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  1. Article ; Online: Effects of low-dose intravenous heparin therapy in aneurysmal subarachnoid hemorrhage: a randomized controlled clinical trial protocol.

    Zhang, Yifan / Hu, Jiangang

    Trials

    2023  Volume 24, Issue 1, Page(s) 447

    Abstract: Background: Heparin anticoagulation therapy is a widely used method to prevent cerebral vasospasm (CV) and venous thrombosis in patients with subarachnoid hemorrhage caused by ruptured cerebral aneurysms. Subcutaneous heparin injection is considered ... ...

    Abstract Background: Heparin anticoagulation therapy is a widely used method to prevent cerebral vasospasm (CV) and venous thrombosis in patients with subarachnoid hemorrhage caused by ruptured cerebral aneurysms. Subcutaneous heparin injection is considered safe and effective, whereas continuous intravenous heparin infusion is still being debated due to the risk of bleeding. Although most retrospective studies have confirmed the safety and effectiveness of unfractionated heparin (UFH) after aneurysm embolization therapy and its ability to reduce CV, there is still no randomized clinical trial comparing UFH and subcutaneous low-molecular-weight heparin (LMWH) injection in this population. Therefore, this study aims to compare the clinical outcomes associated with these two treatment approaches.
    Methods: The study is an open-label, single-center, randomized controlled trial and aims to recruit 456 patients, with 228 patients in each group. The primary outcome was CV; the second outcomes measures are occurrence of bleeding events, ischemic events, heparin-induced thrombocytopenia, deep vein thrombosis, cerebral venous circulation time, brain edema score, and hydrocephalus incidence.
    Ethics and dissemination: This study protocol obtained ethical approval from the Ethics Committee of Baoan People's Hospital, Shenzhen, Guangdong (approval number: BYL20220805). This work will be published in peer-reviewed international medical journals and presented at medical conferences.
    Trial registration: ClinicalTrials ID: NCT05696639. Registered on March 30, 2023.
    MeSH term(s) Humans ; Heparin/adverse effects ; Heparin, Low-Molecular-Weight/therapeutic use ; Subarachnoid Hemorrhage/diagnosis ; Subarachnoid Hemorrhage/drug therapy ; Retrospective Studies ; Anticoagulants/therapeutic use ; Randomized Controlled Trials as Topic
    Chemical Substances Heparin (9005-49-6) ; Heparin, Low-Molecular-Weight ; Anticoagulants
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07493-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The

    Zuo, Wei / Yang, Denghui / Wu, Xiaojun / Zhang, Beibei / Wang, Xinyu / Hu, Jiangang / Qi, Jingjing / Tian, Mingxing / Bao, Yanqing / Wang, Shaohui

    Vaccines

    2024  Volume 12, Issue 2

    Abstract: ... ...

    Abstract Salmonella
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12020162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Causal discovery approach with reinforcement learning for risk factors of type II diabetes mellitus.

    Gao, Xiu-E / Hu, Jian-Gang / Chen, Bo / Wang, Yun-Ming / Zhou, Sheng-Bin

    BMC bioinformatics

    2023  Volume 24, Issue 1, Page(s) 296

    Abstract: Background: Statistical correlation analysis is currently the most typically used approach for investigating the risk factors of type 2 diabetes mellitus (T2DM). However, this approach does not readily reveal the causal relationships between risk ... ...

    Abstract Background: Statistical correlation analysis is currently the most typically used approach for investigating the risk factors of type 2 diabetes mellitus (T2DM). However, this approach does not readily reveal the causal relationships between risk factors and rarely describes the causal relationships visually.
    Results: Considering the superiority of reinforcement learning in prediction, a causal discovery approach with reinforcement learning for T2DM risk factors is proposed herein. First, a reinforcement learning model is constructed for T2DM risk factors. Second, the process involved in the causal discovery method for T2DM risk factors is detailed. Finally, several experiments are designed based on diabetes datasets and used to verify the proposed approach.
    Conclusions: The experimental results show that the proposed approach improves the accuracy of causality mining between T2DM risk factors and provides new evidence to researchers engaged in T2DM prevention and treatment research.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2 ; Risk Factors ; Learning ; Research Design
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-023-05405-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The functions of EF-hand proteins from host and zoonotic pathogens.

    Zuo, Wei / Tian, Mingxing / Qi, Jingjing / Zhang, Guangdong / Hu, Jiangang / Wang, Shaohui / Bao, Yanqing

    Microbes and infection

    2023  , Page(s) 105276

    Abstract: EF-hand proteins not only regulate biological processes, but also influence immunity and infection. In this review, we summarize EF-hand proteins' functions in host and zoonotic pathogens, with details in structures, ... ...

