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Article ; Online: Experimental study of synergistic reinforcement of silty clay with glutinous rice paste and MICP.

Hu, Qizhi / Chen, Qian

2023 Volume 18, Issue 5, Page(s) e0284633

Abstract: The use of microbially induced calcium carbonate precipitation (MICP) technology can improve the mechanical properties of silty clay, and glutinous rice paste can enhance microbial activity, improve the conversion rate of CaCO3 precipitation, and help ... ...

Abstract	The use of microbially induced calcium carbonate precipitation (MICP) technology can improve the mechanical properties of silty clay, and glutinous rice paste can enhance microbial activity, improve the conversion rate of CaCO3 precipitation, and help increase soil strength. An MICP solidification test of silty clay was carried out by adding different concentrations of aged glutinous rice slurry and cementing liquid, and unconfined compressive strength tests and scanning electron microscope analysis of the solidified samples were carried out. The strength growth mechanism of the glutinous rice paste was investigated, and the results revealed that glutinous rice slurry can improve the enzymatic activity of microorganisms, that is, the microorganisms can produce more urease to decompose urea, and as the amount of urease increases, the concentration of the cementing solution increases, and the calcium carbonate generated by the MICP precipitates. When the concentration of the added cooked glutinous rice slurry was 5%, the unconfined compressive strength of the soil was the largest. In addition, the scanning electron microscope analysis revealed that cooled glutinous rice slurry can be used as a bridge to generate a large amount of ineffective carbonic acid. Calcium atoms are connected together to form effective calcium carbonate, which fills in the pores of the soil as a whole, increasing the compactness of the soil and greatly improving its macroscopic mechanical strength.
MeSH term(s)	Calcium Carbonate ; Clay ; Oryza ; Urease ; Soil
Chemical Substances	Calcium Carbonate (H0G9379FGK) ; Clay (T1FAD4SS2M) ; Urease (EC 3.5.1.5) ; Soil
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0284633
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [A case report of metatarsal seed joint gout synovitis with hallux valgus].

Wang, Ding / Yuan, Jian-Hua / Hu, Qi-Zhi / Xu, Xiao-Jian

Zhongguo gu shang = China journal of orthopaedics and traumatology

2022 Volume 35, Issue 12, Page(s) 1197–1199

MeSH term(s)	Humans ; Bunion/complications ; Hallux Valgus/diagnostic imaging ; Hallux Valgus/surgery ; Metatarsal Bones ; Metatarsophalangeal Joint ; Gout ; Synovitis
Language	Chinese
Publishing date	2022-12-25
Publishing country	China
Document type	Case Reports ; Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2022.12.017
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Article ; Online: Hydrochemical and microbial community characteristics and the sources of inorganic nitrogen in groundwater from different aquifers in Zhanjiang, Guangdong Province, China.

Liu, Rentao / Qiu, Jinrong / Wang, Shuang / Fu, Renchuan / Qi, Xiaochen / Jian, Chuanqi / Hu, Qizhi / Zeng, Jingwen / Liu, Na

Environmental research

2024 Volume 252, Issue Pt 3, Page(s) 119022

Abstract: Groundwater from different aquifers in the Zhanjiang area suffers from different degrees of nitrogen pollution, which poses a serious threat to the health of urban and rural residents as well as the surrounding aquatic ecological environment. However, ... ...

Abstract	Groundwater from different aquifers in the Zhanjiang area suffers from different degrees of nitrogen pollution, which poses a serious threat to the health of urban and rural residents as well as the surrounding aquatic ecological environment. However, neither the water chemistry and microbial community characteristics in different aquifer media nor the sources of inorganic nitrogen pollution have been extensively studied. This study integrated water quality parameters, dual isotopes (δ
Language	English
Publishing date	2024-04-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.119022
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Article ; Online: Ambient-Temperature Reductive Amination of 5-Hydroxymethylfurfural Over Al

Hu, Qizhi / Jiang, Shi / Wu, Yue / Xu, Hongzhong / Li, Guoqing / Zhou, Yu / Wang, Jun

ChemSusChem

2022 Volume 15, Issue 13, Page(s) e202200192

Abstract: An efficient catalytic system for the conversion of 5-hydroxymethylfurfural (HMF) into N-containing compounds over low-cost non-noble-metal catalysts is preferable, but it is challenging to reach high conversion and selectivity under mild conditions. ... ...

