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  1. Book ; Online ; E-Book: Oral Bioavailability and Drug Delivery

    Hu, Ming / Li, Xiaoling

    From Basics to Advanced Concepts and Applications

    (Wiley Series in Drug Discovery and Development Series)

    2024  

    Series title Wiley Series in Drug Discovery and Development Series
    Language English
    Size 1 online resource (931 pages)
    Edition 1st ed.
    Publisher John Wiley & Sons, Incorporated
    Publishing place Newark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-66069-6 ; 1-119-66066-1 ; 9781119660651 ; 978-1-119-66069-9 ; 978-1-119-66066-8 ; 1119660653
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Oral bioavailability

    Hu, Ming / Li, Xiaoling

    basic principles, advanced concepts, and applications

    (Wiley series in drug discovery and development)

    2011  

    Author's details ed. by Ming Hu ; Xiaoling Li
    Series title Wiley series in drug discovery and development
    Keywords Biological Availability ; Intestinal Absorption ; Drug Delivery Systems ; Bioverfügbarkeit ; Orales Arzneimittel ; Arzneimittelentwicklung
    Subject Arzneimittel ; Drug Development ; Biologische Verfügbarkeit ; Bioavailability
    Language English
    Size XVII, 540 S., [4] Bl. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT016955909
    ISBN 978-0-470-26099-9 ; 0-470-26099-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 3520 order for loan Magazin

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  3. Article ; Online: Decision-Making Model of Product Modeling Big Data Design Scheme Based on Neural Network Optimized by Genetic Algorithm.

    Hu, Ming

    publication RETRACTED

    Computational intelligence and neuroscience

    2021  Volume 2021, Page(s) 9315700

    Abstract: At present, machine learning artificial neural network technology, as one of the core technologies of enterprises, has received unprecedented attention. This technology is widely used in automatic driving, pattern recognition, teaching aid, product ... ...

    Abstract At present, machine learning artificial neural network technology, as one of the core technologies of enterprises, has received unprecedented attention. This technology is widely used in automatic driving, pattern recognition, teaching aid, product modeling, and other fields. According to the development of product design, this paper analyzes the factors that affect the decision-making of product design. The neural network optimized by genetic algorithm is studied, and the technical analysis of neural network algorithm before and after optimization is mainly carried out. The basic process of product modeling design model based on image processing under the background of big data is introduced. The multidirectional group decision-making model of product modeling design scheme in big data cloud environment is constructed. The final decision model can improve the overall design efficiency, shorten the manufacturing period, and provide a new idea for product modeling design.
    MeSH term(s) Algorithms ; Big Data ; Decision Making ; Humans ; Machine Learning ; Neural Networks, Computer
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2021/9315700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of a fluorescent ligand that can illuminate nuclear G-quadruplexes and modulate oncogene expression.

    Zhang, Xiao / Hu, Ming-Hao

    Bioorganic & medicinal chemistry

    2024  Volume 104, Page(s) 117713

    Abstract: In this study, we developed a promising dual-function fluorescent ligand termed KS-1 by a slight structural modification on a reported carbazole-based scaffold. KS-1 was then found to mainly bind and illuminate the nuclear DNA G-quadruplexes (G4s) in a ... ...

    Abstract In this study, we developed a promising dual-function fluorescent ligand termed KS-1 by a slight structural modification on a reported carbazole-based scaffold. KS-1 was then found to mainly bind and illuminate the nuclear DNA G-quadruplexes (G4s) in a sandwich-like interacting mode, and also effectively modulate the oncogene expression through a G4-mediated manner. Furthermore, KS-1 was proved to inhibit cancer cell growth either in 2D monolayer cells or 3D multicellular tumor spheroids. To be noted, this ligand could overcome the shortcomings of other reported dual-function ligands that appeared to accumulate in the lysosomes or mitochondria, and may be used as a theranostic agent in the future.
    MeSH term(s) G-Quadruplexes ; Ligands ; Oncogenes ; Coloring Agents
    Chemical Substances Ligands ; Coloring Agents
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2024.117713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Molecular engineering of a near-infrared fluorescent ligand for tracking mitochondrial DNA G-quadruplexes.

    Hu, Ming-Hao

    Analytica chimica acta

    2021  Volume 1169, Page(s) 338600

    Abstract: G-quadruplexes are supposed to exist in mitochondrial DNA, which may participate in the regulation of mitochondrial metabolism. However, their formation dynamics and cellular roles are still unknown, calling for the development of promising small- ... ...

    Abstract G-quadruplexes are supposed to exist in mitochondrial DNA, which may participate in the regulation of mitochondrial metabolism. However, their formation dynamics and cellular roles are still unknown, calling for the development of promising small-molecule fluorescent probes for detecting mitochondrial DNA (mtDNA) G4s in live cells. In this study, we engineered a NIR fluorescent probe termed IZIN-1 by conjugating a typical G4 ligand and a mitochondrion-targeting AIE luminogen, which was then found to be able to emit NIR fluorescence by binding to mtDNA G4s via a distinctive mode. Cell-based experiments demonstrated that IZIN-1 may track mtDNA G4 formation in live cells. Collectively, this work provides a promising example about how to design a fluorescent probe targeting mtDNA G4s, and also offers a feasible chemical tool for investigating mtDNA G4s in live cells.
    MeSH term(s) Fluorescence ; Fluorescent Dyes ; G-Quadruplexes ; Ligands ; Mitochondria/genetics
    Chemical Substances Fluorescent Dyes ; Ligands
    Language English
    Publishing date 2021-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2021.338600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mitochondrial DNA-triggered innate immune response: mechanisms and diseases.

