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  1. Article ; Online: Editorial: The progress and challenges of hematological malignancies in the era of big data and new therapy.

    Hu, Hongbo

    Cancer letters

    2023  Volume 575, Page(s) 216399

    MeSH term(s) Humans ; Big Data ; Hematologic Neoplasms/therapy ; Hematologic Neoplasms/pathology
    Language English
    Publishing date 2023-09-22
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2023.216399
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Not to be and how not to be: the questions of Tregs controlled by RIPK1.

    Peng, Zhengcai / Zhang, Huiyuan / Hu, Hongbo

    Cellular & molecular immunology

    2024  Volume 21, Issue 2, Page(s) 205–206

    MeSH term(s) T-Lymphocytes, Regulatory/metabolism ; Cell Death ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Homeostasis
    Chemical Substances Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-01-15
    Publishing country China
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-024-01129-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Liver protecting effects and molecular mechanisms of icariin and its metabolites.

    Ma, Yurong / Zhao, Chong / Hu, Hongbo / Yin, Shutao

    Phytochemistry

    2023  Volume 215, Page(s) 113841

    Abstract: As a detoxification and metabolism organ, the liver plays a vital role in human health. However, an excessive consumption of drugs and toxins, exposure to pathogenic viruses, and unhealthy living habits can lead to liver damage, which may even develop ... ...

    Abstract As a detoxification and metabolism organ, the liver plays a vital role in human health. However, an excessive consumption of drugs and toxins, exposure to pathogenic viruses, and unhealthy living habits can lead to liver damage, which may even develop into liver cirrhosis and liver cancer. Epimedium brevicornum Maxim. is a traditional Chinese medicine and dietary supplement in which the flavonoid icariin is a main functional component. Although the protective mechanisms of icariin and its metabolites against liver injury are not yet comprehensively understood, an increasing number of studies have confirmed their liver-protective and anticancer effects. Indeed, icaritin, one of the metabolites of icariin, is currently utilized as an active component of an anti-cancer drug. This paper presents a review of the molecular mechanisms through which icariin and its metabolites actively protect against the occurrence and development of liver injury, and, thus, provides a comprehensive reference for further research and their application in liver protection.
    MeSH term(s) Humans ; Plant Extracts ; Flavonoids/pharmacology ; Liver ; Epimedium
    Chemical Substances icariin (VNM47R2QSQ) ; Plant Extracts ; Flavonoids
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113841
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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

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  4. Article ; Online: Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis.

    Cao, Lixing / Han, Kai / Fan, Lihong / Zhao, Chong / Yin, Shutao / Hu, Hongbo

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat ... ...

    Abstract Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative coumarin compound isolated from licorice that demonstrates various pharmacological activities. However, its potential for a protective effect against kidney injury remains unknown. We hypothesized that GC might be able to protect against AKI via suppression of ferroptosis. This hypothesis was tested in a cell-culture model of RSL3-induced nephrocyte ferroptosis and a mouse model of folic acid-induced AKI. The results showed that GC exerted a significant protective effect against nephrocyte ferroptosis in vitro and was effective against folic acid-induced AKI in vivo, where it was mechanistically associated with suppressing HO-1-mediated heme degradation. Collectively, the findings of the present study support the hypothesis that GC holds considerable potential to be developed as a novel agent for treating ferroptosis-related AKI.
    MeSH term(s) Animals ; Mice ; Acute Kidney Injury ; Flavonoids ; Cell Culture Techniques ; Folic Acid
    Chemical Substances glycyrol ; Flavonoids ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: cGAS-STING, an important signaling pathway in diseases and their therapy.

    Li, Qijie / Wu, Ping / Du, Qiujing / Hanif, Ullah / Hu, Hongbo / Li, Ka

    MedComm

    2024  Volume 5, Issue 4, Page(s) e511

    Abstract: Since cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS- ...

