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  1. Article: [Application of specific staining in the diagnosis of secretory meningioma].

    Hu, L W / Li, G P / Zhang, S / Wang, X F

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2022  Volume 51, Issue 4, Page(s) 350–353

    MeSH term(s) Humans ; Meningeal Neoplasms/diagnosis ; Meningioma/diagnosis ; Staining and Labeling
    Language Chinese
    Publishing date 2022-03-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20210914-00673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2958: Show issues Location:
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  2. Article: [The study on the association of long-term ambient fine particulate matters exposure and elevated blood pressure in children].

    Mi, X / Zhang, Y T / Hu, L W / Liu, K K / Yang, B Y / Zeng, X W / Guo, Y M / Dong, G H

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2018  Volume 53, Issue 1, Page(s) 45–50

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; China/epidemiology ; Cities ; Environmental Exposure/adverse effects ; Environmental Exposure/statistics & numerical data ; Humans ; Hypertension/epidemiology ; Particulate Matter/toxicity ; Time Factors
    Chemical Substances Particulate Matter
    Language Chinese
    Publishing date 2018-12-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2019.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Circle RNA FOXP1 promotes cell proliferation in lung cancer by regulating miR-185-5p/Wnt1 signaling pathway.

    Li, O / Kang, J / Zhang, J-J / Wang, J / Hu, L-W / Li, L / Sun, Y-Y / Bai, Y / Wei, Q-Q / Yan, Y-P / Yi, X

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 12, Page(s) 6767–6778

    Abstract: Objective: It is reported that circular RNA plays an important role in various cancers in recent years. However, there is less investigation reported in lung adenocarcinoma (LUAD) about circRNA. This study aims to explore the role and molecular ... ...

    Abstract Objective: It is reported that circular RNA plays an important role in various cancers in recent years. However, there is less investigation reported in lung adenocarcinoma (LUAD) about circRNA. This study aims to explore the role and molecular mechanism of circle RNA FOXP1 in LUAD procession.
    Patients and methods: The levels of circFOXP1 and miR-185-5p in LUAD cell lines and LUAD cancer samples were examined by RT-PCR. The functions of circFOXP1 and miR-185-5p at LUAD cells were detected by cell transfection of the overexpression or repression. The A549 and H1299 cell proliferation were detected by MTT assay and colony formation assay. And the cell apoptosis was detected by TUNEL assay. The expression levels WNT1 were measured by Western blot in A549 and H1299 cells. Furthermore, the luciferase assay detected the direct interaction between circFOXP1 and miR-185-5p or miR-185-5p and WNT1.
    Results: The circFOXP1 expression was increased in LUAD patients and LUAD cell lines. The downregulation of circFOXP1 significantly repressed LUAD cell proliferation and promoted cell apoptosis. Moreover, the luciferase assay results confirmed that circFOXP1 directly interacted with miR-185-5p. Overexpression of miR-185-5p could reverse the effect of circFOXP1 in LUAD cell. Besides, the luciferase results showed that miR-185-5p directly interacted with WNT1. miR-185-5p overexpression inhibited the WNT1 expression, while circFOXP1 repression decreased the WNT1 level in LUAD cell lines. The downregulating WNT1 could reverse the effects of miR-185-5p inhibition in LUAD cell lines. Furthermore, WNT1 was significantly upregulated in LUAD cancer tissues. In addition, circFOXP1 level was negatively correlated with miR-185-5p expression and positively correlated with WNT1 expression in LUAD cancer tissues.
    Conclusions: These data suggested that circFOXP1 promoted cell proliferation and repressed cell apoptosis in LUAD by regulating miR-185-5p/WNT1 signaling pathway. It provides a novel potential therapeutic agent for the treatment of LUAD.
    MeSH term(s) A549 Cells ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Adult ; Cell Proliferation/physiology ; Female ; Forkhead Transcription Factors/biosynthesis ; Humans ; Male ; MicroRNAs/biosynthesis ; Middle Aged ; RNA, Circular/biosynthesis ; Repressor Proteins/biosynthesis ; Signal Transduction/physiology ; Wnt1 Protein/biosynthesis
    Chemical Substances FOXP1 protein, human ; Forkhead Transcription Factors ; MIRN185 microRNA, human ; MicroRNAs ; RNA, Circular ; Repressor Proteins ; WNT1 protein, human ; Wnt1 Protein
    Language English
    Publishing date 2020-07-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202006_21665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
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  4. Article ; Online: Prospective ECG-triggering cardiac CT for infants with complex congenital heart disease using low-dose contrast medium, low tube voltage, and adaptive statistical iterative reconstruction.

