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Article: What's charisma got to do with it? Three faces of charismatic leadership and corporate social responsibility engagement.

Hu, Jinyu / Dutta, Tanurima

2022 Volume 13, Page(s) 829584

Abstract: In response to both internal and external expectations and pressures, companies increasingly consider corporate social responsibility (CSR) as an essential factor in their strategic planning, but in a very diverse manner. To help synthesize the ... ...

Abstract	In response to both internal and external expectations and pressures, companies increasingly consider corporate social responsibility (CSR) as an essential factor in their strategic planning, but in a very diverse manner. To help synthesize the flourishing research in CSR variation across firms, we propose a three-orientation framework to map out a wide range of CSR strategies in current literature. Furthermore, we emphasize the importance of executive leadership and suggest that differences in leader's values are the key drivers of CSR heterogeneity. This study offers a parsimonious model that maps out three primary pathways between leadership values and CSR strategic configurations. Drawing from charismatic leadership theory, we argue that three distinct types of leader power motives define three modes of leader's strategic decision frames, which, in turn, influence corresponding CSR orientations. Specifically, socialized charismatic leaders favor prosocial decision frame that results in integrative CSR orientation; neutralized charismatic leaders embrace instrumental decision frame leading to strategic CSR mode; and personalized charismatic leaders tend to adopt self-serving CSR strategies driven by the self-serving decision frame. This holistic view advances the knowledge about the micro-foundations of CSR drivers and the essential role of leader values.
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.829584
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Article: Research Trends of Acupuncture Therapy on Chronic Pelvic Pain Syndrome from 2000 to 2022: A Bibliometric Analysis.

Hu, Jinyu / Xiao, Yuanyi / Jiang, Guilin / Hu, Xiaorong

Journal of pain research

2023 Volume 16, Page(s) 4049–4069

Abstract: Background: Acupuncture is considered an important means of analgesic, which has been widely used in chronic pelvic pain syndrome (CPPS) management and treatment in recent years, published a large number of related documents. However, the relevant ... ...

Abstract	Background: Acupuncture is considered an important means of analgesic, which has been widely used in chronic pelvic pain syndrome (CPPS) management and treatment in recent years, published a large number of related documents. However, the relevant literature in this field has not been summarized and quantitatively analyzed. Therefore, this study aims to analyze the hotspots and predicting future research trends of acupuncture on pelvic pain syndrome. Methods: Search for the relevant publications of the web of science database from 2000 to 2022 about the treatment of acupuncture on chronic pelvic pain syndrome. The Citespace software and VosViewer software are used to analyze the visualization of the countries, institutions, authors, keywords and references and references in the literature. Results: A total of 173 publications were included. The annual number of essays gradually showed an overall growth trend over time. Medicine magazine is the most published journal in this field. J UROLOGY and Acupunct Med are the most cited journals and the most influential magazines; The most active and influential country is China, and the most produced institutions are Beijing University of Chinese Medicine; The most produced authors are Liu Zhishun. The most cited and most influential authors are Nickel JC and Armour M; keywords and cited reference analysis show that the quality of life, mechanism research, alternative medicine and electro-acupuncture will be the scientific hotspot of acupuncture treatment for chronic pelvic pain syndrome. Conclusion: This study shows that acupuncture on CPPS is increasingly valued and recognized. The future research hotspots will focus on the effects and mechanisms. In the future, more high-quality animal basic research will be required to explore the exact mechanism of acupuncture on CPPS. In addition, different parameters of acupuncture such as electric-acupuncture, stimulating frequency, duration and strength are also the focus of future research. More clinical trials are required to verify its safety and effectiveness.
Language	English
Publishing date	2023-11-30
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S434333
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Article ; Online: Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics.

Yu, Yige / Hu, Jinyu / Chen, Xiaohai / Wu, Hua-Lu / Wang, Anzhou / Tang, Congrong

BMC chemistry

2024 Volume 18, Issue 1, Page(s) 37

Abstract: Broad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clinical treatment. The purpose of this study was to establish a rapid and reliable method ... ...