    Abstract Since cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS-STING signaling pathway in the past decade. Meanwhile, the triggering and transduction mechanisms have been continuously illuminated. cGAS-STING plays a key role in human diseases, particularly DNA-triggered inflammatory diseases, making it a potentially effective therapeutic target for inflammation-related diseases. Here, we aim to summarize the ancient origin of the cGAS-STING defense mechanism, as well as the triggers, transduction, and regulating mechanisms of the cGAS-STING. We will also focus on the important roles of cGAS-STING signal under pathological conditions, such as infections, cancers, autoimmune diseases, neurological diseases, and visceral inflammations, and review the progress in drug development targeting cGAS-STING signaling pathway. The main directions and potential obstacles in the regulating mechanism research and therapeutic drug development of the cGAS-STING signaling pathway for inflammatory diseases and cancers will be discussed. These research advancements expand our understanding of cGAS-STING, provide a theoretical basis for further exploration of the roles of cGAS-STING in diseases, and open up new strategies for targeting cGAS-STING as a promising therapeutic intervention in multiple diseases.
    Language English
    Publishing date 2024-03-23
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.511
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  6. Article ; Online: Engineering

    Deng, Ru-Xiang / Li, Hui-Ling / Wang, Wei / Hu, Hong-Bo / Zhang, Xue-Hong

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 15, Page(s) 8684–8692

    Abstract: Polyhydroxyalkanoates (PHAs) are promising alternatives to petroleum-based plastics, owing to their biodegradability and superior material properties. Here, the controllable biosynthesis of scl- ...

    Abstract Polyhydroxyalkanoates (PHAs) are promising alternatives to petroleum-based plastics, owing to their biodegradability and superior material properties. Here, the controllable biosynthesis of scl-
    MeSH term(s) 3-Hydroxybutyric Acid ; Pseudomonas chlororaphis/genetics ; Pseudomonas chlororaphis/metabolism ; Acyltransferases/genetics ; Acyltransferases/metabolism ; Polyhydroxyalkanoates ; Glucose/metabolism
    Chemical Substances 3-Hydroxybutyric Acid (TZP1275679) ; Acyltransferases (EC 2.3.-) ; Polyhydroxyalkanoates ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.4c00777
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis.

    Li, Zhuoqun / Cao, Lixing / Han, Kai / Fan, Lihong / Zhao, Chong / Yin, Shutao / Hu, Hongbo

    Biochemical and biophysical research communications

    2024  Volume 710, Page(s) 149895

    Abstract: Neurotoxicity is a common side effect of certain types of therapeutic drugs, posing a major hurdle for their clinical application. Accumulating evidence suggests that ferroptosis is involved in the neurotoxicity induced by these drugs. Therefore, ... ...

    Abstract Neurotoxicity is a common side effect of certain types of therapeutic drugs, posing a major hurdle for their clinical application. Accumulating evidence suggests that ferroptosis is involved in the neurotoxicity induced by these drugs. Therefore, targeting ferroptosis is considered to be a reasonable approach to prevent such side effect. Arctigenin (ATG) is a major bioactive ingredient of Arctium lappa L., a popular medicinal plant in Asia, and has been reported to have multiple bioactivities including neuroprotection. However, the mechanisms underlying the neuroprotection of ATG has not been well elucidated. The purpose of this study was to investigate whether the neuroprotection of ATG was associated with its ability to protect neuronal cells from ferroptosis. Using neuronal cell ferroptosis model induced by either classic ferroptosis induces or therapeutic drugs, we demonstrated for the first time that ATG in the nanomolar concentration range effectively prevented neuronal cell ferroptosis induced by classic ferroptosis inducer sulfasalazine (SAS) and erastin (Era), or therapeutic drug oxaliplatin (OXA) and 5-fluorouracil (5-FU). Mechanistically, we uncovered that the anti-ferroptotic effect of ATG was attributed to its ability to activate SLC7A11-cystine-cysteine axis. The findings of the present study implicate that ATG holds great potential to be developed as a novel agent for preventing SLC7A11 inhibition-mediated neurotoxicity.
    MeSH term(s) Humans ; Cysteine ; Cystine ; Ferroptosis ; Fluorouracil ; Neurotoxicity Syndromes ; Antineoplastic Agents/pharmacology ; Amino Acid Transport System y+ ; Furans ; Lignans
    Chemical Substances arctigenin (U76MR9VS6M) ; Cysteine (K848JZ4886) ; Cystine (48TCX9A1VT) ; Fluorouracil (U3P01618RT) ; Antineoplastic Agents ; Amino Acid Transport System y+ ; SLC7A11 protein, human ; Furans ; Lignans
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149895
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection.

