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  1. AU="Hu, Xinfeng"
  2. AU=Sugarman Jeremy AU=Sugarman Jeremy
  3. AU="Tandale, Babasaheb"
  4. AU="Xie, Xinming"

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  1. Artikel: Clinical Characteristics and Current Status of Treatment for Recurrent Bladder Cancer after Surgeries on Upper Tract Urothelial Carcinoma.

    Hu, Xinfeng / Xue, Yufan / Zhu, Guodong

    Diagnostics (Basel, Switzerland)

    2023  Band 13, Heft 5

    Abstract: Upper tract urothelial carcinoma (UTUC) is a relatively rare, but highly malignant, disease with an estimated annual incidence of 2 cases per 100,000 people. The main surgical treatment modalities for UTUC are radical nephroureterectomy (RNU) with ... ...

    Abstract Upper tract urothelial carcinoma (UTUC) is a relatively rare, but highly malignant, disease with an estimated annual incidence of 2 cases per 100,000 people. The main surgical treatment modalities for UTUC are radical nephroureterectomy (RNU) with bladder cuff resection. After surgery, intravesical recurrence (IVR) can occur in up to 47% of patients, and 75% of them present with non-muscle invasive bladder cancer (NMIBC). However, there are few studies focused on the diagnosis and treatment of postoperatively recurrent bladder cancer for patients with previous UTUC history (UTUC-BC), and many of the influencing factors are still controversial. In this article, we performed a narrative review of the recent literature, mainly summarizing the factors influencing postoperative IVR in patients with UTUC and discussing the subsequent prevention, monitoring, and treatment tools for it.
    Sprache Englisch
    Erscheinungsdatum 2023-03-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13051004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Investigating the Role of

    Xu, Shan / Hu, Xinfeng / Chong, Yue / Zhu, Guodong

    International journal of molecular sciences

    2023  Band 24, Heft 15

    Abstract: Forkhead box protein P3 ( ...

    Abstract Forkhead box protein P3 (
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Kidney Neoplasms/metabolism ; Mice, Nude ; Mutation ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics ; Histone Methyltransferases/metabolism
    Chemische Substanzen BAP1 protein, human ; BAP1 protein, mouse ; FOXP3 protein, human ; Transcription Factors ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Histone Methyltransferases (EC 2.1.1.-)
    Sprache Englisch
    Erscheinungsdatum 2023-08-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512301
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Clinical Characteristics of Molecularly Defined Renal Cell Carcinomas.

    Hu, Xinfeng / Tan, Congzhu / Zhu, Guodong

    Current issues in molecular biology

    2023  Band 45, Heft 6, Seite(n) 4763–4777

    Abstract: Kidney tumors comprise a broad spectrum of different histopathological entities, with more than 0.4 million newly diagnosed cases each year, mostly in middle-aged and older men. Based on the description of the 2022 World Health Organization (WHO) ... ...

    Abstract Kidney tumors comprise a broad spectrum of different histopathological entities, with more than 0.4 million newly diagnosed cases each year, mostly in middle-aged and older men. Based on the description of the 2022 World Health Organization (WHO) classification of renal cell carcinoma (RCC), some new categories of tumor types have been added according to their specific molecular typing. However, studies on these types of RCC are still superficial, many types of these RCC currently lack accurate diagnostic standards in the clinic, and treatment protocols are largely consistent with the treatment guidelines for clear cell RCC (ccRCC), which might result in worse treatment outcomes for patients with these types of molecularly defined RCC. In this article, we conduct a narrative review of the literature published in the last 15 years on molecularly defined RCC. The purpose of this review is to summarize the clinical features and the current status of research on the detection and treatment of molecularly defined RCC.
    Sprache Englisch
    Erscheinungsdatum 2023-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45060303
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5122: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Artikel ; Online: Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.

    Zhong, Baisen / Peng, Weiyu / Du, Shan / Chen, Bingyi / Feng, Yajuan / Hu, Xinfeng / Lai, Qi / Liu, Shujie / Zhou, Zhong-Wei / Fang, Pengfei / Wu, Yan / Gao, Feng / Zhou, Huihao / Sun, Litao

    Small science

    2022  Band 2, Heft 6, Seite(n) 2270012

    Abstract: Oridonin Inhibits SARS-CoV-2 Oridonin, a natural product extracted ... ...

