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Article ; Online: HER2

Hu, Hui-Hui / Wang, Sai-Qi / Zhao, Huichen / Chen, Zhe-Sheng / Shi, Xiaojing / Chen, Xiao-Bing

2024 Volume 64, Issue 4

Abstract: Human epidermal growth factor receptor 2 (HER2) ...

Abstract	Human epidermal growth factor receptor 2 (HER2)
MeSH term(s)	Humans ; Stomach Neoplasms/metabolism ; Trastuzumab/therapeutic use ; Receptor, ErbB-2/metabolism ; Antineoplastic Agents/therapeutic use ; Prognosis ; Immunotherapy
Chemical Substances	Trastuzumab (P188ANX8CK) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Antineoplastic Agents
Language	English
Publishing date	2024-02-23
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2024.5624
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Article: Roles and inhibitors of FAK in cancer: current advances and future directions.

Hu, Hui-Hui / Wang, Sai-Qi / Shang, Hai-Li / Lv, Hui-Fang / Chen, Bei-Bei / Gao, She-Gan / Chen, Xiao-Bing

Frontiers in pharmacology

2024 Volume 15, Page(s) 1274209

Abstract: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression in various tumors and is associated with a poor prognosis. FAK activation promotes tumor growth, invasion, metastasis, and angiogenesis via both kinase-dependent ... ...

Abstract	Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression in various tumors and is associated with a poor prognosis. FAK activation promotes tumor growth, invasion, metastasis, and angiogenesis via both kinase-dependent and kinase-independent pathways. Moreover, FAK is crucial for sustaining the tumor microenvironment. The inhibition of FAK impedes tumorigenesis, metastasis, and drug resistance in cancer. Therefore, developing targeted inhibitors against FAK presents a promising therapeutic strategy. To date, numerous FAK inhibitors, including IN10018, defactinib, GSK2256098, conteltinib, and APG-2449, have been developed, which have demonstrated positive anti-tumor effects in preclinical studies and are undergoing clinical trials for several types of tumors. Moreover, many novel FAK inhibitors are currently in preclinical studies to advance targeted therapy for tumors with aberrantly activated FAK. The benefits of FAK degraders, especially in terms of their scaffold function, are increasingly evident, holding promising potential for future clinical exploration and breakthroughs. This review aims to clarify FAK's role in cancer, offering a comprehensive overview of the current status and future prospects of FAK-targeted therapy and combination approaches. The goal is to provide valuable insights for advancing anti-cancer treatment strategies.
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1274209
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Article ; Online: Impact of Area-Level Socioeconomic and Environmental Measures on Reduced Visual Acuity Among Children and Adolescents.

Kai, Jia-Yan / Li, Dan-Lin / Hu, Hui-Hui / Zhang, Xiao-Feng / Pan, Chen-Wei

Investigative ophthalmology & visual science

2023 Volume 64, Issue 7, Page(s) 23

Abstract: Purpose: To assess the impacts of area-level socioeconomic and environmental measures on reduced visual acuity (VA).: Methods: This ecological study used the nationally representative cross-sectional data from the Chinese National Survey on Students' ...

Abstract	Purpose: To assess the impacts of area-level socioeconomic and environmental measures on reduced visual acuity (VA). Methods: This ecological study used the nationally representative cross-sectional data from the Chinese National Survey on Students' Constitution and Health in 2014 (CNSSCH 2014), which included 261,833 participants aged 7 to 22 years randomly selected from 30 mainland provinces in China. Area-level socioeconomic measures assessed included gross domestic product (GDP), population density, density of hospital beds, and nighttime light data measured as the mean digital number (DN) of each region; environmental factors assessed included latitude, annual sunlight duration, and park green space density. The main outcome measure was the prevalence of reduced VA in each province of Mainland China. Results: GDP (coefficient: 0.221; P < 0.001), mean DN (coefficient: 0.461; P < 0.001), latitude (coefficient: 0.093; P < 0.001), and annual sunlight duration (coefficient: 0.112; P < 0.001) were positively associated with the prevalence of reduced VA, while population density (coefficient: -0.256; P < 0.001), park green space per 10,000 people (coefficient: -0.145; P < 0.001), and number of hospital beds per 10,000 people (coefficient: -0.146; P < 0.001) were negatively associated with reduced VA prevalence. Factor analysis indicated a marginally nonsignificant positive correlation between socioeconomic factors and the prevalence of reduced VA (coefficient: 0.034; P = 0.07). Conclusions: Increased GDP and mean DN, which reflect economic development, were associated with a higher prevalence of reduced VA, while larger park green space and number of hospital beds per 10,000 people seemed to play a protective role, which could be targeted to design preventive strategies for myopia.
MeSH term(s)	Adolescent ; Child ; Humans ; Asian People ; China ; Cross-Sectional Studies ; Socioeconomic Factors ; Vision Disorders/epidemiology ; Visual Acuity ; Young Adult
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.64.7.23
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Article: PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer.

