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Article ; Online: Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study

Dai, Weibo / Yang, Jing / Liu, Xin / Mei, Quanxi / Peng, Weijie / Hu, Xianjing

BMC Complement Med Ther. 2023 Dec., v. 23, no. 1 p.4-4

2023

Abstract: BACKGROUND: Ardisia gigantifolia Stapf. (AGS), a Chinese folk medicine widely grows in the south of China and several studies reported that AGS could inhibit the proliferation of breast cancer, liver cancer, and bladder cancer cell lines. However, little ...

Abstract	BACKGROUND: Ardisia gigantifolia Stapf. (AGS), a Chinese folk medicine widely grows in the south of China and several studies reported that AGS could inhibit the proliferation of breast cancer, liver cancer, and bladder cancer cell lines. However, little is known about its anti-colorectal cancer (CRC) efficiency. METHODS: In the present study, a combination of MTT assay, network pharmacological analysis, bioinformatics, molecular docking, and molecular dynamics simulation study was used to investigate the active ingredients, and targets of AGS against CRC, as well as the potential mechanism. RESULTS: MTT assay showed that three kinds of fractions from AGS, including the n-butanol extract (NBAGS), ethyl acetate fraction (EAAGS), and petroleum ether fraction (PEAGS) significantly inhibited the proliferation of CRC cells, with the IC₅₀ values of 197.24, 264.85, 15.45 µg/mL on HCT116 cells, and 523.6, 323.59, 150.31 µg/mL on SW620 cells, respectively. Eleven active ingredients, including, 11-O-galloylbergenin, 11-O-protocatechuoylbergenin, 11-O-syringylbergenin, ardisiacrispin B, bergenin, epicatechin-3-gallate, gallic acid, quercetin, stigmasterol, stigmasterol-3-o-β-D-glucopyranoside were identified. A total of 173 targets related to the bioactive components and 21,572 targets related to CRC were picked out through database searching. Based on the crossover targets of AGS and CRC, a protein-protein interaction network was built up by the String database, from which it was concluded that the core targets would be SRC, MAPK1, ESR1, HSP90AA1, MAPK8. Besides, GO analysis showed that the numbers of biological process, cellular component, and molecular function of AGS against CRC were 1079, 44, and 132, respectively, and KEGG pathway enrichment indicated that 96 signaling pathways in all would probably be involved in AGS against CRC, among which MAPK signaling pathway, lipid, and atherosclerosis, proteoglycans in cancer, prostate cancer, adherens junction would probably be the major pathways. The docking study verified that AGS had multiple ingredients and multiple targets against CRC. Molecular dynamics (MD) simulation analysis showed that the binding would be stable via forming hydrogen bonds. CONCLUSION: Our study showed that AGS had good anti-CRC potency with the characteristics of multi-ingredients, -targets, and -signaling pathways.
Keywords	Ardisia gigantifolia ; atherosclerosis ; bioinformatics ; breast neoplasms ; butanol ; complement ; databases ; ethyl acetate ; gallic acid ; hydrogen ; liver neoplasms ; molecular dynamics ; neoplasm cells ; petroleum ; pharmacology ; prediction ; prostatic neoplasms ; protein-protein interactions ; proteoglycans ; quercetin ; simulation models ; stigmasterol ; toxicity testing ; traditional medicine ; urinary bladder neoplasms ; China
Language	English
Dates of publication	2023-12
Size	p. 4.
Publishing place	BioMed Central
Document type	Article ; Online
ISSN	2662-7671
DOI	10.1186/s12906-022-03822-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Recent Progress in Electrochemical Nano-Biosensors for Detection of Pesticides and Mycotoxins in Foods.

Gong, Zhaoyuan / Huang, Yueming / Hu, Xianjing / Zhang, Jianye / Chen, Qilei / Chen, Hubiao

Biosensors

2023 Volume 13, Issue 1

Abstract: Pesticide and mycotoxin residues in food are concerning as they are harmful to human health. Traditional methods, such as high-performance liquid chromatography (HPLC) for such detection lack sensitivity and operation convenience. Efficient, accurate ... ...

