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Article ; Online: Response to letter to the editor "plasma biomarkers and delirium in critically ill patients after cardiac surgery: A prospective observational cohort study".

Su, Li-Jing / Hu, Rong-Fang

Heart & lung : the journal of critical care

2023 Volume 63, Page(s) 176

Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Observational Study ; Letter
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2023.09.008
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Zs.A 1035: Show issues

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Article ; Online: Chemical Biology Perspectives on STING Agonists as Tumor Immunotherapy.

Xuan, Chenyuan / Hu, Rong

ChemMedChem

2023 Volume 18, Issue 23, Page(s) e202300405

Abstract: Stimulator of interferon genes (STING) is a crucial adaptor protein in the innate immune response. STING activation triggers cytokine secretion, including type I interferon and initiates T cell-mediated adaptive immunity. The activated immune system ... ...

Abstract	Stimulator of interferon genes (STING) is a crucial adaptor protein in the innate immune response. STING activation triggers cytokine secretion, including type I interferon and initiates T cell-mediated adaptive immunity. The activated immune system converts "cold tumors" into "hot tumors" that are highly responsive to T cells by recruiting them to the tumor microenvironment, ultimately leading to potent and long-lasting antitumor effects. Unlike most immune checkpoint inhibitors, STING agonists represent a groundbreaking class of innate immune agonists that hold great potential for effectively targeting various cancer populations and are poised to become a blockbuster in tumor immunotherapy. This review will focus on the correlation between the STING signaling pathway and tumor immunity, as well as explore the impact of STING activation on other biological processes. Ultimately, we will summarize the development and optimization of STING agonists from a medicinal chemistry perspective, evaluate their potential in cancer therapy, and identify possible challenges for future advancement.
MeSH term(s)	Humans ; Membrane Proteins/metabolism ; Neoplasms/drug therapy ; Immunotherapy ; Immunity, Innate ; Biology ; Tumor Microenvironment
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2023-10-20
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202300405
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Zs.A 6280: Show issues

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Article: Knowledge map of thrombopoietin receptor agonists: A bibliometric analysis.

Hu, Rong / Guo, Songbin / Liu, Min

Heliyon

2024 Volume 10, Issue 1, Page(s) e24051

Abstract: Thrombopoietin receptor agonists (TPO-RAs) have been widely used to treat thrombocytopenia, however, a scientometric profile of TPO-RAs research is lacking. ...

Abstract	Thrombopoietin receptor agonists (TPO-RAs) have been widely used to treat thrombocytopenia, however, a scientometric profile of TPO-RAs research is lacking.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24051
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Article ; Online: Sulforaphane suppresses cell proliferation and induces apoptosis in glioma via the ACTL6A/PGK1 axis.

Peng, Zi-Tan / Hu, Rong / Fu, Jing-Yu

Toxicology mechanisms and methods

2024 , Page(s) 1–10

Abstract: This study aimed to examine the expression and biological functions of ACTL6A in glioma cells (U251), the effects of sulforaphane on the growth of U251 cells and the involvement of the ACTL6A/PGK1 pathway in those effects. The U251 cell line was ... ...

Abstract	This study aimed to examine the expression and biological functions of ACTL6A in glioma cells (U251), the effects of sulforaphane on the growth of U251 cells and the involvement of the ACTL6A/PGK1 pathway in those effects. The U251 cell line was transfected with ACTL6A over-expression plasmids to upregulate the protein, or with ACTL6A inhibitor to underexpress it, then treated with different concentrations of sulforaphane. Cell viability, proliferation, and apoptosis were assessed using standard assays, and levels of mRNAs encoding ACTL6A, PGK1, cyclin D1, Myc, Bax or Bcl-2 were measured using quantitative real-time polymerase chain reaction (qRT-PCR). ACTL6A and PGK1 were expressed at higher levels in glioma cell lines than in normal HEB cells. ACTL6A overexpression upregulated PGK1, whereas ACTL6A inhibition had the opposite effect. ACTL6A overexpression induced proliferation, whereas its inhibition repressed proliferation, enhanced apoptosis, and halted the cell cycle. Moreover, sulforaphane suppressed the growth of U251 cells by inactivating the ACTL6A/PGK1 axis. ACTL6A acts
Language	English
Publishing date	2024-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2081252-8
ISSN	1537-6524 ; 1537-6516 ; 1051-7235
ISSN (online)	1537-6524
ISSN	1537-6516 ; 1051-7235
DOI	10.1080/15376516.2024.2306375
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Zs.A 3215: Show issues