    Ma, Bingbing / Zhou, Jie / Zhou, Weijuan / Ma, Zhanzhong / Chen, Juan / Hu, Hongbo

    Virology journal

    2024  Volume 21, Issue 1, Page(s) 90

    Abstract: Purpose: To determine the correlation between HPV (human papillomavirus) 52 viral load, multiple infections and ThinPrep cytology test (TCT), to inform clinical management of HPV52-positive women after cervical cancer screening.: Methods: A total of ... ...

    Abstract Purpose: To determine the correlation between HPV (human papillomavirus) 52 viral load, multiple infections and ThinPrep cytology test (TCT), to inform clinical management of HPV52-positive women after cervical cancer screening.
    Methods: A total of 1,882 female patients who had positive quantitative HPV tests at Yuebei People's Hospital from January 2020 to December 2022, of whom 533 tested positive for HPV52. We excluded patients who combined HPV16 and/or HPV 18 positivity and whom HPV52 viral load could not be calculated. The final enrollment was 488 patients, including 400 NILM, 48 ASC-US, 28 LSIL and 12 HSIL. The HPV test is a quantitative multiplexed fluorescent PCR assay that provides both HPV genotyping and viral load.
    Results: In our study, there were differences in the median distribution of viral loads among various cytological class categories. The risk of TCT results (LSIL or worse) was increased with the increase of HPV52 viral load, for every LOG unit increase in HPV52 viral load, the risk increased by 26.6%. More importantly, we found a nonlinear relationship between HPV52 viral load and TCT results (LSIL or worse) in both single and multiple infections. When the viral load reaches a threshold, the risk of abnormal cytological results increases significantly.
    Conclusion: HPV52 viral load is an independent risk factor for TCT results (LSIL or worse). The relationship between HPV52 viral load and TCT results (LSIL or worse) is not linear. Viral load may be used as a triage indicator for HPV52-positive patients, thus improving the post-screening clinical management of HPV52-positive women.
    MeSH term(s) Humans ; Female ; Viral Load ; Papillomavirus Infections/virology ; Papillomavirus Infections/diagnosis ; Adult ; Middle Aged ; Uterine Cervical Neoplasms/virology ; Uterine Cervical Neoplasms/diagnosis ; Early Detection of Cancer/methods ; Papillomaviridae/genetics ; Papillomaviridae/classification ; Papillomaviridae/isolation & purification ; Genotype ; Aged ; Vaginal Smears ; Coinfection/virology ; Young Adult ; Uterine Cervical Dysplasia/virology ; Uterine Cervical Dysplasia/diagnosis ; DNA, Viral/genetics ; Human Papillomavirus Viruses ; Alphapapillomavirus
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-024-02356-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The research progress on the impact of antibiotics on the male reproductive system.

    Hou, Lirui / Fu, Yuhan / Zhao, Chong / Fan, Lihong / Hu, Hongbo / Yin, Shutao

    Environment international

    2024  Volume 187, Page(s) 108670

    Abstract: Antibiotics are extensively utilized in the livestock and poultry industry and can accumulate in animals and the environment, leading to potential health risks for humans via food and water consumption. Research on antibiotic toxicity, particularly their ...

    Abstract Antibiotics are extensively utilized in the livestock and poultry industry and can accumulate in animals and the environment, leading to potential health risks for humans via food and water consumption. Research on antibiotic toxicity, particularly their impact as endocrine disruptors on the male reproductive system, is still in its nascent stages. This review highlights the toxic effect of antibiotics on the male reproductive system, detailing the common routes of exposure and the detrimental impact and mechanisms of various antibiotic classes. Additionally, it discusses the protective role of food-derived active substances against the reproductive toxicity induced by antibiotics. This review aims to raise awareness about the reproductive toxicity of antibiotics in males and to outline the challenges that must be addressed in future research.
    Language English
    Publishing date 2024-04-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108670
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Possible Involvement of Infection with Human Rhinoviruses in Children with Kawasaki Disease.

    Li, Ya-Wei / Wan, Qing / Cheng, Ying / Hu, Hong-Bo

    Mediterranean journal of hematology and infectious diseases

    2023  Volume 15, Issue 1, Page(s) e2023049

    Language English
    Publishing date 2023-09-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2023.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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