2019 to September 2020 were selected for this study. All subjects were examined by ultrasound, and the mitral orifice's early-to-late diastolic blood flow velocity ratio (E/A), left ventricular end-diastolic volume (LVDd), and left atrial diameter (LAD) were measured. Values were compared between the study group and healthy group, and the correlation between the ultrasonic parameters of patients with different cardiac function grades and the degree of CHD were assessed. In addition, the ultrasonic parameters of patients with different prognoses were compared after a follow-up for 6 mo. Results: E/A (1.46 ± 0.34) of the study group was smaller than that of the control group (1.88 ± 0.44), while LVDd (58.24 ± 5.05 mm) and LAD (43.31 ± 4.38 mm) were larger (48.15 ± 3.93 and 34.94 ± 2.81, respectively; Conclusion: The ultrasonic parameters of patients with CHD are abnormal, and differ significantly in patients with different cardiac function grades, lesion degree, and prognosis.
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i28.8366
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Article: Identification of a Novel

Zhu, Hong-Xia / Hu, Lin-Feng / Hu, Hai-Yan / Zhou, Feng / Wu, Liu-Liu / Wang, Shi-Wen / Rozhkova, Tetiana / Li, Cheng-Wei

Plant disease

2023 Volume 107, Issue 4, Page(s) 1139–1150

Abstract: Wheat sharp eyespot is a serious disease caused by the ... ...

Abstract	Wheat sharp eyespot is a serious disease caused by the phytopathogens
MeSH term(s)	Rhizoctonia/physiology ; Triticum/microbiology ; Antifungal Agents ; Phylogeny ; Plant Diseases/microbiology ; Streptomyces ; Plant Extracts
Chemical Substances	Antifungal Agents ; Plant Extracts
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-06-22-1493-RE
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Article ; Online: Identification of a Novel Streptomyces sp. Strain HU2014 Showing Growth Promotion and Biocontrol Effect Against Rhizoctonia spp. in Wheat

Zhu, Hong-xia / Hu, Lin-feng / Hu, Hai-yan / Zhou, Feng / Wu, Liu-liu / Wang, Shi-wen / Rozhkova, Tetiana / Li, Cheng-Wei

Plant Disease. 2023 Apr. 03, v. 107, no. 4 p.1139-1150

2023

Abstract: Wheat sharp eyespot is a serious disease caused by the phytopathogens Rhizoctonia cerealis and R. solani. Some species in the genus Streptomyces have been identified as potential biocontrol agents against phytopathogens. In this investigation, the ... ...

Abstract	Wheat sharp eyespot is a serious disease caused by the phytopathogens Rhizoctonia cerealis and R. solani. Some species in the genus Streptomyces have been identified as potential biocontrol agents against phytopathogens. In this investigation, the physiological, biochemical, phylogenetic, and genomic characteristics of strain HU2014 indicate that it is a novel Streptomyces sp. most closely related to Streptomyces albireticuli. Strain HU2014 exhibited strong antifungal activity against R. cerealis G11 and R. solani YL-3. Ultraperformance liquid chromatography–mass spectrometry on the four extracts from the extracellular filtrate of strain HU2014 identified 10 chemical constituents in the Natural Products Atlas with high match levels (more than 90%). In an antifungal efficiency test on wheat sharp eyespot, two extracts significantly reduced the lesion areas on bean leaves infected by R. solani YL-3. The drenching of wheat in pots with spore suspension of strain HU2014 demonstrated a control efficiency of 65.1% against R. cerealis G11 (compared with 66.9% when treated by a 30% hymexazol aqueous solution). Additionally, in vitro and pot experiments demonstrated that strain HU2014 can produce indoleacetic acid, siderophores, extracellular enzymes, and solubilized phosphate, and it can promote plant growth. We conclude that strain HU2014 could be a valuable microbial resource for growth promotion of wheat and biological control of wheat sharp eyespot.
Keywords	Rhizoctonia cerealis ; Streptomyces albireticuli ; antifungal properties ; aqueous solutions ; beans ; biological control ; filtrates ; genomics ; growth promotion ; hymexazol ; indole acetic acid ; liquid chromatography ; mass spectrometry ; phosphates ; phylogeny ; plant growth ; plant pathogens ; siderophores ; solubilization ; spores ; wheat ; antifungal activity ; biocontrol ; plant-growth promotion ; Streptomyces ; wheat sharp eyespot
Language	English
Dates of publication	2023-0403
Size	p. 1139-1150.
Publishing place	The American Phytopathological Society
Document type	Article ; Online
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-06-22-1493-RE
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Baseline Pydiflumetofen Sensitivity of Fusarium pseudograminearum Isolates Collected from Henan, China, and Potential Resistance Mechanisms

