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  1. Article: Editorial: Recent Research of Complex Structure Machining Technology for Hard-to-Machine Materials.

    Fan, Shukai / Hu, Xiaoyun / Li, Hansong

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: With the development of machining technology, the application scenarios of national defense and military equipment, civil aviation vehicles, and reciprocating air and space vehicles are becoming more and more complicated [ ... ]. ...

    Abstract With the development of machining technology, the application scenarios of national defense and military equipment, civil aviation vehicles, and reciprocating air and space vehicles are becoming more and more complicated [...].
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17020340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Machining Surface Improvement through Electric- and Flow-Field Adjustments in Flying Electrochemical Milling of AA 2219.

    Fan, Shukai / Hu, Xiaoyun / Shen, Junzhi / Ma, Xin / Li, Hansong

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: Electrochemical milling is an ideal technique for machining large-scale 3D structures that consist of aerospace aluminum alloys. The distribution of the electric and flow fields are vital to the quality of the machined surface, and the structures of the ... ...

    Abstract Electrochemical milling is an ideal technique for machining large-scale 3D structures that consist of aerospace aluminum alloys. The distribution of the electric and flow fields are vital to the quality of the machined surface, and the structures of the inner flow channel and bottom outlet have different effects on the electric and flow fields on the machining surface. In this study, two specialized structures of a tool cathode were optimized by simulating the electric and flow fields, and a reasonable design basis for the tool cathode was obtained. Based on this, an ECM experiment was performed with the same machining parameters using different tools, and a 20 mm × 20 mm plane was machined. The experimental results showed that using an appropriate tool cathode can create ideal flow and electric fields, resulting in better processing. After optimizing, the machining plane arithmetic mean deviation decreased by 43% (from 14.050 μm to 6.045 μm), and the region elevation difference decreased by 52% (from 105.93 μm to 55.17 μm).
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17040829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Factors affecting nasal drug delivery and design strategies for intranasal drug delivery.

    Hu, Xiaoyun / Yue, Xiao / Wu, Chuanbin / Zhang, Xuejuan

    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

    2023  Volume 52, Issue 3, Page(s) 328–337

    Abstract: Intranasal drug delivery system is a non-invasive drug delivery route with the advantages of no first-pass effect, rapid effect and brain targeting. It is a feasible alternative to drug delivery via injection, and a potential drug delivery route for the ... ...

    Title translation 鼻腔药物递送的影响因素和提高递送效率的设计策略.
    Abstract Intranasal drug delivery system is a non-invasive drug delivery route with the advantages of no first-pass effect, rapid effect and brain targeting. It is a feasible alternative to drug delivery via injection, and a potential drug delivery route for the central nervous system. However, the nasal physiological environment is complex, and the nasal delivery system requires "integration of medicine and device". Its delivery efficiency is affected by many factors such as the features and formulations of drug, delivery devices and nasal cavity physiology. Some strategies have been designed to improve the solubility, stability, membrane permeability and nasal retention time of drugs. These include the use of prodrugs, adding enzyme inhibitors and absorption enhancers to preparations, and new drug carriers, which can eventually improve the efficiency of intranasal drug delivery. This article reviews recent publications and describes the above mentioned aspects and design strategies for nasal intranasal drug delivery systems to provide insights for the development of intranasal drug delivery systems.
    MeSH term(s) Administration, Intranasal ; Drug Delivery Systems ; Pharmaceutical Preparations ; Drug Carriers ; Brain ; Nasal Cavity/physiology ; Nasal Mucosa
    Chemical Substances Pharmaceutical Preparations ; Drug Carriers
    Language Chinese
    Publishing date 2023-07-20
    Publishing country China
    Document type Review ; Journal Article
    ISSN 1008-9292
    ISSN 1008-9292
    DOI 10.3724/zdxbyxb-2023-0069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mechanochemical asymmetric three-component Mannich reaction involving unreactive arylamines.

    Hu, Xiaoyun / Li, Kang / Yu, Huiting

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 31, Page(s) 6348–6355

    Abstract: We report here a mechanochemical protocol for an asymmetric three-component Mannich reaction involving unreactive arylamines with simple cyclic ketones and arylaldehydes catalyzed by ( ...

