LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1573

Search options

  1. Article ; Online: Inhibitory effect of a novel Curcumin derivative DMC-HA on keloid fibroblasts.

    Hu, Liang / Bao, Zhicheng

    Aging

    2024  Volume 16, Issue 3, Page(s) 2398–2409

    Abstract: Keloids pose a significant dermatological challenge, marked by abnormal fibroblast proliferation and excessive collagen deposition in response to skin injury or trauma. In the present study, we introduce DMC-HA, a derivative of Curcumin, as a promising ... ...

    Abstract Keloids pose a significant dermatological challenge, marked by abnormal fibroblast proliferation and excessive collagen deposition in response to skin injury or trauma. In the present study, we introduce DMC-HA, a derivative of Curcumin, as a promising candidate for keloid treatment. DMC-HA is poised to provide superior therapeutic benefits compared to Curcumin due to its structural modifications. Examining the comparative effects of DMC-HA and Curcumin on keloid fibroblasts can offer insights into their potential as therapeutic agents and the underlying mechanisms in keloid pathogenesis. In our study, CCK-8 experiments revealed that, at equivalent concentrations, DMC-HA demonstrated greater efficacy in inhibiting the proliferation of keloid fibroblasts compared to Curcumin. Flow cytometry analysis indicated that DMC-HA induced fibroblast apoptosis more significantly than Curcumin at the same concentration. Further data demonstrated that DMC-HA notably increased the production of reactive oxygen species (ROS), upregulated the expression levels of Bax, cleaved PARP, and cleaved Caspase-3. Interestingly, the impact of DMC-HA was reversed upon the application of the antioxidant NAC. Additionally, DMC-HA could suppress IL-6-induced increased expression of p-STAT3. Collectively, our findings suggest that DMC-HA is more effective than Curcumin in inhibiting the proliferation of keloid fibroblasts. The underlying mechanism of its action appears to be associated with the augmentation of ROS induction and the concurrent inhibition of STAT3 activation.
    MeSH term(s) Humans ; Curcumin/therapeutic use ; Keloid/drug therapy ; Reactive Oxygen Species/metabolism ; Collagen/metabolism ; Apoptosis ; Fibroblasts/metabolism ; Cell Proliferation
    Chemical Substances Curcumin (IT942ZTH98) ; Reactive Oxygen Species ; Collagen (9007-34-5)
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205487
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Letter to the Editor Regarding "Novel Decompressive Hemicraniectomy Technique for Traumatic Brain Injury: Technical Note".

    Low, Hu Liang

    World neurosurgery

    2021  Volume 150, Page(s) 245–246

    MeSH term(s) Brain Injuries, Traumatic/surgery ; Decompressive Craniectomy ; Humans
    Language English
    Publishing date 2021-05-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.03.086
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Editorial: Liquid metal-based flexible bioelectronics and biointerfaces.

    Li, Liangtao / Hu, Liang

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1254744

    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1254744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Current agreement between ActiGraph and CUPAR in measuring moderate to vigorous intensity physical activity for adolescents.

    Lu, Yijuan / Hu, Liang / Yu, Kehong

    BMC pediatrics

    2024  Volume 24, Issue 1, Page(s) 63

    Abstract: The study aims to develop and validate the Curriculum-related Physical Activity Recall questionnaire (CUPAR) as a measure of physical activity in adolescents. 83 middle-school students (13.23 ± 0.74 yrs) completed the CUPAR and whore ActiGraph ... ...