Abstract	An efficient catalytic system for the conversion of 5-hydroxymethylfurfural (HMF) into N-containing compounds over low-cost non-noble-metal catalysts is preferable, but it is challenging to reach high conversion and selectivity under mild conditions. Herein, an Al
MeSH term(s)	Amination ; Amines/chemistry ; Carbon/chemistry ; Furaldehyde/analogs & derivatives ; Nickel/chemistry ; Temperature
Chemical Substances	Amines ; 5-hydroxymethylfurfural (70ETD81LF0) ; Carbon (7440-44-0) ; Nickel (7OV03QG267) ; Furaldehyde (DJ1HGI319P)
Language	English
Publishing date	2022-03-16
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202200192
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Article: Acoustic Cluster Therapy (ACT®) enhances accumulation of polymeric micelles in the murine brain

Olsman, Marieke / Mühlenpfordt, Melina / Olsen, Emma Bøe / Torp, Sverre H. / Kotopoulis, Spiros / Rijcken, Cristianne J.F. / Hu, Qizhi / Thewissen, Marielle / Snipstad, Sofie / de Lange Davies, Catharina

Journal of controlled release. 2021 Sept. 10, v. 337

2021

Abstract: The restrictive nature of the blood-brain barrier (BBB) prevents efficient treatment of many brain diseases. Focused ultrasound in combination with microbubbles has shown to safely and transiently increase BBB permeability. Here, the potential of ... ...

Abstract	The restrictive nature of the blood-brain barrier (BBB) prevents efficient treatment of many brain diseases. Focused ultrasound in combination with microbubbles has shown to safely and transiently increase BBB permeability. Here, the potential of Acoustic Cluster Therapy (ACT®), a microbubble platform specifically engineered for theranostic purposes, to increase the permeability of the BBB and improve accumulation of IRDye® 800CW-PEG and core-crosslinked polymeric micelles (CCPM) in the murine brain, was studied. Contrast enhanced magnetic resonance imaging (MRI) showed increased BBB permeability in all animals after ACT®. Near infrared fluorescence (NIRF) images of excised brains 1 h post ACT® revealed an increased accumulation of the IRDye® 800CW-PEG (5.2-fold) and CCPM (3.7-fold) in ACT®-treated brains compared to control brains, which was retained up to 24 h post ACT®. Confocal laser scanning microscopy (CLSM) showed improved extravasation and penetration of CCPM into the brain parenchyma after ACT®. Histological examination of brain sections showed no treatment related tissue damage. This study demonstrated that ACT® increases the permeability of the BBB and enhances accumulation of macromolecules and clinically relevant nanoparticles to the brain, taking a principal step in enabling improved treatment of various brain diseases.
Keywords	acoustics ; blood-brain barrier ; brain ; fluorescence ; histology ; magnetism ; mice ; micelles ; microbubbles ; parenchyma (animal tissue) ; permeability ; polymers ; therapeutics ; ultrasonics
Language	English
Dates of publication	2021-0910
Size	p. 285-295.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2021.07.019
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Article ; Online: Orthogonal Covalent Entrapment of Cargo into Biodegradable Polymeric Micelles via Native Chemical Ligation.