    Abstract We report here a mechanochemical protocol for an asymmetric three-component Mannich reaction involving unreactive arylamines with simple cyclic ketones and arylaldehydes catalyzed by (
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00954h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: Mechanochemical asymmetric three-component Mannich reaction involving unreactive arylamines.

    Hu, Xiaoyun / Li, Kang / Yu, Huiting

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 31, Page(s) 6425

    Abstract: Correction for 'Mechanochemical asymmetric three-component Mannich reaction involving unreactive arylamines' by Xiaoyun ... ...

    Abstract Correction for 'Mechanochemical asymmetric three-component Mannich reaction involving unreactive arylamines' by Xiaoyun Hu
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob90113k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: LncRNA POU6F2-AS2 contributes to malignant phenotypes and paclitaxel resistance by promoting SKP2 expression in stomach adenocarcinoma.

    Jin, Yanzhao / Cao, Jiaqing / Cheng, Hua / Hu, Xiaoyun

    Journal of chemotherapy (Florence, Italy)

    2023  Volume 35, Issue 7, Page(s) 638–652

    Abstract: This study aimed to investigate the role and mechanism of POU6F2-AS2 in the development of gastric cancer. POU6F2-AS2 expression was considerably higher in clinical stomach adenocarcinoma (STAD) tissues and gastric cancer cell lines (MKN-28 and MGC-803) ... ...

    Abstract This study aimed to investigate the role and mechanism of POU6F2-AS2 in the development of gastric cancer. POU6F2-AS2 expression was considerably higher in clinical stomach adenocarcinoma (STAD) tissues and gastric cancer cell lines (MKN-28 and MGC-803) than in neighbouring normal tissues and gastric mucosa epithelial cells (GES-1). POU6F2-AS2 overexpression resulted in a low overall survival probability, progression-free survival probability and post progression survival probability, as well as increased cell viability, migration and invasion of gastric cancer cells, thereby inhibiting apoptosis. Based on RNA pull-down, cycloheximide and MG132 incubation experiments, POU6F2-AS2 promoted SKP2 by stabilizing NONO expression. In addition,
    MeSH term(s) Humans ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Cell Line, Tumor ; Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Phenotype ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; POU Domain Factors/genetics ; POU Domain Factors/metabolism
    Chemical Substances MicroRNAs ; RNA, Long Noncoding ; Paclitaxel (P88XT4IS4D) ; POU6F2 protein, human ; POU Domain Factors
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2023.2177807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2701: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 387: Show issues

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  7. Article ; Online: Explanation of the “Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection 2015”： non-invasive assessment of liver fibrosis, treatment strategy and implementation of national programs

    HU Xiaoyun

    Journal of Clinical Hepatology, Vol 31, Iss 6, Pp 829-

    2015  Volume 832

    Keywords hepatitis B ; chronic； liver cirrhosis; developing countries; World Health Organization；guidelines ; Medicine (General) ; R5-920 ; Medicine ; R
    Language Chinese
    Publishing date 2015-06-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study.

    Shan, Jiayi / Hu, Xiaoyun / Chen, Tianzhu / Wang, Yuyang / Huang, Baoyi / Xin, Yijun / Xu, Hua

    Frontiers in public health

    2024  Volume 12, Page(s) 1322140

    Abstract: Background: In recent times, reports have emerged suggesting that a variety of autoimmune disorders may arise after the coronavirus disease 2019 (COVID-19) vaccination. However, causality and underlying mechanisms remain unclear.: Methods: We ... ...

    Abstract Background: In recent times, reports have emerged suggesting that a variety of autoimmune disorders may arise after the coronavirus disease 2019 (COVID-19) vaccination. However, causality and underlying mechanisms remain unclear.
    Methods: We collected summary statistics of COVID-19 vaccination and 31 autoimmune diseases from genome-wide association studies (GWAS) as exposure and outcome, respectively. Random-effects inverse variance weighting (IVW), MR Egger, weighted median, simple mode, and weighted mode were used as analytical methods through Mendelian randomization (MR), and heterogeneity and sensitivity analysis were performed.
    Results: We selected 72 instrumental variables for exposure (
    Conclusion: Our study provided potential evidence for the impact of COVID-19 vaccination on the risk of MS and UC occurrence, but it lacks sufficient robustness, which could provide a new idea for public health policy.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; COVID-19/epidemiology ; COVID-19/prevention & control ; Autoimmune Diseases/etiology ; Autoimmune Diseases/genetics ; Colitis, Ulcerative ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1322140
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  9. Article ; Online: Reversible and irreversible stimuli-responsive chromism of a square-planar platinum(ii) salt.