Abstract	Pesticide and mycotoxin residues in food are concerning as they are harmful to human health. Traditional methods, such as high-performance liquid chromatography (HPLC) for such detection lack sensitivity and operation convenience. Efficient, accurate detection approaches are needed. With the recent development of nanotechnology, electrochemical biosensors based on nanomaterials have shown solid ability to detect trace pesticides and mycotoxins quickly and accurately. In this review, English articles about electrochemical biosensors in the past 11 years (2011-2022) were collected from PubMed database, and various nanomaterials are discussed, including noble metal nanomaterials, magnetic metal nanoparticles, metal-organic frameworks, carbon nanotubes, as well as graphene and its derivatives. Three main roles of such nanomaterials in the detection process are summarized, including biomolecule immobilization, signal generation, and signal amplification. The detection targets involve two types of pesticides (organophosphorus and carbamate) and six types of mycotoxins (aflatoxin, deoxynivalenol, zearalenone, fumonisin, ochratoxin A, and patulin). Although significant achievements have been made in the evolution of electrochemical nano-biosensors, many challenges remain to be overcome.
MeSH term(s)	Humans ; Pesticides ; Nanotubes, Carbon/chemistry ; Nanostructures/chemistry ; Nanotechnology ; Biosensing Techniques ; Patulin
Chemical Substances	Pesticides ; Nanotubes, Carbon ; Patulin (95X2BV4W8R)
Language	English
Publishing date	2023-01-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13010140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polysaccharides from Garlic Protect against Liver Injury in DSS-Induced Inflammatory Bowel Disease of Mice via Suppressing Pyroptosis and Oxidative Damage.

Zhan, Xinyi / Peng, Weijie / Wang, Zhuqiang / Liu, Xin / Dai, Weibo / Mei, Quanxi / Hu, Xianjing

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 2042163

Abstract: Inflammatory bowel disease (IBD), a widespread intestinal disease threatening human health, is commonly accompanied by secondary liver injury (SLI). Pyroptosis and oxidative stress act as an important role underlying the pathophysiology of SLI, during ... ...

Abstract	Inflammatory bowel disease (IBD), a widespread intestinal disease threatening human health, is commonly accompanied by secondary liver injury (SLI). Pyroptosis and oxidative stress act as an important role underlying the pathophysiology of SLI, during which a large number of proinflammatory cytokines and oxidative intermediates can be produced, thereby causing the liver severely damaged. Suppression of pyroptosis and oxidative damage can be considered one of the critical strategies for SLI therapy. Garlic, a natural food with eatable and medicinal functions, is widely used in people's daily life. There is no study about the alleviation of garlic against IBD accompanied with SLI. This study is aimed at investigating the efficacy of the polysaccharides from garlic (PSG) in treating IBD and SLI, as well as its pharmacological mechanism. The results showed that PSG significantly alleviated dextran sulfate sodium-induced IBD determined by evaluating the bodyweight loss, disease activity index, colon length, and colonic pathological examination of mice. PSG significantly reduced the colonic inflammation by reversing the levels of myeloperoxidase, diamine oxidase activity, iNOS, and COX2 and strengthened the intestinal barrier by increasing the expressions of ZO1, occludin, and MUC2 of IBD mice. Furthermore, PSG strongly alleviated SLI determined by assessing the liver morphological change, liver index, levels of ALT and AST, and liver pathological change of mice. Mechanically, PSG reduced the high levels of LPS, IL-1
MeSH term(s)	Animals ; Antioxidants/metabolism ; Dextran Sulfate/toxicity ; Garlic ; Inflammation/pathology ; Inflammatory Bowel Diseases/pathology ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Oxidative Stress ; Polysaccharides/metabolism ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Pyroptosis
Chemical Substances	Antioxidants ; NF-kappa B ; Polysaccharides ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/2042163
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of a prediction model for predicting the prevalence of nonalcoholic fatty liver disease in Chinese nurses: the first-year follow data of a web-based ambispective cohort study.

Che, Ying / Tang, Rongsong / Zhang, Heli / Yang, Min / Geng, Rongmei / Zhuo, Lin / Wang, Peng / Hu, Xianjing / Zhou, Yujie / Wang, Panfeng / Zhan, Siyan / Li, Baohua

BMC gastroenterology

2024 Volume 24, Issue 1, Page(s) 72

Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is gradually becoming a huge threat to public health. With complex working characteristics, female nurses had been found with high risk of NAFLD. To develop and validate a prediction model to predict ... ...