Zhang, Ying / Hu, Hui-Hui / Zhou, Shi-Hong / Xia, Wu-Yan / Zhang, Yan / Zhang, Jian-Ping / Fu, Xiao-Long / Yu, Wen

Biomarker research

2023 Volume 11, Issue 1, Page(s) 10

Abstract: Background: Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The overall ... ...

Abstract	Background: Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The overall infiltration and exhausted subpopulations of tumor-infiltrating CD8 Methods: Basing on tumor-bearing mice model, we investigated the dynamics of overall infiltration and exhausted subpopulations of CD8 Results: CD8 Conclusions: We proposed a non-invasive imaging predictor which accurately assessed heterogeneous T cell exhaustion status relevant to ICI treatment and irradiation, and might serve as a promising solution to timely estimate immune-responsiveness of tumor microenvironment and the optimal timing of combined therapy.
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2699926-2
ISSN	2050-7771
ISSN	2050-7771
DOI	10.1186/s40364-023-00454-z
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Article: 儿童造血干细胞移植后急性肾损伤相关危险因素的回顾性研究.

Liu, Jian / Chen, Zhi-Wei / Wang, Ying-Jie / Mai, Yu-Miao / Hu, Hui-Hui / Ren, Bing / Wang, Ying-Chao / Liu, Yu-Feng

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2022 Volume 24, Issue 10, Page(s) 1136–1142

Abstract: Objectives: To investigate the risk factors for acute kidney injury (AKI) after hematopoietic stem cell transplantation (HSCT) in children.: Methods: A retrospective analysis was performed on the medical data of 111 children who underwent HSCT from ... ...

Title translation	Risk factors for acute kidney injury after hematopoietic stem cell transplantation in children: a retrospective study.
Abstract	Objectives: To investigate the risk factors for acute kidney injury (AKI) after hematopoietic stem cell transplantation (HSCT) in children. Methods: A retrospective analysis was performed on the medical data of 111 children who underwent HSCT from January 2018 to January 2020. A multivariate logistic regression analysis was used to identify the risk factors for AKI. The Kaplan-Meier survival analysis was used to compare the prognosis in children with different grades of AKI. Results: Graft-versus-host disease (grade Ⅱ-Ⅳ) ( Conclusions: Children with stage Ⅲ AKI after HSCT have a higher mortality rate. Graft-versus-host disease, hepatic veno-occlusive disease, and thrombotic microangiopathy are closely associated with the development of AKI after HSCT.
MeSH term(s)	Child ; Humans ; Retrospective Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease/complications ; Risk Factors ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Thrombotic Microangiopathies/complications
Language	Chinese
Publishing date	2022-10-27
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2205007
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Article ; Online: Probe Type II Band Alignment in One-Dimensional Van Der Waals Heterostructures Using First-Principles Calculations.

Hu, HuiHui / Lu, DeBen / Dou, Kun Peng / Shi, Xing-Qiang

Journal of visualized experiments : JoVE

2019 , Issue 152

Abstract: Computational tools based on density-functional theory (DFT) enable the exploration of the qualitatively new, experimentally attainable nanoscale compounds for a targeted application. Theoretical simulations provide a profound understanding of the ... ...

Abstract	Computational tools based on density-functional theory (DFT) enable the exploration of the qualitatively new, experimentally attainable nanoscale compounds for a targeted application. Theoretical simulations provide a profound understanding of the intrinsic electronic properties of functional materials. The goal of this protocol is to search for photocatalyst candidates by computational dissection. Photocatalytic applications require suitable band gaps, appropriate band edge positions relative to the redox potentials. Hybrid functionals can provide accurate values of these properties but are computationally expensive, whereas the results at the Perdew-Burke-Ernzerhof (PBE) functional level could be effective for suggesting strategies for band structure engineering via electric field and tensile strain aiming to enhance the photocatalytic performance. To illustrate this, in the present manuscript, the DFT based simulation tool VASP is used to investigate the band alignment of nanocomposites in combinations of nanotubes and nanoribbons in the ground state. To address the lifetime of photogenerated holes and electrons in the excited state, nonadiabatic dynamics calculations are needed.
MeSH term(s)	Biophysical Phenomena/physiology ; Electrons ; Nanotechnology/methods
Language	English
Publishing date	2019-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/60180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Treatment of secondary benign airway stenosis after tracheotomy with Montgomery T-tube.

