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  1. Article ; Online: Postharvest ripening of newly harvested corn: Weakened interactions between starch and protein.

    Hu, Nannan / Qi, Weihua / Zhu, Jinying / Li, Sheng / Zheng, Mingzhu / Zhao, Chengbin / Liu, Jingsheng

    Food chemistry

    2024  Volume 451, Page(s) 139450

    Abstract: The effects of postharvest ripening of corn on the mechanisms of starch and protein interactions were investigated using molecular dynamics and several chemical substances. Sodium dodecyl sulfate (SDS) treatment all significantly affected the starch ... ...

    Abstract The effects of postharvest ripening of corn on the mechanisms of starch and protein interactions were investigated using molecular dynamics and several chemical substances. Sodium dodecyl sulfate (SDS) treatment all significantly affected the starch content, molecular weight of proteins, relative crystallinity, pasting characteristics and dynamic viscoelasticity in samples before and after postharvest ripening. In the corn that had not undergone postharvest ripening, there were also significant electrostatic interactions and hydrogen bonds between starch and protein. In addition, molecular dynamics had demonstrated that the forces between starch and protein in corn were mainly hydrophobic interactions, electrostatic interaction, and hydrogen bonds. Compared with zein, corn glutelin was more tightly bound to starch. The binding energy of starch to both proteins was reduced in after postharvest-ripened corn. This study laid a rationale for investigating the change mechanism of corn postharvest ripening quality and improving processing property and edible quality of corn.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.139450
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  2. Article ; Online: Current status of application of Traditional Chinese Medicine nursing for patients with dysphagia after stroke

    CHEN Shanshan / GUO Hong / GONG Shaohua / HU Nannan

    中西医结合护理, Vol 7, Iss 10, Pp 130-

    2021  Volume 135

    Abstract: This article combined the pathogenesis and syndrome types of dysphagia in Traditional Chinese Medicine(TCM) after stroke, and the application of TCM techniques in patients with dysphagia after stroke in recent years. It discussed the methods, effects and ...

    Abstract This article combined the pathogenesis and syndrome types of dysphagia in Traditional Chinese Medicine(TCM) after stroke, and the application of TCM techniques in patients with dysphagia after stroke in recent years. It discussed the methods, effects and potential problems of TCM nursing in alleviating dysphagia after stroke. The promotion and application value of TCM characteristic nursing in post-stroke dysphagia, and proposes the existing problems, aiming to provide reference for exploring the best TCM nursing methods and carrying out related research for patients with stroke dysphagia.
    Keywords traditional chinese medicine nursing ; stroke ; dysphagia ; acupuncture ; acupoint ; nursing based on syndrome differentiation ; Nursing ; RT1-120
    Language Chinese
    Publishing date 2021-10-01T00:00:00Z
    Publisher Association of Integrative Nursing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Factors influencing the efficiency of cellphone-based CBT for treating sleep disorders.

    Hu, Nannan / Xu, You / Mao, Hongjing

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 974888

    Abstract: Objective: This survey aimed to better comprehend the factors influencing patient response to insomnia treatment.: Methods: We conducted an online survey. A total of 1,395 patients completed the questionnaire at baseline. Insomnia, anxiety and ... ...

    Abstract Objective: This survey aimed to better comprehend the factors influencing patient response to insomnia treatment.
    Methods: We conducted an online survey. A total of 1,395 patients completed the questionnaire at baseline. Insomnia, anxiety and depressive symptoms were evaluated using the Pittsburgh Sleep Quality Index (PSQI), 7-item Generalized Anxiety Disorder assessment (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9), respectively. A total of 488 patients completed at least two surveys (baseline and monthly surveys thereafter) and reported that the online CBT was effective at the 1-year follow-up. The 488 patients were divided into three groups: the rapid (treatment effective at 4 weeks), intermediate (4-16 weeks), and delayed-response group (over 16 weeks).
    Results: Analysis of the demographic characteristics of the 488 patients did not reveal significant sex differences among the three groups (
    Conclusion: Many factors affected the efficiency of insomnia treatment. Male sex, junior school education, and a high PSQI score predicted delayed response to insomnia treatment.
    Language English
    Publishing date 2022-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.974888
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  4. Article: Emergency Management of Mental Hospitals during the Outbreak of COVID-19.