Zhou, Feng / Cui, Ye-Xian / Zhou, Yu-Dong / Duan, Si-Tong / Wang, Zi-Yi / Xia, Zhi-Hao / Hu, Hai-Yan / Liu, Run-Qiang / Li, Cheng-Wei

Plant Disease. 2023 Aug. 01, v. 107, no. 8 p.2417-2423

2023

Abstract: Fusarium crown rot (FCR), caused by Fusarium pseudograminearum, is one of the most important diseases impacting wheat production in the Huanghuai region, the most important wheat-growing region of China. The current study found that the SDHI fungicide ... ...

Abstract	Fusarium crown rot (FCR), caused by Fusarium pseudograminearum, is one of the most important diseases impacting wheat production in the Huanghuai region, the most important wheat-growing region of China. The current study found that the SDHI fungicide pydiflumetofen, which was recently developed by Syngenta Crop Protection, provided effective control of 67 wild-type F. pseudograminearum isolates in potato dextrose agar, with an average EC₅₀ value of 0.060 ± 0.0098 μg/ml (SE). Further investigation revealed that the risk of fungicide resistance in pydiflumetofen was medium to high. Four F. pseudograminearum mutants generated by repeated exposure to pydiflumetofen under laboratory conditions indicated that pydiflumetofen resistance was associated with fitness penalties. Mutants exhibited significantly (P < 0.05) reduced sporulation in mung bean broth and significantly (P < 0.05) reduced pathogenicity in wheat seedlings. Sequence analysis indicated that the observed pydiflumetofen resistance of the mutants was likely associated with amino acid changes in the different subunits of the succinate dehydrogenase target protein, including R18L and V160M substitutions in the FpSdhA sequence; D69V, D147G, and C257R in FpSdhB; and W78R in FpSdhC. This study found no evidence of cross-resistance between pydiflumetofen and the alternative fungicides tebuconazole, fludioxonil, carbendazim, or fluazinam, which all have distinct modes of action and could therefore be used in combination or rotation with pydiflumetofen to reduce the risk of resistance emerging in the field. Taken together, these results indicate that pydiflumetofen has potential as a novel fungicide for the control of FCR caused by F. pseudograminearum and could therefore be of great significance in ensuring high and stable wheat yields in China.
Keywords	Fusarium pseudograminearum ; amino acids ; carbendazim ; cross resistance ; crown rot ; culture media ; fludioxonil ; fungicide resistance ; mung beans ; pathogenicity ; plant protection ; risk ; risk reduction ; sequence analysis ; sporulation ; succinate dehydrogenase (quinone) ; tebuconazole ; wheat ; China ; cross-resistance ; pydiflumetofen ; resistance mechanism
Language	English
Dates of publication	2023-0801
Size	p. 2417-2423.
Publishing place	The American Phytopathological Society
Document type	Article ; Online
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-08-22-1852-RE
Database	NAL-Catalogue (AGRICOLA)

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Article: [Effect of CPNE7 siRNA on cell proliferation and osteogenic differentiation in human periodontal ligament cells].

Liu, Cai-Hong / Hu, Hai-Yan

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2016 Volume 25, Issue 4, Page(s) 420–425

Abstract: Purpose: To investigate the effect and mechanism of CPNE7 siRNA on proliferation and osteogenic differentiation in human periodontal ligament cells (hPDLs).: Methods: hPDLs were isolated by enzyme digestion, transfected with pSUPER-CPNE7 in order to ... ...

