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Article ; Online: MCC950 Ameliorates Acute Exogenous Lipoid Pneumonia Induced by Sewing Machine Oil in Rats

Ye, Wan-Ding / Wang, Hua-Min / Xu, Zi-Jin / Liang, Dong-Shi / Huang, Ai-Rong / Xu, Zhi-Wei / Hu, Xiao-Guang / Jin, Yi-Mei

In vivo (Athens, Greece)

2023 Volume 37, Issue 6, Page(s) 2533–2542

Abstract: Background/aim: Acute exogenous lipoid pneumonia (AELP) is a rare disorder caused by intake of lipid formulations and is often underdiagnosed. Meanwhile, the mechanism of AELP is still underlying. MCC950, was previously found to significantly suppress ... ...

Abstract	Background/aim: Acute exogenous lipoid pneumonia (AELP) is a rare disorder caused by intake of lipid formulations and is often underdiagnosed. Meanwhile, the mechanism of AELP is still underlying. MCC950, was previously found to significantly suppress the release of inflammatory cytokines IL-18 and IL-1β. However, the effect of MCC950 on AELP induced by sewing machine oil has not been reported. Materials and methods: The NLRP3, NF-[Formula: see text]B p65, caspase-1 and IL-1β expression in lung tissues were compared between a rat model of AELP and control rats using western blotting and real-time quantitative assay. Moreover, haematoxylin and eosin (H&E) staining was performed to elucidate the mechanisms by which MCC950 ameliorates sewing machine oil-induced AELP in vivo. Results: MCC950 reduced the expression of NF-[Formula: see text]B p65 in the lung samples of the treatment group and further down-regulated the NLRP3 and caspase-1 levels while inhibited the production of IL-1β. Besides, decreases in inflammatory cell infiltration in the lung were shown using H&E staining. Conclusion: MCC950 ameliorates sewing machine oil-induced acute exogenous lipoid pneumonia in rats through inhibition of the NF-[Formula: see text]B/NLRP3 inflammasome pathway.
MeSH term(s)	Rats ; Animals ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pneumonia, Lipid ; Sulfonamides/pharmacology ; Caspases
Chemical Substances	Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Sulfonamides ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2023-10-30
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13361
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Zs.A 2288: Show issues

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Article: Protective Effects of NaHS/miR-133a-3p on Lipopolysaccharide-Induced Cardiomyocytes Injury.

Jin, Yi-Mei / Huang, Ai-Rong / Yu, Mei-Qian / Ye, Wan-Ding / Hu, Xiao-Guang / Wang, Hua-Min / Xu, Zhi-Wei / Liang, Dong-Shi

Journal of toxicology

2023 Volume 2023, Page(s) 2566754

Abstract: Objective: The aim of this study was to investigate the effects of sodium hydrosulfide (NaHS) on Lipopolysaccharide (LPS)-induced cardiomyocyte injury in H9c2 cells.: Methods: H9c2 cardiomyocytes cultivated with medium containing 10 : Results: ... ...

Abstract	Objective: The aim of this study was to investigate the effects of sodium hydrosulfide (NaHS) on Lipopolysaccharide (LPS)-induced cardiomyocyte injury in H9c2 cells. Methods: H9c2 cardiomyocytes cultivated with medium containing 10 Results: Compared with the control group, the expressions of miR-133a-3p ( Conclusion: Our research demonstrated that NaHS relieved LPS-induced myocardial injury in H9c2 by promoting the expression of miR-133a-3p, inhibiting autophagy in cardiomyocytes, and restoring cellular ATP levels.
Language	English
Publishing date	2023-12-08
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2495098-1
ISSN	1687-8205 ; 1687-8191
ISSN (online)	1687-8205
ISSN	1687-8191
DOI	10.1155/2023/2566754
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Article ; Online: Pharmacokinetics of Voriconazole in Peritoneal Fluid of Critically Ill Patients.

Lin, Xiao-Bin / Hu, Xiao-Guang / Tang, Zhao-Xia / Guo, Peng-Hao / Liu, Xiao-Man / Liang, Tao / Xia, Yan-Zhe / Lui, Ka Yin / Chen, Pan / Tang, Ke-Jing / Chen, Xiao / Cai, Chang-Jie

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 5, Page(s) e0172122

Abstract: Data on the distribution of voriconazole (VRC) in the human peritoneal cavity are sparse. This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the peritoneal fluid of critically ill patients. A total of 19 patients were ... ...

