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  1. AU="Hu, Tony Y"
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  1. Article ; Online: Nanotechnology Powered CRISPR-Cas Systems for Point of Care Diagnosis and Therapeutic.

    Li, Chen-Zhong / Hu, Tony Y

    Research (Washington, D.C.)

    2022  Volume 2022, Page(s) 9810237

    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Editorial
    ISSN 2639-5274
    ISSN (online) 2639-5274
    DOI 10.34133/2022/9810237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nickel affinity: A sensible approach for extracellular vesicles isolation?

    Hu, Tony Y

    EBioMedicine

    2019  Volume 44, Page(s) 14–15

    MeSH term(s) Biomarkers, Tumor ; Cell Fractionation ; Extracellular Vesicles ; Nickel
    Chemical Substances Biomarkers, Tumor ; Nickel (7OV03QG267)
    Language English
    Publishing date 2019-05-14
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CRISPR-based assays for low-resource settings.

    Huang, Zhen / Lyon, Christopher J / Hu, Tony Y

    Nature reviews bioengineering

    2023  Volume 1, Issue 4, Page(s) 230–231

    Abstract: CRISPR-based assays can be adopted as ultrasensitive molecular diagnostics in resource-limited settings, but point-of-care applications must address additional requirements. Here, we discuss the major obstacles for developing these assays and offer ... ...

    Abstract CRISPR-based assays can be adopted as ultrasensitive molecular diagnostics in resource-limited settings, but point-of-care applications must address additional requirements. Here, we discuss the major obstacles for developing these assays and offer insights into how to surmount them.
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ISSN 2731-6092
    ISSN (online) 2731-6092
    DOI 10.1038/s44222-023-00026-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Strategies for advanced personalized tuberculosis diagnosis: Current technologies and clinical approaches.

    Chen, Xuerong / Hu, Tony Y

    Precision clinical medicine

    2021  Volume 4, Issue 1, Page(s) 35–44

    Abstract: Diagnosis of tuberculosis can be difficult as advances in molecular diagnosis approaches (especially nanoparticles combined with high-throughput mass spectrometry for detecting mycobacteria peptide) and personalized medicine result in many changes to the ...

    Abstract Diagnosis of tuberculosis can be difficult as advances in molecular diagnosis approaches (especially nanoparticles combined with high-throughput mass spectrometry for detecting mycobacteria peptide) and personalized medicine result in many changes to the diagnostic framework. This review will address issues concerning novel technologies from bench to bed and new strategies for personalized tuberculosis diagnosis.
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2948341-4
    ISSN 2516-1571 ; 2096-5303
    ISSN (online) 2516-1571
    ISSN 2096-5303
    DOI 10.1093/pcmedi/pbaa041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Can sugarcoated fingerprints be used to identify lurking viruses?

    Hu, Tony Y

    Proteomics

    2016  Volume 16, Issue 13, Page(s) 1947–1948

    Abstract: Comparative proteomics is increasingly used to detect biomarkers and therapeutic targets that differ between healthy and diseased populations; however, differences in posttranslational modifications have received less attention. In this issue, Yang et al. ...

    Abstract Comparative proteomics is increasingly used to detect biomarkers and therapeutic targets that differ between healthy and diseased populations; however, differences in posttranslational modifications have received less attention. In this issue, Yang et al. (Proteomics 2016, 16, 1872-1880) present data indicating that a glycoproteomics approach can detect N-glycosylated membrane protein differences between non-HIV-infected and latently infected human CD4(+) T-cell lines, identifying 172 proteins differentially expressed by these cells. Latently infected CD4(+) T cells are thought to represent the major barrier to eventual HIV cure, but do not express detectable levels of viral protein and have not been shown to express biomarkers that can distinguish them from the vastly more abundant uninfected CD4(+) T-cell population. The findings of Yang et al. suggest that glycoproteomic analyses may have untapped potential to identify novel biomarkers and therapeutic targets in cell populations not readily distinguishable be standard proteomic analyses.
    MeSH term(s) CD4-Positive T-Lymphocytes/virology ; HIV Infections/virology ; HIV-1 ; Humans ; Proteomics ; Virus Latency
    Language English
    Publishing date 2016
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.201600197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
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    Zs.A 1868: Show issues Location:
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  6. Article ; Online: Clinical Peptidomics: Advances in Instrumentation, Analyses, and Applications.

    Li, Lin / Wu, Jing / Lyon, Christopher J / Jiang, Li / Hu, Tony Y

    BME frontiers

    2023  Volume 4, Page(s) 19

    Abstract: Extensive effort has been devoted to the discovery, development, and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions. Genomic and transcriptomic profiling are ... ...

    Abstract Extensive effort has been devoted to the discovery, development, and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions. Genomic and transcriptomic profiling are well-established means to identify disease-associated biomarkers. However, analysis of disease-associated peptidomes can also identify novel peptide biomarkers or signatures that provide sensitive and specific diagnostic and prognostic information for specific malignant, chronic, and infectious diseases. Growing evidence also suggests that peptidomic changes in liquid biopsies may more effectively detect changes in disease pathophysiology than other molecular methods. Knowledge gained from peptide-based diagnostic, therapeutic, and imaging approaches has led to promising new theranostic applications that can increase their bioavailability in target tissues at reduced doses to decrease side effects and improve treatment responses. However, despite major advances, multiple factors can still affect the utility of peptidomic data. This review summarizes several remaining challenges that affect peptide biomarker discovery and their use as diagnostics, with a focus on technological advances that can improve the detection, identification, and monitoring of peptide biomarkers for personalized medicine.
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2765-8031
    ISSN (online) 2765-8031
    DOI 10.34133/bmef.0019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Outlook for CRISPR-based tuberculosis assays now in their infancy.

