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Article ; Online: Study on effects and relevant mechanisms of Mudan granules on renal fibrosis in streptozotocin-induced diabetes rats.

Qi, Mushuang / Hu, Xiangka / Zhu, Wanjun / Ren, Ying / Dai, Chunmei

2024 Volume 46, Issue 1, Page(s) 2310733

Abstract: Aims: The effects and relevant mechanisms of Mudan granules in the renal fibrosis of diabetic rats were explored through : Methods: Male SD rats were given a single intraperitoneal injection of STZ (65 mg/kg) to induce diabetes rat models. After ... ...

Abstract	Aims: The effects and relevant mechanisms of Mudan granules in the renal fibrosis of diabetic rats were explored through Methods: Male SD rats were given a single intraperitoneal injection of STZ (65 mg/kg) to induce diabetes rat models. After treatment with Mudan granules, the general condition of rats was recorded. Blood glucose, blood lipids, and renal function-related indicators were detected, renal tissue morphological changes and fibrosis-related indicators were observed, and the expression of pathway-related proteins were examined. Results: The general condition of diabetes rats was improved after the treatment of Mudan granules, the 24-h urinary protein and urinary albumin to creatinine ratio were reduced, and the renal function and lipid results were modified. The tissue damage to the rat kidney has been repaired. Expression of TGF-β1/Smad-related pathway proteins was suppressed in kidney tissues, and the fibrosis factor CO-IV, FN, and LN were reduced in serum. Conclusion: Mudan granules may inhibit of TGF-β1/Smad pathway, inhibit the production of ECM, reduce the levels of fibrosis factors CO-IV, FN, and LN, to have a protective effect on kidney in diabetes rats.
MeSH term(s)	Rats ; Male ; Animals ; Diabetes Mellitus, Experimental/metabolism ; Transforming Growth Factor beta1/metabolism ; Streptozocin ; Rats, Sprague-Dawley ; Kidney Diseases/pathology ; Kidney/pathology ; Fibrosis ; Diabetic Nephropathies/drug therapy
Chemical Substances	Transforming Growth Factor beta1 ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2024.2310733
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Article ; Online: Value of cystatin C in predicting recurrence in patients with severe diabetic foot and diabetic foot ulcer.

An, Jingsi / Yu, Hongwei / Gao, Zhenyu / Hu, Xiangka / Wang, Xueying

Biomarkers in medicine

2023 Volume 17, Issue 5, Page(s) 287–296

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Cystatin C/blood ; Diabetic Foot/diagnosis ; Risk Factors ; Recurrence
Chemical Substances	Cystatin C
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2022-0837
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Zs.A 6985: Show issues

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Article ; Online: Protective Effect of Panax Notoginseng Saponins on Apolipoprotein-E-deficient Atherosclerosis-prone Mice.

Yang, He / Liu, Zuodong / Hu, Xiangka / Liu, Xiaojuan / Gui, Liuming / Cai, Zengxiaorui / Dai, Chunmei

Current pharmaceutical design

2022 Volume 28, Issue 8, Page(s) 671–677

Abstract: Background: It is widely recognized that atherosclerosis (AS) is related to vascular inflammation. Panax notoginseng saponins (PNS) extracted from the roots of Panax notoginseng have been shown to possess anti-inflammatory activity. It is widely used in ...

