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Article: [Clinical Applications of Aromatherapy].

Chen, Shuo-Fei / Hu, Tsung-Ming

Hu li za zhi The journal of nursing

2023 Volume 70, Issue 6, Page(s) 6–11

Abstract: Aromatherapy is a natural therapy that utilizes essential oils that enter the body through the skin, inhalation, or ingestion to promote health. Clinical aromatherapy refers to the incorporation of essential oils as a complementary therapy within the ... ...

Abstract	Aromatherapy is a natural therapy that utilizes essential oils that enter the body through the skin, inhalation, or ingestion to promote health. Clinical aromatherapy refers to the incorporation of essential oils as a complementary therapy within the medical field and is conducted in accordance with medical safety, ethical, and regulatory requirements. Healthcare professionals must have a comprehensive understanding of clinical aromatherapy management and enhance their knowledge of aromatherapy. Based on a meta-analysis of the related literature, clinical aromatherapy management procedures and the various applications of aromatherapy for anxiety, depression, sleep disorders, and pain are introduced. The goal is to help appropriately integrate aromatherapy into the healthcare system to enhance quality of care and improve well-being in patients and healthcare providers.
MeSH term(s)	Humans ; Aromatherapy ; Health Promotion ; Oils, Volatile/therapeutic use ; Anxiety ; Health Personnel
Chemical Substances	Oils, Volatile
Language	Chinese
Publishing date	2023-12-20
Publishing country	China (Republic : 1949- )
Document type	Meta-Analysis ; English Abstract ; Journal Article
ISSN	0047-262X
ISSN	0047-262X
DOI	10.6224/JN.202312_70(6).02
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Article ; Online: Fluconazole-induced delirium in an older patient with schizophrenia.

Hu, Tsung-Ming / Wu, Chia-Liang

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

2022 Volume 22, Issue 4, Page(s) 588–589

MeSH term(s)	Delirium/chemically induced ; Fluconazole/adverse effects ; Humans ; Schizophrenia/drug therapy
Chemical Substances	Fluconazole (8VZV102JFY)
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Letter
ZDB-ID	2213105-X
ISSN	1479-8301 ; 1346-3500
ISSN (online)	1479-8301
ISSN	1346-3500
DOI	10.1111/psyg.12844
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Article: Social cognition and apathy between two cognitive subtypes of schizophrenia: Are there the same or different profiles?

Chiang, Shih-Kuang / Lai, Shih-Min / Hu, Tsung-Ming

Schizophrenia research. Cognition

2023 Volume 33, Page(s) 100287

Abstract: Objective: Cognitive impairment is an essential feature of schizophrenia, and it involves a broad array of nonsocial and social cognitive domains. This study aimed to examine whether there are the same or different social cognition profiles between two ... ...

Abstract	Objective: Cognitive impairment is an essential feature of schizophrenia, and it involves a broad array of nonsocial and social cognitive domains. This study aimed to examine whether there are the same or different social cognition profiles between two cognitive subtypes of schizophrenia. Method: There were one hundred and two chronic and institutionalized patients with schizophrenia from two referral tracks. One group is "Cognitively Normal Range" (CNR) (N = 52), and another group is "Below Normal Range" (BNR) (N = 50). We assessed or collected their apathy, emotional perception judgment, facial expression judgment, and empathy by the Apathy Evaluation Scale, the International Affective Picture System, the Japanese and Caucasian Facial Expression of Emotion, and the Interpersonal Reactivity Index, respectively. Results: We found different impairment profiles depending on the cognitive subtypes of the patient with schizophrenia. Surprisingly, the CNR presented impairments in apathy, emotional perception judgment, facial expression judgment, and empathy and feature impairment in empathy and affective apathy. In contrast, even though the BNR had significant neurocognition impairments, they had almost intact empathy with significantly impaired cognitive apathy. Both groups' global deficit scores (GDSs) were comparable, and all reached at least a mild impairment level. Conclusions: The CNR and the BNR had similar abilities in emotional perception judgment and facial emotion recognition. They also had differentiable deficits in apathy and empathy. Our findings provide important clinical implications for neuropsychological pathology and treatment in schizophrenia.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2800609-4
ISSN	2215-0013
ISSN	2215-0013
DOI	10.1016/j.scog.2023.100287
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Article ; Online: The effect of computerized working memory training on working memory and emotion perception for patients with chronic schizophrenia and normal cognition.