Abstract	Data on the distribution of voriconazole (VRC) in the human peritoneal cavity are sparse. This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the peritoneal fluid of critically ill patients. A total of 19 patients were included. Individual pharmacokinetic curves, drawn after single (first dose on day 1) and multiple (steady-state) doses, displayed a slower rise and lower fluctuation of VRC concentrations in peritoneal fluid than in plasma. Good but variable penetration of VRC into the peritoneal cavity was observed, and the median (range) peritoneal fluid/plasma ratios of the area under the concentration-time curve (AUC) were 0.54 (0.34 to 0.73) and 0.67 (0.63 to 0.94) for single and multiple doses, respectively. Approximately 81% (13/16) of the VRC steady-state trough concentrations (
MeSH term(s)	Humans ; Voriconazole/pharmacokinetics ; Ascitic Fluid ; Critical Illness ; Prospective Studies ; Antifungal Agents/pharmacokinetics ; Candida glabrata ; Microbial Sensitivity Tests
Chemical Substances	Voriconazole (JFU09I87TR) ; Antifungal Agents
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01721-22
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Voriconazole pharmacokinetics in a critically ill patient during extracorporeal membrane oxygenation.

Lin, Xiao-Bin / Hu, Xiao-Guang / Xia, Yan-Zhe / Liu, Xiao-Man / Liang, Tao / Chen, Xiao / Cai, Chang-Jie

Journal of chemotherapy (Florence, Italy)

2021 Volume 34, Issue 4, Page(s) 272–276

Abstract: The pharmacokinetics (PK) of several drugs including antimicrobials might be highly altered during extracorporeal membrane oxygenation (ECMO) therapy. We present the change of voriconazole (VRC) PK during ECMO in a critically ill patient who received ... ...

Abstract	The pharmacokinetics (PK) of several drugs including antimicrobials might be highly altered during extracorporeal membrane oxygenation (ECMO) therapy. We present the change of voriconazole (VRC) PK during ECMO in a critically ill patient who received intravenous VRC at a maintenance dose of 200 mg every 12 h for empirical antifungal therapy. Two PK profiles were drawn before and after the initiation of ECMO therapy. Though the trough levels (both
MeSH term(s)	Administration, Intravenous ; Antifungal Agents/pharmacokinetics ; Antifungal Agents/therapeutic use ; Critical Illness/therapy ; Extracorporeal Membrane Oxygenation ; Humans ; Voriconazole/therapeutic use
Chemical Substances	Antifungal Agents ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2021-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1080/1120009X.2021.2014725
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Zs.A 2701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Novel photochromic infinite coordination polymer particles derived from a diarylethene photoswitch.

Hu, Xiao Guang / Li, XiaoLiang / Yang, Sung Ik

Chemical communications (Cambridge, England)

2015 Volume 51, Issue 53, Page(s) 10636–10639

Abstract: A novel infinite coordination polymer (DAE-ICP) based on zinc nitrite and a diarylethene photoswitch, with reversible photochromic properties in solution and the solid state upon applying photostimuli, was synthesized and characterized by FT-IR, EDX, FE- ... ...

Abstract	A novel infinite coordination polymer (DAE-ICP) based on zinc nitrite and a diarylethene photoswitch, with reversible photochromic properties in solution and the solid state upon applying photostimuli, was synthesized and characterized by FT-IR, EDX, FE-SEM and FE-TEM.
Language	English
Publishing date	2015-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c5cc02447a
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Article: [Advances in the study of myeloid-derived suppressor cells in sepsis].

Hu, Xiao-guang / Liu, En-he / Cai, Chang-jie

Zhonghua wei zhong bing ji jiu yi xue

2013 Volume 25, Issue 4, Page(s) 251–253

MeSH term(s)	Animals ; Humans ; Myeloid Cells/pathology ; Myeloid Cells/physiology ; Sepsis/pathology ; Sepsis/physiopathology
Language	Chinese
Publishing date	2013-04
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.issn.2095-4352.2013.04.021
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Article ; Online: Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction.