Abstract	Background: It is widely recognized that atherosclerosis (AS) is related to vascular inflammation. Panax notoginseng saponins (PNS) extracted from the roots of Panax notoginseng have been shown to possess anti-inflammatory activity. It is widely used in the clinical treatment of cardiovascular and cerebrovascular diseases, but the protective effect of PNS on atherosclerosis is not fully understood. This study was designed to test the effects of PNS administration in apolipoprotein (apo)-E-deficient (ApoE-/-) mice on the activation of NF-κB p65, IL-1β, IL-6, TNF-α and Calpain1 proteins. Methods: 24 ApoE-/- mice fed with high-fat diet for 8 weeks to create the AS model. PNS, dissolved in three distilled water, was administered orally to two treatment groups at dosages of 60 mg/kg/d/mice and 180 mg/kg/d/mice. After 8 weeks, peripheral blood was collected for assessing the levels of TG, TC, LDL-C and HDL-C in serum by Biochemical Analyzer. HE staining was used to observe pathomorphological changes in the aortic root. Oil Red O staining was used to observe the lipid deposition in the aortic root. ELISA kits were used to assess the levels of IL-1β and TNF-α in serum. The expression levels of NF-κB p65, IL-1β, IL-6, TNF-α, and Calpain1 proteins in the aortic root were identified by Western blot. Results: After PNS administration for 8 weeks, the levels of TG, TC, LDL-C, IL-1β and TNF-α were decreased, the level of HDL-C was increased in apoE-/- mice. The arrangement of the tissue of aortic root tended to be normal, the cell morphology was restored, and the lipid depositions were reduced in apoE-/- mice treated with PNS. Moreover, PNS inhibited the expression levels of NF-κB p65, IL-6, IL-1β, TNF-α and Calpain1 proteins of aortic root tissues in apoE-/- mice. Conclusion: PNS may inhibit the progression of atherosclerotic lesions via their anti-inflammatory biological property. PNS suppress the NF-κB signaling pathway and inhibits the expression of pro-inflammatory factors such as NF-κB p65, IL-6, IL-1β, TNF-α and Calpain1 proteins in aortic root tissues of apoE-/- mice.
MeSH term(s)	Animals ; Apolipoproteins E/therapeutic use ; Atherosclerosis/metabolism ; Cholesterol, LDL ; Humans ; Interleukin-6 ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-kappa B/metabolism ; Panax notoginseng/chemistry ; Panax notoginseng/metabolism ; Saponins/pharmacology ; Saponins/therapeutic use ; Tumor Necrosis Factor-alpha
Chemical Substances	Apolipoproteins E ; Cholesterol, LDL ; Interleukin-6 ; NF-kappa B ; Saponins ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-01-28
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612828666220128104636
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Article ; Online: Study on the therapeutic effect and mechanism of Tangningtongluo Tablet on diabetic mice.

Cai, Zengxiaorui / Hu, Xiangka / Gui, Liuming / Qi, Mushuang / Zhu, Wanjun / Ren, Ying / Yang, Shuyu / Dai, Chunmei

Journal of diabetes and its complications

2023 Volume 37, Issue 8, Page(s) 108523

Abstract: Aims: To investigate the therapeutic effects of Tangningtongluo Tablet on diabetic mice and its mechanism. This study was established the scientific basis for the clinical application of Tangningtongluo Tablet in the treatment of diabetes mellitus and ... ...

Abstract	Aims: To investigate the therapeutic effects of Tangningtongluo Tablet on diabetic mice and its mechanism. This study was established the scientific basis for the clinical application of Tangningtongluo Tablet in the treatment of diabetes mellitus and provided data supporting the transformation of Tangningtongluo Tablet from an in-hospital preparation to a new Chinese medicine. Methods: In this study, a diabetic mouse model was established by high-glucose and high-fat diet feeding in combination with STZ injection for 4 weeks. Glucose metabolism, lipid metabolism, liver histomorphological changes and liver function related indexes were detected, pancreatic histomorphological changes and insulin resistance related indexes were observed, and the expression of pathway related proteins and inflammatory factors were examined. Results: Glycemia and glycated hemoglobin were reduced in diabetic mice after the treatment of Tangningtongluo Tablet, and glucose tolerance and lipid results were modified. The insulin resistance status of the mice was diminished and tissue damage to the pancreas and liver was repaired. Expression of ERS/NF-κB related pathway proteins was reduced in liver tissues, and inflammatory factors such as TNF-α, IL-6 and IL-1β were reduced in serum. Conclusions: Tangningtongluo Tablet could reduce blood glucose in diabetic mice, regulate the disorder of lipid metabolism, enhance insulin sensitivity, improve insulin resistance, repair pancreatic tissue damage and protect mouse liver in diabetic mice. The mechanism of action might be related to the regulation of ERS/NF-κB signaling pathway and the reduction of TNF-α, IL-6 and IL-1β production.
MeSH term(s)	Animals ; Mice ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat/adverse effects ; Insulin Resistance ; Interleukin-6 ; NF-kappa B ; Tablets/pharmacology ; Tablets/therapeutic use ; Tumor Necrosis Factor-alpha
Chemical Substances	Blood Glucose ; Interleukin-6 ; NF-kappa B ; Tablets ; tangningtongluo ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2023.108523
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Zs.A 2225: Show issues

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Article ; Online: Study on the Anti-Inflammatory Effect and Mechanism of Yuxuebi Tablet Based on Network Pharmacology.