Abstract	Purpose: To investigate the effect and mechanism of CPNE7 siRNA on proliferation and osteogenic differentiation in human periodontal ligament cells (hPDLs). Methods: hPDLs were isolated by enzyme digestion, transfected with pSUPER-CPNE7 in order to knock down CPNE7. The expression of CPNE7 mRNA and protein was detected by Western blot and RT-PCR; ELISA was carried out for the activity of NF-κB; hPDLs were pretreated with PDTC (10 μmol/L) for 30 min, CCK8 was used to evaluate the proliferation; ALP activity was assayed with ELISA; The expression of RUNX2, OSX and OCN was measured with RT-PCR and Western blot. The data were analyzed with SPSS11.0 software package. Results: After transfection with pSUPER-CPNE7, CPNE7 expression was significantly decreased (P<0.05). ELISA assay indicated that CPNE7 siRNA enhanced NF-κB activity. CCK8 and RT-PCR assay showed that CPNE7 siRNA inhibited cell proliferation, ALP activity and decreased the expression of RUNX2, OSX and OCN in hPDLs; however, these effects were abolished by PDTC. Conclusions: CPNE7 siRNA inhibits the proliferation and osteogenic differentiation of hPDLs through NF-κB pathway.
MeSH term(s)	Alkaline Phosphatase ; Blotting, Western ; Cell Differentiation ; Cell Proliferation ; Humans ; Membrane Proteins ; NF-kappa B ; Osteogenesis ; Periodontal Ligament ; RNA, Small Interfering ; Signal Transduction ; Transfection
Chemical Substances	CPNE7 protein, human ; Membrane Proteins ; NF-kappa B ; RNA, Small Interfering ; Alkaline Phosphatase (EC 3.1.3.1)
Language	Chinese
Publishing date	2016-08
Publishing country	China
Document type	Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Article: [Effects and mechanisms of Egr-1 on inflammatory responses induced by mechanical stress in human periodontal ligament cells].

Hu, Hai-Yan / Gao, Zhi-Biao

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2016 Volume 25, Issue 5, Page(s) 553–559

Abstract: Purpose: To investigate the effects and mechanisms of silencing Egr-1 on MS-mediated secretion and expression of inflammatory cytokines in hPDLs.: Methods: The secretion and expression of IL-1β, IL-6, IL-8 and IL-11 were detected using ELISA and RT- ... ...

Abstract	Purpose: To investigate the effects and mechanisms of silencing Egr-1 on MS-mediated secretion and expression of inflammatory cytokines in hPDLs. Methods: The secretion and expression of IL-1β, IL-6, IL-8 and IL-11 were detected using ELISA and RT-PCR when cells were cultured with or without various duration (6, 12, 24 and 48 h) and force (3%, 6%, 12%, 15%) of mechanica stress (MS). RT-PCR and Western blotting were used to evaluate the expression of Egr-1 under a 12% MS for 24 h. The roles of silencing Egr-1 in MS-mediated expression of inflammatory cytokines were determined using ELISA and RT-PCR. The protein levels of PTEN/PI3K/Akt signaling pathway were determined using Western blotting. Moreover, cells were pretreated with 20 μmol/L LY294002 for 30 min, in order to study the mechanisms of Egr-1 in MS-mediated secretion and expression of inflammatory cytokines. Statistical analysis was performed using SPSS 11.0 software package. Results: The secretion and expression of IL-1β, IL-6, IL-8 and IL-11 were increased gradually with the time under a MS force of 12% in hPDLs, and peaked in cells after exposure to MS for 24 h. The mRNA and protein levels of Egr-1 were elevated in hPDLs after exposure to 12% MS for 24 h. Moreover, depletion of Egr-1 inhibited MS-mediated secretion and expression of inflammatory cytokines. Knockdown of Egr-1 reduced the protein level of PTEN, and increased the protein expression of p-PI3K and p-Akt in hPDLs. LY294002 blocked partially the inhibitory roles of Egr-1 in the secretion and expression of inflammatory cytokines. Conclusions: Depletion of Egr-1 suppressed the secretion and expression of inflammatory cytokines induced by MS through PTEN/PI3K/Akt pathway.
MeSH term(s)	Blotting, Western ; Cells, Cultured ; Chromones ; Cytokines ; Early Growth Response Protein 1/metabolism ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interleukin-11 ; Interleukin-1beta ; Interleukin-6 ; Interleukin-8 ; Morpholines ; Periodontal Ligament/physiology ; Phosphatidylinositol 3-Kinases ; RNA, Messenger ; Signal Transduction ; Stress, Mechanical
Chemical Substances	Chromones ; Cytokines ; EGR1 protein, human ; Early Growth Response Protein 1 ; IL11 protein, human ; Interleukin-11 ; Interleukin-1beta ; Interleukin-6 ; Interleukin-8 ; Morpholines ; RNA, Messenger ; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	Chinese
Publishing date	2016-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Article: [MiR-142-3p inhibits lipopolysaccharide-induced inflammatory response in human periodontal ligament cells through targeting IRAK1].