    Abstract EF-hand proteins not only regulate biological processes, but also influence immunity and infection. In this review, we summarize EF-hand proteins' functions in host and zoonotic pathogens, with details in structures, Ca
    Language English
    Publishing date 2023-12-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2023.105276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Avian Pathogenic Escherichia coli through Pfs Affects the Tran-Scription of Membrane Proteins to Resist β-Lactam Antibiotics

    Hu, Jiangang / Che, Chuanyan / Jiang, Wei / Chen, Zhaoguo / Tu, Jian / Han, Xiangan / Qi, Kezong

    Veterinary sciences. 2022 Feb. 23, v. 9, no. 3

    2022  

    Abstract: Avian pathogenic Escherichia coli (APEC) is a causative agent of colibacillosis, one of the principal causes of morbidity and mortality in poultry worldwide. Nowadays, antibiotics are mainly used to prevent and control poultry colibacillosis, but the ... ...

    Abstract Avian pathogenic Escherichia coli (APEC) is a causative agent of colibacillosis, one of the principal causes of morbidity and mortality in poultry worldwide. Nowadays, antibiotics are mainly used to prevent and control poultry colibacillosis, but the situation of drug resistance is serious. 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) is involved in methylation reactions, polyamine synthesis, vitamin synthesis, and quorum sensing (QS) pathways. In this study, compared with the APEC wild-type strain DE17, the pfs deletion strain DE17Δpfs was more susceptible to β-lactam antibiotics (amoxicillin, ceftazidime, cefuroxime) by drug sensitivity test and minimum inhibitory concentration (MIC), and the MIC of the DE17Δpfs was half that of the DE17. Quorum sensing signal molecule AI-2 is involved in antibiotic resistance. In the case of pfs inactivation, the DE17Δpfs cannot synthesize AI-2, so it is necessary to add AI-2 to study whether it affects APEC resistance. When the exogenous AI-2 was added, the MIC of all APEC did not change. Transcriptome sequencing indicated that the transcription levels of a lot of outer membrane protein genes and metabolic genes had changed due to the deletion of pfs. Moreover, the transcription levels of the efflux pump gene tolC and penicillin binding protein (fstI and mrcA) were significantly reduced (p < 0.05), while the transcription levels of the porin protein genes (ompF, ompC, and ompD) were significantly increased (p < 0.05). In addition, it was also found that the outer membrane permeability of the DE17Δpfs was significantly increased (p < 0.05). The results indicated that pfs does not affect APEC strain DE17 resistance to β-lactam antibiotics through AI-2, but pfs affects the sensitivity of APEC to β-lactam antibiotics by affecting antibiotic-related genes. This study can provide a reference for screening new drug targets.
    Keywords Escherichia coli ; amoxicillin ; antibiotic resistance ; birds ; ceftazidime ; cefuroxime ; etiological agents ; genes ; membrane permeability ; methylation ; minimum inhibitory concentration ; morbidity ; mortality ; outer membrane proteins ; polyamines ; porins ; poultry ; transcriptome ; transporters
    Language English
    Dates of publication 2022-0223
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2768971-2
    ISSN 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9030098
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Avian Pathogenic

    Hu, Jiangang / Che, Chuanyan / Jiang, Wei / Chen, Zhaoguo / Tu, Jian / Han, Xiangan / Qi, Kezong

    Veterinary sciences

    2022  Volume 9, Issue 3

    Abstract: Avian pathogenic Escherichia coli (APEC) is a causative agent of colibacillosis, one of the principal causes of morbidity and mortality in poultry worldwide. Nowadays, antibiotics are mainly used to prevent and control poultry colibacillosis, but the ... ...

    Abstract Avian pathogenic Escherichia coli (APEC) is a causative agent of colibacillosis, one of the principal causes of morbidity and mortality in poultry worldwide. Nowadays, antibiotics are mainly used to prevent and control poultry colibacillosis, but the situation of drug resistance is serious. 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) is involved in methylation reactions, polyamine synthesis, vitamin synthesis, and quorum sensing (QS) pathways. In this study, compared with the APEC wild-type strain DE17, the pfs deletion strain DE17Δpfs was more susceptible to β-lactam antibiotics (amoxicillin, ceftazidime, cefuroxime) by drug sensitivity test and minimum inhibitory concentration (MIC), and the MIC of the DE17Δpfs was half that of the DE17. Quorum sensing signal molecule AI-2 is involved in antibiotic resistance. In the case of pfs inactivation, the DE17Δpfs cannot synthesize AI-2, so it is necessary to add AI-2 to study whether it affects APEC resistance. When the exogenous AI-2 was added, the MIC of all APEC did not change. Transcriptome sequencing indicated that the transcription levels of a lot of outer membrane protein genes and metabolic genes had changed due to the deletion of pfs. Moreover, the transcription levels of the efflux pump gene tolC and penicillin binding protein (fstI and mrcA) were significantly reduced (p < 0.05), while the transcription levels of the porin protein genes (ompF, ompC, and ompD) were significantly increased (p < 0.05). In addition, it was also found that the outer membrane permeability of the DE17Δpfs was significantly increased (p < 0.05). The results indicated that pfs does not affect APEC strain DE17 resistance to β-lactam antibiotics through AI-2, but pfs affects the sensitivity of APEC to β-lactam antibiotics by affecting antibiotic-related genes. This study can provide a reference for screening new drug targets.
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9030098
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  7. Article: The Transcription Regulator

    Xue, Mei / Fu, Dandan / Hu, Jiangang / Shao, Ying / Tu, Jian / Song, Xiangjun / Qi, Kezong

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 9

    Abstract: ... Avian ... ...