    Abstract Oridonin Inhibits SARS-CoV-2 Oridonin, a natural product extracted from
    Sprache Englisch
    Erscheinungsdatum 2022-06-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 3042766-6
    ISSN 2688-4046 ; 2688-4046
    ISSN (online) 2688-4046
    ISSN 2688-4046
    DOI 10.1002/smsc.202270012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.

    Zhong, Baisen / Peng, Weiyu / Du, Shan / Chen, Bingyi / Feng, Yajuan / Hu, Xinfeng / Lai, Qi / Liu, Shujie / Zhou, Zhong-Wei / Fang, Pengfei / Wu, Yan / Gao, Feng / Zhou, Huihao / Sun, Litao

    Small science

    2022  Band 2, Heft 6, Seite(n) 2100124

    Abstract: The current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an enormous threat to public health. The SARS-CoV-2 3C-like protease (3CLpro), which is critical for viral replication and transcription, has been ... ...

    Abstract The current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an enormous threat to public health. The SARS-CoV-2 3C-like protease (3CLpro), which is critical for viral replication and transcription, has been recognized as an ideal drug target. Herein, it is identified that three herbal compounds, Salvianolic acid A (SAA), (-)-Epigallocatechin gallate (EGCG), and Oridonin, directly inhibit the activity of SARS-CoV-2 3CLpro. Further, blocking SARS-CoV-2 infectivity by Oridonin is confirmed in cell-based experiments. By solving the crystal structure of 3CLpro in complex with Oridonin and comparing it to that of other ligands with 3CLpro, it is identified that Oridonin binds at the 3CLpro catalytic site by forming a C-S covalent bond, which is confirmed by mass spectrometry and kinetic study, blocking substrate binding through a nonpeptidomimetic covalent binding mode. Thus, Oridonin is a novel candidate to develop a new antiviral treatment for COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2022-03-13
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 3042766-6
    ISSN 2688-4046 ; 2688-4046
    ISSN (online) 2688-4046
    ISSN 2688-4046
    DOI 10.1002/smsc.202100124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: [An experimental study on effect of autologous platelet-rich plasma on treatment of early intervertebral disc degeneration].

    Hu, Xinfeng / Wang, Chen / Rui, Yunfeng

    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

    2012  Band 26, Heft 8, Seite(n) 977–983

    Abstract: Objective: Platelet-rich plasma (PRP) can stimulate intervertebral disc cell proliferation, promote extracellular matrix synthesis, and inhibit annulus fibrosus cell apoptosis. To investigate the effects of autologous PRP on the treatment of the early ... ...

    Abstract Objective: Platelet-rich plasma (PRP) can stimulate intervertebral disc cell proliferation, promote extracellular matrix synthesis, and inhibit annulus fibrosus cell apoptosis. To investigate the effects of autologous PRP on the treatment of the early intervertebral disc degeneration (IDD) so as to provide the experimental basis for its clinical application.
    Methods: Forty-five healthy New Zealand white rabbits (male or female, weighing 2.5-3.0 kg) were randomly divided into the experimental group (n = 15), the control group (n = 15), and the sham group (n = 15). PRP was prepared from the arterial blood of rabbit's ears of the experimental group with Landesberg's method. The platelet concentrations in both whole blood and PRP were detected. The rabbit model of early IDD was established by annulus fibrosus puncture (L4, 5, L5, 6) in both the experimental group and the control group; 100 microL autologous PRP and 100 microL PBS were injected into the degenerative intervertebral discs respectively after 2 weeks of models creation. In sham group, intervertebral discs were separated and exposed without treatment. The general conditions of the rabbits were observed after building models; at 2 weeks after degeneration, 1 and 2 weeks after intervention, 5 rabbits were selected randomly from each group respectively for MRI observation, histological observation by using HE staining and collagen type II immunohistochemical staining. The signal of lumbar MRI was assessed and the contents of collagen type II were detected.
    Results: The platelet concentration of PRP was about 4.92 times as much as that of the whole blood. All the animals survived to the end of the experiment. At 2 weeks after degeneration, a lower T2 signal was observed in both the experimental group and the control group; the nucleus pulposus cells decreased and extracellular matrix degenerated; and the expression of collagen type II decreased in both the experimental group and control group. The degenerative grade of lumbar MRI in the experimental group and control group were significantly higher than that in the sham group (P < 0.05), and the content of collagen type II were significantly lower than that in the sham group (P < 0.05). At 1, 2 weeks after intervention, disc degeneration in the experimental group was significantly lower than that in control group (P < 0.05), and significant difference was found between experimental group and sham group (P < 0.05). The nucleus pulposus cells and chondroid matrix in the experimental group were more than those in the control group, showing slight stromal fibrosis; but the expression of collage type II was significantly higher than that in the control group (P < 0.05).
    Conclusion: The disc injection of autologous PRP may terminate or even reverse the progress of rabbit early IDD, which may be associated with the role of multiple growth factors of PRP in regulating cell function, improving the tissue microenvironment, and promoting tissue regeneration.
    Mesh-Begriff(e) Animals ; Biological Therapy/methods ; Cell Proliferation ; Collagen Type II/metabolism ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Female ; Immunohistochemistry ; Injections, Spinal ; Intervertebral Disc/diagnostic imaging ; Intervertebral Disc/metabolism ; Intervertebral Disc/pathology ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/therapy ; Lumbar Vertebrae ; Magnetic Resonance Imaging ; Male ; Platelet-Rich Plasma ; Rabbits ; Radiography ; Random Allocation ; Treatment Outcome
    Chemische Substanzen Collagen Type II
    Sprache Chinesisch
    Erscheinungsdatum 2012-08
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 1420212-8
    ISSN 1002-1892
    ISSN 1002-1892
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4866: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel ; Online: Intervertebral disc regeneration using platelet‑rich plasma‑containing bone marrow‑derived mesenchymal stem cells: A preliminary investigation.