Hu, Hai-Yan / Wang, Jun-Qiang

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2016 Volume 25, Issue 6, Page(s) 682–687

Abstract: Purpose: To investigate the effects of miR-142-3p overexpression on secretion of inflammatory factors in human periodontal ligament cells (hPDLCs) induced by lipopolysaccharide (LPS) and its underlying mechanism.: Methods: hPDLCs were cultured by ... ...

Abstract	Purpose: To investigate the effects of miR-142-3p overexpression on secretion of inflammatory factors in human periodontal ligament cells (hPDLCs) induced by lipopolysaccharide (LPS) and its underlying mechanism. Methods: hPDLCs were cultured by tissue cultivation in vitro and treated with various concentrations of LPS for 6, 12, 24 and 48 h. hPDLCs were treated with miR-142-3p mimics for 24 h in the presence of 2.0 μg/mL LPS and the expression levels of inflammatory factors (TNF-α, IL-6 and IL-1β) were detected by ELISA assay. The target relationship between miR-142-3p and interleukin-1 receptor- associated kinase 1 (IRAK1) was detected by dual-luciferase reporter assay. The miR-142-3p and IRAK1 mRNA expression was measured by qRT-PCR. The protein expression levels of IRAK1, TLR4 and NF-κB were detected by Western blotting. Statistical analysis was performed using SPSS 16.0 software package. Results: The miR-142-3p expression level was decreased significantly at 24 h in 2.0 μg/mL LPS-treated hPDLCs (P<0.01). Transfection of miR-142-3p mimics remarkably increased miR-142-3p expression (P<0.01). The secretion of inflammatory factors (TNF-α, IL-6 and IL-1β) in LPS-treated hPDLCs was significantly decreased by miR-142-3p overexpression (P<0.05). Dual-luciferase reporter assay showed a directly targeting relationship between miR-142-3p and IRAK1. Overexpression of miR-142-3p significantly reduced the IRAK1 protein expression in LPS-treated hPDLCs (P<0.05), whereas no obvious effect on IRAK1 mRNA expression was noted (P>0.05). Moreover, miR-142-3p overexpression markedly diminished the protein expression of TLR4 and phosphorylated NF-κB in LPS-treated hPDLCs (P<0.05). Conclusions: Overexpression of miR-142-3p can alleviate the inflammatory response induced by LPS in hPDLCs and the underlying mechanism may be associated with targeting and inhibiting IRAK1 expression leading to suppression of TLR4/NF-κB inflammatory signaling pathway through which miR-142-3p overexpression protects peridentium against inflammation.
MeSH term(s)	Cell Line ; Humans ; Inflammation ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Interleukin-6 ; Lipopolysaccharides/metabolism ; MicroRNAs ; NF-kappa B ; Periodontal Ligament/physiology ; Signal Transduction ; Transfection ; Tumor Necrosis Factor-alpha
Chemical Substances	Interleukin-6 ; Lipopolysaccharides ; MicroRNAs ; NF-kappa B ; Tumor Necrosis Factor-alpha ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1)
Language	Chinese
Publishing date	2016-12
Publishing country	China
Document type	Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Article ; Online: Assessment of compliance with oral nutritional supplementation and exploration of barriers and facilitators for patients after gastrectomy: A mixed-methods study.

Wan, Guang-Ying / Yuan, Hua / Xue, Hui / Li, Hui-Qin / Hu, Hai-Yan / Zhang, Xiu-Ying

Journal of advanced nursing

2021 Volume 77, Issue 6, Page(s) 2845–2859

Abstract: Aims: To evaluate the compliance of patients after gastrectomy in taking oral nutritional supplementation and to explore the promoting and hindering factors.: Design: A mixed-methods design with an explanatory sequential approach was employed.: ... ...