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Article ; Online: Three-dimensional molar enamel thickness and distribution patterns in Late Miocene Lufengpithecus lufengensis from Shihuiba, Southwest China.

Zhang, Lizhao / Du, Baopu / Hu, Rong / Zhao, Lingxia

Anatomical record (Hoboken, N.J. : 2007)

2024

Abstract: Enamel thickness and distribution provide dietary insights in hominoids. Yet, three-dimensional (3D) enamel analysis of the Late Miocene Lufengpithecus from southwest China is lacking. We digitally reconstructed 68 unworn or lightly worn Lufengpithecus ( ... ...

Abstract	Enamel thickness and distribution provide dietary insights in hominoids. Yet, three-dimensional (3D) enamel analysis of the Late Miocene Lufengpithecus from southwest China is lacking. We digitally reconstructed 68 unworn or lightly worn Lufengpithecus (L.) lufengensis molars using micro-computed tomography (micro-CT). Comparisons with modern humans, Homo erectus, extant/fossil Pongo, Pan, and Gorilla reveal L. lufengensis has "intermediate/thick" enamel, thicker than Pongo and Gorilla, but thinner than modern humans and H. erectus. In enamel distribution, relatively thicker enamel lies on the lingual cusps of the maxillary molars. The hypoconid, hypoconulid, and entoconid exhibit relatively thicker enamel compared to the metaconid and protoconid of the mandibular molars. L. lufengensis also exhibits an uneven pattern on the lingual and buccal walls. With relatively intermediate/thick enamel and distinctive distribution pattern, L. lufengensis may be able to respond to dietary variation in seasonal habitats.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.25428
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Ub I Zs.65: Show issues

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Article: MiR

Zhou, Xuewen / Guo, Gangwen / Yu, Shanzi / Hu, Rong

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2024 Volume 49, Issue 1, Page(s) 29–39

Abstract: Objectives: Trigeminal neuralgia (TN) is a common neuropathic pain. Voltage-gated potassium channel (Kv) has been confirmed to be involved in the occurrence and development of TN, but the specific mechanism is still unclear. MicroRNA may be involved in ... ...

Title translation	MiR
Abstract	Objectives: Trigeminal neuralgia (TN) is a common neuropathic pain. Voltage-gated potassium channel (Kv) has been confirmed to be involved in the occurrence and development of TN, but the specific mechanism is still unclear. MicroRNA may be involved in neuropathic pain by regulating the expression of Kv channels and neuronal excitability in trigeminal ganglion (TG). This study aims to explore the relationship between Kv1.1 and Methods: A total of 48 SD rats were randomly divided into 6 groups: 1) a sham group ( Results: Compared with the baseline pain threshold, the facial mechanical pain threshold of rats in the TN group was significantly decreased from the 5th to 15th day after the surgery ( Conclusions: Both Kv1.1 and
MeSH term(s)	Animals ; Rats ; Antagomirs ; Down-Regulation ; Luciferases ; MicroRNAs/genetics ; Neuralgia/genetics ; Rats, Sprague-Dawley ; RNA, Messenger ; Trigeminal Neuralgia/genetics ; Kv1.1 Potassium Channel/genetics
Chemical Substances	Antagomirs ; Luciferases (EC 1.13.12.-) ; MicroRNAs ; mirn21 microRNA, rat ; RNA, Messenger ; Kcna1 protein, rat ; Kv1.1 Potassium Channel (147173-20-4)
Language	Chinese
Publishing date	2024-04-13
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2024.230273
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Zs.B 2681: Show issues

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Article: [Research Advances in Multiple Myeloma with Chromosome 1q21 Amplification].