Chiang, Shih Kuang / Liu, Wan-Yu / Hu, Tsung-Ming

Applied neuropsychology. Adult

2022 , Page(s) 1–9

Abstract: Background: Cognitive impairment and affective symptoms are hallmark features of patients with schizophrenia. This study determines whether a computerized working memory training program improves the patient's working memory and affective perception.: ...

Abstract	Background: Cognitive impairment and affective symptoms are hallmark features of patients with schizophrenia. This study determines whether a computerized working memory training program improves the patient's working memory and affective perception. Methods: Thirty-nine male patients with schizophrenia, aged 25-65, participated in this study. The study uses a single-blind randomized controlled design. Twenty subjects were assigned to the experimental group and received an eight-week working memory computerized training course comprising four modules of the CogniPlus system. Nineteen subjects were assigned to the control group and received treatment as usual. All subjects received the same assessments twice, including the Mini-Mental Status Examination (MMSE), Working Memory Index (WMI) of Wechsler Adult Intelligence Scale-Third Edition, and the subjective rating of pictures of the International affective picture system by Self-Assessment Manikin (SAM). Results: This study shows that computerized working memory training improves WMI and the score for MMSE and produces a significant increase in the pleasure score for S.A.M. for negative pictures, between the pretest and post-test for the experimental group. Conclusions: Working memory training improves working memory and emotion perception for patients with chronic schizophrenia and normal cognition. The limitations of this study and suggestions for future study are also discussed.
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673736-X
ISSN	2327-9109 ; 2327-9095
ISSN (online)	2327-9109
ISSN	2327-9095
DOI	10.1080/23279095.2022.2159825
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Zs.A 4952: Show issues

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Article ; Online: Effectiveness of aromatherapy for intrapartum and postpartum emotional problems among parturient women: A meta-analysis of randomized controlled trials.

Hu, Tsung-Ming / Lee, Szu-Han / Loh, El-Wui

Japan journal of nursing science : JJNS

2022 Volume 19, Issue 3, Page(s) e12471

Abstract: Aim: Perinatal negative emotions are common in parturient women, but the problems are often ignored. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that investigated the effectiveness of aromatherapy for ... ...

Abstract	Aim: Perinatal negative emotions are common in parturient women, but the problems are often ignored. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that investigated the effectiveness of aromatherapy for intrapartum anxiety (IPA) and postpartum emotional symptoms (PES). Methods: We searched PubMed, Embase, Cochrane library, and ClinicalTrials.gov to identify suitable RCTs for analysis, and the study was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Results: Nine RCTs were included. The meta-analysis showed aromatherapy reduced IPA during the early to active phase (standardized mean difference [SMD]: -1.56 [-2.55, -0.61]) and during the transition phase (SMD: -3.30 [-4.97, -1.63]) when compared with controls. For the postpartum period, the meta-analyses showed a reduction of postpartum depression (PPD) at week 2 (SMD: -0.43 [-0.82, -0.03]), and a non-significant trend toward the reduction of PPD at weeks 4-6 (SMD: -0.70 [-1.40, 0.01]). Conclusion: Our study found some evidence supporting the effectiveness of aromatherapy in reducing intrapartum anxiety and PES. We recommend the optional use of aromatherapy for intrapartum and postpartum care.
MeSH term(s)	Anxiety/therapy ; Aromatherapy ; Depression, Postpartum/therapy ; Female ; Humans ; Postpartum Period ; Pregnancy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-02-02
Publishing country	Japan
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2156618-5
ISSN	1742-7924 ; 1742-7932
ISSN (online)	1742-7924
ISSN	1742-7932
DOI	10.1111/jjns.12471
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Article ; Online: Use of noninvasive brain stimulation and neurorehabilitation devices to enhance poststroke recovery: review of the current evidence and pitfalls.

Wang, Chien-Chih / Hu, Tsung-Ming / Lin, Yung-Jie / Chen, Chien-Lung / Hsu, Yu-Chuan / Kao, Chung-Lan

The Journal of international medical research

2024 Volume 52, Issue 4, Page(s) 3000605241238066

Abstract: Neurorehabilitation devices and technologies are crucial for enhancing stroke recovery. These include noninvasive brain stimulation devices that provide repetitive transcranial magnetic stimulation or transcranial direct current stimulation, which can ... ...