Hu, Xiangka / Shao, Ping / Liu, Xiaojuan / Han, Ling / Gui, Liuming / Cai, Zengxiaorui / Qi, Mushuang / Dai, Chunmei

ACS omega

2022 Volume 7, Issue 36, Page(s) 32784–32794

Abstract: Yuxuebi tablet (YXB) is a Chinese patent medicine with the effect of activating blood circulation and dissipating blood stasis and has been used to treat "Bi" syndrome in China. The aim of this study was to reveal its anti-inflammatory efficacy and ... ...

Abstract	Yuxuebi tablet (YXB) is a Chinese patent medicine with the effect of activating blood circulation and dissipating blood stasis and has been used to treat "Bi" syndrome in China. The aim of this study was to reveal its anti-inflammatory efficacy and mechanism. A carrageenan-induced inflammation mouse model was established to demonstrate the anti-inflammatory efficacy of YXB by detecting the paw swelling degree and inflammatory cell infiltration in paws. The active chemical ingredients and anti-inflammatory targets of YXB were obtained through network pharmacology analysis. Finally, the core anti-inflammatory targets of YXB were determined by the ELISA method and western blot. YXB significantly reduced the paw swelling degree and inflammatory cell infiltration in paws. A total of 120 key active components included in YXB interacted with 56 core inflammatory targets (such as TNF, IL1B, IL6, PTGS2, RELA, MAPK1, MAPK8, and MAPK14), mainly involving in the TNF signaling pathway, Toll-like receptor signaling pathway, NF-kappaB signaling pathway, and NOD-like receptor signaling pathway. Further studies in vivo found that YXB reduced the levels of TNF-α, IL-1β, and IL-6 in serum and inhibited the expression of COX-2 and the phosphorylation levels of NF-κB p65, JNK, and p38 protein in paws. Taken together, YXB had a good anti-inflammatory effect, which might be related to inhibiting the phosphorylation of NF-κB, JUN, and p38 and the decrease of COX-2 expression and the levels of inflammatory factors.
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c04641
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Article ; Online: A Review of Traditional Chinese Medicine on Treatment of Diabetic Nephropathy and the Involved Mechanisms.

Liu, Xiao-Juan / Hu, Xiang-Ka / Yang, He / Gui, Liu-Ming / Cai, Zeng-Xiaorui / Qi, Mu-Shuang / Dai, Chun-Mei

The American journal of Chinese medicine

2022 Volume 50, Issue 7, Page(s) 1739–1779

Abstract: Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM), which can lead to renal failure in diabetic patients. At present, the first-line drugs for DN are mainly the renin-angiotensin system (RAS) inhibitors or ... ...

Abstract	Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM), which can lead to renal failure in diabetic patients. At present, the first-line drugs for DN are mainly the renin-angiotensin system (RAS) inhibitors or angiotensin receptor blockers, and the latest approved aldosterone receptor antagonist finerenone, which delay the progression of DN to end-stage renal disease (ESRD), but the therapeutic effect is still not ideal. With a history of thousands of years, traditional Chinese medicine (TCM) has rich experience in the treatment of DN. Based on the theory of TCM, the clinical treatment of DN mainly focuses on generating fluid and nourishing blood, nourishing
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/etiology ; Drugs, Chinese Herbal/therapeutic use ; Antihypertensive Agents/therapeutic use ; Diabetes Mellitus/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Antihypertensive Agents
Language	English
Publishing date	2022-10-12
Publishing country	Singapore
Document type	Review ; Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X22500744
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Article ; Online: Epigallocatechin Gallate Protects Diabetes Mellitus Rats Complicated with Cardiomyopathy through TGF-β1/JNK Signaling Pathway.

Gui, Liuming / Wang, Fengxian / Hu, Xiangka / Liu, Xiaojuan / Yang, He / Cai, Zengxiaorui / Qi, Mushuang / Dai, Chunmei

Current pharmaceutical design

2022 Volume 28, Issue 33, Page(s) 2758–2770

Abstract: Background: Epigallocatechin gallate (EGCG) is the main component of rhubarb tannin, with antioxidant, anti-angiogenic, anti-cancer and antiviral activities. Diabetes mellitus (DM) is a high blood sugar and protein metabolism disorder syndrome, which is ...