    Abstract Avian pathogenic
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12091160
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  8. Article ; Online: Genetic distribution, characterization, and function of

    Wang, Xinyu / Zhu, Hong / Hu, Jiangang / Zhang, Beibei / Guo, Weiqi / Wang, Zhiyang / Wang, Di / Qi, Jingjing / Tian, Mingxing / Bao, Yanqing / Si, Fusheng / Wang, Shaohui

    iScience

    2024  Volume 27, Issue 5, Page(s) 109763

    Abstract: Many Gram-negative bacteria use type Ⅲ secretion system (T3SS) to inject effector proteins and subvert host signaling pathways, facilitating the growth, survival, and virulence. Notably, some bacteria harbor multiple distinct T3SSs with different ... ...

    Abstract Many Gram-negative bacteria use type Ⅲ secretion system (T3SS) to inject effector proteins and subvert host signaling pathways, facilitating the growth, survival, and virulence. Notably, some bacteria harbor multiple distinct T3SSs with different functions. An extraordinary T3SS, the
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acetoacetyl-CoA transferase ydiF regulates the biofilm formation of avian pathogenic Escherichia coli.

    Gu, Yi / Lu, Huiqi / Shao, Ying / Fu, Dandan / Wu, Jianmei / Hu, Jiangang / Tu, Jian / Song, Xiangjun / Qi, Kezong

    Research in veterinary science

    2022  Volume 153, Page(s) 144–152

    Abstract: Avian pathogenic Escherichia coli (APEC) causes persistent infection of poultry and multi-system diseases, which seriously endanger the development of the poultry industry. Biofilm allows bacteria to adapt to the natural environment and plays an ... ...

    Abstract Avian pathogenic Escherichia coli (APEC) causes persistent infection of poultry and multi-system diseases, which seriously endanger the development of the poultry industry. Biofilm allows bacteria to adapt to the natural environment and plays an important role in resistance to the external environment and the pathogenicity of APEC, but the mechanism of its formation and regulatory network have not been clarified. In this study, we used a Tn5 transposon random mutation library constructed with APEC and identified ydiF, a gene that has not previously been recognized in E. coli biofilm formation. To confirm that the ydiF gene really can regulate the formation of APEC biofilm, the ydiF gene deletion strain was constructed using APEC81. Protein association networks prediction results show that ydiF is mainly associated with genes related to the metabolism of sugars and fatty acids. Deletion of the ydiF gene significantly reduces the formation of APEC biofilm and scanning electron microscopy indicated that the degree of adhesion between the bacteria was also reduced. The deletion of the ydiF gene also significantly reduced the motility of APEC81 and through transmission electron microscopy APEC81 was observed to have significantly fewer flagella. However, the colony morphology of APEC81 on Congo red and Coomassie brilliant blue media was unaffected. The results of fluorescence quantification showed that the deletion of the ydiF gene caused a down-regulation in the transcription of genes related to the second messenger, sugar metabolism, and quorum sensing. These results indicate that ydiF plays an important role in biofilm formation and the movement of APEC. In addition, it may be possible to regulate the formation of APEC biofilms by different methods such as by regulating the second messenger and metabolic system.
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2022.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A lytic phage to control multidrug-resistant avian pathogenic

    Yao, Lan / Bao, Yinli / Hu, Jiangang / Zhang, Beibei / Wang, Zhiyang / Wang, Xinyu / Guo, Weiqi / Wang, Di / Qi, Jingjing / Tian, Mingxing / Bao, Yanqing / Li, Haihua / Wang, Shaohui

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1253815

    Abstract: The inappropriate use of antibiotics has led to the emergence of multidrug-resistant strains. Bacteriophages (phages) have gained renewed attention as promising alternatives or supplements to antibiotics. In this study, a lytic avian ... ...

    Abstract The inappropriate use of antibiotics has led to the emergence of multidrug-resistant strains. Bacteriophages (phages) have gained renewed attention as promising alternatives or supplements to antibiotics. In this study, a lytic avian pathogenic
    MeSH term(s) Animals ; Mice ; Bacteriophages ; Escherichia coli ; Phylogeny ; Escherichia coli Infections/therapy ; Escherichia coli Infections/veterinary ; Anti-Bacterial Agents/pharmacology ; Birds
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1253815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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