Hebels, Erik R / Bindt, Felix / Walther, Johanna / van Geijn, Michiel / Weterings, Jimmy / Hu, Qizhi / Colombo, Claudio / Liskamp, Rob / Rijcken, Cristianne / Hennink, Wim E / Vermonden, Tina

Biomacromolecules

2022 Volume 24, Issue 10, Page(s) 4385–4396

Abstract: Polymeric micelles (PMs) are promising platforms for enhanced tissue targeting of entrapped therapeutic agents. Strategies to circumvent premature release of entrapped drugs include cross-linking of the micellar core as well as covalent attachment of the ...

Abstract	Polymeric micelles (PMs) are promising platforms for enhanced tissue targeting of entrapped therapeutic agents. Strategies to circumvent premature release of entrapped drugs include cross-linking of the micellar core as well as covalent attachment of the drug cargo. The chemistry employed to obtain cross-linked micelles needs to be mild to also allow entrapment of fragile molecules, such as certain peptides, proteins, oligonucleotides, and fluorescent dyes. Native chemical ligation (NCL) is a mild bio-orthogonal reaction between a
MeSH term(s)	Micelles ; Fluorescent Dyes/chemistry ; Azides ; Cysteine ; Polymers/chemistry ; Polyethylene Glycols/chemistry
Chemical Substances	Micelles ; Fluorescent Dyes ; Azides ; Cysteine (K848JZ4886) ; Polymers ; monomethoxypolyethylene glycol (9004-74-4) ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.2c00865
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Article ; Online: Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles.

De Lorenzi, Federica / Rizzo, Larissa Yokota / Daware, Rasika / Motta, Alessandro / Baues, Maike / Bartneck, Matthias / Vogt, Michael / van Zandvoort, Marc / Kaps, Leonard / Hu, Qizhi / Thewissen, Marielle / Casettari, Luca / Rijcken, Cristianne J F / Kiessling, Fabian / Sofias, Alexandros Marios / Lammers, Twan

Drug delivery and translational research

2022 Volume 13, Issue 5, Page(s) 1195–1211

Abstract: Polymeric micelles are increasingly explored for tumor-targeted drug delivery. CriPec® technology enables the generation of core-crosslinked polymeric micelles (CCPMs) based on thermosensitive (mPEG-b- ... ...

Abstract	Polymeric micelles are increasingly explored for tumor-targeted drug delivery. CriPec® technology enables the generation of core-crosslinked polymeric micelles (CCPMs) based on thermosensitive (mPEG-b-pHPMAmLac
MeSH term(s)	Micelles ; Tissue Distribution ; Integrin beta3 ; Drug Delivery Systems ; Polymers ; Cell Line, Tumor ; Peptides, Cyclic
Chemical Substances	Micelles ; Integrin beta3 ; Polymers ; Peptides, Cyclic
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-022-01204-8
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Article ; Online: PET-CT Imaging of Polymeric Nanoparticle Tumor Accumulation in Patients.

Miedema, Iris H C / Zwezerijnen, Gerben J C / Huisman, Marc C / Doeleman, Ellen / Mathijssen, Ron H J / Lammers, Twan / Hu, Qizhi / van Dongen, Guus A M S / Rijcken, Cristianne J F / Vugts, Danielle J / Menke-van der Houven van Oordt, C Willemien

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 34, Issue 21, Page(s) e2201043

Abstract: Several FDA/EMA-approved nanomedicines have demonstrated improved pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic counterparts. The next step to increase therapeutic efficacy depends on tumor accumulation, which can ...

Abstract	Several FDA/EMA-approved nanomedicines have demonstrated improved pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic counterparts. The next step to increase therapeutic efficacy depends on tumor accumulation, which can be highly heterogeneous. A clinical tool for patient stratification is urgently awaited. Therefore, a docetaxel-entrapping polymeric nanoparticle (
MeSH term(s)	Docetaxel/therapeutic use ; Humans ; Nanoparticles ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/pathology ; Polymers/therapeutic use ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Zirconium
Chemical Substances	Polymers ; Docetaxel (15H5577CQD) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2022-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202201043
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Article ; Online: Acoustic Cluster Therapy (ACT®) enhances accumulation of polymeric micelles in the murine brain.