    Wang, S-Y / Gao, W / Zhong, Y-M / Sun, A-M / Wang, Q / Hu, L-W / Qiu, H-S / Li, J-Y

    Clinical radiology

    2017  Volume 72, Issue 6, Page(s) 502–507

    Abstract: Aim: To demonstrate the clinical value of prospective electrocardiography (ECG)-triggered cardiac computed tomography (CT) with low concentration contrast medium, low tube voltage, and adaptive statistic iterative reconstruction (ASIR) to reduce both ... ...

    Abstract Aim: To demonstrate the clinical value of prospective electrocardiography (ECG)-triggered cardiac computed tomography (CT) with low concentration contrast medium, low tube voltage, and adaptive statistic iterative reconstruction (ASIR) to reduce both radiation and contrast dose in examining infants with complex congenital heart disease (CHD).
    Materials and methods: Forty-four consecutive infants (19 male, 25 female, age: 8.06±4.33 months, weight: 7.31±1.36 kg) with complex CHD underwent prospective ECG-triggered low-dose cardiac CT using 80 kVp and 120 mA. The contrast agent was iodixanol (270 mg iodine/ml, Visipaque, GE Healthcare, Co. Cork, Ireland). Cardiac CT images were reconstructed with 70% ASIR. The quantitative CT image quality was assessed by image noise in adipose tissue and contrast-to-noise ratio (CNR) in the aorta. The qualitative image analysis was performed on a five-point grading scale by two independent reviewers and interobserver variability was calculated. The results of 32 CT examinations were also compared with the available surgical results for diagnostic accuracy evaluation.
    Results: The effective dose was 0.55±0.10 mSv for the patient population. The iodine load was 3.95±0.73 g iodine. Image noise in adipose tissue was 16.24±1.42 HU and CNR in aorta was 21.90±7.10. All images were acceptable for diagnosis with an average score of 4.52±0.38 and good agreement between reviewers (kappa=0.75). Compared to the surgery results in 32 cases, CT was 97% and 88% accurate diagnosing extracardiac and intracardiac defects, respectively.
    Conclusion: Prospective ECG-triggered cardiac CT using 80 kVp, low-concentration iodinated contrast agent (270 mg iodine/ml) and 70% ASIR reconstruction provides excellent image quality and accurate diagnosis for complex congenital heart disease in infants with reduced contrast medium dose and low radiation dose.
    MeSH term(s) Cardiac Imaging Techniques ; Contrast Media/administration & dosage ; Electrocardiography ; Female ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/physiopathology ; Humans ; Image Processing, Computer-Assisted ; Infant ; Male ; Prospective Studies ; Tomography, X-Ray Computed/methods ; Triiodobenzoic Acids/administration & dosage
    Chemical Substances Contrast Media ; Triiodobenzoic Acids ; iodixanol (HW8W27HTXX)
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2017.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dental anxiety and trait anxiety: an investigation of their relationship.

    Fuentes, D / Gorenstein, C / Hu, L W

    British dental journal

    2009  Volume 206, Issue 8, Page(s) E17

    Abstract: Background: Anxiety related to dental treatment is a fairly common phenomenon. Some studies have shown that there is an association between dental anxiety and general fears and anxiety, neuroticism and general psychological distress.: Aim: This study ...

    Abstract Background: Anxiety related to dental treatment is a fairly common phenomenon. Some studies have shown that there is an association between dental anxiety and general fears and anxiety, neuroticism and general psychological distress.
    Aim: This study was designed to examine the relationship between dental anxiety and trait anxiety.
    Subjects and methods: The sample consisted of 1,030 individuals (688 women; 342 men), aged 30.8 +/- 11.7 years. The Portuguese version of Corah's Dental Anxiety Scale (DAS) and State-Trait Anxiety Inventory (STAI-T) were used.
    Results: A statistically significant association between high DAS and high STAI-T, but not between high STAI-T and high DAS, was found. The data indicated that subjects with high dental anxiety tend to present with high trait anxiety, but high trait anxiety seems not to predispose to high dental anxiety.
    Conclusions: Our results indicate that dental anxiety is specific, with its own features, and its development is not necessarily associated with trait anxiety.
    MeSH term(s) Adult ; Anxiety/psychology ; Dental Anxiety/psychology ; Disease Susceptibility ; Fear/psychology ; Female ; Humans ; Male ; Neurotic Disorders/psychology ; Sex Factors ; Stress, Psychological/psychology
    Language English
    Publishing date 2009-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2009.253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.143: Show issues Location:
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    Zs.MO 447: Show issues

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  6. Article ; Online: Pre-natal and post-natal exposure to pet ownership and lung function in children: The Seven Northeastern Cities Study.