    Wang, Shan-Zheng / Jin, Ji-Yang / Guo, Yu-Dong / Ma, Liang-Yu / Chang, Qing / Peng, Xin-Gui / Guo, Fang-Fang / Zhang, Hai-Xiang / Hu, Xin-Feng / Wang, Chen

    Molecular medicine reports

    2016  Band 13, Heft 4, Seite(n) 3475–3481

    Abstract: Platelet‑rich plasma (PRP) is a promising strategy for intervertebral disc degeneration (IDD). However, the short half‑life of growth factors released from PRP cannot continuously stimulate the degenerated discs. Thus, the present study hypothesized that ...

    Abstract Platelet‑rich plasma (PRP) is a promising strategy for intervertebral disc degeneration (IDD). However, the short half‑life of growth factors released from PRP cannot continuously stimulate the degenerated discs. Thus, the present study hypothesized that the combined use of PRP and bone marrow‑derived mesenchymal stem cells (BMSCs) may repair the early degenerated discs in the long term for their synergistic reparative effect. In the present study, following the induction of early IDD by annular puncture in rabbits, PRP was prepared and mixed with BMSCs (PRP‑BMSC group) for injection into the early degenerated discs. As controls, phosphate‑buffered saline (PBS; PBS group) and PRP (PRP group) were similarly injected. Rabbits without any intervention served as a control group. At 8 weeks following treatment, histological changes of the injected discs were assessed. Magnetic resonance imaging (MRI) was used to detect the T2‑weighted signal intensity of the targeted discs at weeks 1, 2 and 8 following treatment. Annular puncture resulted in disc narrowing and decreased T2‑weighted signal intensity. At weeks 1 and 3, MRI examinations showed regenerative changes in the PRP‑BMSC group and PRP group, whereas the PBS group exhibited a continuous degenerative process of the discs. At 8 weeks post‑injection, the PRP‑BMSCs induced a statistically significant restoration of discs, as shown by MRI (PRP‑BMSCs, vs.PRP and PBS; P<0.05), which was also confirmed by histological evaluations. Thus, compared with PRP, the administration of PRP‑containing BMSCs resulted in a superior regenerative effect on the early degenerated discs, which may be a promising therapeutic strategy for the restoration of early degenerated discs.
    Mesh-Begriff(e) Animals ; Bone Marrow Cells/cytology ; Cell Differentiation ; Cells, Cultured ; Collagen Type II/metabolism ; Disease Models, Animal ; Intervertebral Disc/diagnostic imaging ; Intervertebral Disc/metabolism ; Intervertebral Disc/pathology ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Degeneration/therapy ; Magnetic Resonance Imaging ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/metabolism ; Microscopy, Fluorescence ; Platelet-Rich Plasma ; Rabbits
    Chemische Substanzen Collagen Type II
    Sprache Englisch
    Erscheinungsdatum 2016-04
    Erscheinungsland Greece
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1791-3004
    ISSN (online) 1791-3004
    DOI 10.3892/mmr.2016.4983
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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