Abstract	Broad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clinical treatment. The purpose of this study was to establish a rapid and reliable method for the detection of abexinostat concentrations in rat plasma using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The mobile phase we used was acetonitrile and 0.1% formic acid, and the internal standard (IS) was givinostat. Selective reaction monitoring (SRM) was used for detection with ion transitions at m/z 397.93 → 200.19 for abexinostat and m/z 422.01 → 186.11 for givinostat, respectively. The intra-day and inter-day precision of abexinostat were less than 11.5% and the intra-day and inter-day accuracy ranged from - 10.7% to 9.7% using this method. During the analysis process, the stability of the test sample was reliable. In addition, the recovery and matrix effects of this method were within acceptable limits. Finally, the method presented in this paper enabled accurate and quick determination of abexinostat levels in rat plasma from the pharmacokinetic study following gavage at a dose of 8.0 mg/kg abexinostat.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ISSN	2661-801X
ISSN (online)	2661-801X
DOI	10.1186/s13065-024-01144-z
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Article: Exploring the spatial and temporal driving mechanisms of landscape patterns on habitat quality in a city undergoing rapid urbanization based on GTWR and MGWR: The case of Nanjing, China

Hu, Jinyu / Zhang, Jiaxin / Li, Yunqin

Ecological indicators. 2022 Oct., v. 143

2022

Abstract: Landscape pattern significantly impacts habitat quality, especially in cities undergoing rapid urbanization, where landscape patterns are changing dramatically. However, the spatial and temporal driving mechanisms of landscape pattern on habitat quality ... ...

Abstract	Landscape pattern significantly impacts habitat quality, especially in cities undergoing rapid urbanization, where landscape patterns are changing dramatically. However, the spatial and temporal driving mechanisms of landscape pattern on habitat quality are still unclear, and the proposed methods of Geographically and Temporally Weighted Regression (GTWR) and Multiscale Geographic Weighted Regression (MGWR) provide possibilities for the exploration of these mechanisms. This study was conducted in Nanjing from 2001 to 2020. Landscape pattern indices indicating aggregation, connectivity, diversity and compactness were calculated using Fragstats from 2001 to 2020. The habitat quality was computed using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model. By combining two new spatial measurement models, GTWR and MGWR, the spatial and temporal driving mechanisms of landscape patterns on habitat quality were explored. The results show that (1) as Nanjing’s land under construction has expanded, habitat quality has decreased significantly, and the overall landscape pattern has fluctuated drastically. (2) GTWR and MGWR are well-suited to such analysis and provide important insights. (3) Overall, aggregation and compactness were negatively associated with habitat quality in areas of low-quality habitat. Increased connectivity on low habitat substrates had a positive effect on habitat. The increase of diversity in proximity had a positive effect on habitat, while the opposite was true in high habitat zones. (4) As the urbanization level increases, the negative effects of aggregation expand, as do the positive effects of connectivity and diversity. (5) The extent of influence of landscape pattern effects are ranked from largest to smallest: compactness, diversity, connectivity, and aggregation, while the intensity of effects is reversed. Based on these findings, a reference point for urban planners is provided to plan urban landscape patterns in a sustainable and rational manner. It also provides a new means of integrating GTWR and MGWR into the study of landscape ecology.
Keywords	ecosystems ; habitats ; landscape ecology ; landscapes ; models ; urbanization ; China
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2022.109333
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Article ; Online: Comparative study of the physiological responses, secondary metabolites, and gene expression of medicinal plant Prunella vulgaris L. treated with exogenous methyl jasmonate and salicylic acid

Tang, Hong / Hu, Jinyu / Zhao, Miao / Cao, Liping / Chen, Yuhang

Acta Physiol Plant. 2023 Feb., v. 45, no. 2 p.20-20

2023

Abstract: Prunella vulgaris L. is medicinally important due to its treatment of mastitis, thyroid gland malfunctions, and infectious hepatitis in northeastern Asia and Europe. However, little is known about the physiological responses, secondary metabolites, and ... ...