    Hu, Ming-Ming / Shu, Hong-Bing

    Cellular & molecular immunology

    2023  Volume 20, Issue 12, Page(s) 1403–1412

    Abstract: Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector ... ...

    Abstract Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate immune response to viral infection and other stress factors. The deregulation of these processes causes autoimmune diseases, inflammatory metabolic disorders and cancer. Therefore, the cGAS-MITA/STING pathway is a potential target for intervention in infectious, inflammatory and autoimmune diseases as well as cancer. In this review, we focus on the mechanisms underlying the mtDNA-triggered activation of the cGAS-MITA/STING pathway, the effects of the pathway under various physiological and pathological conditions, and advances in the development of drugs that target cGAS and MITA/STING.
    MeSH term(s) Humans ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Signal Transduction ; Immunity, Innate ; Nucleotidyltransferases/metabolism ; Mitochondria/metabolism ; Autoimmune Diseases/pathology ; Neoplasms/pathology
    Chemical Substances DNA, Mitochondrial ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2023-11-07
    Publishing country China
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-023-01086-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
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  7. Article ; Online: New triazole-attached quinoxalines selectively recognize the telomeric multimeric G-quadruplexes and inhibit breast cancer cell growth.

    Hu, Ming-Hao / Lin, Jia-Hong

    International journal of biological macromolecules

    2023  Volume 241, Page(s) 124548

    Abstract: The telomeric 3'-overhang had potential to form into higher-order structures termed multimeric G-quadruplexes (G4s), which may mainly exist in telomeres, representing an attractive drug target for development of anticancer agents with few side effects. ... ...

    Abstract The telomeric 3'-overhang had potential to form into higher-order structures termed multimeric G-quadruplexes (G4s), which may mainly exist in telomeres, representing an attractive drug target for development of anticancer agents with few side effects. However, only a few molecules that selectively bind to multimeric G4s have been found by random screening, which means a lot of room for improvement. In this study, we raised a feasible strategy to design small-molecule ligands with possible selectivity to multimeric G4s, and then synthesized a focused library of multi-aryl compounds by attaching triazole rings to the quinoxaline skeleton. Among them, QTR-3 was identified as the most promising selective ligand that may bind at the G4-G4 interface, which accordingly stabilized multimeric G4s and induced DNA damage in telomeric region, thereby leading to cell cycle arrest and apoptosis. Notably, QTR-3 showed more significant inhibition on breast cancer cells against normal mammary cells.
    MeSH term(s) Humans ; Female ; G-Quadruplexes ; Quinoxalines/pharmacology ; Breast Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Telomere ; Ligands
    Chemical Substances Quinoxalines ; Antineoplastic Agents ; Ligands
    Language English
    Publishing date 2023-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2374: Show issues Location:
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  8. Article ; Online: Discovery of a minimalistic DIE-based fluorescent probe for detection of parallel G-quadruplex forms.

    Dong, Yun / Hu, Ming-Hao

    Bioorganic chemistry

    2023  Volume 141, Page(s) 106879

    Abstract: G-quadruplexes (G4s) are considered to be involved in some key biological processes, leading to the development of a large number of G4 fluorescent probes, which offer possibilities to study G4 dynamics as well as their biological roles. However, the ... ...

    Abstract G-quadruplexes (G4s) are considered to be involved in some key biological processes, leading to the development of a large number of G4 fluorescent probes, which offer possibilities to study G4 dynamics as well as their biological roles. However, the structures of G4s show high polymorphism, which can be classified into parallel, hybrid and antiparallel forms, and the probes targeting a certain topology are limited. In this study, we have developed a minimalistic fluorescent probe by exploiting the disaggregation-induced emission (DIE) principle. The further studies demonstrated that this probe exhibited promising selectivity toward parallel DNA and RNA G4 forms in vitro. Moreover, it was found that this probe could be applied to map the RNA G4s that always form into parallel topologies in live cells, which distinguished it from other reported DIE-based probes that often targeted the mitochondrial or nuclear DNA G4s. To the best of our knowledge, this was the first DIE-based fluorescent probe for mapping cellular RNA G4s.
    MeSH term(s) Fluorescent Dyes/chemistry ; G-Quadruplexes ; DNA/chemistry ; RNA
    Chemical Substances Fluorescent Dyes ; DNA (9007-49-2) ; RNA (63231-63-0)
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Editorial: The association between viral infection and human cancers.

    Hu, Ming / Wang, Bin / Li, Jinlin / Wu, Chengjun

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1371581

    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1371581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quantum Teleportation and Dense Coding in Multiple Bosonic Reservoirs.

    Wang, Yu / Hu, Ming-Liang

    Entropy (Basel, Switzerland)

    2022  Volume 24, Issue 8

    Abstract: The effect of a reservoir on quantum communication depends on its spectral density. The efficiency of quantum teleportation and dense coding is explored when each one of the channel qubits is coupled simultaneously to multiple bosonic reservoirs. It is ... ...

    Abstract The effect of a reservoir on quantum communication depends on its spectral density. The efficiency of quantum teleportation and dense coding is explored when each one of the channel qubits is coupled simultaneously to multiple bosonic reservoirs. It is shown that the non-Markovianity triggered by increasing the reservoir number can induce revivals of quantum advantages of the two protocols after their disappearance. However, the backflow of information to the system that signifies non-Markovianity does not always induce immediate revivals of the quantum advantages. There may be a delayed effect for some initial states, and only as the backflow of information accumulates to a certain extent can the revivals of quantum advantages be triggered.
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e24081114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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