Lin, Xiao-Bin / Lui, Ka Yin / Guo, Peng-Hao / Liu, Xiao-Man / Liang, Tao / Hu, Xiao-Guang / Tong, Li / Wu, Jing-Jing / Xia, Yan-Zhe / Chen, Pan / Zhong, Guo-Ping / Chen, Xiao / Cai, Chang-Jie

Pharmacotherapy

2021 Volume 42, Issue 1, Page(s) 23–33

Abstract: Study objectives: This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and to explore the optimal dosing strategies in specific clinical scenarios for ... ...

Abstract	Study objectives: This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and to explore the optimal dosing strategies in specific clinical scenarios for invasive fungal infections (IFIs) caused by common Aspergillus and Candida species. Design: Prospective pharmacokinetics study. Setting: The intensive care unit in a tertiary-care medical center. Patients: A total of 297 plasma VRC concentrations from 26 critically ill patients with liver dysfunction were included in the PPK analysis. Methods: Model-based simulations with therapeutic range of 2-6 mg/L as the plasma trough concentration (C Results: A two-compartment model with first-order elimination adequately described the data. Significant covariates in the final model were body weight on both central and peripheral distribution volume and Child-Pugh class on clearance. Intravenous VRC loading dose of 5 mg/kg every 12 h (q12h) for the first day was adequate for CP-A/B and CP-C patients to attain the C Conclusions: For critically ill patients with liver dysfunction, the loading dose of intravenous VRC should be reduced to 5 mg/kg q12h. Additionally, based on the types of fungal pathogens and their susceptibility to VRC, the adjusted maintenance dose regimens with lower doses or longer dosing intervals should be considered for CP-A/B and CP-C patients.
MeSH term(s)	Administration, Intravenous ; Antifungal Agents/administration & dosage ; Antifungal Agents/pharmacokinetics ; Critical Illness ; Dose-Response Relationship, Drug ; Humans ; Liver Diseases/drug therapy ; Microbial Sensitivity Tests ; Prospective Studies ; Voriconazole/administration & dosage ; Voriconazole/pharmacokinetics
Chemical Substances	Antifungal Agents ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2021-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.2634
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

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Article: Novel photochromic infinite coordination polymer particles derived from a diarylethene photoswitch

Hu, Xiao Guang / Li, XiaoLiang / Yang, Sung Ik

Chemical communications. 2015 June 18, v. 51, no. 53

2015

Abstract	A novel infinite coordination polymer (DAE-ICP) based on zinc nitrite and a diarylethene photoswitch, with reversible photochromic properties in solution and the solid state upon applying photostimuli, was synthesized and characterized by FT-IR, EDX, FE-SEM and FE-TEM.
Keywords	Fourier transform infrared spectroscopy ; chemical reactions ; coordination polymers ; energy-dispersive X-ray analysis ; nitrites ; scanning electron microscopy ; zinc
Language	English
Dates of publication	2015-0618
Size	p. 10636-10639.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c5cc02447a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Clinical Impacts and Outcomes With Possible Donor-Derived Infection in Infected Donor Liver Transplantation: A Single-Center Retrospective Study in China.

Tong, Li / Hu, Xiao-Guang / Huang, Fa / Huang, Shun-Wei / Li, Li-Fen / Tang, Zhao-Xia / Yao, Ji-You / Xu, Jing-Hong / Zhu, Yan-Ping / Chen, Yin-Hua / He, Xiao-Shun / Guan, Xiang-Dong / Cai, ChangJie

The Journal of infectious diseases

2020 Volume 221, Issue Suppl 2, Page(s) S164–S173

Abstract: Background: Information on possible donor-derived transmission events in China is limited. We evaluated the impacts of liver transplantation from infected deceased-donors, analyzed possible donor-derived bacterial or fungal infection events in ... ...