Abstract	Neurorehabilitation devices and technologies are crucial for enhancing stroke recovery. These include noninvasive brain stimulation devices that provide repetitive transcranial magnetic stimulation or transcranial direct current stimulation, which can remodulate an injured brain. Technologies such as robotics, virtual reality, and telerehabilitation are suitable add-ons or complements to physical therapy. However, the appropriate application of these devices and technologies, which target specific deficits and stages, for stroke therapy must be clarified. Accordingly, a literature review was conducted to evaluate the theoretical and practical evidence on the use of neurorehabilitation devices and technologies for stroke therapy. This narrative review provides a practical guide for the use of neurorehabilitation devices and describes the implications of use and potential integration of these devices into healthcare.
MeSH term(s)	Humans ; Transcranial Direct Current Stimulation ; Stroke/therapy ; Transcranial Magnetic Stimulation ; Brain ; Neurological Rehabilitation ; Stroke Rehabilitation
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605241238066
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Article: Functional, antioxidant, and sensory properties of mixed-fruit (pitaya, watermelon, and mint) and pitaya wines.

Hu, Tsung-Ming / Gavahian, Mohsen / Pradhan, Rojina / Lu, Si-Yu / Chu, Yung-Lin

Food science & nutrition

2023 Volume 11, Issue 6, Page(s) 3442–3449

Abstract: Fermentation of fruits offers a diverse range of flavors, smells, and colors. Colored fruits are rich in naturally occurring pigments, such as betacyanin. Hence, they are considered to possess powerful antioxidant activities. However, in wine production, ...

Abstract	Fermentation of fruits offers a diverse range of flavors, smells, and colors. Colored fruits are rich in naturally occurring pigments, such as betacyanin. Hence, they are considered to possess powerful antioxidant activities. However, in wine production, such pigments often diversify the flavor and color of the wine. The objective of this study was to compare the quality of two types of wines: a single-fruit (pitaya) wine and a mixed-fruit wine that contains watermelon (
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3334
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Article: Chromosomal Microarray Analysis as First-Tier Genetic Test for Schizophrenia.

Chen, Chia-Hsiang / Cheng, Min-Chih / Hu, Tsung-Ming / Ping, Lieh-Yung

Frontiers in genetics

2021 Volume 12, Page(s) 620496

Abstract: Schizophrenia is a chronic, devastating mental disorder with complex genetic components. Given the advancements in the molecular genetic research of schizophrenia in recent years, there is still a lack of genetic tests that can be used in clinical ... ...

Abstract	Schizophrenia is a chronic, devastating mental disorder with complex genetic components. Given the advancements in the molecular genetic research of schizophrenia in recent years, there is still a lack of genetic tests that can be used in clinical settings. Chromosomal microarray analysis (CMA) has been used as first-tier genetic testing for congenital abnormalities, developmental delay, and autism spectrum disorders. This study attempted to gain some experience in applying chromosomal microarray analysis as a first-tier genetic test for patients with schizophrenia. We consecutively enrolled patients with schizophrenia spectrum disorder from a clinical setting and conducted genome-wide copy number variation (CNV) analysis using a chromosomal microarray platform. We followed the 2020 "Technical Standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen)" to interpret the clinical significance of CNVs detected from patients. We recruited a total of 60 patients (36 females and 24 males) into this study. We detected three pathogenic CNVs and one likely pathogenic CNV in four patients, respectively. The detection rate was 6.7% (4/60, 95% CI: 0.004-0.13), comparable with previous studies in the literature. Also, we detected thirteen CNVs classified as uncertain clinical significance in nine patients. Detecting these CNVs can help establish the molecular genetic diagnosis of schizophrenia patients and provide helpful information for genetic counseling and clinical management. Also, it can increase our understanding of the pathogenesis of schizophrenia. Hence, we suggest CMA is a valuable genetic tool and considered first-tier genetic testing for schizophrenia spectrum disorders in clinical settings.
Language	English
Publishing date	2021-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.620496
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Article ; Online: Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.