    Hu, Nannan / Mao, Hongjing

    Psychiatry investigation

    2020  Volume 17, Issue 5, Page(s) 489–490

    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2414364-9
    ISSN 1976-3026 ; 1738-3684
    ISSN (online) 1976-3026
    ISSN 1738-3684
    DOI 10.30773/pi.2020.0086
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  5. Article ; Online: Engineered elastin-like polypeptide-based hydrogel delivering chemotherapeutics and PD-L1 antibodies for potentiated cancer immunotherapy.

    Chen, Jinguang / Cui, Meiying / He, Lianping / Mu, Yeteng / Hu, Nannan / Guan, Xingang

    Journal of materials chemistry. B

    2023  Volume 11, Issue 43, Page(s) 10355–10361

    Abstract: Immune checkpoint inhibitors (ICIs) have effectively eradicated advanced tumors by inducing durable and systematic antitumor immune responses. However, when used as a standalone treatment, ICIs typically exhibit a low response rate in many cancers. In ... ...

    Abstract Immune checkpoint inhibitors (ICIs) have effectively eradicated advanced tumors by inducing durable and systematic antitumor immune responses. However, when used as a standalone treatment, ICIs typically exhibit a low response rate in many cancers. In this study, we engineered an
    MeSH term(s) Animals ; Mice ; CD8-Positive T-Lymphocytes ; B7-H1 Antigen ; Hydrogels/therapeutic use ; Elastin/therapeutic use ; Immunotherapy ; Antibodies, Monoclonal/therapeutic use ; Melanoma/drug therapy
    Chemical Substances B7-H1 Antigen ; Hydrogels ; Elastin (9007-58-3) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb01974h
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  6. Article ; Online: Harnessing PD-1 cell membrane-coated paclitaxel dimer nanoparticles for potentiated chemoimmunotherapy.

    Hu, Nannan / Xue, Han / Zhang, Ting / Fan, Yuxin / Guo, Fenglin / Li, Zhimin / Huo, Mingge / Guan, Xingang / Chen, Guofu

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 174, Page(s) 116482

    Abstract: Chemoimmunotherapy has emerged as a promising strategy for improving the efficacy of cancer treatment. Herein, we present PD-1 receptor-presenting membrane-coated paclitaxel dimers nanoparticles (PD-1@ ... ...

    Abstract Chemoimmunotherapy has emerged as a promising strategy for improving the efficacy of cancer treatment. Herein, we present PD-1 receptor-presenting membrane-coated paclitaxel dimers nanoparticles (PD-1@PTX
    MeSH term(s) Paclitaxel/pharmacology ; Paclitaxel/administration & dosage ; Animals ; Nanoparticles/chemistry ; Programmed Cell Death 1 Receptor/metabolism ; Female ; Humans ; Immunotherapy/methods ; Mice ; Cell Line, Tumor ; Mice, Inbred BALB C ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/immunology ; Cell Membrane/metabolism ; Cell Membrane/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/administration & dosage ; Xenograft Model Antitumor Assays ; Dimerization ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; B7-H1 Antigen/metabolism
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Programmed Cell Death 1 Receptor ; Antineoplastic Agents, Phytogenic ; B7-H1 Antigen
    Language English
    Publishing date 2024-03-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116482
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    Ud II Zs.198: Show issues Location:
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  7. Article ; Online: The coupling of sulfide and Fe-Mn mineral promotes the migration of lead and zinc in the redox cycle of high pH floodplain soils.

    Yu, Qianqian / Wen, Junwei / Zhang, Sili / Wu, Chen / Ouyang, Hao / Hu, Nannan / Li, Xu / Qiu, Xinhong

    Journal of hazardous materials

    2024  Volume 472, Page(s) 134546

    Abstract: In this study, we investigated the impact of fluctuating water levels on the distribution of lead (Pb) and zinc (Zn) in soil and sediments at a historical Pb-Zn smelting site along the Xiangjiang River. Despite the high pH levels (7 to 11) in the study ... ...