    Abstract The study aims to develop and validate the Curriculum-related Physical Activity Recall questionnaire (CUPAR) as a measure of physical activity in adolescents. 83 middle-school students (13.23 ± 0.74 yrs) completed the CUPAR and whore ActiGraph accelerometers for seven consecutive days. Correlations and Bland-Altman plots were to examine the agreement between these two measures. Significant correlations were observed between the CUPAR and ActiGraph accelerometer for 5-day MPA (r = 0.29, p < 0.01), and for both 5-day and 7-day VPA (r = 0.47 and 0.79, ps < 0.01), and MVPA (r = 0.79 and 0.42, ps < 0.01). Plots showed reasonable agreement between the CUPAR and ActiGraph estimates of VPA and MVPA. The agreement between CUPAR and ActiGraph was higher for in-school VPA (r = 0.58, p < 0.01) and MVPA (r = 0.44, p < 0.01) as compared to the out-school VPA (r = 0.22, p < 0.05) and MVPA (r = 0.26, p < 0.05). The CUPAR can reduce respondents' burden, representing a reliable and efficient measure of physical activity among adolescents, especially for PA occurred during in-school sessions and at vigorous intensity.
    MeSH term(s) Humans ; Adolescent ; Accelerometry ; Exercise ; Schools ; Curriculum
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-024-04541-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: A rhodamine coumarin-derived fluorescence probe that selectively detects Fe

    Qin, Danni / Han, Yaqi / Jiang, Hao / Hu, Liang

    Analytical methods : advancing methods and applications

    2024  Volume 16, Issue 3, Page(s) 403–410

    Abstract: We synthesized a fluorescence ratiometric probe by combining coumarin and rhodamine B with ethylenediamine to sense ... ...

    Abstract We synthesized a fluorescence ratiometric probe by combining coumarin and rhodamine B with ethylenediamine to sense Fe
    MeSH term(s) Rhodamines/chemistry ; Fluorescent Dyes/chemistry ; Fluorescence Resonance Energy Transfer/methods ; Coumarins/chemistry ; Radiation Dosage
    Chemical Substances Rhodamines ; Fluorescent Dyes ; Coumarins
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01875j
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Management of chronic pancreatitis: recent advances and future prospects.

    Han, Chao / Lv, Yan-Wei / Hu, Liang-Hao

    Therapeutic advances in gastroenterology

    2024  Volume 17, Page(s) 17562848241234480

    Abstract: As a progressive fibroinflammatory disease, chronic pancreatitis (CP) often manifests as recurrent bouts of abdominal pain with or without complications, causing a heavy burden of health care. In recent years, some meaningful insights into the management ...

    Abstract As a progressive fibroinflammatory disease, chronic pancreatitis (CP) often manifests as recurrent bouts of abdominal pain with or without complications, causing a heavy burden of health care. In recent years, some meaningful insights into the management of CP have been obtained from randomized controlled trials, systematic reviews, and meta-analyses, which were of great importance. Based on this research, it is shown that there are various treatments for CP. Therefore, it is of great importance to choose a suitable strategy for patients with CP individually. Relevant evidence on the management of CP was summarized in this review, including nutrition supplements, medication, endoscopy, surgery, exploration of novel therapies as well as evaluation and prediction of treatment response.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848241234480
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Floating phalanx with mallet finger and middle-phalanx base fracture: A case report.

    Jin, Neng / Hu, Liang / Xu, Yueyang / Ye, Shuming

    Asian journal of surgery

    2024  Volume 47, Issue 5, Page(s) 2284–2285

    MeSH term(s) Humans ; Finger Phalanges/injuries ; Finger Phalanges/diagnostic imaging ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Finger Injuries/surgery ; Finger Injuries/diagnostic imaging ; Male ; Radiography ; Adult ; Fracture Fixation, Internal/methods
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.01.154
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Challenges and Optimization Paths of Guzheng Professional Education in Colleges under Big Data Era.

    Cheng, Li / Hu, Liang

    publication RETRACTED

    Journal of environmental and public health

    2022  Volume 2022, Page(s) 4941860

    Abstract: As a treasure among Chinese national musical instruments, guzheng is an important part of traditional Chinese music. As the art of national music goes to the world, the art of guzheng has been widely promoted. As the best form to carry forward the art of ...