Abstract	Background: Nonalcoholic fatty liver disease (NAFLD) is gradually becoming a huge threat to public health. With complex working characteristics, female nurses had been found with high risk of NAFLD. To develop and validate a prediction model to predict the prevalence of NAFLD based on demographic characteristics, work situation, daily lifestyle and laboratory tests in female nurses. Methods: This study was a part of the Chinese Nurse Cohort Study (The National Nurse Health Study, NNHS), and data were extracted from the first-year follow data collected from 1st June to 1st September 2021 by questionnaires and physical examination records in a comprehensive tertiary hospital. The questionnaires included demographic characteristics, work situation and daily lifestyle. Logistic regression and a nomogram were used to develop and validate the prediction model. Results: A total of 824 female nurses were included in this study. Living situation, smoking history, monthly night shift, daily sleep time, ALT/AST, FBG, TG, HDL-C, UA, BMI, TBil and Ca were independent risk factors for NAFLD occurance. A prediction model for predicting the prevalence of NAFLD among female nurses was developed and verified in this study. Conclusion: Living situation, smoking history, monthly night shift, daily sleep time, ALT/AST, FBG, TG, UA, BMI and Ca were independent predictors, while HDL-C and Tbil were independent protective indicators of NAFLD occurance. The prediction model and nomogram could be applied to predict the prevalence of NAFLD among female nurses, which could be used in health improvement. Trial registration: This study was a part of the Chinese Nurse Cohort Study (The National Nurse Health Study, NNHS), which was a ambispective cohort study contained past data and registered at Clinicaltrials.gov ( https://clinicaltrials.gov/ct2/show/NCT04572347 ) and the China Cohort Consortium ( http://chinacohort.bjmu.edu.cn/project/102/ ).
MeSH term(s)	Humans ; Female ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Cohort Studies ; Prevalence ; Risk Factors ; Internet ; China/epidemiology
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03121-1
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Article ; Online: Ficus pandurata

Dai, Weibo / Zhan, Xinyi / Peng, Weijie / Liu, Xin / Peng, Weiwen / Mei, Quanxi / Hu, Xianjing

Oxidative medicine and cellular longevity

2021 Volume 2021, Page(s) 2617881

Abstract: Inflammatory bowel disease (IBD), a global disease threatening human health, is commonly accompanied by secondary liver damage (SLD) mediated by the gut-liver axis. Oxidative stress acts a critical role in the onset of IBD, during which excessive ... ...

Abstract	Inflammatory bowel disease (IBD), a global disease threatening human health, is commonly accompanied by secondary liver damage (SLD) mediated by the gut-liver axis. Oxidative stress acts a critical role in the onset of IBD, during which excessive oxidation would destroy the tight junctions between intestinal cells, promote proinflammatory factors to penetrate, and thereby damage the intestinal mucosa.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Colitis, Ulcerative/drug therapy ; Disease Models, Animal ; Ficus/chemistry ; Humans ; Liver Diseases/drug therapy ; Male ; Mice
Chemical Substances	Antioxidants
Language	English
Publishing date	2021-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2021/2617881
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis

Dai, Weibo / Chen, Chang / Feng, Huiting / Li, Guangru / Peng, Weiwen / Liu, Xin / Yang, Jing / Hu, Xianjing

Journal of ethnopharmacology. 2021 July 15, v. 275

2021

Abstract: Ficus pandurata Hance (FPH) is a traditional Chinese herbal medicine, which is commonly used for liver protection in the folk of Southeast China. However, the medicinal part and pharmacological mechanism have not been clarified yet.This study aims to ... ...