    Huang, Zhen / Zhang, Guoliang / Lyon, Christopher J / Hu, Tony Y / Lu, Shuihua

    Frontiers in immunology

    2023  Volume 14, Page(s) 1172035

    Abstract: Tuberculosis (TB) remains a major underdiagnosed public health threat worldwide, being responsible for more than 10 million cases and one million deaths annually. TB diagnosis has become more rapid with the development and adoption of molecular tests, ... ...

    Abstract Tuberculosis (TB) remains a major underdiagnosed public health threat worldwide, being responsible for more than 10 million cases and one million deaths annually. TB diagnosis has become more rapid with the development and adoption of molecular tests, but remains challenging with traditional TB diagnosis, but there has not been a critical review of this area. Here, we systematically review these approaches to assess their diagnostic potential and issues with the development and clinical evaluation of proposed CRISPR-based TB assays. Based on these observations, we propose constructive suggestions to improve sample pretreatment, method development, clinical validation, and accessibility of these assays to streamline future assay development and validation studies.
    MeSH term(s) Humans ; Biological Assay ; Public Health ; Tuberculosis/diagnosis ; Tuberculosis/genetics
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1172035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CRISPR Assays for Disease Diagnosis: Progress to and Barriers Remaining for Clinical Applications.

    Huang, Zhen / Lyon, Christopher J / Wang, Jin / Lu, Shuihua / Hu, Tony Y

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 20, Page(s) e2301697

    Abstract: Numerous groups have employed the special properties of CRISPR/Cas systems to develop platforms that have broad potential applications for sensitive and specific detection of nucleic acid (NA) targets. However, few of these approaches have progressed to ... ...

    Abstract Numerous groups have employed the special properties of CRISPR/Cas systems to develop platforms that have broad potential applications for sensitive and specific detection of nucleic acid (NA) targets. However, few of these approaches have progressed to commercial or clinical applications. This review summarizes the properties of known CRISPR/Cas systems and their applications, challenges associated with the development of such assays, and opportunities to improve their performance or address unmet assay needs using nano-/micro-technology platforms. These include rapid and efficient sample preparation, integrated single-tube, amplification-free, quantifiable, multiplex, and non-NA assays. Finally, this review discusses the current outlook for such assays, including remaining barriers for clinical or point-of-care applications and their commercial development.
    MeSH term(s) CRISPR-Cas Systems/genetics ; Nucleic Acids ; Specimen Handling
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2023-05-10
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202301697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: 2D metal carbides and nitrides (MXenes) for sensors and biosensors

    Alwarappan, Subbiah / Nesakumar, Noel / Sun, Dali / Hu, Tony Y. / Li, Chen-Zhong

    Biosensors & bioelectronics. 2022 June 01, v. 205

    2022  

    Abstract: MXenes are layered two-dimensional (2D) materials discovered in 2011 (Ti₃C₂X) and are otherwise called 2D transition metal carbides, carbonitrides, and nitrides. These 2D layered materials have been in the limelight for a decade due to their interesting ... ...

    Abstract MXenes are layered two-dimensional (2D) materials discovered in 2011 (Ti₃C₂X) and are otherwise called 2D transition metal carbides, carbonitrides, and nitrides. These 2D layered materials have been in the limelight for a decade due to their interesting properties such as large surface area, high ion transport, biocompatibility, and low diffusion barrier. Therefore, MXenes are widely preferred by researchers for applications in electronics, sensing, biosensing, electrocatalysis, super-capacitors and fuel cells. There are a number of methods available for the bulk synthesis of MXene-based nanomaterials. In addition, the possibility of structural modification as required and its outstanding surface chemistry offer a fascinating interface for the development of novel biosensors. In this review, we specifically discuss important MXene synthesis routes. Moreover, critical parameters such as surface functionalization that can dictate the mechanical, electronic, magnetic, and optical properties of MXenes are also discussed. Following this, methods available for the surface functionalization and modification strategies of MXenes are also discussed. Furthermore, the emergence of gas, electrochemical, and optical biosensors based on MXenes since its first report is discussed in detail. Finally, future directions of MXenes biosensors for critical applications are discussed.
    Keywords biocompatibility ; biosensors ; electrochemical capacitors ; electrochemistry ; electronics ; magnetism ; surface area
    Language English
    Dates of publication 2022-0601
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2021.113943
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Multidisciplinary efforts driving translational theranostics.

    Hu, Tony Y

    Theranostics

    2014  Volume 4, Issue 12, Page(s) 1209–1210

    Abstract: This themed issue summarizes significant efforts aimed at using "biological language" to discern between "friends" and "foes" in the context of theranostics for true clinical application. It is expected that the success of theranostics depends on ... ...

    Abstract This themed issue summarizes significant efforts aimed at using "biological language" to discern between "friends" and "foes" in the context of theranostics for true clinical application. It is expected that the success of theranostics depends on multidisciplinary efforts, combined to expedite our understanding of host responses to "customized" theranostic agents and formulating individualized therapies.
    MeSH term(s) Diagnosis ; Drug Therapy ; Humans ; Precision Medicine ; Translational Medical Research
    Language English
    Publishing date 2014-09-19
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.10503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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