Abstract	Prunella vulgaris L. is medicinally important due to its treatment of mastitis, thyroid gland malfunctions, and infectious hepatitis in northeastern Asia and Europe. However, little is known about the physiological responses, secondary metabolites, and gene expression of P. vulgaris in response to hormone treatment. In this study, field P. vulgaris was transplanted into pots, the role of methyl jasmonate (MeJA: 1 mM) and salicylic acid (SA: 4 mM) was comparatively evaluated in antioxidant systems, secondary metabolites, and gene expression in P. vulgaris 24 h after treatment. The results indicated that the activities of enzymes (ascorbate peroxidase (APX), peroxidase (POD), superoxide dismutase (SOD), and phenylalanine ammonia-lyase (PAL)) and the contents of glutathione (GSH), soluble protein (SP), hydrogen peroxide (H₂O₂), total phenols (TP), total flavonoids (TF), rosmarinic acid (RA), and hyperoside (Hyp) increased significantly in response to MeJA treatment. Furthermore, MeJA also effectively enhanced the expression levels of PvPAL, 4-coumaroyl CoA ligase (Pv4CL), coumarate 4-hydroxylase (PvC4H), and tyrosine aminotransferase (PvTAT). The effects of SA on the activities of antioxidant enzymes were less obvious, and inhibiting phenylpropanoid biosynthesis-related gene expression resulted in reduced contents of TP, TF, RA, and Hyp. Therefore, the application of MeJA or SA had remarkable impacts of P. vulgaris, which can improve the antioxidant capacity of P. vulgaris, enhance the stress resistance of plants, and can accumulate secondary metabolites by regulating the content of H₂O₂. These results clarify the mechanism of P. vulgaris adversity regulation and provide a scientific basis for improving the quality of medicinal plants.
Keywords	Prunella vulgaris ; antioxidant activity ; ascorbate peroxidase ; comparative study ; flavonoids ; gene expression ; glutathione ; hepatitis A ; hydrogen peroxide ; ligases ; mastitis ; medicinal plants ; methyl jasmonate ; peroxidase ; phenylalanine ammonia-lyase ; rosmarinic acid ; salicylic acid ; secondary metabolites ; stress tolerance ; superoxide dismutase ; thyroid gland ; tyrosine transaminase ; Asia ; Europe
Language	English
Dates of publication	2023-02
Size	p. 20.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	783102-x
ISSN	1861-1664 ; 0137-5881
ISSN (online)	1861-1664
ISSN	0137-5881
DOI	10.1007/s11738-022-03498-0
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Article: Thyroid dysfunction and risk of cutaneous malignant melanoma: a bidirectional two-sample Mendelian randomization study.

Dong, Hua / Pan, Lei / Shen, Yanhui / Xu, Qinxuan / Hu, Jinyu / Hu, Zhiwei / Fei, Yuchang

Frontiers in endocrinology

2023 Volume 14, Page(s) 1239883

Abstract: Background: Epidemiologic and observational data have found a risk association between thyroid dysfunction and cutaneous malignant melanoma (CMM), however, the cause and direction of these effects are yet unknown. By using a bidirectional two-sample ... ...

Abstract	Background: Epidemiologic and observational data have found a risk association between thyroid dysfunction and cutaneous malignant melanoma (CMM), however, the cause and direction of these effects are yet unknown. By using a bidirectional two-sample Mendelian randomization (MR) methodology, we hoped to further investigate the causal link between thyroid dysfunction and CMM in this work. Methods: A genome-wide association study (GWAS) of 9,851,867 single nucleotide polymorphisms (SNPs) in a European population was used to develop genetic tools for thyroid dysfunction. Hypothyroidism was linked to 22,687 cases and 440,246 controls. For hyperthyroidism, there were 3545 cases and 459,388 controls. A total of 3751 cases and 372016 controls were included in the genetic data for CMM from UK Biobank (http://www.nealelab.is/uk-biobank) (the Dataset: ieu - b - 4969). Among them, inverse variance weighting (IVW) is the main MR Analysis method for causality assessment. MR-Egger method, MR Pleiotropic residual and outlier test (MR-PRESSO), and simple and weighted median (VM) were used to supplement the IVW method. Sensitivity analyses, mainly Cochran's Q test, leave-one-out analysis, and MR Egger intercept test were performed to assess the robustness of the outcomes. Results: The two-sample MR Analysis results revealed a negative correlation between genetically predicted hypothyroidism and the probability of CMM (OR=0.987, 95%CI =0.075-0.999, Conclusion: Although the magnitude of the causal association is weak and further investigation of the mechanism of this putative causal relationship is required, our findings imply that hypothyroidism may be a protective factor for CMM.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Melanoma/epidemiology ; Melanoma/genetics ; Skin Neoplasms ; Hypothyroidism/complications ; Hypothyroidism/epidemiology ; Hypothyroidism/genetics ; Hyperthyroidism
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1239883
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Article ; Online: The effect of Resveratrol on the pharmacokinetic profile of tofacitinib and the underlying mechanism.