Abstract	Ficus pandurata Hance (FPH) is a traditional Chinese herbal medicine, which is commonly used for liver protection in the folk of Southeast China. However, the medicinal part and pharmacological mechanism have not been clarified yet.This study aims to investigate the medicinal part of FPH for liver protection and uncover the potential mechanism.Acute alcoholic liver damage (ALD) mice model induced by intragastric administration with 50% alcohol was used to evaluate the liver protection of FPH. Different parts of FPH, including the root (FPHR), stem (FPHS), leaf (FPHL), and whole plant (FPHWP), were selected to investigate the liver-protected efficacy and determine which part is the medicinal part. Acute oral toxicity (AOT) test was performed to determine the acute toxicity of FPH on Kunming mice. The liver-protected effect of FPH was determined by evaluating the liver function, liver morphological changes, and liver pathological changes. The underlying mechanism was investigated by evaluating the effect on oxidative stress, inflammation, and apoptosis in liver tissues via ELISA, H&E staining, Western Blot, and TUNEL staining assays.In the screening test for medicinal parts of FPH, all of the extracts from FPHR, FPHS, FPHL, and FPHWP could alleviate the acute ALD of mice, including reducing abnormal levels of AST, ALT, and relative liver weight. Especially, the alleviated efficacies of FPHS and FPHL were better than those of FPHWP and FPHR, showing that the aerial part (FPHAP, including the stem and leaf), is probably the medicinal part of FPH against acute ALD. In the AOT test, FPHAP at the maximum administration dosage (480 g/kg, calculated based on the quantity of crude material) did not induce obvious abnormality and death of mice, and had no significant influence on body weight, as well as the relative organ weight, showing that the maximum tolerated dose (MTD) of FPHAP was 480 g/kg on Kunming mice. In the anti-acute ALD study, FPHAP significantly reduced the levels of AST, ALT, LDH, ROS, MDA, TNF-α, IL-1β, IL-18, and IL-6, alleviated the morphology of liver injury, increased the levels of SOD and GSH, up-regulated the expressions of Nrf-2, HO-1 and NQO1, and reduced apoptosis of liver cells in acute ALD mice, indicating that FPHAP could significantly alleviate acute ALD by suppressing oxidative stress, inflammation, and apoptosis.FPH could protect acute alcohol-induced liver damage of mice by suppressing oxidative stress, inflammation, and apoptosis. Our study provides scientific evidence for the therapeutic effect of Ficus pandurata Hance in acute ALD mice and suggests its potential development in humans for liver protection, supporting its traditional application.
Keywords	Ficus pandurata ; Oriental traditional medicine ; Western blotting ; acute oral toxicity ; aerial parts ; alcohols ; apoptosis ; death ; inflammation ; interleukin-18 ; interleukin-6 ; intragastric administration ; leaves ; liver ; liver function ; oxidative stress ; therapeutics ; tissue weight ; China
Language	English
Dates of publication	2021-0715
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114140
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Article ; Online: Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation.

Dai, Weibo / Chen, Chang / Dong, Gengting / Li, Guangru / Peng, Weiwen / Liu, Xin / Yang, Jing / Li, Leyu / Xu, Ruiyan / Hu, Xianjing

Journal of ethnopharmacology

2022 Volume 294, Page(s) 115338

Abstract: Ethnopharmacological relevance: Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear.: Aim of the study: To validate the ... ...

Abstract	Ethnopharmacological relevance: Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear. Aim of the study: To validate the efficacy and explore the potential mechanisms of FFSLD in treating T2DM via integrating a network pharmacological approach and experimental evaluation. Materials and methods: T2DM mice model induced by high-fat diet feeding combined with streptozotocin injection was selected to investigate the alleviation of FFSLD against T2DM, via detecting the levels of glucose, insulin, glucagon (GC), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Network pharmacological analysis was used to predict the potential mechanisms, including the pharmacokinetics and drug-likeness screening, active ingredients and potential targets prediction, network analysis, and enrichment analysis. The candidate bioactive molecules of FFSLD, and targets information excavated through TCMSP, Uniprot, GeneCards, OMIM databases, were combined for comprehensive analysis by constructing "drug-compound-target-disease" and "protein-protein interaction" networks. Enrichment analysis was performed via Gene Ontology (GO) and Koto Encyclopedia of Genes and Genomes (KEGG) databases. HepG2 insulin-resistance (IR) cells model induced by high glucose was used to verify the potential mechanisms of FFSLD against T2DM which were predicted by the network pharmacology. Results: The animal study showed that FFSLD significantly decreased the blood glucose, and reversed the abnormal levels of insulin, GC, TG, TC, HDL-C, and LDL-C in T2DM mice. Network pharmacological analysis indicated that 106 active compounds of FFSLD might be correlated with 628 targets in treating T2DM, and the mechanism would probably be related to insulin resistance that harbored a high response value (P = 5.88844 E Conclusions: This study demonstrated that the therapeutic effect of FFSLD on T2DM was related to IR alleviation. The underlying mechanisms were associated with the regulation of PI3K/AKT, JAK/STAT, oxidative stress, and ESR signaling pathways.
MeSH term(s)	Animals ; Cholesterol, LDL ; Diabetes Mellitus, Type 2/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glucose ; Insulin ; Insulin Resistance ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Cholesterol, LDL ; Drugs, Chinese Herbal ; Insulin ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-05-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115338
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Article: Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation

Dai, Weibo / Chen, Chang / Dong, Gengting / Li, Guangru / Peng, Weiwen / Liu, Xin / Yang, Jing / Li, Leyu / Xu, Ruiyan / Hu, Xianjing

Journal of ethnopharmacology. 2022 Aug. 10, v. 294

2022

Abstract: Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear. To validate the efficacy and explore the potential mechanisms of FFSLD in ... ...

Abstract	Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear. To validate the efficacy and explore the potential mechanisms of FFSLD in treating T2DM via integrating a network pharmacological approach and experimental evaluation. T2DM mice model induced by high-fat diet feeding combined with streptozotocin injection was selected to investigate the alleviation of FFSLD against T2DM, via detecting the levels of glucose, insulin, glucagon (GC), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Network pharmacological analysis was used to predict the potential mechanisms, including the pharmacokinetics and drug-likeness screening, active ingredients and potential targets prediction, network analysis, and enrichment analysis. The candidate bioactive molecules of FFSLD, and targets information excavated through TCMSP, Uniprot, GeneCards, OMIM databases, were combined for comprehensive analysis by constructing “drug-compound-target-disease” and “protein-protein interaction” networks. Enrichment analysis was performed via Gene Ontology (GO) and Koto Encyclopedia of Genes and Genomes (KEGG) databases. HepG2 insulin-resistance (IR) cells model induced by high glucose was used to verify the potential mechanisms of FFSLD against T2DM which were predicted by the network pharmacology. The animal study showed that FFSLD significantly decreased the blood glucose, and reversed the abnormal levels of insulin, GC, TG, TC, HDL-C, and LDL-C in T2DM mice. Network pharmacological analysis indicated that 106 active compounds of FFSLD might be correlated with 628 targets in treating T2DM, and the mechanism would probably be related to insulin resistance that harbored a high response value (P = 5.88844 E⁻³³) though regulating Akt1, ESR1, oxidoreductase activity, and JAK/STAT signalings. Experimental validation showed that FFSLD reduced the ROS level, up-regulated the expressions of p-AKT, Nrf-2, and ESR1, and down-regulated the expressions of JAK2, STAT3, and Keap-1 in the HepG2-IR cells model. This study demonstrated that the therapeutic effect of FFSLD on T2DM was related to IR alleviation. The underlying mechanisms were associated with the regulation of PI3K/AKT, JAK/STAT, oxidative stress, and ESR signaling pathways.
Keywords	blood glucose ; gene ontology ; glucagon ; glucose ; herbal medicines ; high density lipoprotein cholesterol ; high fat diet ; insulin ; insulin resistance ; low density lipoprotein cholesterol ; noninsulin-dependent diabetes mellitus ; oxidative stress ; pharmacokinetics ; prediction ; streptozotocin ; therapeutics ; traditional medicine ; triacylglycerols
Language	English
Dates of publication	2022-0810
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115338
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Liver Protection of a Low-Polarity Fraction from

Dai, Weibo / Pang, Xiaoyan / Peng, Weiwen / Zhan, Xinyi / Chen, Chang / Zhao, Wenchang / Zeng, Congyan / Mei, Quanxi / Chen, Qilei / Kuang, Weihong / Gou, Zhanping / Hu, Xianjing

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: ... Ficus ... ...

Abstract	Ficus pandurata
MeSH term(s)	Animals ; Mice ; Antioxidants/pharmacology ; Apoptosis ; Carbon Dioxide/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Ferroptosis ; Ficus/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Liver ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress
Chemical Substances	Antioxidants ; Carbon Dioxide (142M471B3J) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052078
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Article ; Online: Corrigendum to "Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity" [Pharmacol. Res. (2020) 152 104586].

Su, Tao / Huang, Chunhua / Yang, Chunfang / Jiang, Ting / Su, Junfang / Chen, Minting / Fatima, Sarwat / Gong, Rui-Hong / Hu, Xianjing / Bian, Zhaoxiang / Liu, Zhongqiu / Kwan, Hiu Yee

Pharmacological research

2023 Volume 193, Page(s) 106816

Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106816
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