Chen, Chia-Hsiang / Cheng, Min-Chih / Hu, Tsung-Ming / Ping, Lieh-Yung / Kushima, Itaru / Aleksic, Branko

Psychiatric genetics

2022 Volume 32, Issue 3, Page(s) 125–130

Abstract: Objective: Studies showed that rare copy number variations (CNVs) encompassing the vasoactive intestinal peptide receptor 2 gene (VIPR2) were associated with schizophrenia, indicating VIPR2 is a risk gene for schizophrenia. We hypothesized that besides ... ...

Abstract	Objective: Studies showed that rare copy number variations (CNVs) encompassing the vasoactive intestinal peptide receptor 2 gene (VIPR2) were associated with schizophrenia, indicating VIPR2 is a risk gene for schizophrenia. We hypothesized that besides CNV, rare pathogenic single-nucleotide variant (SNV) or small insertion/deletion (Indel) of VIPR2 might be present in some patients and contribute to the pathogenesis of schizophrenia. Methods: We performed genome-wide CNV analysis to screen CNV at the VIPR2 locus and targeted sequencing of all the exons of VIPR2 to search for SNV and indel in a sample of patients with chronic schizophrenia from Taiwan. Results: We detected a 230-kb microduplication encompassing the VIPR2 in 1 out of 200 patients. Furthermore, we identified six ultrarare SNVs, including one splicing SNV and five missense SNVs, in 516 patients. In-silico analyses showed these SNVs had a damaging effect on the function of VIPR2. Conclusion: Our findings support the idea that besides CNV, rare pathogenic SNVs of VIPR2 might contribute to the pathogenesis of schizophrenia in some patients.
MeSH term(s)	DNA Copy Number Variations ; Genetic Predisposition to Disease ; Humans ; Mutation ; Receptors, Vasoactive Intestinal Peptide, Type II/genetics ; Schizophrenia/genetics ; Taiwan
Chemical Substances	Receptors, Vasoactive Intestinal Peptide, Type II ; VIPR2 protein, human
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067837-2
ISSN	1473-5873 ; 0955-8829
ISSN (online)	1473-5873
ISSN	0955-8829
DOI	10.1097/YPG.0000000000000313
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Article ; Online: Identification of rare missense mutations in the glutamate ionotropic receptor AMPA type subunit genes in schizophrenia.

Lin, Ko-Huan / Hu, Tsung-Ming / Hsu, Shih-Hsin / Tsai, Hsin-Yao / Cheng, Min-Chih

Psychiatric genetics

2022 Volume 33, Issue 1, Page(s) 20–25

Abstract: Objective: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors significantly regulate the synaptic transmission and functions of various synaptic receptors. This study aimed to identify single nucleotide mutations in the glutamate ...

Abstract	Objective: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors significantly regulate the synaptic transmission and functions of various synaptic receptors. This study aimed to identify single nucleotide mutations in the glutamate receptor, ionotropic, AMPA type (GRIA) gene family, which is associated with schizophrenia. Methods: The exon regions of four genes (GRIA1, GRIA2, GRIA3, and GRIA4) encoding glutamate ionotropic receptor AMPA type proteins were resequenced in 516 patients with schizophrenia. We analyzed the protein function of the identified rare mutants via immunoblotting. Results: A total of 24 coding variants were detected in the GRIA gene family, including six missense mutations, 17 synonymous mutations, and one frameshift insertion. Notably, three ultra-rare missense mutations (GRIA1p.V182A, GRIA2p.P123Q, and GRIA4p.Y491H) were not documented in the single nucleotide polymorphism database, gnomAD genomes, and 1517 healthy controls available from Taiwan BioBank. Immunoblotting revealed GRIA4p.Y491H mutant with altered protein expressions in cultured cells compared with the wild type. Conclusion: Our findings suggest that, in some patients affected by schizophrenia, the GRIA gene family harbors rare functional mutations, which support rare coding variants that could contribute to the genetic architecture of this illness. The in-vitro impacts of these rare pathological mutations on the pathophysiology of schizophrenia are worthy of future investigation.
MeSH term(s)	Humans ; Schizophrenia/genetics ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid ; Glutamic Acid ; Mutation, Missense/genetics ; Exons
Chemical Substances	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0) ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2022-12-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1067837-2
ISSN	1473-5873 ; 0955-8829
ISSN (online)	1473-5873
ISSN	0955-8829
DOI	10.1097/YPG.0000000000000328
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