Ye, Zhize / Hu, Jinyu / Wang, Jing / Liu, Ya-Nan / Hu, Guo-Xin / Xu, Ren-Ai

Chemico-biological interactions

2023 Volume 374, Page(s) 110398

Abstract: The purpose of this study was to (i) investigate the effect of CYP3A4 variants on tofacitinib metabolism, and (ii) investigate the interaction of tofacitinib with resveratrol and its underlying mechanisms. The concentration of M9, the main metabolite of ... ...

Abstract	The purpose of this study was to (i) investigate the effect of CYP3A4 variants on tofacitinib metabolism, and (ii) investigate the interaction of tofacitinib with resveratrol and its underlying mechanisms. The concentration of M9, the main metabolite of tofacitinib, was determined by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The results showed that the clearance rate of CYP3A4.18 variant was significantly decreased compared with CYP3A4.1, and the CYP3A4.28 variant was changed, but not statistically significant. In addition, the potential interaction of resveratrol with tofacitinib was determined based on rat liver microsomes (RLM), human liver microsomes (HLM), and CYP3A4 response systems. Resveratrol has an IC
MeSH term(s)	Rats ; Humans ; Animals ; Resveratrol/pharmacology ; Chromatography, Liquid ; Rats, Sprague-Dawley ; Cytochrome P-450 CYP3A/metabolism ; Tandem Mass Spectrometry/methods ; Microsomes, Liver/metabolism ; Chromatography, High Pressure Liquid/methods
Chemical Substances	Resveratrol (Q369O8926L) ; tofacitinib (87LA6FU830) ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
Language	English
Publishing date	2023-02-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2023.110398
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Article ; Online: Simultaneous determination of iguratimod and its metabolite in rat plasma using a UPLC-MS/MS method: Application for drug-drug interaction.

Shi, Lu / Hu, Jinyu / Wu, Hualu / Shen, Yuxin / Chen, Xiaohai / Weng, Qinghua / Xu, Ren-Ai / Tang, Congrong

Journal of pharmaceutical and biomedical analysis

2024 Volume 243, Page(s) 116079

Abstract: This aim of the work was to establish an acceptable sensitive assay based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for quantitatively analyzing the plasma concentrations of iguratimod (IGR) and its metabolite M2 in ...

Abstract	This aim of the work was to establish an acceptable sensitive assay based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for quantitatively analyzing the plasma concentrations of iguratimod (IGR) and its metabolite M2 in rats, and to further investigate the effect of fluconazole on the pharmacokinetics of IGR and M2. The mobile phase consisted of acetonitrile and water with 0.1% formic acid, was used to separate IGR, M2 and internal standard (IS) fedratinib on a UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) with the flow rate of 0.4 mL/min. Positive ion mode and multiple reaction monitoring (MRM) were used to construct the quantitative analysis. The calibration standard of IGR and M2 covered 2-10000 and 1-1000 ng/mL respectively, with the lower limit of quantification (LLOQ) as 2 ng/mL and 1 ng/mL respectively. In addition, selectivity, recovery, accuracy, precision, matrix effect and stability of the method validation program were well accepted in this work. Subsequently, this approach was used to assess the effect of fluconazole on the pharmacokinetics of IGR and M2 in rats. In the presence of 20 mg/kg fluconazole (experimental group), we found the main pharmacokinetic parameters were significantly altered when compared with 2.5 mg/kg IGR alone (control group). Among them, AUC
MeSH term(s)	Rats ; Animals ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Liquid Chromatography-Mass Spectrometry ; Fluconazole ; Drug Interactions ; Chromatography, High Pressure Liquid/methods ; Reproducibility of Results ; Chromones ; Sulfonamides
Chemical Substances	iguratimod (4IHY34Y2NV) ; Fluconazole (8VZV102JFY) ; Chromones ; Sulfonamides
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.116079
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Article ; Online: Effectiveness and safety of music therapy for insomnia disorder patients: A protocol for systematic review and meta-analysis.