    Abstract As a treasure among Chinese national musical instruments, guzheng is an important part of traditional Chinese music. As the art of national music goes to the world, the art of guzheng has been widely promoted. As the best form to carry forward the art of guzheng, the teaching of guzheng majors in colleges is significant in teaching and continuously improves guzheng art accomplishment. Oral teaching and step-by-step music theory and technique teaching are typical ways of teaching musical instrument performance in colleges. However, under big data, Chinese education is undergoing a profound change, and the combination of big data and education has become a new contemporary education method. This work studies the guzheng professional education in colleges under big data. First, this work aims at the existing outstanding issues of guzheng teaching in colleges and studies the challenges and optimization paths of guzheng professional education in colleges under big data. Second, this work proposes a multiscale residual attention fusion network (MSRAFNET) to evaluate the teaching quality of guzheng majors in colleges in the era of big data. The feature extraction of the network model is mainly completed by the residual module, which is composed of several multiscale residual learning units. Adding an attention mechanism to the multiscale residual learning unit can enhance the feature extraction of key information by the network and reduce the interference of redundant information, which is more conducive to the learning of data features. It adopts the design of GAP and Dropout to reduce spatial parameters in network training, and the effect of antioverfitting is better. Third, this work systematically evaluates the optimization path of Guzheng education and MSRAFNET, and the systematic experiments verify the superiority of the designed method.
    MeSH term(s) Big Data ; Education, Professional ; Humans ; Universities
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2022/4941860
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: How weak twining lianas adapt to competition with host tree trunks: Case of

    Hu, Liang / Lin, Yuwei

    Ecology and evolution

    2022  Volume 12, Issue 4, Page(s) e8800

    Abstract: Fierce competition exists between most stem-twining lianas and the trunks of host trees. However, ...

    Abstract Fierce competition exists between most stem-twining lianas and the trunks of host trees. However,
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.8800
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Distribution patterns of vines within the East Asian island chain

    Hu, Liang / Chen, Wenjie

    Ecological indicators. 2022 Feb., v. 135

    2022  

    Abstract: The northward dispersal of thermophilic plants along the East Asia island chain is influenced by cold stress, strait barrier and island effect. However, the impact of each parameter is not clear. In this study, we try to clarify the contribution of the ... ...

    Abstract The northward dispersal of thermophilic plants along the East Asia island chain is influenced by cold stress, strait barrier and island effect. However, the impact of each parameter is not clear. In this study, we try to clarify the contribution of the above three effects to the geographical patterns of cold-intolerant climbing plants (vines) within the East Asia island chain. We divided the East Asian region into inland, coastal and island chain belts (Belt I, II and III, respectively), and 13/14 latitudinal regions. Distribution patterns of taxa shared by two adjacent belts were compared. We evaluated the impacts of cold stress effects by comparing the northern-most distribution boundary of vines within the island chain with those on the East Asian mainland and matching average January temperature isotherms. We assessed the strait barrier effect by comparing it with non-strait biogeographic lines. The island effect was assessed by quantifying the percentage of discontinuously distributed taxa. The results showed that: The northern-most limit of 54.3% of genera and 63.2% of species shared by Belts II and III coincided with a strait, with 27.2% of genera and 25.0% of species being discontinuously distributed. Cold stress, island effect and strait barrier effects together explained the patterns of 82.1% of genera and 87.7% of species shared by Belts II and III, which was higher than the value explained by cold stress on the mainland (77.7% and 72.4%, respectively). Cold stress, island effect and strait barrier explained 29.6%, 13.6% and 38.9% distribution patterns of taxa at the genus level, and 25.0%, 16.4% and 46.3% at the species level, respectively. Distribution patterns that could not be explained by cold stress were explained by strait barrier and island effect along the East Asian island chain. The East Asian island chain, especially the Ryukyu Islands, might be an efficient avenue for the northward dispersal of terrestrial plants, explaining the low degree of endemism and prevalence of discontinuously distributed taxa in this region.
    Keywords cold stress ; geographical distribution ; indigenous species ; temperature
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036774-0
    ISSN 1872-7034 ; 1470-160X
    ISSN (online) 1872-7034
    ISSN 1470-160X
    DOI 10.1016/j.ecolind.2022.108540
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7436: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top