Wang, Chen / Hu, Rong

Zhongguo shi yan xue ye xue za zhi

2022 Volume 30, Issue 2, Page(s) 649–652

Abstract: Multiple myeloma (MM) is a kind of hematologic malignancy occurring in plasma cells. Cytogenetic technique plays an important role in risk stratification of MM. 1q21 amplification is one of the common chromosomal abnormalities in MM. Studies have shown ... ...

Abstract	Multiple myeloma (MM) is a kind of hematologic malignancy occurring in plasma cells. Cytogenetic technique plays an important role in risk stratification of MM. 1q21 amplification is one of the common chromosomal abnormalities in MM. Studies have shown that 1q21 amplification is associated with poor prognosis in MM patients. At present, with the development of new drugs, cellular immunotherapy, and improvement of hematopoietic stem cell transplantation technology, the remission depth and survival time of MM significantly increased. Rapid and accurate identification of high-risk patients and individualized treatment according to the patient's condition is the key to improve the therapeutic effect of MM. This article reviews the mechanism of 1q21 amplification in MM and the efficacy of new drugs in the treatment of MM with 1q21 chromosome amplification.
MeSH term(s)	Chromosome Aberrations ; Chromosomes ; Chromosomes, Human, Pair 1/genetics ; Hematopoietic Stem Cell Transplantation ; Humans ; Multiple Myeloma/drug therapy ; Prognosis
Language	Chinese
Publishing date	2022-04-11
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2022.02.056
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Zs.A 6603: Show issues

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Article ; Online: Comment on "Prevalence of hot flashes in women of 40 to 65 years of age with metabolic syndrome".

Hu, Rong / Ren, Zhongguo

Revista da Associacao Medica Brasileira (1992)

2022 Volume 67, Issue 10, Page(s) 1515

MeSH term(s)	Female ; Hot Flashes/epidemiology ; Humans ; Menopause ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Prevalence
Language	English
Publishing date	2022-01-12
Publishing country	Brazil
Document type	Journal Article ; Comment
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20210758
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Article ; Online: Outcomes of prophylactic abdominal aortic balloon occlusion in patients with placenta previa accreta: a propensity score matching analysis.

Yin, Huifen / Hu, Rong

BMC pregnancy and childbirth

2022 Volume 22, Issue 1, Page(s) 502

Abstract: Background: Placenta previa accreta is a life-threatening pregnancy complication, and reducing blood loss during operative treatment remains a major challenge. The aim of our study was to investigate the effect of prophylactic abdominal aortic balloon ... ...