Abstract	Background: Information on possible donor-derived transmission events in China is limited. We evaluated the impacts of liver transplantation from infected deceased-donors, analyzed possible donor-derived bacterial or fungal infection events in recipients, and evaluated the etiologic agents' characteristics and cases outcomes. Methods: A single-center observational study was performed from January 2015 to March 2017 to retrospectively collect data from deceased-donors diagnosed with infection. Clinical data were recorded for each culture-positive donor and the matched liver recipient. The microorganisms were isolated and identified, and antibiotic sensitivity testing was performed. The pathogens distribution and incidence of possible donor-derived infection (P-DDI) events were analyzed and evaluated. Results: Information from 211 donors was collected. Of these, 82 donors were infected and classified as the donation after brain death category. Overall, 149 and 138 pathogens were isolated from 82 infected donors and 82 matched liver recipients, respectively. Gram-positive bacteria, Gram-negative bacteria, and fungi accounted for 42.3% (63 of 149), 46.3% (69 of 149), and 11.4% (17 of 149) of pathogens in infected donors. The incidence of multidrug-resistant bacteria was high and Acinetobacter baumannii was the most concerning species. Infections occurred within the first 2 weeks after liver transplantation with an organ from an infected donor. Compared with the noninfection recipient group, the infection recipient group experienced a longer mechanical ventilation time (P = .004) and intensive care unit stay (P = .003), a higher incidence of renal dysfunction (P = .026) and renal replacement therapy (P = .001), and higher hospital mortality (P = .015). Possible donor-derived infection was observed in 14.6% of cases. Recipients with acute-on-chronic liver failure were more prone to have P-DDI than recipients with other diseases (P = .007; odds ratio = 0.114; 95% confidence interval, .025-.529). Conclusions: When a liver recipient receives a graft from an infected deceased-donor, the postoperative incidence of infection is high and the infection interval is short. In addition, when a possible donor-derived, drug-resistant bacterial infection occurs, recipients may have serious complications and poor outcomes.
MeSH term(s)	Adolescent ; Adult ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/prevention & control ; Bacterial Infections/transmission ; Cadaver ; China ; Drug Resistance, Multiple, Bacterial ; Female ; Humans ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Mycoses/prevention & control ; Mycoses/transmission ; Postoperative Complications/microbiology ; Retrospective Studies ; Tissue Donors ; Young Adult
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-03-16
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiz591
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Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

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Article ; Online: Pharmacokinetics of intravenous voriconazole in patients with liver dysfunction: A prospective study in the intensive care unit.

Lin, Xiao-Bin / Huang, Fa / Tong, Li / Xia, Yan-Zhe / Wu, Jing-Jing / Li, Jia / Hu, Xiao-Guang / Liang, Tao / Liu, Xiao-Man / Zhong, Guo-Ping / Cai, Chang-Jie / Chen, Xiao

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 93, Page(s) 345–352

Abstract: Objectives: To characterize the pharmacokinetics (PK) of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction.: Methods: Patients with liver dysfunction in the intensive care unit (ICU) were included prospectively. The ... ...

Abstract	Objectives: To characterize the pharmacokinetics (PK) of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction. Methods: Patients with liver dysfunction in the intensive care unit (ICU) were included prospectively. The Child-Pugh score was used to categorize the degree of liver dysfunction. The initial intravenous VRC dosing regimen comprised a loading dose of 300 mg every 12 h for the first 24 h, followed by 200 mg every 12 h. The first PK curves (PK curve 1) were drawn within one dosing interval of the first dose for 17 patients; the second PK curves (PK curve 2) were drawn within one dosing interval after a minimum of seven doses for 12 patients. PK parameters were estimated by non-compartmental analysis. Results: There were good correlations between the area under the curve (AUC Conclusions: The CL of VRC decreased with increasing severity of liver dysfunction according to the Child-Pugh classification, along with an increased t
MeSH term(s)	Administration, Intravenous ; Adult ; Aged ; Aged, 80 and over ; Antifungal Agents/pharmacokinetics ; Area Under Curve ; Critical Illness ; Female ; Half-Life ; Humans ; Intensive Care Units ; Liver Diseases/metabolism ; Male ; Middle Aged ; Prospective Studies ; Voriconazole/administration & dosage ; Voriconazole/pharmacokinetics
Chemical Substances	Antifungal Agents ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2020-02-25
Publishing country	Canada
Document type	Journal Article ; Observational Study
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.02.041
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