    Li, Depeng / Guan, Qingqing / Hu, Xiaoyun / Su, Yuhong / Su, Zhen

    RSC advances

    2023  Volume 13, Issue 36, Page(s) 24878–24886

    Abstract: A new simple Pt(ii) terpyridyl salt that shows reversible response towards acetonitrile and irreversible response towards methanol has been reported, accompanied with the colorimetric/luminescent changing from red to yellow. Experimentally and ... ...

    Abstract A new simple Pt(ii) terpyridyl salt that shows reversible response towards acetonitrile and irreversible response towards methanol has been reported, accompanied with the colorimetric/luminescent changing from red to yellow. Experimentally and theoretically, the spectroscopic change derives from the hydrogen bonds between crystal water in the Pt(ii) terpyridyl salt and external organic molecules, and the different strength of hydrogen bond leads either reversible or irreversible stimuli-response. Furthermore, this Pt(ii) terpyridyl salt has been on one hand applied as a probe for sensing acetonitrile in water solution, with high selectivity, good reversibility, proper sensitivity and fast response rate, and on the other hand as advanced anticounterfeiting materials. The current study provides a new approach to acquire and design either reversible or irreversible stimuli-responsive luminescent materials.
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03554a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of piperlonguminine on lung injury in severe acute pancreatitis <em>via</em> the TLR4/NF-κB pathway.

    Hu, Qian / Tao, Ran / Hu, Xiaoyun / Wu, Haibo / Xu, Jianjun

    European journal of histochemistry : EJH

    2023  Volume 67, Issue 2

    Abstract: Acute pancreatitis is an inflammatory response in the pancreas, involving activation of pancreatic enzymes. Severe acute pancreatitis (SAP) often causes systemic complications that affect distant organs, including the lungs. The aim of this study was to ... ...

    Abstract Acute pancreatitis is an inflammatory response in the pancreas, involving activation of pancreatic enzymes. Severe acute pancreatitis (SAP) often causes systemic complications that affect distant organs, including the lungs. The aim of this study was to explore the therapeutic potential of piperlonguminine on SAP-induced lung injury in rat models. Acute pancreatitis was induced in rats by repetitive injections with 4% sodium taurocholate. Histological examination and biochemical assays were used to assess the severity of lung injury, including tissue damage, and levels of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4), reactive oxygen species (ROS), and inflammatory cytokines. We found that piperlonguminine significantly ameliorated pulmonary architectural distortion, hemorrhage, interstitial edema, and alveolar thickening in rats with SAP. In addition, NOX2, NOX4, ROS, and inflammatory cytokine levels in pulmonary tissues were notably decreased in piperlonguminine-treated rats. Piperlonguminine also attenuated the expression levels of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB). Together, our findings demonstrate for the first time that piperlonguminine can ameliorate acute pancreatitis-induced lung injury via inhibitory modulation of inflammatory responses by suppression of the TLR4/NF-κB signaling pathway.
    MeSH term(s) Lung Injury/drug therapy ; Lung Injury/etiology ; NF-kappa B/metabolism ; Pancreatitis/complications ; Pancreatitis/metabolism ; Male ; Animals ; Rats ; Rats, Sprague-Dawley ; Cytokines/blood ; Signal Transduction/drug effects
    Chemical Substances piperlongumine (SGD66V4SVJ) ; NF-kappa B ; Tlr4 protein, rat ; Cytokines
    Language English
    Publishing date 2023-03-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1109511-8
    ISSN 2038-8306 ; 0391-7258 ; 1121-4201 ; 1121-760X
    ISSN (online) 2038-8306
    ISSN 0391-7258 ; 1121-4201 ; 1121-760X
    DOI 10.4081/ejh.2023.3639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 739: Show issues Location:
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