Abstract	Background: Placenta previa accreta is a life-threatening pregnancy complication, and reducing blood loss during operative treatment remains a major challenge. The aim of our study was to investigate the effect of prophylactic abdominal aortic balloon occlusion (AABO) during caesarean section in women with placenta previa accreta. Methods: A retrospective study of women with placenta previa accreta was conducted in a tertiary hospital from January 1, 2015, to December 31, 2020. Women were divided into balloon and control groups by whether AABO was performed. Baseline characteristics and pregnancy outcomes were compared in the two groups. A propensity score analysis was applied to minimise the indication bias. The primary outcome was composite, including estimated blood loss (EBL) ≥ 2.0 L, massive transfusion and hysterectomy. Results: A total of 156 patients participated in this study, with 68 in the balloon group and 88 in the control group. Propensity score analysis showed that women in the balloon group had less EBL (1590.36 ± 1567.57 vs. 2830.36 ± 2285.58 mL, P = 0.02) as well as a lower proportion of EBL ≥ 1.0 L (50.00% vs. 78.57%, P = 0.03), EBL ≥ 2.0 L (21.43% vs. 50.00%, P = 0.03) and EBL ≥ 3.0 L (14.29% vs. 42.86%, P = 0.04). In addition, women in the control group received more red blood cell transfusions (8.43 U ± 9.96 vs. 3.43 U ± 6.27, P = 0.03), and the proportion of massive transfusions was higher (35.71% vs. 7.14%, P = 0.02). The proportions of disseminated intravascular coagulation (0% vs. 28.57%, P < 0.01), haemorrhagic shock (3.57% vs. 32.14%, P = 0.02) and hysterectomy (10.71% vs. 39.29%, P = 0.03) were significantly lower in the balloon group. Sutures were performed more often in the balloon group (64.29% vs. 17.86%, P < 0.01). Multivariate logistic regression analysis showed that AABO was associated with the primary outcome (adjusted odds ratio 0.46, 95% confidence interval 0.23 ~ 0.96, P = 0.04). No serious balloon catheter-related complications occurred in the balloon group. Conclusion: AABO was an effective and safe approach to improve maternal outcomes for patients with placenta previa accreta.
MeSH term(s)	Balloon Occlusion ; Blood Loss, Surgical/prevention & control ; Cesarean Section/adverse effects ; Female ; Humans ; Hysterectomy ; Placenta Accreta/etiology ; Placenta Accreta/surgery ; Placenta Previa/etiology ; Postoperative Complications/etiology ; Postpartum Hemorrhage/etiology ; Postpartum Hemorrhage/prevention & control ; Postpartum Hemorrhage/surgery ; Pregnancy ; Propensity Score ; Retrospective Studies
Language	English
Publishing date	2022-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-022-04837-2
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Article ; Online: Risk factors of maternal intrapartum fever and the effect of fever duration on neonatal morbidity in different temperature.

Yin, Huifen / Hu, Rong

The journal of obstetrics and gynaecology research

2022 Volume 48, Issue 10, Page(s) 2522–2527

Abstract: Aim: To investigate the clinical risk factors of intrapartum fever and explore the relationship between fever duration and neonatal morbidity of different fever peak.: Methods: A case-control study was conducted, and 714 pregnant women were divided ... ...

Abstract	Aim: To investigate the clinical risk factors of intrapartum fever and explore the relationship between fever duration and neonatal morbidity of different fever peak. Methods: A case-control study was conducted, and 714 pregnant women were divided into fever and nonfever group. Multivariable logistic regression model was estimated to evaluate the risk factors for maternal intrapartum fever. Receiver operating characteristic curve was adopted to explore the relationship between fever duration and fetal distress of different fever peak to find the cut-off point, then the neonatal outcomes of women with fever ≥38°C in two groups of different fever duration were compared. Results: Epidural analgesia (odds ratio [OR]: 6.89, p < 0.001), longer time of membrane rupture (OR: 1.06, p < 0.001) and longer time of first stage of labor (OR: 1.04, p = 0.03) were considered as independent risk factors for maternal fever. For women with temperature <38°C, fever duration was not associated with fetal distress, whereas the women with temperature ≥38°C, fever duration longer than 93.5 min was a good predictor of fetal distress (Area under curve (AUC) = 0.82, p < 0.05). Further analysis showed that infants of women with fever peak ≥38°C and fever duration longer than 90 min had a higher rate of 1 min Apgar score <7 (15.5% vs. 2.2%, p = 0.03), assisted ventilation (29.6% vs. 11.1%, p = 0.02), and admission to neonatal ward (87.3% vs. 60.0%, p = 0.001). Conclusions: Epidural analgesia, longer time of membrane rupture, and longer time of first stage of labor were considered as independent risk factors for maternal intrapartum fever. For women with fever ≥38°C, controlling fever time less than 90 min might be helpful to reduce neonatal morbidity.
MeSH term(s)	Analgesia, Epidural/adverse effects ; Analgesia, Obstetrical/adverse effects ; Case-Control Studies ; Female ; Fetal Distress/complications ; Fetal Membranes, Premature Rupture/etiology ; Fever/epidemiology ; Fever/etiology ; Humans ; Infant, Newborn ; Morbidity ; Obstetric Labor Complications/etiology ; Pregnancy ; Risk Factors ; Temperature
Language	English
Publishing date	2022-07-12
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15362
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