Abstract	Background: Epigallocatechin gallate (EGCG) is the main component of rhubarb tannin, with antioxidant, anti-angiogenic, anti-cancer and antiviral activities. Diabetes mellitus (DM) is a high blood sugar and protein metabolism disorder syndrome, which is caused by absolute or relative factors, such as deficiency of insulin and oxidative stress. Diabetes cardiomyopathy (DCM) is one of the most frequent complications of DM. Objective: This study aims to explore whether EGCG can improve diabetic complication, myocardial fibrosis, in diabetic rats with an intraperitoneal injection of streptozotocin (STZ) through the transforming growth factor β1 (TGF-β1)/C-Jun N -terminal kinase (JNK) signaling pathway. Methods: 50 male SD rats were randomly divided into five groups, including the control group, model group, and EGCG drug groups (10 mg/kg, 20 mg/kg, 40 mg/kg), with 10 rats in each group. Rats, except for the control group, were intraperitoneally injected with STZ (65 mg/kg) to induce the diabetic rats model. EGCG drug groups were given distilled water according to the dose, while the control group and model group were given the same volume of distilled water for 12 weeks. The levels of glucose (GLU), triglyceride (TG), cholesterol (CHO), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) in serum were detected by ELISA of all rats. Myocardial function was observed by HE, Masson staining and Sirius red staining in DCM rats. Immunohistochemistry was used to detect the expression of Collagen I (COL-I) and Collagen III (COL-III), and detect the degree of myocardial fibrosis of DM rats. Western blot was used to detect the expression of matrix metalloproteinases (MMPs), tissue inhibitor of matrix metalloproteinase (TIMPs), TGF-β1, JNK and p-JNK in the myocardium. Results: Compared to the model group, the levels of GLU, TG, CHO, and LDL in serum were decreased while the level of HDL in serum was increased in EGCG groups rats; cardiac index and left ventricular mass index were decreased while heart function was improved in EGCG groups rats; the expressions of the COL-I and COL-III were decreased in EGCG groups, and the high dose group was the best; the expressions of TGF-β1, JNK, p-JNK, and TIMP-1 were down-regulated, and the expression of MMP-9 was up-regulated in EGCG groups. Conclusion: The results demonstrated that EGCG could improve STZ-induced diabetic complication, i.e., myocardial fibrosis, in diabetic rats, and protect their heart through TGF-β1/JNK signaling pathway.
MeSH term(s)	Animals ; Male ; Rats ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies ; Fibrosis ; MAP Kinase Signaling System ; Rats, Sprague-Dawley ; Streptozocin ; Transforming Growth Factor beta1/metabolism
Chemical Substances	epigallocatechin gallate (BQM438CTEL) ; Streptozocin (5W494URQ81) ; Transforming Growth Factor beta1
Language	English
Publishing date	2022-09-28
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612828666220902115437
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Article ; Online: Retraction: Efficient

Li, Kuo / Li, Dan / Li, Cheng-Hsuan / Zhuang, Pengfei / Dai, Chunmei / Hu, Xiangka / Wang, Dahao / Liu, Yuanye / Mei, Xifan / Rotello, Vincent M

Nanoscale

2022 Volume 14, Issue 10, Page(s) 3972

Abstract: Retraction of ' ... ...

Abstract	Retraction of 'Efficient
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d2nr90041f
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Article ; Online: Efficient in vivo wound healing using noble metal nanoclusters.

Li, Kuo / Li, Dan / Li, Cheng-Hsuan / Zhuang, Pengfei / Dai, Chunmei / Hu, Xiangka / Wang, Dahao / Liu, Yuanye / Mei, Xifan / Rotello, Vincent M

publication RETRACTED

Nanoscale

2021 Volume 13, Issue 13, Page(s) 6531–6537

Abstract: The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not been ... ...

Abstract	The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not been extensively explored. We report the use of ultra-small noble metal nanoclusters (NCs) for the treatment of skin wounds. Both in vitro and in vivo studies indicate NCs have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.
MeSH term(s)	Cell Proliferation ; Nanostructures ; Skin ; Wound Healing
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d0nr07176e
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