    Abstract In this study, we investigated the impact of fluctuating water levels on the distribution of lead (Pb) and zinc (Zn) in soil and sediments at a historical Pb-Zn smelting site along the Xiangjiang River. Despite the high pH levels (7 to 11) in the study area, which generally inhibits heavy metal solubility, we found that regular changes in water levels still affect Pb-Zn movement. Soil analysis revealed distinct redox zones within the unconfined aquifer, as shown by the variable Fe/Mn and Ce/Ce* ratios. Advanced techniques such as Mn K-edge XAFS, Mössbauer spectroscopy, and TOF-SIMS indicated persistent Fe-Mn redox cycling and highlighted the presence of Pb and Zn-rich manganese oxides near sulfur-bearing minerals. These findings suggest that acidic microzones produced by the oxidation of sulfur-bearing minerals become "refuges" for microbial and heavy metal activity. Considering that sulfur-containing minerals are widespread waste types in nonferrous metal smelting sites, these findings are instructive for a better understanding of the transformation mechanisms of heavy metal ions in nonferrous metal smelting-polluted environments and for guiding pollution remediation strategies.
    Language English
    Publishing date 2024-05-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.134546
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  8. Article: Influence of modification methods on physicochemical and structural properties of soluble dietary fiber from corn bran

    Li, Sheng / Hu, Nannan / Zhu, Jinying / Zheng, Mingzhu / Liu, Huimin / Liu, Jingsheng

    Food chemistry: X. 2022 June 30, v. 14

    2022  

    Abstract: Soluble dietary fiber (SDF), which is a component of dietary fibers exhibit many physiological functions, biological activity, and good gel forming ability. In this study, extraction of SDF from corn bran was evaluated using twin-screw extrusion and ... ...

    Abstract Soluble dietary fiber (SDF), which is a component of dietary fibers exhibit many physiological functions, biological activity, and good gel forming ability. In this study, extraction of SDF from corn bran was evaluated using twin-screw extrusion and ultrasonic treatment and the combinations of the respective methods with dual enzyme hydrolysis. The monosaccharide compositions, molecular weight, physicochemical properties, and structural and functional characteristics were determined. The results showed that ultrasonic and twin-extrusion treatments significantly increased the SDF content from 2.42 to 4.58 and 6.54%, respectively. Dual enzyme hydrolysis further increased the SDF content. Modification treatment changed the monosaccharide composition, improved physicochemical and functional properties, such as water and oil holding capacity, nitrite adsorption, and antioxidative ability. In conclusion, physical modification combined with enzyme treatment distinctly improved the extraction yield, physicochemical and functional properties of SDF. Therefore, the modified SDF is suitable as a functional food additive.
    Keywords adsorption ; bioactive properties ; corn bran ; dietary fiber ; enzymatic hydrolysis ; enzymatic treatment ; extrusion ; food additives ; food chemistry ; functional foods ; gels ; molecular weight ; nitrites ; oils ; ultrasonic treatment ; ultrasonics
    Language English
    Dates of publication 2022-0630
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2590-1575
    DOI 10.1016/j.fochx.2022.100298
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Effects of Soluble and Insoluble Dietary Fiber from Corn Bran on Pasting, Thermal, and Structural Properties of Corn Starch

    Li, Sheng / Liu, Huimin / Zheng, Qihang / Hu, Nannan / Zheng, Mingzhu / Liu, Jingsheng

    Stärke =. 2022 May, v. 74, no. 5-6

    2022  

    Abstract: In this study, the effects of various concentrations (1%, 2%, 3%, 5%) soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) from corn bran on the pasting, rheological, and thermal properties and the microstructure of corn starch (CS) are ... ...

    Abstract In this study, the effects of various concentrations (1%, 2%, 3%, 5%) soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) from corn bran on the pasting, rheological, and thermal properties and the microstructure of corn starch (CS) are investigated. The findings show that the addition of dietary fiber inhibits the short‐term retrogradation of starch and decreases the relaxation time of weakly bound water. The SDF and IDF reduce endothermic enthalpy from 11.79 to 8.81 and 8.80 (J g⁻¹), respectively (p < 0.05). The addition of SDF significantly inhibits the gelatinization of starch (p < 0.05), which reduces viscosity during CS pasting. In addition, 5% of SDF significantly (p < 0.05) reduces the wavenumber ratio value (1047 cm–¹/1022 cm–¹) from 0.906 to 0.861 and decreases the strength of the CS gel from 653.29 to 75.66. The CS‐SDF gel shows a sheet‐like network structure, while in the CS‐IDF gel, IDF is embedded in a network structure. This research further expands the understanding of the interaction between dietary fiber and starch during processing and allows the improvement of high dietary fiber product quality.
    Keywords corn bran ; corn starch ; dietary fiber ; endothermy ; enthalpy ; gelatinization ; gels ; microstructure ; product quality ; retrogradation ; starch ; viscosity
    Language English
    Dates of publication 2022-05
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 241168-4
    ISSN 0038-9056
    ISSN 0038-9056
    DOI 10.1002/star.202100254
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