Ding, Jie / Huang, Tianqi / Hu, Jinyu / Yuan, Fuqiang

Medicine

2021 Volume 100, Issue 26, Page(s) e26399

Abstract: Background: Music therapy has been widely used clinically to relieve insomnia disorder patients. However, the efficacy of music therapy in the treatment of insomnia disorder patients is uncertain. The purpose of this study is to determine the ... ...

Abstract	Background: Music therapy has been widely used clinically to relieve insomnia disorder patients. However, the efficacy of music therapy in the treatment of insomnia disorder patients is uncertain. The purpose of this study is to determine the effectiveness and safety of music therapy in the treatment of insomnia disorder patients. Methods: Search PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, China Biomedical Literature Database, and search-related randomized controlled trials. Two reviewers will independently select studies, collect data, and evaluate methodological quality through the Cochrane Deviation Risk Tool. Revman V.5.3 will be used for meta-analysis. Results: This study will evaluate the current status of music therapy treatment for insomnia disorder patients, aiming to illustrate the effectiveness and safety of music therapy treatment. Conclusion: This study will provide a basis for judging whether music therapy is effective in treating insomnia disorder patients. Inplasy registration number: INPLASY202150087.
MeSH term(s)	Humans ; Meta-Analysis as Topic ; Music Therapy ; Sleep Initiation and Maintenance Disorders/therapy ; Systematic Reviews as Topic
Language	English
Publishing date	2021-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026399
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Article: Temperature and Photoperiod Change the Flowering Process in Prunella vulgaris by Inducing Changes in Morphology, Endogenous Hormones, Carbon/Nitrogen Metabolites, and Gene Expression

Li, Zanzan / Hu, Jinyu / Tang, Hang / Cao, Liping / Chen, Yuhang / Guo, Qiaosheng / Wang, Changlin

Journal of the American Society for Horticultural Science. 2022 Mar., v. 147, no. 2

2022

Abstract: The spicas of Prunella vulgaris are widely used in the medical, beverage, and ornamental fields. Temperature and photoperiod are the two main ecological factors that determine the transformation of many plants from vegetative growth to reproductive ... ...

Abstract	The spicas of Prunella vulgaris are widely used in the medical, beverage, and ornamental fields. Temperature and photoperiod are the two main ecological factors that determine the transformation of many plants from vegetative growth to reproductive growth. To explore the response of P. vulgaris flowering to temperature and photoperiod induction, we adopted vernalization long-day, vernalization short-day, nonvernalization long-day, and nonvernalization short-day treatments. The results showed that the morphology (total number of leaves, number of branches, number of leaves per branch, and branch length) of the vernalization treatment groups was significantly different from that of other nonvernalization groups, and the photosynthetic pigments, net photosynthetic rate, water use efficiency, stomatal conductance, intercellular CO₂ concentration, and transpiration rate increased in the vernalization treatment group. However, the gibberellin 3 (GA₃), indole-3-acetic acid and zeatin riboside (ZR) contents were significantly increased under the short-day treatments groups, and the results were the same for the expression of endogenous hormone synthesis genes, except for abscisic acid (ABA). The flowering-related genes soc1, elf3, svp, ga20ox, and cry1 were highly expressed under the vernalization short-day. Therefore, the induction of vernalization is more conducive to the increase in the photosynthetic rate. Temperature and photoperiod synergistically induced the synthesis and accumulation of starch, sugar, amino acids, and protein and affected the content of endogenous hormones and the expression of genes involved in their synthesis. GA₃ and ZR had thresholds for their regulation of the flowering process in P. vulgaris, and high concentrations of ABA promoted flowering. Temperature and photoperiod coordinate the expression of the flowering-related genes soc1, elf3, svp, ga20ox, and cry1, thereby affecting the flowering process in P. vulgaris.
Keywords	Prunella vulgaris ; abscisic acid ; beverages ; carbon ; carbon dioxide ; gene expression ; horticulture ; indole acetic acid ; metabolites ; nitrogen ; photosynthesis ; starch ; stomatal conductance ; sugars ; temperature ; vegetative growth ; vernalization ; water use efficiency ; zeatin
Language	English
Dates of publication	2022-03
Size	p. 73-81.
Publishing place	American Society for Horticultural Science
Document type	Article
ZDB-ID	2040057-3
ISSN	2327-9788
ISSN	2327-9788
DOI	10.21273/JASHS05144-21
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