Olsman, Marieke / Mühlenpfordt, Melina / Olsen, Emma Bøe / Torp, Sverre H / Kotopoulis, Spiros / Rijcken, Cristianne J F / Hu, Qizhi / Thewissen, Marielle / Snipstad, Sofie / de Lange Davies, Catharina

Journal of controlled release : official journal of the Controlled Release Society

2021 Volume 337, Page(s) 285–295

Abstract	The restrictive nature of the blood-brain barrier (BBB) prevents efficient treatment of many brain diseases. Focused ultrasound in combination with microbubbles has shown to safely and transiently increase BBB permeability. Here, the potential of Acoustic Cluster Therapy (ACT®), a microbubble platform specifically engineered for theranostic purposes, to increase the permeability of the BBB and improve accumulation of IRDye® 800CW-PEG and core-crosslinked polymeric micelles (CCPM) in the murine brain, was studied. Contrast enhanced magnetic resonance imaging (MRI) showed increased BBB permeability in all animals after ACT®. Near infrared fluorescence (NIRF) images of excised brains 1 h post ACT® revealed an increased accumulation of the IRDye® 800CW-PEG (5.2-fold) and CCPM (3.7-fold) in ACT®-treated brains compared to control brains, which was retained up to 24 h post ACT®. Confocal laser scanning microscopy (CLSM) showed improved extravasation and penetration of CCPM into the brain parenchyma after ACT®. Histological examination of brain sections showed no treatment related tissue damage. This study demonstrated that ACT® increases the permeability of the BBB and enhances accumulation of macromolecules and clinically relevant nanoparticles to the brain, taking a principal step in enabling improved treatment of various brain diseases.
MeSH term(s)	Acoustics ; Animals ; Blood-Brain Barrier ; Brain ; Drug Delivery Systems ; Magnetic Resonance Imaging ; Mice ; Micelles ; Microbubbles
Chemical Substances	Micelles
Language	English
Publishing date	2021-07-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2021.07.019
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Zs.A 2055: Show issues

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Article: Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles

Hu, Qizhi / Cristianne J. Rijcken / Gert Storm / Jai Prakash / Ruchi Bansal / Wim E. Hennink

Biomaterials. 2015 June, v. 53

2015

Abstract: Treatment with chemotherapy such as docetaxel (DTX) is associated with significant toxicity and tumour recurrence. In this study, we developed DTX-entrapped core-cross-linked polymeric micelles (DTX-CCL-PMs, 66 nm size) by covalently conjugating DTX to ... ...

Abstract	Treatment with chemotherapy such as docetaxel (DTX) is associated with significant toxicity and tumour recurrence. In this study, we developed DTX-entrapped core-cross-linked polymeric micelles (DTX-CCL-PMs, 66 nm size) by covalently conjugating DTX to CCL-PMs via a hydrolysable ester bond. The covalent conjugation allowed for sustained release of DTX under physiological conditions in vitro. In vivo, DTX-CCL-PMs demonstrated superior therapeutic efficacy in mice bearing MDA-MB-231 tumour xenografts as compared to the marketed formulation of DTX (Taxotere®). Strikingly, a single intravenous injection of DTX-CCL-PMs enabled complete regression of both small (∼150 mm3) and established (∼550 mm3) tumours, leading to 100% survival of the animals. These remarkable antitumour effects of DTX-CCL-PMs are attributed to its enhanced tumour accumulation and anti-stromal activity. Furthermore, DTX-CCL-PMs exhibited superior tolerability in healthy rats as compared to Taxotere. These preclinical data strongly support clinical translation of this novel nanomedicinal product for the treatment of cancer.
Keywords	breast neoplasms ; chemical bonding ; drug therapy ; intravenous injection ; mice ; micelles ; nanomedicine ; rats ; toxicity
Language	English
Dates of publication	2015-06
Size	p. 370-378.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2015.02.085
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