Abstract	Aims: To evaluate the compliance of patients after gastrectomy in taking oral nutritional supplementation and to explore the promoting and hindering factors. Design: A mixed-methods design with an explanatory sequential approach was employed. Methods: We conducted a 12-week longitudinal study to evaluate the oral nutritional supplementation compliance of 122 patients after gastric cancer surgery and the factors that affected their compliance. After the quantitative phase, we selected the interview subjects and developed the interview outline based on the analysis of the quantitative results. In-depth interviews (n = 15) were conducted to explain and supplement the quantitative phase results. Data were collected from October 2019 to May 2020. Results: The average overall compliance rate of oral nutritional supplementation in patients with gastric cancer over 12 weeks was 30.59%. Adverse reactions to oral nutritional supplementation, the identity of the main caregivers and the patient's financial ability were independent factors that affected patient compliance. In subsequent interviews, we extracted four themes: social support plays an important role in patients taking oral nutritional supplementation, adverse reactions discourage patients from continuing to take oral nutritional supplementation, patients' attitudes affect their motivation to take oral nutritional supplementation, and the different needs of patients for oral nutritional supplementation affect patient compliance. Conclusion: Patients' compliance with oral nutritional supplementation after gastric cancer surgery is very low. Health education should pay more attention to the management of adverse reactions and the role of patients' peers and family members. Oral nutritional supplementation products should be diversified to provide patients with more choices. Impact: This study clarifies the factors that hinder and promote oral nutritional supplementation compliance and provides an important reference for the establishment and revision of health education strategies for patients after gastric cancer surgery.
MeSH term(s)	Dietary Supplements ; Gastrectomy ; Humans ; Longitudinal Studies ; Patient Compliance ; Stomach Neoplasms/surgery
Language	English
Publishing date	2021-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	197634-5
ISSN	1365-2648 ; 0309-2402
ISSN (online)	1365-2648
ISSN	0309-2402
DOI	10.1111/jan.14851
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Article ; Online: Mechanism of Pydiflumetofen Resistance in

Zhou, Feng / Zhou, Huan-Huan / Han, Ao-Hui / Guo, Kou-Yun / Liu, Tian-Cheng / Wu, Yan-Bing / Hu, Hai-Yan / Li, Cheng-Wei

Journal of fungi (Basel, Switzerland)

2022 Volume 9, Issue 1

Abstract: Fusarium head blight (FHB), which is primarily caused by Fusarium graminearum, is a widespread and devastating disease of wheat. In the absence of resistant varieties, the control of FHB relies heavily on the application of fungicides, and the new ... ...

Abstract	Fusarium head blight (FHB), which is primarily caused by Fusarium graminearum, is a widespread and devastating disease of wheat. In the absence of resistant varieties, the control of FHB relies heavily on the application of fungicides, and the new generation SDHI fungicide, pydiflumetofen, has recently been registered in China for the control of FHB in wheat. The current study explored three genetically stable, highly resistant laboratory mutants (S2-4-2R, S27-3R, and S28-2R, with EC50 values of 25.10, 28.57, and 19.22 μg/mL, respectively) to investigate the potential risks associated with pydiflumetofen resistance. Although the mycelial growth of the mutants differed little compared to their parental isolates, the study found that the resistant mutants exhibited significantly reduced (p < 0.05) levels of sporulation and pathogenicity, which suggests a significant fitness cost associated with pydiflumetofen resistance in F. graminearum. Sequence analysis of the Sdh target protein identified numerous amino acid substitutions in the predicted sequences of the four subunits: FgSdhA, FgSdhB, FgSdhC, and FgSdhD. Indeed, the mutants were found to have a series of substitution in multiple subunits such that all three exhibited five identical changes, including Y182F in the FgSdhA subunit; H53Q, C90S, and A94V in FgSdhB; and S31F in FgSdhC. In addition, gene expression analysis revealed that all of the FgSdh genes had significantly altered expression (p < 0.05), particularly FgSdhA and FgdhC, which exhibited remarkably low levels of expression. However, the study found no evidence of cross-resistance between pydiflumetofen and tebuconazole, fludioxonil, prochloraz, fluazinam, carbendazim, pyraclostrobin, or difenoconazole, which indicates that these fungicides, either in rotation or combination with pydiflumetofen, could mitigate the risk of resistance emerging and provide ongoing control of FHB to ensure high and stable wheat yields.
Language	English
Publishing date	2022-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9010062
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