Hu, Hui Hui / Wu, Feng Jie / Zhang, Ji Song / Chen, Enguo

Mathematical biosciences and engineering : MBE

2019 Volume 16, Issue 6, Page(s) 7839–7849

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; Aged ; Bronchoscopy ; Constriction, Pathologic/physiopathology ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Postoperative Period ; Quality of Life ; Retrospective Studies ; Trachea/surgery ; Tracheostomy/adverse effects ; Tracheostomy/instrumentation ; Tracheostomy/methods ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1547-1063
ISSN (online)	1551-0018
ISSN	1547-1063
DOI	10.3934/mbe.2019394
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Article: Probe type ii band alignment in one-dimensional van der waals heterostructures using first-principles calculations

Hu, HuiHui / Dou, Kun Peng / Lu, DeBen / Shi, Xing-Qiang

Journal of visualized experiments. 2019 Oct. 12, , no. 152

2019

Abstract	Computational tools based on density-functional theory (DFT) enable the exploration of the qualitatively new, experimentally attainable nanoscale compounds for a targeted application. Theoretical simulations provide a profound understanding of the intrinsic electronic properties of functional materials. The goal of this protocol is to search for photocatalyst candidates by computational dissection. Photocatalytic applications require suitable band gaps, appropriate band edge positions relative to the redox potentials. Hybrid functionals can provide accurate values of these properties but are computationally expensive, whereas the results at the Perdew-Burke-Ernzerhof (PBE) functional level could be effective for suggesting strategies for band structure engineering via electric field and tensile strain aiming to enhance the photocatalytic performance. To illustrate this, in the present manuscript, the DFT based simulation tool VASP is used to investigate the band alignment of nanocomposites in combinations of nanotubes and nanoribbons in the ground state. To address the lifetime of photogenerated holes and electrons in the excited state, nonadiabatic dynamics calculations are needed.
Keywords	density functional theory ; electric field ; electrons ; engineering ; nanocomposites ; nanotubes ; photocatalysis ; photocatalysts ; redox potential ; simulation models ; tensile strength ; van der Waals forces
Language	English
Dates of publication	2019-1012
Size	p. e60180.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/60180
Database	NAL-Catalogue (AGRICOLA)

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Article: [Expression of apolipoprotein A-I in eight histological types of renal neoplasms].

Gong, Bei / Hu, Hui-hui / Zhang, Man

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2015 Volume 47, Issue 1, Page(s) 155–159

Abstract: Objective: To investigate the expression of apolipoprotein A-I(ApoA-I) in eight histological types of renal neoplasms and to explore a new biomarker for differential diagnosis.: Methods: The immunochemistry was used to detect the expression of ApoA-I ...

Abstract	Objective: To investigate the expression of apolipoprotein A-I(ApoA-I) in eight histological types of renal neoplasms and to explore a new biomarker for differential diagnosis. Methods: The immunochemistry was used to detect the expression of ApoA-I in 23 cases of renal tumors, including clear cell carcinoma,papillary cell carcinoma, chromophobe cell carcinoma, oncocytoma,multilocular cystic carcinoma, renal pelvis invasive urothelial carcinoma,metanephric adenoma and collecting ducts carcinoma. Five cases of cancer-adjacent normal tissues were obtained from another five renal tumor patients and were chosen as control group. Results: In the 23 cases of renal tumors, ApoA-I was expressed in 21 cases (positive rate was 91.3%). There were only two in five cases of normal tissues which expressed this protein (positive rate was 40.0%). A significant differentiation was observed between the two groups(Z=-2.829,P=0.003). In renal clear cell carcinoma (RCC), ApoA-I expression level was correlated with the grade and stage of tumor tissues. ApoA-I was stained much more stronger in RCC II-III than in RCC I (Z=-2.070,P=0.038).In various histological types of renal cancer, ApoA-I was all expressed to some degrees. Conclusion: ApoA-I can be chosen as a tumor biomarker to differentiate various histological types of renal neoplasms.
MeSH term(s)	Adenoma, Oxyphilic/metabolism ; Apolipoprotein A-I/metabolism ; Biomarkers, Tumor/metabolism ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Transitional Cell/metabolism ; Diagnosis, Differential ; Humans ; Kidney Neoplasms/metabolism ; Neoplasms, Glandular and Epithelial/metabolism
Chemical Substances	Apolipoprotein A-I ; Biomarkers, Tumor
Language	Chinese
Publishing date	2015-02-18
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1671-167X
ISSN	1671-167X
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Article: Preclinical studies of the triazolo[1,5-

Wang, Sai-Qi / Teng, Qiu-Xu / Wang, Shuai / Lei, Zi-Ning / Hu, Hui-Hui / Lv, Hui-Fang / Chen, Bei-Bei / Wang, Jian-Zheng / Shi, Xiao-Jing / Xu, Wei-Feng / Liu, Hong-Min / Chen, Xiao-Bing / Chen, Zhe-Sheng / Yu, Bin

Acta pharmaceutica Sinica. B

2022 Volume 12, Issue 8, Page(s) 3263–3280

Abstract: Multidrug resistance (MDR) is the main cause of clinical treatment failure and poor prognosis in cancer. Targeting P-glycoprotein (P-gp) has been regarded as an effective strategy to overcome MDR. In this work, we reported our preclinical studies of the ... ...

Abstract	Multidrug resistance (MDR) is the main cause of clinical treatment failure and poor prognosis in cancer. Targeting P-glycoprotein (P-gp) has been regarded as an effective strategy to overcome MDR. In this work, we reported our preclinical studies of the triazolo[1,5-
Language	English
Publishing date	2022-04-02
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2022.03.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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