    Hu, L-W / Qian, Z / Dharmage, S C / Liu, E / Howard, S W / Vaughn, M G / Perret, J / Lodge, C C / Zeng, X-W / Yang, B-Y / Xu, S-L / Zhang, C / Dong, G-H

    Indoor air

    2017  Volume 27, Issue 6, Page(s) 1177–1189

    Abstract: To evaluate the association between pre-natal and post-natal exposure to pet ownership and lung function in children, a cross-sectional study named Seven Northeastern Cities (SNEC) study was conducted. In this study, children's lung function including ... ...

    Abstract To evaluate the association between pre-natal and post-natal exposure to pet ownership and lung function in children, a cross-sectional study named Seven Northeastern Cities (SNEC) study was conducted. In this study, children's lung function including the forced expiratory volume in 1 second (FEV
    MeSH term(s) Adolescent ; Animals ; Birds ; Cats ; Child ; Cross-Sectional Studies ; Dogs ; Female ; Humans ; Lung/physiology ; Male ; Pets ; Pregnancy ; Prenatal Exposure Delayed Effects ; Respiratory Function Tests
    Language English
    Publishing date 2017-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.12401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 7724: Show issues

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  7. Article: Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling.

    Hu, L W / Benvenuti, L A / Liberti, E A / Carneiro-Ramos, M S / Barreto-Chaves, M L M

    American journal of physiology. Regulatory, integrative and comparative physiology

    2003  Volume 285, Issue 6, Page(s) R1473–80

    Abstract: The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy. Hemodynamic parameters, heart weight (HW), ratio of HW to body weight (HW/BW) ...

    Abstract The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy. Hemodynamic parameters, heart weight (HW), ratio of HW to body weight (HW/BW), and myocyte width were evaluated in absence of thyroid hormone (hypothyroidism) and after T4 administration. Male Wistar rats were used. Some were subjected to thyroidectomies, whereas hyperthyroidism was induced in others via daily intraperitoneal injection of T4 (25 or 100 microg x 100 g BW(-1) x day(-1)) for 7 days. In some cases, T4 administration was combined with the angiotensin I-converting enzyme inhibitor enalapril (Ena), with the angiotensin type 1 (AT1) receptor blocker losartan (Los) or with the beta-adrenergic blocker propanolol (Prop). Hemodynamics and morphology were then evaluated. Systolic blood pressure (SBP) was not altered by administration of either T4 alone or T4 in combination with the specific inhibitors. However, SBP decreased significantly in hypothyroid rats. An increased heart rate was seen after administration of either T4 alone or T4 in combination with either Los or Ena. Although the higher dose of T4 significantly increased HW, HW/BW increased in both T4-treated groups. Ena and Prop inhibited the increase in HW or HW/BW in hyperthyroid rats. Morphologically, both T4 dose levels significantly increased myocyte width, an occurrence prevented by RAS or SNS blockers. There was a good correlation between changes in HW/BW and myocyte width. These results indicate that T4-induced cardiac hypertrophy is associated with both the SNS and the RAS.
    MeSH term(s) Animals ; Blood Pressure ; Cardiomegaly/chemically induced ; Cardiomegaly/pathology ; Cardiomegaly/physiopathology ; Connective Tissue/pathology ; Fibrosis ; Heart Rate ; Male ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; Rats ; Rats, Wistar ; Receptors, Adrenergic/physiology ; Receptors, Angiotensin/physiology ; Renin-Angiotensin System/physiology ; Sympathetic Nervous System/physiology ; Thyroxine/pharmacology ; Ventricular Remodeling/physiology
    Chemical Substances Receptors, Adrenergic ; Receptors, Angiotensin ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2003-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00269.2003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Mechanical properties of metals

    Hu, L. W / Marin, Joseph

    ; A short course held at The Pennsylvania State Univ., July 7-11, 1958

    1958  

    Author's details by D. McLean
    Size 4°
    Publishing place New Ed. by L. W. Hu and Joseph Marin
    Document type Book
    Note [Umschlagt.]: Proceedings for Short Course Mechanical Properties of metals
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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